{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAfter an extensive review of the available abstracts, we found no experimental evidence or direct discussion of SCNM1 per se. In contrast, the provided studies almost uniformly focus on the diverse roles of key adaptor and scaffold proteins—particularly beta‐arrestins—in modulating G protein–coupled receptor (GPCR) signaling, regulating receptor trafficking (including internalization and desensitization), and engaging multiple downstream pathways that control cell survival, proliferation, inflammation, and stress responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nWhile many of these studies delineate the functions of beta‐arrestin isoforms—in processes ranging from stress‐induced p53 suppression and DNA damage accumulation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "and receptor internalization"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "to mediation of signaling cascades in diverse disease contexts such as cancer, cardiovascular dysfunction, and neuroprotection"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "10"}]}, {"type": "t", "text": "—none of these works mention or characterize SCNM1. Thus, no functional attributes, regulatory mechanisms, or involvement in any of the described signaling or homeostatic processes can be ascribed to SCNM1 based on these publications."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn summary, while these studies provide an in‐depth view of how adaptor proteins (especially beta‐arrestin isoforms) orchestrate cell signaling—by engaging different kinases, modulating receptor fate, and influencing cellular responses to stress, inflammation, and hormonal cues"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "19"}]}, {"type": "t", "text": "—there is no mention or implication of SCNM1 participating in these processes. In the absence of any direct data or discussion linking SCNM1 to such roles"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "20", "end_ref": "26"}]}, {"type": "t", "text": ", we must conclude that the current body of literature represented by these abstracts does not define or support any specific function for SCNM1. Future studies will be needed to determine whether SCNM1 might have roles analogous to other adaptor proteins or is involved in distinct regulatory pathways not covered by these reports.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Makoto R Hara, Jeffrey J Kovacs, Erin J Whalen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature10368"}], "href": "https://doi.org/10.1038/nature10368"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21857681"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21857681"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "X Edward Zhou, Yuanzheng He, Parker W de Waal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2017.07.002"}], "href": "https://doi.org/10.1016/j.cell.2017.07.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28753425"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28753425"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jiuhong Kang, Yufeng Shi, Bin Xiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2005.09.011"}], "href": "https://doi.org/10.1016/j.cell.2005.09.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16325578"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16325578"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jeffrey J Kovacs, Erin J Whalen, Renshui Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Beta-arrestin-mediated localization of smoothened to the primary cilium."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1157983"}], "href": "https://doi.org/10.1126/science.1157983"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18497258"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18497258"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Robert W Walters, Arun K Shukla, Jeffrey J Kovacs, et al. "}, {"type": "b", "children": [{"type": "t", "text": "beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI36806"}], "href": "https://doi.org/10.1172/JCI36806"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19349687"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19349687"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Thomas J Povsic, Trudy A Kohout, Robert J Lefkowitz "}, {"type": "b", "children": [{"type": "t", "text": "Beta-arrestin1 mediates insulin-like growth factor 1 (IGF-1) activation of phosphatidylinositol 3-kinase (PI3K) and anti-apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M309968200"}], "href": "https://doi.org/10.1074/jbc.M309968200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14534298"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14534298"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Julie Quoyer, Christine Longuet, Christophe Broca, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GLP-1 mediates antiapoptotic effect by phosphorylating Bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic beta-cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.067207"}], "href": "https://doi.org/10.1074/jbc.M109.067207"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19915011"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19915011"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Leonard Girnita, Sudha K Shenoy, Bita Sehat, et al. "}, {"type": "b", "children": [{"type": "t", "text": "{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M501129200"}], "href": "https://doi.org/10.1074/jbc.M501129200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15878855"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15878855"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Sudha K Shenoy, Larry S Barak, Kunhong Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M700852200"}], "href": "https://doi.org/10.1074/jbc.M700852200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17666399"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17666399"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Pei Wang, Tian-Ying Xu, Kai Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ARRB1/β-arrestin-1 mediates neuroprotection through coordination of BECN1-dependent autophagy in cerebral ischemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/auto.29203"}], "href": "https://doi.org/10.4161/auto.29203"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24988431"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24988431"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Jana N Radin, Carlos J Orihuela, Gopal Murti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "beta-Arrestin 1 participates in platelet-activating factor receptor-mediated endocytosis of Streptococcus pneumoniae."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Infect Immun (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/IAI.73.12.7827-7835.2005"}], "href": "https://doi.org/10.1128/IAI.73.12.7827-7835.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16299272"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16299272"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Kwang H Ahn, Mariam M Mahmoud, Joong-Youn Shim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinct roles of β-arrestin 1 and β-arrestin 2 in ORG27569-induced biased signaling and internalization of the cannabinoid receptor 1 (CB1)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.438804"}], "href": "https://doi.org/10.1074/jbc.M112.438804"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23449980"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23449980"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Chad E Groer, Cullen L Schmid, Alex M Jaeger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Agonist-directed interactions with specific beta-arrestins determine mu-opioid receptor trafficking, ubiquitination, and dephosphorylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.248310"}], "href": "https://doi.org/10.1074/jbc.M111.248310"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21757712"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21757712"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Jihee Kim, Lisheng Zhang, Karsten Peppel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.108.172338"}], "href": "https://doi.org/10.1161/CIRCRESAHA.108.172338"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18519945"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18519945"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Ashley Bathgate-Siryk, Samalia Dabul, Krunal Pandya, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Negative impact of β-arrestin-1 on post-myocardial infarction heart failure via cardiac and adrenal-dependent neurohormonal mechanisms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hypertension (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/HYPERTENSIONAHA.113.02043"}], "href": "https://doi.org/10.1161/HYPERTENSIONAHA.113.02043"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24218435"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24218435"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Chun-Hua Liu, Zheng Gong, Zong-Lai Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms14335"}], "href": "https://doi.org/10.1038/ncomms14335"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28181498"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28181498"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Alysia Kern Lovgren, Jeffrey J Kovacs, Ting Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "β-arrestin deficiency protects against pulmonary fibrosis in mice and prevents fibroblast invasion of extracellular matrix."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Transl Med (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scitranslmed.3001564"}], "href": "https://doi.org/10.1126/scitranslmed.3001564"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21411739"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21411739"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Hongkuan Fan, Louis M Luttrell, George E Tempel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Beta-arrestins 1 and 2 differentially regulate LPS-induced signaling and pro-inflammatory gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Immunol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molimm.2007.02.009"}], "href": "https://doi.org/10.1016/j.molimm.2007.02.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17418896"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17418896"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Scott M DeWire, Jihee Kim, Erin J Whalen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Beta-arrestin-mediated signaling regulates protein synthesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M710515200"}], "href": "https://doi.org/10.1074/jbc.M710515200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18276584"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18276584"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Owen P Gross, Marie E Burns "}, {"type": "b", "children": [{"type": "t", "text": "Control of rhodopsin's active lifetime by arrestin-1 expression in mammalian rods."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.5391-09.2010"}], "href": "https://doi.org/10.1523/JNEUROSCI.5391-09.2010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20203204"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20203204"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Stéphane Dalle, Takeshi Imamura, David W Rose, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Insulin induces heterologous desensitization of G-protein-coupled receptor and insulin-like growth factor I signaling by downregulating beta-arrestin-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.22.17.6272-6285.2002"}], "href": "https://doi.org/10.1128/MCB.22.17.6272-6285.2002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12167719"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12167719"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Simona Buelli, Laura Rosanò, Elena Gagliardini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "β-arrestin-1 drives endothelin-1-mediated podocyte activation and sustains renal injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Soc Nephrol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1681/ASN.2013040362"}], "href": "https://doi.org/10.1681/ASN.2013040362"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24371298"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24371298"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Xiaosong Liu, Xiaohui Zhao, Xianglu Zeng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "β-arrestin1 regulates γ-secretase complex assembly and modulates amyloid-β pathology."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cr.2012.167"}], "href": "https://doi.org/10.1038/cr.2012.167"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23208420"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23208420"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Makoto R Hara, Benjamin D Sachs, Marc G Caron, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pharmacological blockade of a β(2)AR-β-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cc.23368"}], "href": "https://doi.org/10.4161/cc.23368"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23287463"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23287463"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Dao-Lai Zhang, Yu-Jing Sun, Ming-Liang Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.33432"}], "href": "https://doi.org/10.7554/eLife.33432"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29393851"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29393851"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Aylin C Hanyaloglu, Ruth M Seeber, Trudy A Kohout, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M209340200"}], "href": "https://doi.org/10.1074/jbc.M209340200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12393857"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12393857"}]}]}]}