SAFB Gene

HGNC Family	RNA binding motif containing (RBM)
Name	scaffold attachment factor B
Description	This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nScaffold attachment factor B (SAFB) proteins, including SAFB1 and SAFB2, are multifunctional nuclear matrix‐associated regulators central to coordinating chromatin architecture and transcription. They act as corepressors for various nuclear receptors—including estrogen receptor α, peroxisome proliferator–activated receptors, and others—by interacting with the basal transcription machinery and co‐repressors, such as N-CoR. Furthermore, post‐translational modifications like SUMOylation enhance their repressive capacities, thereby fine-tuning gene expression programs."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond transcriptional control, SAFB proteins contribute to overall nuclear organization and the DNA damage response. They help stabilize higher-order chromatin structures—modulating heterochromatin condensation—and are dynamically recruited to sites of DNA damage to facilitate efficient γH2AX spreading. In addition, regulated proteolytic processing of SAFB is observed during apoptosis, implying an important role in nuclear reorganization during cell death."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSAFB proteins also function as key platforms in RNA processing and splicing regulation. They bind directly to RNA and interact with other RNA-binding proteins—such as FUS—and regulators of splicing kinase activity. Genome-wide mapping studies reveal that SAFB1 extensively associates with both coding and noncoding transcripts, underscoring its role in coupling promoter activity with mRNA processing and alternative splicing control."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the realm of oncogenesis, SAFB proteins have emerged as significant tumor suppressors. In breast, colorectal, and prostate cancers, altered expression or mutation of SAFB correlates with deregulated nuclear receptor signaling and disrupted control of genes involved in proliferation, apoptosis, and differentiation. By repressing targets—for example, through downregulation of TAK1 and modulation of NF-κB and androgen receptor pathways—they help maintain cellular homeostasis and inhibit tumor progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "17", "end_ref": "22"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, SAFB1 contributes to additional signaling pathways and stress responses. It can repress HIV-1 transcription by interfering with RNA polymerase II recruitment, influence RAS membrane association via regulation of prenyltransferase expression, and participate in oncogenic complexes with factors such as HOXA9 and SKA1 that modulate signaling cascades linked to metastasis and cellular stress resistance. Its involvement in forming nuclear granules during thermal stress further emphasizes a role in mediating adaptive responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "23", "end_ref": "27"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiangru Huo, Luzhang Ji, Yuwen Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Nuclear Matrix Protein SAFB Cooperates with Major Satellite RNAs to Stabilize Heterochromatin Architecture Partially through Phase Separation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2019.10.001"}], "href": "https://doi.org/10.1016/j.molcel.2019.10.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31677973"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31677973"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Steven M Townson, Kaiyan Kang, Adrian V Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure-function analysis of the estrogen receptor alpha corepressor scaffold attachment factor-B1: identification of a potent transcriptional repression domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M313726200"}], "href": "https://doi.org/10.1074/jbc.M313726200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15066997"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15066997"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Shiming Jiang, Rene Meyer, Kaiyan Kang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Scaffold attachment factor SAFB1 suppresses estrogen receptor alpha-mediated transcription in part via interaction with nuclear receptor corepressor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2005-0100"}], "href": "https://doi.org/10.1210/me.2005-0100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16195251"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16195251"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "M-B Debril, L Dubuquoy, J-N Feige, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Scaffold attachment factor B1 directly interacts with nuclear receptors in living cells and represses transcriptional activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Endocrinol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1677/jme.1.01856"}], "href": "https://doi.org/10.1677/jme.1.01856"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16326836"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16326836"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Stephanie Hammerich-Hille, Valerie J Bardout, Susan G Hilsenbeck, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Low SAFB levels are associated with worse outcome in breast cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer Res Treat (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10549-008-0297-6"}], "href": "https://doi.org/10.1007/s10549-008-0297-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19137425"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19137425"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Takashi Hashimoto, Ken-Ichi Matsuda, Mitsuhiro Kawata "}, {"type": "b", "children": [{"type": "t", "text": "Scaffold attachment factor B (SAFB)1 and SAFB2 cooperatively inhibit the intranuclear mobility and function of ERα."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.24182"}], "href": "https://doi.org/10.1002/jcb.24182"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22566185"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22566185"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jason P Garee, Rene Meyer, Steffi Oesterreich "}, {"type": "b", "children": [{"type": "t", "text": "Co-repressor activity of scaffold attachment factor B1 requires sumoylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2011.04.040"}], "href": "https://doi.org/10.1016/j.bbrc.2011.04.040"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21527249"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21527249"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Matthias Altmeyer, Luis Toledo, Thorkell Gudjonsson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The chromatin scaffold protein SAFB1 renders chromatin permissive for DNA damage signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2013.08.025"}], "href": "https://doi.org/10.1016/j.molcel.2013.08.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24055346"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24055346"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Youn-Bok Lee, Shane Colley, Michel Norman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SAFB re-distribution marks steps of the apoptotic process."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2007.06.023"}], "href": "https://doi.org/10.1016/j.yexcr.2007.06.023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17643427"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17643427"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Philippos Peidis, Nikolaos Voukkalis, Eleni Aggelidou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SAFB1 interacts with and suppresses the transcriptional activity of p53."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2010.11.054"}], "href": "https://doi.org/10.1016/j.febslet.2010.11.054"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21130767"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21130767"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Hui-wen Liu, Tapahsama Banerjee, Xiaoyan Guan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The chromatin scaffold protein SAFB1 localizes SUMO-1 to the promoters of ribosomal protein genes to facilitate transcription initiation and splicing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkv246"}], "href": "https://doi.org/10.1093/nar/gkv246"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25800734"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25800734"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Atsushi Yamaguchi, Keisuke Takanashi "}, {"type": "b", "children": [{"type": "t", "text": "FUS interacts with nuclear matrix-associated protein SAFB1 as well as Matrin3 to regulate splicing and ligand-mediated transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep35195"}], "href": "https://doi.org/10.1038/srep35195"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27731383"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27731383"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Caroline Rivers, Jalilah Idris, Helen Scott, et al. "}, {"type": "b", "children": [{"type": "t", "text": "iCLIP identifies novel roles for SAFB1 in regulating RNA processing and neuronal function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12915-015-0220-7"}], "href": "https://doi.org/10.1186/s12915-015-0220-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26694817"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26694817"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Sotiria Drakouli, Aggeliki Lyberopoulou, Maria Papathanassiou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enhancer of rudimentary homologue interacts with scaffold attachment factor B at the nuclear matrix to regulate SR protein phosphorylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS J (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/febs.14141"}], "href": "https://doi.org/10.1111/febs.14141"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28627136"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28627136"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Dora Tsianou, Eleni Nikolakaki, Alexandra Tzitzira, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The enzymatic activity of SR protein kinases 1 and 1a is negatively affected by interaction with scaffold attachment factors B1 and 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS J (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1742-4658.2009.07217.x"}], "href": "https://doi.org/10.1111/j.1742-4658.2009.07217.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19674106"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19674106"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Elaine Hong, Andrew Best, Hannah Gautrey, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Unravelling the RNA-Binding Properties of SAFB Proteins in Breast Cancer Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2015/395816"}], "href": "https://doi.org/10.1155/2015/395816"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26273616"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26273616"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Steffi Oesterreich "}, {"type": "b", "children": [{"type": "t", "text": "Scaffold attachment factors SAFB1 and SAFB2: Innocent bystanders or critical players in breast tumorigenesis?"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.10685"}], "href": "https://doi.org/10.1002/jcb.10685"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14587024"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14587024"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Stephanie Hammerich-Hille, Benny A Kaipparettu, Anna Tsimelzon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SAFB1 mediates repression of immune regulators and apoptotic genes in breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.066431"}], "href": "https://doi.org/10.1074/jbc.M109.066431"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19901029"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19901029"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Annika Bergman, Frida Abel, Afrouz Behboudi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "No germline mutations in supposed tumour suppressor genes SAFB1 and SAFB2 in familial breast cancer with linkage to 19p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Med Genet (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2350-9-108"}], "href": "https://doi.org/10.1186/1471-2350-9-108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19077293"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19077293"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Hong-Li Jiao, Ya-Ping Ye, Run-Wei Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "SAFB"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Sustains the NF-"}, {"type": "a", "children": [{"type": "t", "text": "b"}], "href": "b"}, {"type": "t", "text": "κ"}, {"type": "a", "children": [{"type": "t", "text": "/b"}], "href": "/b"}, {"type": "t", "text": "B Pathway by Targeting "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "TAK1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " during the Progression of Colorectal Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-17-0747"}], "href": "https://doi.org/10.1158/1078-0432.CCR-17-0747"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28912140"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28912140"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "N K Mukhopadhyay, J Kim, S You, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Scaffold attachment factor B1 regulates the androgen receptor in concert with the growth inhibitory kinase MST1 and the methyltransferase EZH2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2013.294"}], "href": "https://doi.org/10.1038/onc.2013.294"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23893242"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23893242"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Junji Lin, Ping Xu, Patricia LaVallee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of proteins binding to E-Box/Ku86 sites and function of the tumor suppressor SAFB1 in transcriptional regulation of the human xanthine oxidoreductase gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M802076200"}], "href": "https://doi.org/10.1074/jbc.M802076200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18772145"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18772145"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Li Ma, Li Sun, Xia Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Scaffold attachment factor B suppresses HIV-1 infection of CD4"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "+"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": " T cells by preventing binding of RNA polymerase II to HIV-1's long terminal repeat."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA118.002018"}], "href": "https://doi.org/10.1074/jbc.RA118.002018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29887524"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29887524"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Mo Zhou, Leena Kuruvilla, Xiarong Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.2005712117"}], "href": "https://doi.org/10.1073/pnas.2005712117"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33257571"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33257571"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Shuchi Agrawal-Singh, Jaana Bagri, George Giotopoulos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HOXA9 forms a repressive complex with nuclear matrix-associated protein SAFB to maintain acute myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood.2022016528"}], "href": "https://doi.org/10.1182/blood.2022016528"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36577137"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36577137"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Chrysa Taze, Sotiria Drakouli, Martina Samiotaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Short-term hypoxia triggers ROS and SAFB mediated nuclear matrix and mRNA splicing remodeling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Redox Biol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.redox.2022.102545"}], "href": "https://doi.org/10.1016/j.redox.2022.102545"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36427398"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36427398"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Kazunori Watanabe, Takashi Ohtsuki "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of HSF1 and SAFB Granule Formation Enhances Apoptosis Induced by Heat Stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms22094982"}], "href": "https://doi.org/10.3390/ijms22094982"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34067147"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34067147"}]}]}]}
Synonyms	SAFB1, SAB-B1, SAF-B1, SAF-B
Proteins	SAFB1_HUMAN
NCBI Gene ID	6294
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SAFB has 7,168 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 122 datasets.

Click the + buttons to view associations for SAFB from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SAFB Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by SAFB gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SAFB gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SAFB gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SAFB gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SAFB gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SAFB gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SAFB gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SAFB gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SAFB gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SAFB gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of SAFB gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SAFB gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SAFB gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with SAFB protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SAFB gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SAFB gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SAFB gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing SAFB protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SAFB gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SAFB protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SAFB protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing SAFB protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing SAFB protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SAFB protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SAFB protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SAFB gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with SAFB gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with SAFB gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with SAFB gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SAFB gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SAFB gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SAFB gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SAFB gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SAFB gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SAFB gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SAFB gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SAFB gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of SAFB gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with SAFB gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing SAFB from the GeneSigDB Published Gene Signatures dataset.