SEC62 Gene

Name	SEC62 homolog (S. cerevisiae)
Description	The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSec62 is an integral membrane protein of the endoplasmic reticulum (ER) that plays dual roles in maintaining ER homeostasis. Notably, it functions as an ER‐resident autophagy receptor during recovery from ER stress by mediating a selective form of ER turnover termed recovER‐phagy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, Sec62 contributes to the translocation of proteins into the ER; while the classical co‐translational pathway predominates for most precursors, Sec62 is specifically required for the posttranslational import of certain small, signal peptide–bearing proteins through the Sec61 channel."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Detailed analyses reveal that substrates requiring Sec62 often contain slowly gating signal peptides whose properties necessitate assistance from Sec62, potentially through mechanisms involving interactions with auxiliary factors such as BiP, as further supported by findings in intact human cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its fundamental roles in protein homeostasis, aberrant overexpression and gene amplification of SEC62—frequently mapped to the oncogenic 3q26 region—are observed in a variety of human cancers, including colorectal, gastric, lung, prostate, head and neck, cervical, and triple‐negative breast cancers."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "17"}]}, {"type": "t", "text": " Functionally, elevated Sec62 levels have been linked to enhanced cell migration, invasion, and resistance to ER stress, thereby promoting metastatic dissemination and chemoresistance in these tumor types. Moreover, regulatory mechanisms affecting SEC62 mRNA stability—such as m6A modifications mediated by METTL3/IGF2BP1 and regulation by microRNAs—further underscore its role as an oncogenic driver. In addition, a circular RNA derived from SEC62 (circSEC62) has been shown to modulate gene expression, thereby enhancing epithelial‐to‐mesenchymal transition and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Fiorenza Fumagalli, Julia Noack, Timothy J Bergmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb3423"}], "href": "https://doi.org/10.1038/ncb3423"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27749824"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27749824"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Sven Lang, Julia Benedix, Sorin V Fedeles, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.096727"}], "href": "https://doi.org/10.1242/jcs.096727"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22375059"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22375059"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Asvin K K Lakkaraju, Ratheeshkumar Thankappan, Camille Mary, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Efficient secretion of small proteins in mammalian cells relies on Sec62-dependent posttranslational translocation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E12-03-0228"}], "href": "https://doi.org/10.1091/mbc.E12-03-0228"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22648169"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22648169"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Stefan Schorr, Duy Nguyen, Sarah Haßdenteufel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of signal peptide features for substrate specificity in human Sec62/Sec63-dependent ER protein import."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS J (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/febs.15274"}], "href": "https://doi.org/10.1111/febs.15274"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32133789"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32133789"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xiaofeng Liu, Kunqi Su, Xiaoyan Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sec62 promotes stemness and chemoresistance of human colorectal cancer through activating Wnt/β-catenin pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-021-01934-6"}], "href": "https://doi.org/10.1186/s13046-021-01934-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33858476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33858476"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Huabo He, Wei Wu, Zhener Sun, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer drivers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Discov (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/2159-8290.CD-12-0592"}], "href": "https://doi.org/10.1158/2159-8290.CD-12-0592"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23764425"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23764425"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Maximilian Linxweiler, Johannes Linxweiler, Monika Barth, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sec62 bridges the gap from 3q amplification to molecular cell biology in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajpath.2011.10.039"}], "href": "https://doi.org/10.1016/j.ajpath.2011.10.039"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22197383"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22197383"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Maximilian Linxweiler, Stefan Schorr, Nico Schäuble, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeting cell migration and the endoplasmic reticulum stress response with calmodulin antagonists: a clinically tested small molecule phenocopy of SEC62 gene silencing in human tumor cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-13-574"}], "href": "https://doi.org/10.1186/1471-2407-13-574"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24304694"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24304694"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Markus Greiner, Birgit Kreutzer, Volker Jung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing of the SEC62 gene inhibits migratory and invasive potential of various tumor cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.25580"}], "href": "https://doi.org/10.1002/ijc.25580"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20669223"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20669223"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Volker Jung, Roland Kindich, Jörn Kamradt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genomic and expression analysis of the 3q25-q26 amplification unit reveals TLOC1/SEC62 as a probable target gene in prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-05-0165"}], "href": "https://doi.org/10.1158/1541-7786.MCR-05-0165"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16547154"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16547154"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Markus Greiner, Birgit Kreutzer, Sven Lang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sec62 protein level is crucial for the ER stress tolerance of prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Prostate (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pros.21324"}], "href": "https://doi.org/10.1002/pros.21324"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21557272"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21557272"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Florian Bochen, Hana Adisurya, Silke Wemmert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effect of 3q oncogenes SEC62 and SOX2 on lymphatic metastasis and clinical outcome of head and neck squamous cell carcinomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.13986"}], "href": "https://doi.org/10.18632/oncotarget.13986"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28002801"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28002801"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Maximilian Linxweiler, Florian Bochen, Bernhard Schick, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of SEC62 as a potential marker for 3q amplification and cellular migration in dysplastic cervical lesions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-016-2739-6"}], "href": "https://doi.org/10.1186/s12885-016-2739-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27553742"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27553742"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Song Su, Yan-Ting Shi, Yi Chu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sec62 promotes gastric cancer metastasis through mediating UPR-induced autophagy activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-022-04143-2"}], "href": "https://doi.org/10.1007/s00018-022-04143-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35165763"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35165763"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Ferenc Zoltan Takacs, Julia Caroline Radosa, Maximilian Linxweiler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of 3q oncogene SEC62 as a marker for distant metastasis and poor clinical outcome in invasive ductal breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Gynecol Obstet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00404-019-05081-4"}], "href": "https://doi.org/10.1007/s00404-019-05081-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30747329"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30747329"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Julia C Radosa, Mariz Kasoha, Merle Doerk, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Splicing factor SNRPA associated with microvascular invasion promotes hepatocellular carcinoma metastasis through activating NOTCH1/Snail pathway and is mediated by circSEC62/miR-625-5p axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Environ Toxicol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/tox.23745"}], "href": "https://doi.org/10.1002/tox.23745"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36715182"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36715182"}]}]}]}
Synonyms	HTP1, TLOC1, DTRP1, TP-1
Proteins	SEC62_HUMAN
NCBI Gene ID	7095
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SEC62 has 7,247 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 117 datasets.

Click the + buttons to view associations for SEC62 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SEC62 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by SEC62 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SEC62 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SEC62 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SEC62 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SEC62 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SEC62 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SEC62 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SEC62 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SEC62 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of SEC62 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SEC62 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SEC62 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with SEC62 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SEC62 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SEC62 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SEC62 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SEC62 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of SEC62 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing SEC62 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SEC62 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SEC62 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SEC62 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing SEC62 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing SEC62 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SEC62 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SEC62 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SEC62 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SEC62 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with SEC62 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with SEC62 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of SEC62 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SEC62 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with SEC62 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SEC62 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SEC62 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SEC62 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SEC62 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SEC62 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SEC62 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SEC62 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.