{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRUVBL1, also known as Pontin or TIP49, is an evolutionarily conserved AAA+ ATPase that plays central roles in nuclear homeostasis. It helps assemble and regulate major ribonucleoprotein complexes—for example, it is essential for telomerase RNP biogenesis, where it interacts directly with the telomerase reverse transcriptase and associated factors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Moreover, RUVBL1 is an integral subunit of chromatin‐remodeling assemblies such as the INO80 and Tip60/NuA4 complexes, thereby contributing to nucleosome sliding and transcriptional regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " It also influences oncogenic transcriptional networks—including beta‐catenin/TCF–dependent gene activation—and participates in RNAPII-associated cofactor assemblies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": " In addition, RUVBL1 contributes to the assembly of snoRNPs and the stabilization of phosphatidylinositol 3‐kinase–related kinases (PIKKs), further underscoring its multifaceted nuclear functions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in chromatin and RNP assembly, RUVBL1 is pivotal for an efficient DNA damage response and repair. It enables the acetyltransferase activity of the Tip60 complex needed for proper γ‐H2AX dephosphorylation following genotoxic stress"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ", and it appears to facilitate chromatin accessibility during homologous recombination—enhancing RAD51 recruitment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " Structural studies reveal that RUVBL1, in association with RUVBL2, forms dynamic hexameric and dodecameric assemblies with a unique DNA/RNA–binding domain that modulates access to nucleic acids."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "16"}]}, {"type": "t", "text": " Its functions also extend to ensuring the proper abundance and activity of PIKK family proteins, with additional support from its role in nonsense‐mediated mRNA decay."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}, {"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the cytoplasmic realm and during cell division, RUVBL1 is equally indispensable. Its interactions aid in the proper assembly of the microtubule‐organizing machinery by engaging with the γ–tubulin ring complex"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": ", and its regulated dissociation—and phosphorylation by PLK1—is critical for accurate chromosome segregation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": " In addition, RUVBL1 displays intrinsic protein disaggregase activity that helps resolve misfolded protein assemblies"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": ", and its participation in the R2TP/Prefoldin-like complex supports the biogenesis of ribonucleoproteins such as the U5 snRNP."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": " Importantly, aberrant expression of RUVBL1 is linked to oncogenesis, as it is overexpressed in various tumors—including hepatocellular, renal, and breast carcinomas—and promotes cell invasion and epithelial-to-mesenchymal transition."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "22", "end_ref": "26"}]}, {"type": "t", "text": " Its role in cell cycle control is further highlighted by interactions with regulators such as Ecdysoneless"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "27"}]}, {"type": "t", "text": ", and its immunological significance is evidenced by the detection of autoantibodies against the RUVBL1/2 complex in systemic sclerosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "28"}]}, {"type": "t", "text": " Finally, RUVBL1 is exploited by pathogens—for example, Ebola virus nucleoprotein recruits the R2TP complex, including RUVBL1, to assist capsid assembly."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "29"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Andrew S Venteicher, Zhaojing Meng, Philip J Mason, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2008.01.019"}], "href": "https://doi.org/10.1016/j.cell.2008.01.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18358808"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18358808"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jingji Jin, Yong Cai, Tingting Yao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M509128200"}], "href": "https://doi.org/10.1074/jbc.M509128200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16230350"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16230350"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Teena Puri, Petra Wendler, Barbara Sigala, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dodecameric structure and ATPase activity of the human TIP48/TIP49 complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2006.11.030"}], "href": "https://doi.org/10.1016/j.jmb.2006.11.030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17157868"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17157868"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ying Feng, Nana Lee, Eric R Fearon "}, {"type": "b", "children": [{"type": "t", "text": "TIP49 regulates beta-catenin-mediated neoplastic transformation and T-cell factor target gene induction via effects on chromatin remodeling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2003)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14695187"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14695187"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Alexandra Rowe, Jörg Weiske, Tobias S Kramer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phorbol ester enhances KAI1 transcription by recruiting Tip60/Pontin complexes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasia (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1593/neo.08850"}], "href": "https://doi.org/10.1593/neo.08850"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19048121"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19048121"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Philippe Cloutier, Racha Al-Khoury, Mathieu Lavallée-Adam, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High-resolution mapping of the protein interaction network for the human transcription machinery and affinity purification of RNA polymerase II-associated complexes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Methods (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ymeth.2009.05.005"}], "href": "https://doi.org/10.1016/j.ymeth.2009.05.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19450687"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19450687"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Sudhakar Jha, Anindya Dutta "}, {"type": "b", "children": [{"type": "t", "text": "RVB1/RVB2: running rings around molecular biology."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2009.05.016"}], "href": "https://doi.org/10.1016/j.molcel.2009.05.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19524533"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19524533"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Natsuko Izumi, Akio Yamashita, Akihiro Iwamatsu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.2000468"}], "href": "https://doi.org/10.1126/scisignal.2000468"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20371770"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20371770"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jason S Lee, Yunho Kim, Jinhyuk Bhin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypoxia-induced methylation of a pontin chromatin remodeling factor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1106106108"}], "href": "https://doi.org/10.1073/pnas.1106106108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21825155"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21825155"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Ricardo J Aramayo, Oliver Willhoft, Rafael Ayala, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cryo-EM structures of the human INO80 chromatin-remodeling complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41594-017-0003-7"}], "href": "https://doi.org/10.1038/s41594-017-0003-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29323271"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29323271"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Sudhakar Jha, Etsuko Shibata, Anindya Dutta "}, {"type": "b", "children": [{"type": "t", "text": "Human Rvb1/Tip49 is required for the histone acetyltransferase activity of Tip60/NuA4 and for the downregulation of phosphorylation on H2AX after DNA damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01983-07"}], "href": "https://doi.org/10.1128/MCB.01983-07"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18285460"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18285460"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Thomas L Clarke, Maria Pilar Sanchez-Bailon, Kelly Chiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2017.01.019"}], "href": "https://doi.org/10.1016/j.molcel.2017.01.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28238654"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28238654"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Fenghua Yang, David L Aiello, W Glen Pyle "}, {"type": "b", "children": [{"type": "t", "text": "Cardiac myofilament regulation by protein phosphatase type 1alpha and CapZ."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1139/o07-150"}], "href": "https://doi.org/10.1139/o07-150"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18364747"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18364747"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Pedro M Matias, Sabine Gorynia, Peter Donner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Crystal structure of the human AAA+ protein RuvBL1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M605625200"}], "href": "https://doi.org/10.1074/jbc.M605625200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17060327"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17060327"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Andrés López-Perrote, Hugo Muñoz-Hernández, David Gil, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Conformational transitions regulate the exposure of a DNA-binding domain in the RuvBL1-RuvBL2 complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gks871"}], "href": "https://doi.org/10.1093/nar/gks871"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23002137"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23002137"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Sabine Gorynia, Tiago M Bandeiras, Filipa G Pinho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural and functional insights into a dodecameric molecular machine - the RuvBL1/RuvBL2 complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Struct Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jsb.2011.09.001"}], "href": "https://doi.org/10.1016/j.jsb.2011.09.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21933716"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21933716"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Rosario Machado-Pinilla, Dominique Liger, Nicolas Leulliot, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mechanism of the AAA+ ATPases pontin and reptin in the biogenesis of H/ACA RNPs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "RNA (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1261/rna.034942.112"}], "href": "https://doi.org/10.1261/rna.034942.112"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22923768"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22923768"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Y Zhao, C Zhang, X Yue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pontin, a new mutant p53-binding protein, promotes gain-of-function of mutant p53."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cdd.2015.33"}], "href": "https://doi.org/10.1038/cdd.2015.33"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25857266"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25857266"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Christian Gentili, Dennis Castor, Svenja Kaden, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chromosome Missegregation Associated with RUVBL1 Deficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0133576"}], "href": "https://doi.org/10.1371/journal.pone.0133576"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26201077"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26201077"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Nava Zaarur, Xiaobin Xu, Patrick Lestienne, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RuvbL1 and RuvbL2 enhance aggresome formation and disaggregate amyloid fibrils."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embj.201591245"}], "href": "https://doi.org/10.15252/embj.201591245"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26303906"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26303906"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Philippe Cloutier, Christian Poitras, Mathieu Durand, et al. "}, {"type": "b", "children": [{"type": "t", "text": "R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms15615"}], "href": "https://doi.org/10.1038/ncomms15615"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28561026"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28561026"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Mary L Carlson, Ellen T Wilson, Stephen M Prescott "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of COX-2 transcription in a colon cancer cell line by Pontin52/TIP49a."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1476-4598-2-42"}], "href": "https://doi.org/10.1186/1476-4598-2-42"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14675489"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14675489"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Johannes C Lauscher, Sefer Elezkurtaj, Sonja Dullat, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased Pontin expression is a potential predictor for outcome in sporadic colorectal carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2012.1968"}], "href": "https://doi.org/10.3892/or.2012.1968"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22895545"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22895545"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Keisuke Taniuchi, Mutsuo Furihata, Shinji Iwasaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RUVBL1 directly binds actin filaments and induces formation of cell protrusions to promote pancreatic cancer cell invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2014.2380"}], "href": "https://doi.org/10.3892/ijo.2014.2380"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24728183"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24728183"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Xiang Zhang, Juchao Ren, Lei Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cytoplasmic expression of pontin in renal cell carcinoma correlates with tumor invasion, metastasis and patients' survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0118659"}], "href": "https://doi.org/10.1371/journal.pone.0118659"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25751257"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25751257"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Wenjun Fan, Jiajun Xie, Jianglong Xia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RUVBL1-ITFG1 interaction is required for collective invasion in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Gen Subj (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbagen.2017.03.016"}], "href": "https://doi.org/10.1016/j.bbagen.2017.03.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28341484"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28341484"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Riyaz A Mir, Aditya Bele, Sameer Mirza, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Novel Interaction of Ecdysoneless (ECD) Protein with R2TP Complex Component RUVBL1 Is Required for the Functional Role of ECD in Cell Cycle Progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00594-15"}], "href": "https://doi.org/10.1128/MCB.00594-15"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26711270"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26711270"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Kenzou Kaji, Noreen Fertig, Thomas A Medsger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Autoantibodies to RuvBL1 and RuvBL2: a novel systemic sclerosis-related antibody associated with diffuse cutaneous and skeletal muscle involvement."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Care Res (Hoboken) (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/acr.22163"}], "href": "https://doi.org/10.1002/acr.22163"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24023044"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24023044"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "M Jane Morwitzer, Sarah R Tritsch, Lisa H Cazares, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of RUVBL1 and RUVBL2 as Novel Cellular Interactors of the Ebola Virus Nucleoprotein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Viruses (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/v11040372"}], "href": "https://doi.org/10.3390/v11040372"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31018511"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31018511"}]}]}]}