{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSEC61B is a key subunit of the Sec61 translocon complex, critically involved in the translocation and retrograde trafficking of proteins across the endoplasmic reticulum (ER) membrane. Notably, SEC61B facilitates the extraction of membrane‐anchored proteins such as the epidermal growth factor receptor (EGFR) from the lipid bilayer, thereby enabling their nuclear translocation and participation in downstream signaling pathways. Moreover, its physical association with complexes such as the exocyst and its role in basolateral membrane protein delivery—as well as in the regulation of tight junction components like claudin‐4—underscore its broad function in orchestrating protein targeting and secretion at the ER."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its fundamental role in protein biogenesis, alterations in SEC61B function have been implicated in various pathological conditions. Genetic loss‐of‐function mutations affecting SEC61B contribute to defective maturation and trafficking of pivotal proteins such as polycystin-1, as observed in polycystic liver disease. In parallel, downregulation of SEC61B has been associated with resistance to platinum-based chemotherapeutic agents, an effect mediated at least in part by altered expression and distribution of copper transporters. In addition, modest changes in SEC61B expression have been identified in colorectal cancer tissues, suggesting its potential utility as a serological biomarker in oncological contexts."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSEC61B also plays a vital role in maintaining ER homeostasis by interfacing with other cellular systems. Its direct interaction with microtubules serves not only to stabilize translocon complexes and maintain ribosome association with the ER but also to modulate the cell’s response to ER stress. For instance, in models of acute pulmonary embolism, regulatory pathways involving microRNA-mediated upregulation of ER stress-associated proteins converge on SEC61B, ultimately promoting inflammatory responses and apoptosis. These findings extend our understanding of SEC61B as an integrative component linking protein translocation, cytoskeletal dynamics, and stress response."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hong-Jun Liao, Graham Carpenter "}, {"type": "b", "children": [{"type": "t", "text": "Role of the Sec61 translocon in EGF receptor trafficking to the nucleus and gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e06-09-0802"}], "href": "https://doi.org/10.1091/mbc.e06-09-0802"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17215517"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17215517"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ying-Nai Wang, Hirohito Yamaguchi, Longfei Huo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The translocon Sec61beta localized in the inner nuclear membrane transports membrane-embedded EGF receptor to the nucleus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.158659"}], "href": "https://doi.org/10.1074/jbc.M110.158659"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20937808"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20937808"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Soo Young Choi, Ben Fogelgren, Xiaofeng Zuo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exocyst Sec10 is involved in basolateral protein translation and translocation in the endoplasmic reticulum."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nephron Exp Nephrol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000342366"}], "href": "https://doi.org/10.1159/000342366"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23037926"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23037926"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Makiko Washiyama, Naoya Koizumi, Makiko Fujii, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sec61β regulates barrier functions of tight junction through expression of claudin-4 in Madin-Darby canine kidney cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Pharm Bull (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1248/bpb.b13-00936"}], "href": "https://doi.org/10.1248/bpb.b13-00936"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24882410"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24882410"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Chung-Wei Fan, Chung-Chuan Chan, Kuei-Tien Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of SEC61β and its autoantibody as biomarkers for colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Chim Acta (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cca.2011.01.012"}], "href": "https://doi.org/10.1016/j.cca.2011.01.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21255561"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21255561"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Paolo B Abada, Christopher A Larson, Gerald Manorek, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sec61β controls sensitivity to platinum-containing chemotherapeutic agents through modulation of the copper-transporting ATPase ATP7A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Pharmacol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/mol.112.079822"}], "href": "https://doi.org/10.1124/mol.112.079822"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22710939"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22710939"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Whitney Besse, Ke Dong, Jungmin Choi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Isolated polycystic liver disease genes define effectors of polycystin-1 function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI90129"}], "href": "https://doi.org/10.1172/JCI90129"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28375157"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28375157"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yimeng Zhu, Gangming Zhang, Shaoyu Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sec61β facilitates the maintenance of endoplasmic reticulum homeostasis by associating microtubules."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Protein Cell (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13238-017-0492-5"}], "href": "https://doi.org/10.1007/s13238-017-0492-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29168059"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29168059"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Ting-Wei Liu, Fan Liu, Jian Kang "}, {"type": "b", "children": [{"type": "t", "text": "Let-7b-5p is involved in the response of endoplasmic reticulum stress in acute pulmonary embolism through upregulating the expression of stress-associated endoplasmic reticulum protein 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "IUBMB Life (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/iub.2306"}], "href": "https://doi.org/10.1002/iub.2306"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32534478"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32534478"}]}]}]}