{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSEC11A encodes SPC18, a key subunit of the signal peptidase complex (SPC) located in the endoplasmic reticulum (ER). The SPC is essential for processing secretory pre‐proteins by cleaving their signal peptides using a catalytic triad positioned close to the ER membrane. High-resolution structural studies have revealed that the complex forms a distinct transmembrane window that helps determine substrate specificity based on the hydrophobic segment length of the signal peptides"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n<br><br>\nIn several cancer types—including gastric, colorectal, esophageal, bladder, and tongue squamous cell carcinomas—aberrant expression of SEC11A (as SPC18) has been linked to tumor progression. Overexpression of SPC18 correlates with advanced tumor stage, increased invasiveness, and poorer patient survival. Mechanistically, SPC18 facilitates malignant growth and invasiveness by promoting the secretion of growth factors such as transforming growth factor‑α, thereby activating downstream signaling pathways (e.g., EGFR, Erk, and Akt). Its expression can be modulated by non‐coding RNA networks; for example, the long non‐coding RNA DDX11‑AS1 acts as a competing endogenous RNA for miR‑873‑5p to enhance SEC11A expression in gastric cancer. Similar observations in colorectal, bladder, and esophageal cancers underscore the prognostic value of elevated SPC18 levels"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "8"}]}, {"type": "t", "text": "\n<br><br>\nBeyond its oncogenic roles, SEC11A is also implicated in non-cancerous diseases; for instance, a circular RNA derived from SEC11A (circSEC11A) has been associated with the progression of ischemic stroke, indicating that modulation of SEC11A-related pathways may influence a broader spectrum of pathophysiological processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "A Manuel Liaci, Barbara Steigenberger, Paulo Cesar Telles de Souza, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA DDX11-AS1 facilitates gastric cancer progression by regulating miR-873-5p/SPC18 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Artif Cells Nanomed Biotechnol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21691401.2020.1726937"}], "href": "https://doi.org/10.1080/21691401.2020.1726937"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32054332"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32054332"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yuji Yamamoto, Naohide Oue, Ryuichi Asai, et al. 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