RPS7 Gene

HGNC Family	S ribosomal proteins (RPS)
Name	ribosomal protein S7
Description	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRibosomal protein S7 (RPS7) is not only a structural component of the ribosome but also exerts critical extraribosomal functions in regulating cell proliferation and differentiation. One study demonstrated that RPS7 interacts with the oncogenic protein MDM2, forming a ternary complex with p53 that stabilizes p53 by preventing its ubiquitination, thereby promoting apoptosis and inhibiting cell proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In parallel, RPS7 was found to interact with the HMG box domain of SRY within nuclear speckles, suggesting a potential role in testis development and male sex determination."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn various malignancies, RPS7 appears to function predominantly as a tumor suppressor. In ovarian cancer, silencing of RPS7 enhanced cell proliferation, cell cycle progression, migration, and invasion, effects that were linked to activation of the PI3K/AKT and MAPK signaling pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, in colorectal cancer, RPS7 inhibited glycolysis by downregulating hypoxia-inducible factor-1α (HIF-1α) as well as key metabolic proteins such as GLUT4 and LDHB, correlating with reduced tumorigenesis and favorable patient outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In lung adenocarcinoma, the transcriptional regulator SMYD2 was shown to activate RPS7 expression, thereby promoting cell proliferation, migration, and invasion; intriguingly, the proliferative effects mediated by SMYD2 were partially reversed by RPS7."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In another cancer context, hepatitis B virus (HBx) enhanced SIRT7 stability leading to deacetylation events that repressed RPS7 expression, contributing to oncogenic cellular transformation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Finally, in prostate cancer cells, PIM1 kinase was found to promote c-Myc–dependent transcription of RPS7, reinforcing ribosomal stress responses and tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in tumorigenesis, RPS7 is subject to regulation by interacting partners that modulate its distribution and function. The ribosomal protein–interacting factor BCCIPβ was shown to govern the balance between RPS7’s ribosomal and ribosome-free pools; deficiency in BCCIPβ redistributes RPS7, impairs overall protein synthesis, and triggers ribosomal stress."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Furthermore, mutations and splice-site variants in the RPS7 gene have been implicated in Diamond–Blackfan anemia (DBA), an inherited bone marrow failure syndrome. In these cases, structural alterations in RPS7 disrupt proper protein translation and activate ribosomal stress pathways that contribute to erythroid aplasia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "D Chen, Z Zhang, M Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1210327"}], "href": "https://doi.org/10.1038/sj.onc.1210327"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17310983"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17310983"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Youichi Sato, Shojiro Yano, Ashraf A Ewis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SRY interacts with ribosomal proteins S7 and L13a in nuclear speckles."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biol Int (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/CBI20090201"}], "href": "https://doi.org/10.1042/CBI20090201"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21114473"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21114473"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ziliang Wang, Jing Hou, Lili Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Small ribosomal protein subunit S7 suppresses ovarian tumorigenesis through regulation of the PI3K/AKT and MAPK pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0079117"}], "href": "https://doi.org/10.1371/journal.pone.0079117"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24244431"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24244431"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Wen Zhang, Duo Tong, Fei Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RPS7 inhibits colorectal cancer growth via decreasing HIF-1α-mediated glycolysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.6807"}], "href": "https://doi.org/10.18632/oncotarget.6807"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26735579"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26735579"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Lei Wu, Fan Kou, Zhenyu Ji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SMYD2 promotes tumorigenesis and metastasis of lung adenocarcinoma through RPS7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-03720-w"}], "href": "https://doi.org/10.1038/s41419-021-03720-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33935284"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33935284"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Vijaya Pandey, Vijay Kumar "}, {"type": "b", "children": [{"type": "t", "text": "Stabilization of SIRT7 deacetylase by viral oncoprotein HBx leads to inhibition of growth restrictive RPS7 gene and facilitates cellular transformation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep14806"}], "href": "https://doi.org/10.1038/srep14806"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26442981"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26442981"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Changwen Zhang, Yunkai Qie, Tong Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Kinase PIM1 promotes prostate cancer cell growth via c-Myc-RPS7-driven ribosomal stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgy126"}], "href": "https://doi.org/10.1093/carcin/bgy126"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30247545"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30247545"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Qian Ba, Xiaoguang Li, Chao Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BCCIPβ modulates the ribosomal and extraribosomal function of S7 through a direct interaction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Cell Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jmcb/mjx019"}], "href": "https://doi.org/10.1093/jmcb/mjx019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28510697"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28510697"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Agata Kubickova, Zuzana Maceckova, Petr Vojta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Missense mutation in RPS7 causes Diamond-Blackfan anemia via alteration of erythrocyte metabolism, protein translation and induction of ribosomal stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood Cells Mol Dis (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bcmd.2022.102690"}], "href": "https://doi.org/10.1016/j.bcmd.2022.102690"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35871033"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35871033"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Liubov O Skorodumova, Ksenia A Davydenko, Alexandra Y Filatova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Splice-site variant in the RPS7 5'-UTR leads to a decrease in the mRNA level and development of Diamond-Blackfan anemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Genet (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cge.14221"}], "href": "https://doi.org/10.1111/cge.14221"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36057918"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36057918"}]}]}]}
Synonyms	eS7, DBA8
Proteins	RS7_HUMAN
NCBI Gene ID	6201
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RPS7 has 10,817 functional associations with biological entities spanning 9 categories (molecular profile, organism, disease, phenotype or trait, functional term, phrase or reference, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 111 datasets.

Click the + buttons to view associations for RPS7 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RPS7 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RPS7 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of RPS7 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RPS7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RPS7 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of RPS7 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RPS7 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RPS7 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RPS7 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with RPS7 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with RPS7 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RPS7 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RPS7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RPS7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with RPS7 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RPS7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing RPS7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing RPS7 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RPS7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RPS7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing RPS7 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RPS7 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RPS7 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with RPS7 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with RPS7 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of RPS7 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving RPS7 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving RPS7 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with RPS7 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RPS7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RPS7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RPS7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with RPS7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at RPS7 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RPS7 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of RPS7 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing RPS7 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of RPS7 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with RPS7 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing RPS7 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of RPS7 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.