SEC24C Gene

Name	SEC24 family member C
Description	The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The product of this gene may play a role in shaping the vesicle, as well as in cargo selection and concentration. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSEC24C is a pivotal cargo adaptor within the COPII vesicular transport machinery that selectively recognizes and binds discrete ER export motifs present on a diverse array of client proteins. For example, viral proteins such as the Ebola virus matrix protein VP40 exploit a direct interaction with SEC24C for intracellular trafficking toward the plasma membrane"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", and the HIV-1 capsid lattice similarly engages SEC24C via an FG‐motif, thereby enhancing core stability and productive infection."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In neurons and other secretory cells, SEC24C governs the efficient ER export of membrane proteins – a specificity exemplified by its exclusive interaction with the C terminus of the serotonin transporter (SERT)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "and its role in the trafficking of the GPCR α₂B-adrenergic receptor."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Moreover, SEC24C mediates ER export of other critical membrane components, including the anion exchanger (via a hydrophobic export motif;"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "and the tight junction protein claudin-1, a hepatitis C virus coreceptor"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", while related studies further show that SEC24C governs the ER export dynamics of the dopamine transporter family."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "3"}, {"type": "fg_f", "ref": "7"}, {"type": "fg_f", "ref": "5"}, {"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "Disruption or post‐translational modification of COPII components directly affects SEC24C function. COPII proteins, including isoforms of Sec24, undergo regulatory modifications during mitosis – a process that may contribute to the cessation of ER-to-Golgi traffic."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In the nervous system, SEC24C plays an indispensable cell-autonomous role; conditional loss of Sec24c in neural progenitors elicits marked neuronal death and microcephaly"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ", and genetic variations in SEC24C are implicated as potential risk factors in neuropsychiatric conditions, including late-onset Alzheimer’s disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}, {"type": "fg_f", "ref": "10"}, {"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "Additional roles for SEC24C extend to the regulated secretion of soluble proteins. SEC24C, together with its paralogs SEC24A and SEC24B, facilitates the maturation and export of proprotein convertase subtilisin/kexin type 9 (PCSK9) in hepatocytes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " Likewise, the ER export of autotaxin (ATX) and related ENPP family members is executed via a p23-dependent mechanism that selectively requires SEC24C."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " Together, these studies underscore that SEC24C is not only critical for the sorting and export of a broad spectrum of membrane and secretory proteins but also serves as a shared nexus in host-pathogen interactions and in maintaining cellular homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}, {"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Seiya Yamayoshi, Takeshi Noda, Hideki Ebihara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ebola virus matrix protein VP40 uses the COPII transport system for its intracellular transport."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Host Microbe (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.chom.2008.02.001"}], "href": "https://doi.org/10.1016/j.chom.2008.02.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18329616"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18329616"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Stephanie V Rebensburg, Guochao Wei, Ross C Larue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sec24C is an HIV-1 host dependency factor crucial for virus replication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Microbiol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41564-021-00868-1"}], "href": "https://doi.org/10.1038/s41564-021-00868-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33649557"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33649557"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Sonja Sucic, Ali El-Kasaby, Oliver Kudlacek, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The serotonin transporter is an exclusive client of the coat protein complex II (COPII) component SEC24C."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.230037"}], "href": "https://doi.org/10.1074/jbc.M111.230037"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21454670"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21454670"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Chunmin Dong, Charles D Nichols, Jianhui Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A triple arg motif mediates α(2B)-adrenergic receptor interaction with Sec24C/D and export."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Traffic (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1600-0854.2012.01351.x"}], "href": "https://doi.org/10.1111/j.1600-0854.2012.01351.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22404651"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22404651"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Wataru Otsu, Takao Kurooka, Yayoi Otsuka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A new class of endoplasmic reticulum export signal PhiXPhiXPhi for transmembrane proteins and its selective interaction with Sec24C."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.443325"}], "href": "https://doi.org/10.1074/jbc.M112.443325"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23658022"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23658022"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Peiqi Yin, Ye Li, Leiliang Zhang "}, {"type": "b", "children": [{"type": "t", "text": "Sec24C-Dependent Transport of Claudin-1 Regulates Hepatitis C Virus Entry."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.00629-17"}], "href": "https://doi.org/10.1128/JVI.00629-17"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28679754"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28679754"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Sonja Sucic, Florian Koban, Ali El-Kasaby, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Switching the clientele: a lysine residing in the C terminus of the serotonin transporter specifies its preference for the coat protein complex II component SEC24C."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.408237"}], "href": "https://doi.org/10.1074/jbc.M112.408237"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23288844"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23288844"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Pierrick Dudognon, Christine Maeder-Garavaglia, Jean-Louis Carpentier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of a COPII component by cytosolic O-glycosylation during mitosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/S0014-5793(04)00109-7"}], "href": "https://doi.org/10.1016/S0014-5793(04"}, {"type": "t", "text": "00109-7) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15013749"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15013749"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Bo Wang, Joung Hyuck Joo, Rebecca Mount, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The COPII cargo adapter SEC24C is essential for neuronal homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI98194"}], "href": "https://doi.org/10.1172/JCI98194"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29939162"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29939162"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "A R Morgan, D Turic, L Jehu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet B Neuropsychiatr Genet (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.b.30509"}], "href": "https://doi.org/10.1002/ajmg.b.30509"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17373700"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17373700"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Shi-Jun Deng, Yishi Shen, Hong-Mei Gu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role of the C-terminal domain of PCSK9 and SEC24 isoforms in PCSK9 secretion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Mol Cell Biol Lipids (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbalip.2020.158660"}], "href": "https://doi.org/10.1016/j.bbalip.2020.158660"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32058034"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32058034"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Lin Lyu, Baolu Wang, Chaoyang Xiong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Selective export of autotaxin from the endoplasmic reticulum."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M116.774356"}], "href": "https://doi.org/10.1074/jbc.M116.774356"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28298439"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28298439"}]}]}]}
Proteins	SC24C_HUMAN
NCBI Gene ID	9632
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SEC24C has 8,117 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 124 datasets.

Click the + buttons to view associations for SEC24C from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SEC24C Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by SEC24C gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SEC24C gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SEC24C gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SEC24C gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SEC24C gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SEC24C gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SEC24C gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SEC24C gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SEC24C gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SEC24C gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SEC24C gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SEC24C gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with SEC24C protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SEC24C gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SEC24C gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SEC24C gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SEC24C gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing SEC24C protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SEC24C gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SEC24C protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SEC24C protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing SEC24C protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing SEC24C protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SEC24C protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SEC24C protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SEC24C gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SEC24C gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with SEC24C gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with SEC24C gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SEC24C gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with SEC24C gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with SEC24C gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SEC24C gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SEC24C gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SEC24C gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SEC24C gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SEC24C gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SEC24C gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SEC24C gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SEC24C from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.