SDC2 Gene

HGNC Family Proteoglycans, CD molecules (CD)
Name syndecan 2
Description The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. [provided by RefSeq, Jul 2008]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSyndecan‐2 (SDC2) is a multifunctional transmembrane heparan sulfate proteoglycan that modulates cell adhesion, migration, and proliferation in various malignancies. In colon cancer cells, high SDC2 expression promotes cell adhesion and cytoskeletal organization—processes that underlie enhanced proliferation and tumorigenic activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In endothelial cells, inflammatory stimuli upregulate SDC2 and its ectodomain can bind chemokines such as interleukin‐8, thereby contributing to the integration of adhesion and inflammatory signals."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In melanoma, increased SDC2 expression drives cell migration and invasion, while in colon adenocarcinoma SDC2 promotes Rac‐dependent migration through mechanisms involving Tiam1 recruitment."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": " Moreover, studies in fibrosarcoma and pancreatic adenocarcinoma implicate SDC2 in processes such as metastatic spread and perineural invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its direct role in modulating cell behavior, aberrations in the SDC2 gene are emerging as valuable biomarkers. Promoter hypermethylation of SDC2 has been shown to serve as a highly sensitive and specific marker for early colorectal cancer detection in both tissue and blood‐based assays."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "10"}]}, {"type": "t", "text": " Differential methylation of SDC2 is also observed in human papilloma virus–associated head and neck squamous cell carcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ", and comprehensive genetic screens have implicated SDC2 variants in developmental malformations such as nonsyndromic cleft lip with or without cleft palate."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " In esophageal squamous cell carcinoma, SDC2—functionally integrated into transforming growth factor–beta (TGF‐β) signaling networks—correlates with disease aggressiveness"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": ", whereas in colorectal cancer its pivotal roles in tumor development and progression are firmly established."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": " Finally, in prostate cancer, relative stability of SDC2 expression compared to other syndecans suggests a distinct, context‐dependent role in tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAt the molecular level, SDC2 exerts its effects through multiple types of interactions. Biophysical studies reveal that its transmembrane domain dimerizes very strongly—a feature that is required for proper receptor complex formation and the initiation of downstream signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": " Its cytoplasmic tail engages intracellular effectors such as syntenin‐1 to activate Rac and direct cytoskeletal reorganization, which is central to enhanced cell migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": " In addition, SDC2 functions as a ligand for the protein tyrosine phosphatase receptor CD148, thereby modulating β1 integrin‐mediated adhesion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": " Its cell surface availability is further regulated by cytokine‐mediated proteolytic shedding—illustrated by interleukin‐1α–induced extracellular domain release via matrix metalloproteinase‐7 in colon cancer cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": " In osteosarcoma, repression of SDC2 via aberrant Wnt/β‐catenin/TCF signaling contributes to decreased apoptosis and the development of chemoresistance"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": ", underscoring its role as a key regulator of cellular fate.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSDC2 also plays important roles in vascular biology and in the pathogenesis of infections. In endothelial cells, growth factor stimulation regulates SDC2 expression to support cell spreading, adhesion, and the formation of capillary‐like structures during angiogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "23"}]}, {"type": "t", "text": " Notch signaling in vascular smooth muscle cells induces SDC2 expression, which then reinforces proper vessel assembly and differentiation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "24"}]}, {"type": "t", "text": " In the context of viral infection, RNA interference–mediated depletion of SDC2 impairs herpes simplex virus type 1 entry, highlighting its role in mediating viral attachment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "25"}]}, {"type": "t", "text": " Furthermore, in nasopharyngeal carcinoma the Epstein–Barr virus oncoprotein LMP1 upregulates SDC2 (in concert with synaptotagmin‐like‐4) via NF‐κB signaling to promote extracellular vesicle secretion that enhances tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "26"}]}, {"type": "t", "text": " Collectively, these findings underscore the multifaceted roles of SDC2 in cell–cell communication, adhesion, and signaling across a spectrum of pathological states."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "27"}, {"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Haein Park, Yeonhee Kim, Yangmi Lim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Syndecan-2 mediates adhesion and proliferation of colon carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M202435200"}], "href": "https://doi.org/10.1074/jbc.M202435200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12055189"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12055189"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yvonne Halden, Angelika Rek, Werner Atzenhofer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interleukin-8 binds to syndecan-2 on human endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20030729"}], "href": "https://doi.org/10.1042/BJ20030729"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14527339"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14527339"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jung-hyun Lee, Haein Park, Heesung Chung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Syndecan-2 regulates the migratory potential of melanoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.034678"}], "href": "https://doi.org/10.1074/jbc.M109.034678"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19641225"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19641225"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Youngsil Choi, Hyunjung Kim, Heesung Chung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Syndecan-2 regulates cell migration in colon cancer cells through Tiam1-mediated Rac activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2009.11.165"}], "href": "https://doi.org/10.1016/j.bbrc.2009.11.165"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19962968"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19962968"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Z Wang, D Telci, M Griffin "}, {"type": "b", "children": [{"type": "t", "text": "Importance of syndecan-4 and syndecan -2 in osteoblast cell adhesion and survival mediated by a tissue transglutaminase-fibronectin complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2010.10.015"}], "href": "https://doi.org/10.1016/j.yexcr.2010.10.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21036168"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21036168"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Hooi Ching Lim, John R Couchman "}, {"type": "b", "children": [{"type": "t", "text": "Syndecan-2 regulation of morphology in breast carcinoma cells is dependent on RhoGTPases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbagen.2014.01.018"}], "href": "https://doi.org/10.1016/j.bbagen.2014.01.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24447566"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24447566"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Tiago De Oliveira, Ivane Abiatari, Susanne Raulefs, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Syndecan-2 promotes perineural invasion and cooperates with K-ras to induce an invasive pancreatic cancer cell phenotype."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1476-4598-11-19"}], "href": "https://doi.org/10.1186/1476-4598-11-19"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22471946"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22471946"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "TaeJeong Oh, Nayoung Kim, Youngho Moon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide identification and validation of a novel methylation biomarker, SDC2, for blood-based detection of colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Diagn (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmoldx.2013.03.004"}], "href": "https://doi.org/10.1016/j.jmoldx.2013.03.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23747112"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23747112"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Barbara Kinga Barták, Alexandra Kalmár, Bálint Péterfia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Colorectal adenoma and cancer detection based on altered methylation pattern of SFRP1, SFRP2, SDC2, and PRIMA1 in plasma samples."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Epigenetics (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15592294.2017.1356957"}], "href": "https://doi.org/10.1080/15592294.2017.1356957"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28753106"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28753106"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jianping Wang, Side Liu, Hui Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Robust performance of a novel stool DNA test of methylated SDC2 for colorectal cancer detection: a multicenter clinical study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Epigenetics (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13148-020-00954-x"}], "href": "https://doi.org/10.1186/s13148-020-00954-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33126908"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33126908"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Maria J Worsham, Kang Mei Chen, Tamer Ghanem, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic modulation of signal transduction pathways in HPV-associated HNSCC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Otolaryngol Head Neck Surg (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/0194599813490895"}], "href": "https://doi.org/10.1177/0194599813490895"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23736812"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23736812"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Brett T Chiquet, Syed S Hashmi, Robin Henry, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genomic screening identifies novel linkages and provides further evidence for a role of MYH9 in nonsyndromic cleft lip and palate."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ejhg.2008.149"}], "href": "https://doi.org/10.1038/ejhg.2008.149"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18716610"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18716610"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Xin Huang, Da-Wei Xiao, Li-Yan Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic significance of altered expression of SDC2 and CYR61 in esophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or_00000332"}], "href": "https://doi.org/10.3892/or_00000332"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19288017"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19288017"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Ruheng Hua, Jiawei Yu, Xiyue Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Syndecan-2 in colorectal cancer plays oncogenic role via epithelial-mesenchymal transition and MAPK pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2019.109630"}], "href": "https://doi.org/10.1016/j.biopha.2019.109630"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31707342"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31707342"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Cristian E Poblete, Juan Fulla, Marcela Gallardo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased SNAIL expression and low syndecan levels are associated with high Gleason grade in prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2014.2254"}], "href": "https://doi.org/10.3892/ijo.2014.2254"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24424718"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24424718"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Sungmun Choi, Eunjung Lee, Soojin Kwon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transmembrane domain-induced oligomerization is crucial for the functions of syndecan-2 and syndecan-4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M509238200"}], "href": "https://doi.org/10.1074/jbc.M509238200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16253987"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16253987"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Ian C Dews, Kevin R Mackenzie "}, {"type": "b", "children": [{"type": "t", "text": "Transmembrane domains of the syndecan family of growth factor coreceptors display a hierarchy of homotypic and heterotypic interactions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0708909105"}], "href": "https://doi.org/10.1073/pnas.0708909105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18093920"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18093920"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Hawon Lee, Yeonhee Kim, Youngsil Choi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Syndecan-2 cytoplasmic domain regulates colon cancer cell migration via interaction with syntenin-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2011.04.135"}], "href": "https://doi.org/10.1016/j.bbrc.2011.04.135"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21569759"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21569759"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Kenta Okamoto, Hitomi Kinoshita, Maria Del Carmen Parquet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dengue virus strain DEN2 16681 utilizes a specific glycochain of syndecan-2 proteoglycan as a receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gen Virol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1099/vir.0.037853-0"}], "href": "https://doi.org/10.1099/vir.0.037853-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22170634"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22170634"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Mi-Jung Kwon, Eunkyoung Hong, Youngsil Choi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interleukin-1α promotes extracellular shedding of syndecan-2 via induction of matrix metalloproteinase-7 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2014.02.142"}], "href": "https://doi.org/10.1016/j.bbrc.2014.02.142"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24613844"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24613844"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Dominique Modrowski, Armelle Orosco, Judicaël Thévenard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Syndecan-2 overexpression induces osteosarcoma cell apoptosis: Implication of syndecan-2 cytoplasmic domain and JNK signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bone (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bone.2005.04.010"}], "href": "https://doi.org/10.1016/j.bone.2005.04.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15936998"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15936998"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "François-Xavier Dieudonné, Allison Marion, Pierre J Marie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeted inhibition of T-cell factor activity promotes syndecan-2 expression and sensitization to doxorubicin in osteosarcoma cells and bone tumors in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Bone Miner Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jbmr.1650"}], "href": "https://doi.org/10.1002/jbmr.1650"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22550000"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22550000"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Oriol Noguer, Joan Villena, Jordi Lorita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Syndecan-2 downregulation impairs angiogenesis in human microvascular endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2008.11.016"}], "href": "https://doi.org/10.1016/j.yexcr.2008.11.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19073173"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19073173"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Ning Zhao, Hua Liu, Brenda Lilly "}, {"type": "b", "children": [{"type": "t", "text": "Reciprocal regulation of syndecan-2 and Notch signaling in vascular smooth muscle cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.322107"}], "href": "https://doi.org/10.1074/jbc.M111.322107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22437834"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22437834"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Sarolta Bacsa, Ghadah Karasneh, Sandor Dosa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Syndecan-1 and syndecan-2 play key roles in herpes simplex virus type-1 infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gen Virol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1099/vir.0.027052-0"}], "href": "https://doi.org/10.1099/vir.0.027052-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21148276"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21148276"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Chaoliang Liao, Qin Zhou, Zhibao Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epstein-Barr virus-encoded latent membrane protein 1 promotes extracellular vesicle secretion through syndecan-2 and synaptotagmin-like-4 in nasopharyngeal carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.14305"}], "href": "https://doi.org/10.1111/cas.14305"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31930596"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31930596"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Maria Mytilinaiou, Dragana Nikitovic, Aikaterini Berdiaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Emerging roles of syndecan 2 in epithelial and mesenchymal cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "IUBMB Life (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/iub.1678"}], "href": "https://doi.org/10.1002/iub.1678"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28940845"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28940845"}]}]}]}
Synonyms HSPG1, SYND2, CD362
Proteins SDC2_HUMAN
NCBI Gene ID 6383
API
Download Associations
Predicted Functions View SDC2's ARCHS4 Predicted Functions.
Co-expressed Genes View SDC2's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View SDC2's ARCHS4 Predicted Functions.

Functional Associations

SDC2 has 11,882 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 120 datasets.

Click the + buttons to view associations for SDC2 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles tissues with high or low expression of SDC2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles tissues with high or low expression of SDC2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray tissue samples with high or low expression of SDC2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq tissue samples with high or low expression of SDC2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles tissues with high or low expression of SDC2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
BioGPS Cell Line Gene Expression Profiles cell lines with high or low expression of SDC2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
BioGPS Human Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of SDC2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of SDC2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of SDC2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CCLE Cell Line Gene Expression Profiles cell lines with high or low expression of SDC2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
CCLE Cell Line Proteomics Cell lines associated with SDC2 protein from the CCLE Cell Line Proteomics dataset.
CellMarker Gene-Cell Type Associations cell types associated with SDC2 gene from the CellMarker Gene-Cell Type Associations dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of SDC2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of SDC2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ChEA Transcription Factor Targets 2022 transcription factors binding the promoter of SDC2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
CMAP Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of SDC2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores cellular components containing SDC2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 cellular components containing SDC2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Experimental Protein Localization Evidence Scores cellular components containing SDC2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores cellular components co-occuring with SDC2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with SDC2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
CORUM Protein Complexes protein complexs containing SDC2 protein from the CORUM Protein Complexes dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of SDC2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene Mutation Profiles cell lines with SDC2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
CTD Gene-Chemical Interactions chemicals interacting with SDC2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
CTD Gene-Disease Associations diseases associated with SDC2 gene/protein from the curated CTD Gene-Disease Associations dataset.
dbGAP Gene-Trait Associations traits associated with SDC2 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
DepMap CRISPR Gene Dependency cell lines with fitness changed by SDC2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
DISEASES Curated Gene-Disease Association Evidence Scores 2025 diseases involving SDC2 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 diseases associated with SDC2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores diseases co-occuring with SDC2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with SDC2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
DisGeNET Gene-Disease Associations diseases associated with SDC2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
DisGeNET Gene-Phenotype Associations phenotypes associated with SDC2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
DrugBank Drug Targets interacting drugs for SDC2 protein from the curated DrugBank Drug Targets dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at SDC2 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of SDC2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of SDC2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells PubMedIDs of publications reporting gene signatures containing SDC2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
GAD Gene-Disease Associations diseases associated with SDC2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
GAD High Level Gene-Disease Associations diseases associated with SDC2 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
GDSC Cell Line Gene Expression Profiles cell lines with high or low expression of SDC2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with SDC2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing SDC2 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of SDC2 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of SDC2 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations kinase perturbations changing expression of SDC2 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of SDC2 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of SDC2 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of SDC2 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
GlyGen Glycosylated Proteins ligands (chemical) binding SDC2 protein from the GlyGen Glycosylated Proteins dataset.
GO Biological Process Annotations 2015 biological processes involving SDC2 gene from the curated GO Biological Process Annotations 2015 dataset.
GO Biological Process Annotations 2023 biological processes involving SDC2 gene from the curated GO Biological Process Annotations 2023 dataset.
GO Biological Process Annotations 2025 biological processes involving SDC2 gene from the curated GO Biological Process Annotations2025 dataset.
GO Cellular Component Annotations 2015 cellular components containing SDC2 protein from the curated GO Cellular Component Annotations 2015 dataset.
GO Cellular Component Annotations 2023 cellular components containing SDC2 protein from the curated GO Cellular Component Annotations 2023 dataset.
GO Cellular Component Annotations 2025 cellular components containing SDC2 protein from the curated GO Cellular Component Annotations 2025 dataset.
GO Molecular Function Annotations 2015 molecular functions performed by SDC2 gene from the curated GO Molecular Function Annotations 2015 dataset.
GO Molecular Function Annotations 2023 molecular functions performed by SDC2 gene from the curated GO Molecular Function Annotations 2023 dataset.
GO Molecular Function Annotations 2025 molecular functions performed by SDC2 gene from the curated GO Molecular Function Annotations 2025 dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of SDC2 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of SDC2 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of SDC2 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
GWASdb SNP-Disease Associations diseases associated with SDC2 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.
GWASdb SNP-Phenotype Associations phenotypes associated with SDC2 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles cell lines with high or low expression of SDC2 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset.
HMDB Metabolites of Enzymes interacting metabolites for SDC2 protein from the curated HMDB Metabolites of Enzymes dataset.
HPA Cell Line Gene Expression Profiles cell lines with high or low expression of SDC2 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset.
HPA Tissue Gene Expression Profiles tissues with high or low expression of SDC2 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset.
HPA Tissue Protein Expression Profiles tissues with high or low expression of SDC2 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset.
HPA Tissue Sample Gene Expression Profiles tissue samples with high or low expression of SDC2 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset.
Hub Proteins Protein-Protein Interactions interacting hub proteins for SDC2 from the curated Hub Proteins Protein-Protein Interactions dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with SDC2 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
IMPC Knockout Mouse Phenotypes phenotypes of mice caused by SDC2 gene knockout from the IMPC Knockout Mouse Phenotypes dataset.
InterPro Predicted Protein Domain Annotations protein domains predicted for SDC2 protein from the InterPro Predicted Protein Domain Annotations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of SDC2 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
KEA Substrates of Kinases kinases that phosphorylate SDC2 protein from the curated KEA Substrates of Kinases dataset.
KEGG Pathways pathways involving SDC2 protein from the KEGG Pathways dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of SDC2 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of SDC2 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures small molecule perturbations changing expression of SDC2 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset.
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures gene perturbations changing expression of SDC2 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of SDC2 gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
LOCATE Curated Protein Localization Annotations cellular components containing SDC2 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset.
LOCATE Predicted Protein Localization Annotations cellular components predicted to contain SDC2 protein from the LOCATE Predicted Protein Localization Annotations dataset.
MGI Mouse Phenotype Associations 2023 phenotypes of transgenic mice caused by SDC2 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of SDC2 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
MoTrPAC Rat Endurance Exercise Training tissue samples with high or low expression of SDC2 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset.
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations gene perturbations changing expression of SDC2 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles drug perturbations changing expression of SDC2 gene from the NIBR DRUG-seq U2OS MoA Box dataset.
Pathway Commons Protein-Protein Interactions interacting proteins for SDC2 from the Pathway Commons Protein-Protein Interactions dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of SDC2 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations gene perturbations changing expression of SDC2 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PFOCR Pathway Figure Associations 2023 pathways involving SDC2 protein from the PFOCR Pathway Figure Associations 2023 dataset.
PFOCR Pathway Figure Associations 2024 pathways involving SDC2 protein from the Wikipathways PFOCR 2024 dataset.
Phosphosite Textmining Biological Term Annotations biological terms co-occuring with SDC2 protein in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.
PhosphoSitePlus Substrates of Kinases kinases that phosphorylate SDC2 protein from the curated PhosphoSitePlus Substrates of Kinases dataset.
PID Pathways pathways involving SDC2 protein from the PID Pathways dataset.
Reactome Pathways 2014 pathways involving SDC2 protein from the Reactome Pathways dataset.
Reactome Pathways 2024 pathways involving SDC2 protein from the Reactome Pathways 2024 dataset.
Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of SDC2 gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of SDC2 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
Roadmap Epigenomics Cell and Tissue Gene Expression Profiles cell types and tissues with high or low expression of SDC2 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at SDC2 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of SDC2 gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of SDC2 gene from the RummaGEO Gene Perturbation Signatures dataset.
Sanger Dependency Map Cancer Cell Line Proteomics cell lines associated with SDC2 protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset.
SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs drug perturbations changing phosphorylation of SDC2 protein from the SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs dataset.
SynGO Synaptic Gene Annotations synaptic terms associated with SDC2 gene from the SynGO Synaptic Gene Annotations dataset.
Tabula Sapiens Gene-Cell Associations cell types with high or low expression of SDC2 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset.
TargetScan Predicted Conserved microRNA Targets microRNAs regulating expression of SDC2 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset.
TargetScan Predicted Nonconserved microRNA Targets microRNAs regulating expression of SDC2 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of SDC2 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores tissues with high expression of SDC2 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 tissues with high expression of SDC2 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores tissues with high expression of SDC2 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 tissues with high expression of SDC2 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores tissues co-occuring with SDC2 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with SDC2 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.
WikiPathways Pathways 2024 pathways involving SDC2 protein from the WikiPathways Pathways 2024 dataset.