SCRN1 Gene

Name	secernin 1
Description	This gene likely encodes a member of the secernin family of proteins. A similar protein in rat functions in regulation of exocytosis in mast cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSecernin-1 (SCRN1) was initially identified as a novel 50‐kDa cytosolic protein that plays a critical role in regulating exocytosis. In mast cells, SCRN1 enhances the extent of secretion and increases sensitivity to calcium stimulation, suggesting its importance in controlling the dynamics of regulated exocytosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its function in exocytosis, SCRN1 has emerged as an important molecular player in cancer biology. Its expression is altered in several tumor types and appears to have both diagnostic and prognostic significance. Elevated levels of SCRN1 have been observed in gastric cancer cell lines, and it is considered a tumor‐associated antigen in this context, although its role in colorectal cancer remains less clear. Moreover, in synovial sarcoma, higher SCRN1 expression is associated with improved long‐term survival and reduction in metastasis, establishing it as a robust prognostic biomarker. Genetic variations, such as the rs6976789 polymorphism within the SCRN1 3′‐UTR affecting miR-148a binding, have also been linked to increased gastric cancer risk and poorer survival outcomes. In non‐small cell lung cancer, upregulation of SCRN1 contributes to acquired resistance to EGFR‐targeted tyrosine kinase inhibitors through modulation of the PI3K/AKT pathway, while in oral squamous cell carcinoma, SCRN1 promotes proliferation, invasion, and migration through activation of TGF-β/Smad3 signaling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in secretion and tumor biology, SCRN1 is notably implicated in neurodegenerative processes. In Alzheimer’s disease and Down syndrome-related Alzheimer pathology, SCRN1 prominently accumulates in neurons, co-localizing with neurofibrillary tangles and plaque-associated dystrophic neurites. This specific association with tau pathology distinguishes it from other tauopathies such as corticobasal degeneration, progressive supranuclear palsy, and Pick’s disease. The interaction between SCRN1 and phosphorylated tau in Alzheimer’s disease further underscores its potential as both a biomarker and therapeutic target for disorders marked by aberrant tau deposition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Gemma Way, Nicholas Morrice, Carl Smythe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Purification and identification of secernin, a novel cytosolic protein that regulates exocytosis in mast cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e01-10-0094"}], "href": "https://doi.org/10.1091/mbc.e01-10-0094"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12221138"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12221138"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Norikatsu Miyoshi, Hideshi Ishii, Koshi Mimori, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SCRN1 is a novel marker for prognosis in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Surg Oncol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jso.21459"}], "href": "https://doi.org/10.1002/jso.21459"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20039278"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20039278"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yoshiyuki Suehara, Naobumi Tochigi, Daisuke Kubota, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Secernin-1 as a novel prognostic biomarker candidate of synovial sarcoma revealed by proteomics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Proteomics (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jprot.2011.02.033"}], "href": "https://doi.org/10.1016/j.jprot.2011.02.033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21385630"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21385630"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Peng Song, Haixia Zhu, Dong Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A genetic variant of miR-148a binding site in the SCRN1 3'-UTR is associated with susceptibility and prognosis of gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep07080"}], "href": "https://doi.org/10.1038/srep07080"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25399950"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25399950"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Nayoung Kim, Ahye Cho, Hideo Watanabe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrated genomic approaches identify upregulation of SCRN1 as a novel mechanism associated with acquired resistance to erlotinib in PC9 cells harboring oncogenic EGFR mutation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.7318"}], "href": "https://doi.org/10.18632/oncotarget.7318"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26883194"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26883194"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Li Xiao, Ting Zhang, Kaiyue Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of Secernin 1 inhibit cell invasion and migration by activating the TGF-β/Smad3 pathway in oral squamous cell carcinomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-023-41504-8"}], "href": "https://doi.org/10.1038/s41598-023-41504-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37691034"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37691034"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Geoffrey Pires, Sacha McElligott, Shiron Drusinsky, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Secernin-1 is a novel phosphorylated tau binding protein that accumulates in Alzheimer's disease and not in other tauopathies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Neuropathol Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s40478-019-0848-6"}], "href": "https://doi.org/10.1186/s40478-019-0848-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31796108"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31796108"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Sophia Weiner, Mathias Sauer, Gunnar Brinkmalm, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SCRN1: A cerebrospinal fluid biomarker correlating with tau in Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Alzheimers Dement (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/alz.13042"}], "href": "https://doi.org/10.1002/alz.13042"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36946611"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36946611"}]}]}]}
Synonyms	SES1
Proteins	SCRN1_HUMAN
NCBI Gene ID	9805
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SCRN1 has 6,809 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 115 datasets.

Click the + buttons to view associations for SCRN1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SCRN1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SCRN1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SCRN1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SCRN1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SCRN1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SCRN1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SCRN1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SCRN1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SCRN1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SCRN1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of SCRN1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SCRN1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SCRN1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with SCRN1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SCRN1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SCRN1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SCRN1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SCRN1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing SCRN1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SCRN1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SCRN1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SCRN1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing SCRN1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing SCRN1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SCRN1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SCRN1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SCRN1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SCRN1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with SCRN1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with SCRN1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SCRN1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with SCRN1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SCRN1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SCRN1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SCRN1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SCRN1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SCRN1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SCRN1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SCRN1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SCRN1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with SCRN1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.