S100A13 Gene

HGNC Family	S100 calcium binding proteins (S100)
Name	S100 calcium binding protein A13
Description	The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with a high expression level in thyroid gland. In smooth muscle cells, this protein co-expresses with other family members in the nucleus and in stress fibers, suggesting diverse functions in signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nS100A13 is a multifunctional, calcium‐binding protein that plays a central role in non‐classical protein secretion. In response to cellular stress and elevated intracellular calcium—as well as in a copper‐dependent manner—S100A13 participates in the formation of multiprotein complexes that mediate the release of signal peptide–less proteins such as fibroblast growth factor‑1 (FGF‑1) and interleukin‑1α (IL‑1α). This secretory process is essential for propagating proangiogenic and inflammatory signals in diverse cell types. The involvement of S100A13 in these unconventional secretory pathways has been demonstrated through studies on endothelial cells and fibroblast models, where its up-regulation promotes the externalization of key molecules, thereby activating downstream pathways like NF‑κB signaling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nApart from its role in protein export, S100A13 is closely associated with angiogenesis and tumor progression. Its elevated expression has been correlated with increased levels of vascular endothelial growth factor‑A (VEGF‑A) and higher microvessel density in a variety of cancers—including melanomas, gliomas, thyroid and non‐small cell lung cancers—as well as in endometriotic lesions. Through promoting the release of proangiogenic factors, S100A13 contributes to the shift from benign or early lesions toward more aggressive, vascularized, and invasive tumor phenotypes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nStructural and additional functional studies further elucidate the diverse roles of S100A13. Crystallographic and solution structure analyses reveal that S100A13 exists as a Ca²⁺‐bound homodimer with unique amphiphilic α‑helical features that likely facilitate its interaction with key cellular partners, including the receptor for advanced glycation end products (RAGE). Such interactions may trigger downstream signaling cascades—including NF‑κB activation—and influence processes from developmental patterning in the fetal brain to the regulation of the senescence-associated secretory phenotype (SASP) in aging cells. These findings underscore the protein’s multifaceted contributions not only to extracellular signal release but also to receptor-mediated intracellular responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Anna Mandinova, Raffaella Soldi, Irene Graziani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "S100A13 mediates the copper-dependent stress-induced release of IL-1alpha from both human U937 and murine NIH 3T3 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.00471"}], "href": "https://doi.org/10.1242/jcs.00471"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12746488"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12746488"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Fabiana Lica Imai, Koji Nagata, Naoto Yonezawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Crystallization and preliminary X-ray analysis of human S100A13."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Crystallogr Sect F Struct Biol Cryst Commun (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1107/S1744309106042473"}], "href": "https://doi.org/10.1107/S1744309106042473"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17077500"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17077500"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Sepuru K Mohan, Chin Yu "}, {"type": "b", "children": [{"type": "t", "text": "The IL1alpha-S100A13 heterotetrameric complex structure: a component in the non-classical pathway for interleukin 1alpha secretion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.201954"}], "href": "https://doi.org/10.1074/jbc.M110.201954"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21270123"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21270123"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Soren Hayrabedyan, Stanimir Kyurkchiev, Ivan Kehayov "}, {"type": "b", "children": [{"type": "t", "text": "Endoglin (cd105) and S100A13 as markers of active angiogenesis in endometriosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Biol (2005)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15821778"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15821778"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "M Landriscina, G Schinzari, G Di Leonardo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "S100A13, a new marker of angiogenesis in human astrocytic gliomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurooncol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11060-006-9189-y"}], "href": "https://doi.org/10.1007/s11060-006-9189-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16773219"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16773219"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Daniela Massi, Matteo Landriscina, Annamaria Piscazzi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "S100A13 is a new angiogenic marker in human melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mod Pathol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/modpathol.2010.54"}], "href": "https://doi.org/10.1038/modpathol.2010.54"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20208480"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20208480"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Renxian Cao, Bin Yan, Huiling Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effect of human S100A13 gene silencing on FGF-1 transportation in human endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Formos Med Assoc (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/S0929-6646(10)60103-9"}], "href": "https://doi.org/10.1016/S0929-6646(10"}, {"type": "t", "text": "60103-9) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20863990"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20863990"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jing Zhong, Chang Liu, Ya-jun Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The association between S100A13 and HMGA1 in the modulation of thyroid cancer proliferation and invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-016-0824-x"}], "href": "https://doi.org/10.1186/s12967-016-0824-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27008379"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27008379"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Shuncheng Miao, Tong Qiu, Yandong Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of S100A13 protein is associated with tumor angiogenesis and poor survival in patients with early-stage non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Thorac Cancer (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/1759-7714.12797"}], "href": "https://doi.org/10.1111/1759-7714.12797"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30047626"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30047626"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Wood Yee Chan, Chun-Lin Xia, Da-Cui Dong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential expression of S100 proteins in the developing human hippocampus and temporal cortex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Microsc Res Tech (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jemt.10302"}], "href": "https://doi.org/10.1002/jemt.10302"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12645008"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12645008"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Hsiao-Ling Hsieh, Beat W Schäfer, Bernd Weigle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "S100 protein translocation in response to extracellular S100 is mediated by receptor for advanced glycation endproducts in human endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2004.02.135"}], "href": "https://doi.org/10.1016/j.bbrc.2004.02.135"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15033494"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15033494"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Mei Li, Ping-Feng Zhang, Xiao-Wei Pan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Crystal structure study on human S100A13 at 2.0 A resolution."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2007.03.014"}], "href": "https://doi.org/10.1016/j.bbrc.2007.03.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17374362"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17374362"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Sandhya G Rani, Krishna Mohan Sepuru, Chin Yu "}, {"type": "b", "children": [{"type": "t", "text": "Interaction of S100A13 with C2 domain of receptor for advanced glycation end products (RAGE)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbapap.2014.06.017"}], "href": "https://doi.org/10.1016/j.bbapap.2014.06.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24982031"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24982031"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Yuanyuan Su, Chenzhong Xu, Zhaomeng Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "S100A13 promotes senescence-associated secretory phenotype and cellular senescence via modulation of non-classical secretion of IL-1α."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.101760"}], "href": "https://doi.org/10.18632/aging.101760"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30670674"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30670674"}]}]}]}
Proteins	S10AD_HUMAN
NCBI Gene ID	6284
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Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

S100A13 has 7,799 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 115 datasets.

Click the + buttons to view associations for S100A13 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

S100A13 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by S100A13 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of S100A13 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of S100A13 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of S100A13 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of S100A13 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of S100A13 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of S100A13 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of S100A13 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of S100A13 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of S100A13 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of S100A13 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of S100A13 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of S100A13 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with S100A13 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with S100A13 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of S100A13 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of S100A13 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of S100A13 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of S100A13 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing S100A13 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of S100A13 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing S100A13 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing S100A13 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing S100A13 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing S100A13 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with S100A13 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with S100A13 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of S100A13 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with S100A13 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with S100A13 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with S100A13 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by S100A13 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with S100A13 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with S100A13 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with S100A13 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with S100A13 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for S100A13 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at S100A13 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of S100A13 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of S100A13 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.