RYK Gene

HGNC Family	Receptor kinases
Name	receptor-like tyrosine kinase
Description	The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nReceptor‐like tyrosine kinase (RYK) functions as an atypical transmembrane receptor for the Wnt family of secreted glycoproteins. Although it lacks intrinsic kinase activity, RYK binds Wnt ligands through its Wnt inhibitory factor–like (WIF) extracellular domain. Its availability at the plasma membrane is tightly regulated by mechanisms such as MIB1‐mediated ubiquitination, which in turn modulates canonical Wnt/β‐catenin signaling as well as noncanonical pathways including those controlling cytoskeletal dynamics. Structural studies have further revealed that RYK, like other Wnt‐binding receptors, adopts a pseudokinase conformation that is maintained by occlusion of the ATP‐binding pocket, thereby suggesting alternative regulatory functions accomplished via protein–protein interactions rather than catalytic activity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its biochemical role in ligand binding and signal modulation, RYK plays critical functions in developmental processes and tissue morphogenesis. It is implicated in neural patterning, axon guidance, and the regulation of planar cell polarity, with studies showing that perturbations in RYK are linked to defects in orofacial development such as cleft lip and palate. In addition, RYK has been shown to influence vascular endothelial behavior by modulating actin cytoskeletal remodeling and cellular permeability, while comparative analyses have revealed species‐specific differences in its interactions with other receptors such as the Eph family. Collectively, these investigations underscore RYK’s importance in embryonic patterning and organogenesis as well as in maintaining tissue homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of human disease, aberrant RYK signaling has emerged as an influential factor in cancer progression and other pathological conditions. Elevated RYK expression promotes cancer stem cell properties in glioblastoma, facilitates invasive behavior through the induction of matrix metalloproteinases, and drives epithelial-to-mesenchymal transition in gastric cancer models. Mechanistic insights reveal that RYK signals by stabilizing β‐catenin and engaging downstream effectors such as RhoA, while its interactions with co-receptors further refine the specificity of Wnt responses in tumorigenesis. Moreover, emerging studies in additional systems—notably within vascular and breast cancer paradigms—highlight RYK’s potential as a therapeutic target, reinforcing its importance as a nodal regulator in both developmental and disease-related signaling networks."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jason D Berndt, Atsushi Aoyagi, Peitzu Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201107021"}], "href": "https://doi.org/10.1083/jcb.201107021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21875946"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21875946"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Maria L Macheda, Willy W Sun, Kumudhini Kugathasan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Wnt receptor Ryk plays a role in mammalian planar cell polarity signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.362681"}], "href": "https://doi.org/10.1074/jbc.M112.362681"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22773843"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22773843"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Joshua B Sheetz, Sebastian Mathea, Hanna Karvonen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2020.06.018"}], "href": "https://doi.org/10.1016/j.molcel.2020.06.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32619402"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32619402"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Tonia C Carter, Anne M Molloy, Faith Pangilinan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Testing reported associations of genetic risk factors for oral clefts in a large Irish study population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Birth Defects Res A Clin Mol Teratol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/bdra.20639"}], "href": "https://doi.org/10.1002/bdra.20639"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19937600"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19937600"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Tom Skaria, Esther Bachli, Gabriele Schoedon "}, {"type": "b", "children": [{"type": "t", "text": "Wnt5A/Ryk signaling critically affects barrier function in human vascular endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Adh Migr (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/19336918.2016.1178449"}], "href": "https://doi.org/10.1080/19336918.2016.1178449"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27159116"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27159116"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Elisabeth Trivier, Trivadi S Ganesan "}, {"type": "b", "children": [{"type": "t", "text": "RYK, a catalytically inactive receptor tyrosine kinase, associates with EphB2 and EphB3 but does not interact with AF-6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M202486200"}], "href": "https://doi.org/10.1074/jbc.M202486200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11956217"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11956217"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Akira Watanabe, Sadanori Akita, Nguyen Thi Duc Tin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A mutation in RYK is a genetic factor for nonsyndromic cleft lip and palate."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cleft Palate Craniofac J (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1597/04-145.1"}], "href": "https://doi.org/10.1597/04-145.1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16681403"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16681403"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Hyun-Taek Kim, Paolo Panza, Khrievono Kikhi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WNT/RYK signaling functions as an antiinflammatory modulator in the lung mesenchyme."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.2201707119"}], "href": "https://doi.org/10.1073/pnas.2201707119"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35671428"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35671428"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Mārtiņš Vaivads, Ilze Akota, Māra Pilmane "}, {"type": "b", "children": [{"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "PAX7"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": ", "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "PAX9"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " and "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "RYK"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Expression in Cleft Affected Tissue."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Medicina (Kaunas) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/medicina57101075"}], "href": "https://doi.org/10.3390/medicina57101075"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34684112"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34684112"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "James P Roy, Michael M Halford, Steven A Stacker "}, {"type": "b", "children": [{"type": "t", "text": "The biochemistry, signalling and disease relevance of RYK and other WNT-binding receptor tyrosine kinases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Growth Factors (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/08977194.2018.1472089"}], "href": "https://doi.org/10.1080/08977194.2018.1472089"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29806777"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29806777"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Assunta Adamo, Danilo Fiore, Fabio De Martino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RYK promotes the stemness of glioblastoma cells via the WNT/ β-catenin pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.14564"}], "href": "https://doi.org/10.18632/oncotarget.14564"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28086236"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28086236"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Cendrine Tourette, Francesca Farina, Rafael P Vazquez-Manrique, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Wnt receptor Ryk reduces neuronal and cell survival capacity by repressing FOXO activity during the early phases of mutant huntingtin pathogenicity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pbio.1001895"}], "href": "https://doi.org/10.1371/journal.pbio.1001895"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24960609"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24960609"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Mika Habu, Hirofumi Koyama, Michiko Kishida, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ryk is essential for Wnt-5a-dependent invasiveness in human glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biochem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jb/mvu015"}], "href": "https://doi.org/10.1093/jb/mvu015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24621529"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24621529"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Yuil Kim, Mineui Hong, In-Gu Do, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Wnt5a, Ryk and Ror2 expression in glioblastoma subgroups."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2015.10.001"}], "href": "https://doi.org/10.1016/j.prp.2015.10.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26596412"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26596412"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Hirofumi Hirano, Hajime Yonezawa, Shunji Yunoue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Immunoreactivity of Wnt5a, Fzd2, Fzd6, and Ryk in glioblastoma: evaluative methodology for DAB chromogenic immunostaining."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Tumor Pathol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10014-013-0153-1"}], "href": "https://doi.org/10.1007/s10014-013-0153-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23748645"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23748645"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Krithika S Rao, Alexander Aronshtam, Keara L McElory-Yaggy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human epicardial cell-conditioned medium contains HGF/IgG complexes that phosphorylate RYK and protect against vascular injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cardiovasc Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/cvr/cvv168"}], "href": "https://doi.org/10.1093/cvr/cvv168"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26025956"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26025956"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Zhaoyi Liang, Lu Liu, Ruixia Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of exosomal miR-7-5p promotes breast cancer migration and invasion by targeting RYK and participating in the atypical WNT signalling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Biol Lett (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s11658-022-00393-x"}], "href": "https://doi.org/10.1186/s11658-022-00393-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36210461"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36210461"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Yongan Fu, Yilin Chen, Jinghua Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RYK, a receptor of noncanonical Wnt ligand Wnt5a, is positively correlated with gastric cancer tumorigenesis and potential of liver metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Gastrointest Liver Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpgi.00228.2019"}], "href": "https://doi.org/10.1152/ajpgi.00228.2019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31869240"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31869240"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Guojin Zhou, Shoude Zhang, Mao Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive analysis reveals COPB2 and RYK associated with tumor stages of larynx squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-022-09766-z"}], "href": "https://doi.org/10.1186/s12885-022-09766-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35715770"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35715770"}]}]}]}
Synonyms	JTK5, RYK1, D3S3195, JTK5A
Proteins	RYK_HUMAN
NCBI Gene ID	6259
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RYK has 6,664 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 122 datasets.

Click the + buttons to view associations for RYK from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RYK Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by RYK gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RYK gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of RYK gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of RYK gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of RYK gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RYK gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RYK gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of RYK gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RYK gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RYK gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RYK gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of RYK gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with RYK gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with RYK gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RYK gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RYK gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RYK gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RYK gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RYK protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing RYK protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RYK protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RYK protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing RYK protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RYK gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RYK gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with RYK gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with RYK gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of RYK protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with RYK gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RYK gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RYK gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RYK gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with RYK gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at RYK gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RYK gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of RYK gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing RYK from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with RYK gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with RYK gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of RYK gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.