SCIN Gene

Name	scinderin
Description	SCIN is a Ca(2+)-dependent actin-severing and -capping protein (Zunino et al., 2001 [PubMed 11568009]).[supplied by OMIM, May 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSCIN is a calcium‐dependent actin severing and capping protein whose molecular function is intimately linked to cytoskeletal remodeling. Structural studies on its close homolog adseverin have revealed a conserved domain organization and calcium‐binding sites that are essential to expose its F–actin binding interface; indeed, a single mutation at this interface completely abrogates actin sequestration, underscoring the structural basis for its activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn several solid tumors—including gastric, prostate, lung, head and neck, colon cancers, and melanoma—SCIN has been implicated in promoting malignant behaviors. In human gastric cancer, high SCIN expression enhances filopodia formation through regulation of Cdc42, correlating with increased invasion, metastasis, and poorer overall survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In prostate carcinoma cells, RNA‐interference–mediated knockdown of SCIN resulted in impaired proliferation, colony formation, and G0/G1 cell cycle arrest, highlighting its role in cell cycle regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In lung cancer, silencing SCIN similarly inhibited proliferation and induced cell cycle arrest, while in another study using a highly tumorigenic gastric cancer cell line, suppression of SCIN not only reduced proliferation and migration but also reversed epithelial–mesenchymal transition (EMT) markers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Moreover, in head and neck carcinomas, SCIN expression—in concert with molecules such as EPHRIN-A1—has been linked to resistance against cytotoxic T lymphocyte–mediated lysis, while in colon cancer SCIN is required for proliferation through facilitating nuclear translocation of β-catenin and subsequent activation of the WNT pathway; an epistasis analysis further demonstrated a significant functional interaction between SCIN and CDC42 in melanoma progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn hematologic malignancies, SCIN expression displays distinct regulatory patterns. In acute myeloid leukemia, SCIN transcript levels are significantly downregulated due to promoter hypermethylation; this decrease is associated with lower complete remission rates and shorter overall survival, thereby suggesting that SCIN may serve as an independent prognostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Similarly, studies in chronic myeloid leukemia have focused on the clinical significance of SCIN gene expression and its promoter methylation status."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond cancer, SCIN exerts key roles in other physiological and pathological contexts. In developmental dysplasia of the hip, cyclic compressive stress upregulates SCIN expression, which in turn promotes osteogenesis and osteoclastogenesis while concurrently repressing chondrogenesis through activation of p-Smad1/5/8, NF-κB, and MAPK P38 signaling pathways. In addition, in the eye SCIN is implicated in hydrogen peroxide–induced injury of lens epithelial cells—a process relevant to the pathogenesis of age-related cataract."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sakesit Chumnarnsilpa, Wei Lin Lee, Shalini Nag, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The crystal structure of the C-terminus of adseverin reveals the actin-binding interface."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0812383106"}], "href": "https://doi.org/10.1073/pnas.0812383106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19666531"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19666531"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jia-Jia Liu, Jun-Yan Liu, Jun Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Scinderin promotes the invasion and metastasis of gastric cancer cells and predicts the outcome of patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2016.03.035"}], "href": "https://doi.org/10.1016/j.canlet.2016.03.035"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27033455"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27033455"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Dong Wang, Shu-Qing Sun, Ying-Hao Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Suppression of SCIN inhibits human prostate cancer cell proliferation and induces G0/G1 phase arrest."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2013.2170"}], "href": "https://doi.org/10.3892/ijo.2013.2170"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24212916"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24212916"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hongxu Liu, Daiwang Shi, Tieqin Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lentivirus-mediated silencing of SCIN inhibits proliferation of human lung carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2014.10.013"}], "href": "https://doi.org/10.1016/j.gene.2014.10.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25303873"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25303873"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xiao-Min Chen, Jun-Ming Guo, Ping Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Suppression of scinderin modulates epithelial‑mesenchymal transition markers in highly metastatic gastric cancer cell line SGC‑7901."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2014.2523"}], "href": "https://doi.org/10.3892/mmr.2014.2523"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25174406"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25174406"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Meriem Hasmim, Cécile Badoual, Philippe Vielh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of EPHRIN-A1, SCINDERIN and MHC class I molecules in head and neck cancers and relationship with the prognostic value of intratumoral CD8+ T cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-13-592"}], "href": "https://doi.org/10.1186/1471-2407-13-592"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24330498"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24330498"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Lizbeth Perez-Castro, Niranjan Venkateswaran, Roy Garcia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The AHR target gene scinderin activates the WNT pathway by facilitating the nuclear translocation of β-catenin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.260028"}], "href": "https://doi.org/10.1242/jcs.260028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36148682"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36148682"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Amaury Vaysse, Shenying Fang, Myriam Brossard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A comprehensive genome-wide analysis of melanoma Breslow thickness identifies interaction between CDC42 and SCIN genetic variants."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.30245"}], "href": "https://doi.org/10.1002/ijc.30245"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27347659"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27347659"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Zhi-Hui Zhang, Wei Zhang, Jing-Dong Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased SCIN expression, associated with promoter methylation, is a valuable predictor for prognosis in acute myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Carcinog (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mc.22794"}], "href": "https://doi.org/10.1002/mc.22794"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29457658"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29457658"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Zhi-Hui Zhang, Xin-Yue Lian, Xi-Xi Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Clinical Study of SCIN Expression and Dromoter Methylation in Patients with Chronic Myeloid Leukemia]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhongguo Shi Yan Xue Ye Xue Za Zhi (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.19746/j.cnki.issn.1009-2137.2019.03.003"}], "href": "https://doi.org/10.19746/j.cnki.issn.1009-2137.2019.03.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31204912"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31204912"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Cheng-Long Wang, Hui Wang, Fei Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cyclic compressive stress-induced scinderin regulates progress of developmental dysplasia of the hip."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2017.02.065"}], "href": "https://doi.org/10.1016/j.bbrc.2017.02.065"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28213129"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28213129"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Yan Li, Li Tang, Guanxing Dang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Scinderin Promotes Hydrogen Peroxide-induced Lens Epithelial Cell Injury in Age-related Cataract."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Mol Med (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2174/0115665240250050231030110542"}], "href": "https://doi.org/10.2174/0115665240250050231030110542"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37936437"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37936437"}]}]}]}
Proteins	ADSV_HUMAN
NCBI Gene ID	85477
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SCIN has 6,402 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 119 datasets.

Click the + buttons to view associations for SCIN from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SCIN Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SCIN gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SCIN gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SCIN gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SCIN gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SCIN gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SCIN gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SCIN gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SCIN gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SCIN gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of SCIN gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SCIN gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SCIN gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with SCIN protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SCIN gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SCIN gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SCIN gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SCIN gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing SCIN protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SCIN gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SCIN protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SCIN protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing SCIN protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SCIN protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SCIN protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SCIN gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SCIN gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with SCIN gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with SCIN gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with SCIN gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SCIN gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SCIN gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SCIN gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SCIN gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SCIN gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SCIN gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SCIN gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SCIN gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SCIN from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with SCIN gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with SCIN gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.