SCNN1A Gene

HGNC Family	Ion channels
Name	sodium channel, non voltage gated 1 alpha subunit
Description	Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2009]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSCNN1A encodes the α‐subunit of the epithelial sodium channel (ENaC), a critical mediator of sodium influx across diverse epithelial surfaces. In airway epithelia, ENaC constitutes the rate‐limiting step for sodium absorption that regulates airway surface liquid volume and mucociliary clearance, with its activity modulated by extracellular proteases and pH‐dependent gating mechanisms. Structural and biophysical studies further demonstrate that the extracellular domains encoded by SCNN1A contribute to the intricate assembly, diverse ion selectivity, and responsiveness to proteolytic activation. In addition, specialized soluble regulatory proteins, such as SPLUNC1 serving as a volume sensor, interact with the channel to inhibit its proteolytic activation, thereby modulating its function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThe precise regulation of SCNN1A expression and ENaC activity is fundamental to maintaining fluid homeostasis in several tissues. In lung epithelia, inflammatory mediators such as interleukin‐1β down‐regulate αENaC expression, thereby impairing alveolar fluid clearance during acute lung injury. In contrast, in the reproductive tract, activation of ENaC by embryo‐derived proteases triggers intracellular signaling cascades (including Ca²⁺ influx, CREB phosphorylation, and cyclooxygenase‐2 upregulation) that are essential for successful embryo implantation. Moreover, in the kidney, nuclear receptor pathways—mediated by factors such as PPARγ and the androgen receptor—directly enhance SCNN1A transcription, subsequently promoting sodium re‐absorption and influencing blood pressure regulation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMutations and polymorphisms within SCNN1A have profound clinical implications. Gain‐of‐function mutations, such as those identified in Liddle syndrome (for example, the p.W493R variant), result in hyperactive channels, leading to increased sodium re‐absorption and subsequent hypertension; conversely, loss‐of‐function variants are associated with pseudohypoaldosteronism and cystic fibrosis–like manifestations due to impaired sodium transport. In addition, posttranslational modifications—including deubiquitination and regulation by specific microRNAs—further modulate the stability, surface expression, and activity of SCNN1A‐containing channels. These multifaceted regulatory mechanisms not only underpin pathological states ranging from salt‐sensitive hypertension and renal salt‐wasting disorders to aberrant fluid clearance in the lung and even altered cell migration in high‐grade gliomas, but they also highlight the heterogeneity in channel biophysics observed in native preparations."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Scott H Donaldson, Andrew Hirsh, Dong Chen Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of the epithelial sodium channel by serine proteases in human airways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M105044200"}], "href": "https://doi.org/10.1074/jbc.M105044200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11756432"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11756432"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Peter M Snyder, Diane R Olson, Rajesh Kabra, et al. "}, {"type": "b", "children": [{"type": "t", "text": "cAMP and serum and glucocorticoid-inducible kinase (SGK) regulate the epithelial Na(+) channel through convergent phosphorylation of Nedd4-2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M407858200"}], "href": "https://doi.org/10.1074/jbc.M407858200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15328345"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15328345"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Alaina L Garland, William G Walton, Raymond D Coakley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1311999110"}], "href": "https://doi.org/10.1073/pnas.1311999110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24043776"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24043776"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Sigrid Noreng, Arpita Bharadwaj, Richard Posert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure of the human epithelial sodium channel by cryo-electron microscopy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.39340"}], "href": "https://doi.org/10.7554/eLife.39340"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30251954"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30251954"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hong-Long Ji, Xue-Feng Su, Shrestha Kedar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Delta-subunit confers novel biophysical features to alpha beta gamma-human epithelial sodium channel (ENaC) via a physical interaction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M512293200"}], "href": "https://doi.org/10.1074/jbc.M512293200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16423824"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16423824"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Daniel M Collier, Peter M Snyder "}, {"type": "b", "children": [{"type": "t", "text": "Extracellular protons regulate human ENaC by modulating Na+ self-inhibition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M806954200"}], "href": "https://doi.org/10.1074/jbc.M806954200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18990692"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18990692"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yehoshua Enuka, Israel Hanukoglu, Oded Edelheit, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epithelial sodium channels (ENaC) are uniformly distributed on motile cilia in the oviduct and the respiratory airways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histochem Cell Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00418-011-0904-1"}], "href": "https://doi.org/10.1007/s00418-011-0904-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22207244"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22207244"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Agustin Garcia-Caballero, Julia E Rasmussen, Erol Gaillard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SPLUNC1 regulates airway surface liquid volume by protecting ENaC from proteolytic cleavage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0903609106"}], "href": "https://doi.org/10.1073/pnas.0903609106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19541605"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19541605"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jérémie Roux, Hisaaki Kawakatsu, Brandi Gartland, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interleukin-1beta decreases expression of the epithelial sodium channel alpha-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M410561200"}], "href": "https://doi.org/10.1074/jbc.M410561200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15755725"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15755725"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Ye Chun Ruan, Jing Hui Guo, Xinmei Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of the epithelial Na+ channel triggers prostaglandin E₂ release and production required for embryo implantation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.2771"}], "href": "https://doi.org/10.1038/nm.2771"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22729284"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22729284"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Guizhu Hong, Andrew Lockhart, Bill Davis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PPARgamma activation enhances cell surface ENaCalpha via up-regulation of SGK1 in human collecting duct cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.03-0181fje"}], "href": "https://doi.org/10.1096/fj.03-0181fje"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12923071"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12923071"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Marcus Quinkler, Iwona J Bujalska, Kirren Kaur, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Androgen receptor-mediated regulation of the alpha-subunit of the epithelial sodium channel in human kidney."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hypertension (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.HYP.0000184362.61744.c1"}], "href": "https://doi.org/10.1161/01.HYP.0000184362.61744.c1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16172422"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16172422"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Niren Kapoor, Rafal Bartoszewski, Yawar J Qadri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of ASIC1 and epithelial sodium channel subunits inhibits glioblastoma whole cell current and cell migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.037390"}], "href": "https://doi.org/10.1074/jbc.M109.037390"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19561078"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19561078"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Pia Jeggle, Chiara Callies, Antoine Tarjus, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epithelial sodium channel stiffens the vascular endothelium in vitro and in Liddle mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hypertension (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/HYPERTENSIONAHA.111.199455"}], "href": "https://doi.org/10.1161/HYPERTENSIONAHA.111.199455"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23460285"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23460285"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Hung Caohuy, Catherine Jozwik, Harvey B Pollard "}, {"type": "b", "children": [{"type": "t", "text": "Rescue of DeltaF508-CFTR by the SGK1/Nedd4-2 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.035345"}], "href": "https://doi.org/10.1074/jbc.M109.035345"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19617352"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19617352"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Abul Kalam Azad, Robert Rauh, François Vermeulen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in the amiloride-sensitive epithelial sodium channel in patients with cystic fibrosis-like disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.21011"}], "href": "https://doi.org/10.1002/humu.21011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19462466"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19462466"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Michael M Myerburg, Peter R Harvey, Elisa M Heidrich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Acute regulation of the epithelial sodium channel in airway epithelia by proteases and trafficking."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Respir Cell Mol Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1165/rcmb.2009-0348OC"}], "href": "https://doi.org/10.1165/rcmb.2009-0348OC"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20097829"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20097829"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Stephanie M Mutchler, Annet Kirabo, Thomas R Kleyman "}, {"type": "b", "children": [{"type": "t", "text": "Epithelial Sodium Channel and Salt-Sensitive Hypertension."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hypertension (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/HYPERTENSIONAHA.120.14481"}], "href": "https://doi.org/10.1161/HYPERTENSIONAHA.120.14481"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33486988"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33486988"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Sebastian Zeissig, Theresa Bergann, Anja Fromm, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Altered ENaC expression leads to impaired sodium absorption in the noninflamed intestine in Crohn's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.gastro.2008.02.030"}], "href": "https://doi.org/10.1053/j.gastro.2008.02.030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18355814"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18355814"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Kristian B Buhl, Ulla G Friis, Per Svenningsen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Urinary plasmin activates collecting duct ENaC current in preeclampsia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hypertension (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/HYPERTENSIONAHA.112.198879"}], "href": "https://doi.org/10.1161/HYPERTENSIONAHA.112.198879"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22987920"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22987920"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Marc Egli, Hervé Duplain, Mattia Lepori, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Defective respiratory amiloride-sensitive sodium transport predisposes to pulmonary oedema and delays its resolution in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Physiol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1113/jphysiol.2004.066704"}], "href": "https://doi.org/10.1113/jphysiol.2004.066704"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15308680"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15308680"}]}]}]}
Synonyms	SCNN1, LIDLS3, ENACALPHA, BESC2, ENACA, SCNEA
Proteins	SCNNA_HUMAN
NCBI Gene ID	6337
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SCNN1A has 10,943 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 125 datasets.

Click the + buttons to view associations for SCNN1A from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SCNN1A Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SCNN1A gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SCNN1A gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SCNN1A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SCNN1A gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SCNN1A gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SCNN1A gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of SCNN1A gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SCNN1A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SCNN1A gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SCNN1A gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SCNN1A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SCNN1A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SCNN1A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with SCNN1A gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with SCNN1A gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SCNN1A gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SCNN1A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SCNN1A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SCNN1A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SCNN1A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SCNN1A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SCNN1A gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with SCNN1A gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with SCNN1A gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with SCNN1A gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of SCNN1A protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SCNN1A gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with SCNN1A gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SCNN1A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SCNN1A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SCNN1A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SCNN1A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for SCNN1A protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SCNN1A gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SCNN1A gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SCNN1A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SCNN1A from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with SCNN1A gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with SCNN1A gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of SCNN1A gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.