{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSATB2 is a highly conserved nuclear matrix–associated transcription factor essential for normal embryonic development. Its proper dosage is critical for craniofacial patterning, palate formation, and dental as well as skeletal development. Indeed, disruptions in SATB2—whether by translocation breakpoints, microdeletions, or point mutations—have been linked to isolated cleft or high‐arched palates, micrognathia, dental abnormalities, and intellectual disability, collectively defining a distinct syndromic phenotype. These observations highlight its pivotal role in orchestrating developmental programs in craniofacial and skeletal tissues."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAt the molecular level, SATB2 functions by binding AT‐rich sequences in nuclear matrix attachment regions via its CUT domains and homeodomain. This binding facilitates chromatin remodeling and the precise regulation of downstream gene expression programs. SATB2 recruits specific co‐activators such as PCAF—and, in certain contexts, CBP—to activate transcription of target genes, thereby fine‐tuning cellular differentiation pathways. Such epigenetic control mechanisms are fundamental to both normal tissue development and aberrant processes in disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of cancer, SATB2 serves as a highly specific diagnostic biomarker, most notably for colorectal adenocarcinomas. Its expression in glandular cells of the lower gastrointestinal tract allows SATB2 immunohistochemistry to reliably distinguish colorectal origin in metastatic tumors, including liver metastases and neuroendocrine neoplasms. Moreover, SATB2 is expressed in osteogenic tumors such as osteosarcomas, aiding in the differential diagnosis from other small round cell tumors. Thus, the selective expression of SATB2 across various neoplasms underpins its growing clinical utility in tumor classification and prognosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSATB2 is also a critical target and mediator of microRNA‐driven regulatory networks that impact tumorigenesis and differentiation. In colorectal cancer, for example, miR‑31 directly binds to the 3′‑UTR of SATB2 mRNA, repressing its expression and thereby promoting epithelial–mesenchymal transition, invasion, and metastasis. Similar regulatory paradigms have been noted in osteogenesis and in other cancers such as hepatocellular carcinoma and triple‐negative breast cancer, where microRNAs including miR‑31, miR‑211, and miR‑33a‑5p modulate SATB2 levels and function. These findings underscore a broader role for SATB2 in tumor suppression and cellular differentiation as integrated within complex post‐transcriptional networks."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "17", "end_ref": "22"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in peripheral tissues, SATB2 is indispensable for proper neuronal development and higher cognitive function. Reduced dosage or mutations in SATB2 have been linked to significant neurodevelopmental disorders, including intellectual disability, severe speech impairment, and features of autism spectrum disorder and schizophrenia. These findings, supported by studies of de novo mutations and convergent gene networks in neural stem cells, attest to the importance of SATB2 in establishing and maintaining neural circuitry as well as in regulating neurocognitive phenotypes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "23", "end_ref": "26"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its diagnostic and developmental roles, SATB2 has emerged as a modulator of tumor cell behavior and therapeutic response. Studies in head and neck squamous cell carcinoma demonstrate that SATB2 interacts with key oncogenic pathways to promote chemoresistance, while in glioblastoma, it facilitates cell proliferation by recruiting CBP and enhancing FOXM1-mediated transcription. Furthermore, differential SATB2 expression helps distinguish primary ovarian mucinous tumors from metastatic lesions and guides prognostic assessments in periampullary adenocarcinomas, thereby expanding its clinical relevance across a spectrum of malignancies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "27", "end_ref": "31"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "David R FitzPatrick, Ian M Carr, Lorna McLaren, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of SATB2 as the cleft palate gene on 2q32-q33."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddg248"}], "href": "https://doi.org/10.1093/hmg/ddg248"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12915443"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12915443"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jill A Rosenfeld, Blake C Ballif, Ann Lucas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Small deletions of SATB2 cause some of the clinical features of the 2q33.1 microdeletion syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0006568"}], "href": "https://doi.org/10.1371/journal.pone.0006568"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19668335"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19668335"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "M Balasubramanian, K Smith, L Basel-Vanagaite, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Case series: 2q33.1 microdeletion syndrome--further delineation of the phenotype."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Genet (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jmg.2010.084491"}], "href": "https://doi.org/10.1136/jmg.2010.084491"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21343628"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21343628"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jacqueline K Rainger, Shipra Bhatia, Hemant Bengani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disruption of SATB2 or its long-range cis-regulation by SOX9 causes a syndromic form of Pierre Robin sequence."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddt647"}], "href": "https://doi.org/10.1093/hmg/ddt647"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24363063"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24363063"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xiaoying Zhao, Zhihu Qu, Jennifer Tickner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role of SATB2 in skeletogenesis and human disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cytokine Growth Factor Rev (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cytogfr.2013.12.010"}], "href": "https://doi.org/10.1016/j.cytogfr.2013.12.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24411565"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24411565"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Y A Zarate, L Kalsner, A Basinger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genotype and phenotype in 12 additional individuals with SATB2-associated syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cge.12982"}], "href": "https://doi.org/10.1111/cge.12982"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28139846"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28139846"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Li-Quan Zhou, Jie Wu, Wen-Tian Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The AT-rich DNA-binding protein SATB2 promotes expression and physical association of human (G)γ- and (A)γ-globin genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.355271"}], "href": "https://doi.org/10.1074/jbc.M112.355271"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22825848"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22825848"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Weiwei Tao, Aili Zhang, Kui Zhai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SATB2 drives glioblastoma growth by recruiting CBP to promote FOXM1 expression in glioma stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Mol Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/emmm.202012291"}], "href": "https://doi.org/10.15252/emmm.202012291"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33124191"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33124191"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Kristina Magnusson, Meike de Wit, Donal J Brennan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SATB2 in combination with cytokeratin 20 identifies over 95% of all colorectal carcinomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Surg Pathol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/PAS.0b013e31821c3dae"}], "href": "https://doi.org/10.1097/PAS.0b013e31821c3dae"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21677534"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21677534"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "James R Conner, Jason L Hornick "}, {"type": "b", "children": [{"type": "t", "text": "SATB2 is a novel marker of osteoblastic differentiation in bone and soft tissue tumours."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histopathology (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/his.12138"}], "href": "https://doi.org/10.1111/his.12138"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23701429"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23701429"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Nelson G Ordóñez "}, {"type": "b", "children": [{"type": "t", "text": "SATB2 is a novel marker of osteoblastic differentiation and colorectal adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Adv Anat Pathol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/PAP.0000000000000001"}], "href": "https://doi.org/10.1097/PAP.0000000000000001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24316906"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24316906"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Michelle Moh, Gregor Krings, Deniz Ates, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SATB2 Expression Distinguishes Ovarian Metastases of Colorectal and Appendiceal Origin From Primary Ovarian Tumors of Mucinous or Endometrioid Type."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Surg Pathol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/PAS.0000000000000553"}], "href": "https://doi.org/10.1097/PAS.0000000000000553"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26551622"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26551622"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Isidro Machado, Samuel Navarro, Piero Picci, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The utility of SATB2 immunohistochemical expression in distinguishing between osteosarcomas and their malignant bone tumor mimickers, such as Ewing sarcomas and chondrosarcomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2016.06.012"}], "href": "https://doi.org/10.1016/j.prp.2016.06.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27465835"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27465835"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Chen Yang, Li Sun, Lingxin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Diagnostic Utility of SATB2 in Metastatic Krukenberg Tumors of the Ovary: An Immunohistochemical Study of 70 Cases With Comparison to CDX2, CK7, CK20, Chromogranin, and Synaptophysin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Surg Pathol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/PAS.0000000000000951"}], "href": "https://doi.org/10.1097/PAS.0000000000000951"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28914716"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28914716"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Yi-Jun Zhang, Jie-Wei Chen, Xiao-Sheng He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SATB2 is a Promising Biomarker for Identifying a Colorectal Origin for Liver Metastatic Adenocarcinomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EBioMedicine (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ebiom.2018.01.001"}], "href": "https://doi.org/10.1016/j.ebiom.2018.01.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29396302"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29396302"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Andrew M Bellizzi "}, {"type": "b", "children": [{"type": "t", "text": "SATB2 in neuroendocrine neoplasms: strong expression is restricted to well-differentiated tumours of lower gastrointestinal tract origin and is most frequent in Merkel cell carcinoma among poorly differentiated carcinomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histopathology (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/his.13943"}], "href": "https://doi.org/10.1111/his.13943"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31233624"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31233624"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Min-Hui Yang, Jiang Yu, Na Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elevated microRNA-31 expression regulates colorectal cancer progression by repressing its target gene SATB2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0085353"}], "href": "https://doi.org/10.1371/journal.pone.0085353"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24386467"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24386467"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Qing Xie, Zi Wang, Xiaoping Bi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effects of miR-31 on the osteogenesis of human mesenchymal stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2014.02.058"}], "href": "https://doi.org/10.1016/j.bbrc.2014.02.058"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24565840"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24565840"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Guixing Jiang, Yunfu Cui, Xin Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-211 suppresses hepatocellular carcinoma by downregulating SATB2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.3265"}], "href": "https://doi.org/10.18632/oncotarget.3265"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25888635"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25888635"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Mohammed A Mansour, Toshinori Hyodo, Khondker Ayesha Akter, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SATB1 and SATB2 play opposing roles in c-Myc expression and progression of colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.6651"}], "href": "https://doi.org/10.18632/oncotarget.6651"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26701851"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26701851"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Wenxiang Mi, Qiongling Shi, Xipeng Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-33a-5p modulates TNF-α-inhibited osteogenic differentiation by targeting SATB2 expression in hBMSCs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1873-3468.12064"}], "href": "https://doi.org/10.1002/1873-3468.12064"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26785690"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26785690"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Long-Ji Luo, Fan Yang, Jia-Ji Ding, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-31 inhibits migration and invasion by targeting SATB2 in triple negative breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2016.08.057"}], "href": "https://doi.org/10.1016/j.gene.2016.08.057"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27593563"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27593563"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "C O Gigek, E S Chen, V K Ota, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A molecular model for neurodevelopmental disorders."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Psychiatry (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/tp.2015.56"}], "href": "https://doi.org/10.1038/tp.2015.56"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25966365"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25966365"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Hemant Bengani, Mark Handley, Mohsan Alvi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical and molecular consequences of disease-associated de novo mutations in SATB2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Med (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/gim.2016.211"}], "href": "https://doi.org/10.1038/gim.2016.211"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28151491"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28151491"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Ping Wang, Dejian Zhao, Herbert M Lachman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enriched expression of genes associated with autism spectrum disorders in human inhibitory neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Psychiatry (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41398-017-0058-6"}], "href": "https://doi.org/10.1038/s41398-017-0058-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29317598"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29317598"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Laura Whitton, Galina Apostolova, Dietmar Rieder, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genes regulated by SATB2 during neurodevelopment contribute to schizophrenia and educational attainment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1007515"}], "href": "https://doi.org/10.1371/journal.pgen.1007515"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30040823"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30040823"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Jacky Chung, Joanne Lau, Lynn S Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SATB2 augments ΔNp63α in head and neck squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/embor.2010.125"}], "href": "https://doi.org/10.1038/embor.2010.125"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20829881"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20829881"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Jacob Elebro, Margareta Heby, Alexander Gaber, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic and treatment predictive significance of SATB1 and SATB2 expression in pancreatic and periampullary adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-014-0289-8"}], "href": "https://doi.org/10.1186/s12967-014-0289-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25323550"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25323550"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Sarah Strickland, Carlos Parra-Herran "}, {"type": "b", "children": [{"type": "t", "text": "Immunohistochemical characterization of appendiceal mucinous neoplasms and the value of special AT-rich sequence-binding protein 2 in their distinction from primary ovarian mucinous tumours."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histopathology (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/his.12899"}], "href": "https://doi.org/10.1111/his.12899"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26542609"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26542609"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Jun Matsushima, Takuya Yazawa, Masaki Suzuki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinicopathological, immunohistochemical, and mutational analyses of pulmonary enteric adenocarcinoma: usefulness of SATB2 and β-catenin immunostaining for differentiation from metastatic colorectal carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Pathol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.humpath.2017.04.006"}], "href": "https://doi.org/10.1016/j.humpath.2017.04.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28438615"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28438615"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Changqing Ma, Dane Olevian, Caitlyn Miller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SATB2 and CDX2 are prognostic biomarkers in DNA mismatch repair protein deficient colon cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mod Pathol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41379-019-0265-1"}], "href": "https://doi.org/10.1038/s41379-019-0265-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30962505"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30962505"}]}]}]}