SCG2 Gene

HGNC Family	Granins (SCG)
Name	secretogranin II
Description	The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSecretogranin II (SCG2) is a multifunctional member of the granin protein family that is principally expressed in neuroendocrine cells, where it is proteolytically processed into several bioactive peptides—most notably EM66 and secretoneurin. These cleavage products have been shown to serve as diagnostic biomarkers in neuroendocrine tumors; for example, differential levels of the SCG2‐derived peptide EM66 distinguish benign from malignant pheochromocytomas, reflecting underlying differences in SCG2 gene transcription and processing. Moreover, SCG2 is instrumental in supporting neuronal differentiation and survival by counteracting nitric oxide–induced toxicity, thereby promoting neurite extension, synaptic formation, and overall neurodevelopment—a role underscored by findings in neurodegenerative disease models and pediatric developmental delay."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the cardiovascular system, SCG2‐derived secretoneurin exerts potent angiogenic activity, enhancing endothelial cell signaling and vessel formation in settings of tissue ischemia such as myocardial infarction and diabetic foot ulcers. In parallel, common regulatory polymorphisms in SCG2 have been linked to elevated blood pressure and hypertension, while altered SCG2 expression has been associated with the formation of coronary collaterals and serves as a prognostic indicator in heart failure. Collectively, these studies highlight the critical role of SCG2 in vascular remodeling, repair, and hemodynamic regulation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its neuroendocrine and cardiovascular roles, SCG2 contributes to immune modulation and tumor biology. Secretoneurin, for instance, has been implicated in the regulation of leukocyte transendothelial migration through its effects on endothelial calcium signaling, thereby influencing inflammatory responses. In cancer, reduced SCG2 expression correlates with enhanced tumor angiogenesis and aggressive behavior in malignancies such as colorectal and bladder cancer—where SCG2 overexpression disrupts hypoxia‐inducible factor–1α stability and vascular endothelial growth factor expression, hindering tumor growth and invasion. Additionally, SCG2 levels are dynamically modulated during viral infections, suggesting that alterations in its expression may impact host defense mechanisms."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Laurent Yon, Johann Guillemot, Maite Montero-Hadjadje, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of the secretogranin II-derived peptide EM66 in pheochromocytomas as a potential marker for discriminating benign versus malignant tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2002-021748"}], "href": "https://doi.org/10.1210/jc.2002-021748"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12788858"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12788858"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "L Li, A C Hung, A G Porter "}, {"type": "b", "children": [{"type": "t", "text": "Secretogranin II: a key AP-1-regulated protein that mediates neuronal differentiation and protection from nitric oxide-induced apoptosis of neuroblastoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cdd.2008.8"}], "href": "https://doi.org/10.1038/cdd.2008.8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18239671"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18239671"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "A Schrott-Fischer, M Bitsche, C Humpel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chromogranin peptides in amyotrophic lateral sclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Regul Pept (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.regpep.2008.07.009"}], "href": "https://doi.org/10.1016/j.regpep.2008.07.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18721831"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18721831"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "J Guillemot, E Thouënnon, M Guérin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential expression and processing of secretogranin II in relation to the status of pheochromocytoma: implications for the production of the tumoral marker EM66."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Endocrinol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1530/JME-11-0077"}], "href": "https://doi.org/10.1530/JME-11-0077"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22217803"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22217803"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Maïté Courel, Fatima-Zohra El Yamani, David Alexandre, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Secretogranin II is overexpressed in advanced prostate cancer and promotes the neuroendocrine differentiation of prostate cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Cancer (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejca.2014.09.009"}], "href": "https://doi.org/10.1016/j.ejca.2014.09.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25307750"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25307750"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "So-Hee Lim, Yun-Ju Sung, Narae Jo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nanoplasmonic immunosensor for the detection of SCG2, a candidate serum biomarker for the early diagnosis of neurodevelopmental disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-021-02262-7"}], "href": "https://doi.org/10.1038/s41598-021-02262-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34815513"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34815513"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Gen Wen, Jennifer Wessel, Weidong Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An ancestral variant of Secretogranin II confers regulation by PHOX2 transcription factors and association with hypertension."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddm123"}], "href": "https://doi.org/10.1093/hmg/ddm123"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17584765"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17584765"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Helge Røsjø, Mats Stridsberg, Geir Florholmen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Secretogranin II; a protein increased in the myocardium and circulation in heart failure with cardioprotective properties."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0037401"}], "href": "https://doi.org/10.1371/journal.pone.0037401"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22655045"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22655045"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Karin Albrecht-Schgoer, Wilfried Schgoer, Johannes Holfeld, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The angiogenic factor secretoneurin induces coronary angiogenesis in a model of myocardial infarction by stimulation of vascular endothelial growth factor signaling in endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCULATIONAHA.111.076950"}], "href": "https://doi.org/10.1161/CIRCULATIONAHA.111.076950"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23081990"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23081990"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Karin Albrecht-Schgoer, Wilfried Schgoer, Markus Theurl, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Topical secretoneurin gene therapy accelerates diabetic wound healing by interaction between heparan-sulfate proteoglycans and basic FGF."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Angiogenesis (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10456-013-9375-4"}], "href": "https://doi.org/10.1007/s10456-013-9375-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23918206"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23918206"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Zhi Ming Wu, Ke Huang, Yang Dai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating secretoneurin level reflects angiographic coronary collateralization in stable angina patients with chronic total occlusion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cardiovasc Disord (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12872-023-03645-6"}], "href": "https://doi.org/10.1186/s12872-023-03645-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38184555"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38184555"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Łukasz Wołowiec, Daniel Rogowicz, Jacek Budzyński, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic value of plasma secretoneurin concentration in patients with heart failure with reduced ejection fraction in one-year follow-up."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Med (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/07853890.2024.2305309"}], "href": "https://doi.org/10.1080/07853890.2024.2305309"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38261566"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38261566"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Christian M Kähler, Peter Schratzberger, Gerhard Kaufmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transendothelial migration of leukocytes and signalling mechanisms in response to the neuropeptide secretoneurin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Regul Pept (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0167-0115(01)00379-2"}], "href": "https://doi.org/10.1016/s0167-0115(01"}, {"type": "t", "text": "00379-2) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11853870"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11853870"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Rui Xu, Qi Li, Jia Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Secretoneurin induces airway mucus hypersecretion by enhancing the binding of EGF to NRP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000358625"}], "href": "https://doi.org/10.1159/000358625"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24556756"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24556756"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Alicia R Berard, Alberto Severini, Kevin M Coombs "}, {"type": "b", "children": [{"type": "t", "text": "Differential Reovirus-Specific and Herpesvirus-Specific Activator Protein 1 Activation of Secretogranin II Leads to Altered Virus Secretion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.01639-15"}], "href": "https://doi.org/10.1128/JVI.01639-15"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26378181"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26378181"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Chao Fang, Lei Dai, Cun Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Secretogranin II impairs tumor growth and angiogenesis by promoting degradation of hypoxia-inducible factor-1α in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1878-0261.13044"}], "href": "https://doi.org/10.1002/1878-0261.13044"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34160138"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34160138"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Chenyang Jiang, Weidong Jiang "}, {"type": "b", "children": [{"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "AGTR1, PLTP,"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " and "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "SCG2"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " associated with immune genes and immune cell infiltration in calcific aortic valve stenosis: analysis from integrated bioinformatics and machine learning."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Math Biosci Eng (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3934/mbe.2022174"}], "href": "https://doi.org/10.3934/mbe.2022174"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35341274"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35341274"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "J Deng, T Pan, G Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[High expression of secretogranin II increases oxaliplatin resistance of colorectal cancer cells]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nan Fang Yi Ke Da Xue Xue Bao (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12122/j.issn.1673-4254.2023.10.02"}], "href": "https://doi.org/10.12122/j.issn.1673-4254.2023.10.02"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37933640"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37933640"}]}]}]}
Synonyms	CHGC, EM66
Proteins	SCG2_HUMAN
NCBI Gene ID	7857
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SCG2 has 6,566 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 109 datasets.

Click the + buttons to view associations for SCG2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SCG2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SCG2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SCG2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SCG2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SCG2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SCG2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SCG2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SCG2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SCG2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SCG2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of SCG2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SCG2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SCG2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SCG2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SCG2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SCG2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SCG2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SCG2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing SCG2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SCG2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SCG2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing SCG2 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SCG2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with SCG2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with SCG2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with SCG2 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of SCG2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SCG2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with SCG2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with SCG2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SCG2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SCG2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SCG2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SCG2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SCG2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SCG2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SCG2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SCG2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with SCG2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with SCG2 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of SCG2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.