SEMA3C Gene

HGNC Family	Semaphorins (SEMA), Immunoglobulin superfamily domain containing
Name	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
Description	This gene encodes a secreted glycoprotein that belongs to the semaphorin class 3 family of neuronal guidance cues. The encoded protein contains an N-terminal sema domain, integrin and immunoglobulin-like domains, and a C-terminal basic domain. Homodimerization and proteolytic cleavage of the C-terminal propeptide are necessary for the function of the encoded protein. It binds a neuropilin co-receptor before forming a heterotrimeric complex with an associated plexin. An increase in the expression of this gene correlates with an increase in cancer cell invasion and adhesion. Naturally occurring mutations in this gene are associated with Hirschsprung disease. [provided by RefSeq, May 2017]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSEMA3C is a secreted guidance molecule with critical developmental roles. In the embryonic heart, its expression is directly regulated by transcription factors such as GATA6, and its disruption contributes to structural cardiac outflow tract defects."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In parallel, appropriate SEMA3C expression within the enteric nervous system is essential for neural crest cell migration and proper gut innervation—dysregulation in this context has been linked to Hirschsprung disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Furthermore, SEMA3C modulates the levels and responsiveness of neuropilin receptors on motor neuron growth cones, thereby refining axon guidance and circuit formation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Finally, genetic studies have identified intronic variants in SEMA3C that associate with neurodevelopmental disorders such as dyslexia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn cancer, aberrant SEMA3C expression fosters tumor progression by enhancing cellular invasion, migration, and epithelial‐to‐mesenchymal transition. For example, in prostate cancer increased SEMA3C levels correlate with decreased cell adhesion and the activation of autocrine cMET signaling that drives perineural invasion."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "9"}]}, {"type": "t", "text": " In malignant gliomas, SEMA3C secreted by glioma stem cells sustains their survival through an autocrine/paracrine loop engaging Plexin receptors and Rac1/NF‐κB signaling, with its inhibition leading to apoptotic cell death."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Proteolytic processing of SEMA3C, as seen in breast cancer via ADAMTS1 cleavage, liberates bioactive fragments that further promote tumor cell migration"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": ", while in gastric and pancreatic cancers, overexpression of SEMA3C enhances angiogenesis and tumor growth through activation of ERK1/2 signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " Complementary findings in breast cancer models and circulating tumor cell mimetics have shown that dysregulation of SEMA3C signaling—modulated by factors such as miR-146a and Neuropilin2—is integral to metastatic dissemination."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSEMA3C also exerts pronounced effects on vascular remodeling and metabolic as well as endocrine processes. In endothelial settings, signaling via Neuropilin/Plexin complexes triggers cytoskeletal collapse in lymphatic endothelial cells, and a furin cleavage–resistant form of SEMA3C potently inhibits neovascularization in age‐related macular degeneration models."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": " Its circulating levels have been correlated with obesity measures and insulin sensitivity, suggesting that SEMA3C may serve as a novel adipokine biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": " Moreover, regulation by a lymphatic-specific long noncoding RNA (LETR1) underscores its role in endothelial cell growth and migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": " In castration-resistant prostate cancer, SEMA3C further contributes to tumor progression by promoting intratumoral androgen synthesis via alterations in key steroidogenic enzyme expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "22"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond these roles, SEMA3C is overexpressed in polycystic kidney disease, where its elevated levels in cystic epithelial cells may enhance cell survival and modulate paracrine interactions with glomerular endothelial cells in the kidney’s highly vascularized microenvironment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "24"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kazuki Kodo, Tsutomu Nishizawa, Michiko Furutani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GATA6 mutations cause human cardiac outflow tract defects by disrupting semaphorin-plexin signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0904744106"}], "href": "https://doi.org/10.1073/pnas.0904744106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19666519"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19666519"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Qian Jiang, Stacey Arnold, Tiffany Heanue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional loss of semaphorin 3C and/or semaphorin 3D and their epistatic interaction with ret are critical to Hirschsprung disease liability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2015.02.014"}], "href": "https://doi.org/10.1016/j.ajhg.2015.02.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25839327"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25839327"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": " Gunadi, Fiko Ryantono, Raman Sethi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effect of semaphorin 3C gene variants in multifactorial Hirschsprung disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Int Med Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/0300060520987789"}], "href": "https://doi.org/10.1177/0300060520987789"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33557656"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33557656"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Isabelle Sanyas, Muriel Bozon, Frédéric Moret, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Motoneuronal Sema3C is essential for setting stereotyped motor tract positioning in limb-derived chemotropic semaphorins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.080051"}], "href": "https://doi.org/10.1242/dev.080051"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22899844"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22899844"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Amaia Carrion-Castillo, Sara B Estruch, Ben Maassen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Whole-genome sequencing identifies functional noncoding variation in SEMA3C that cosegregates with dyslexia in a multigenerational family."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00439-021-02289-w"}], "href": "https://doi.org/10.1007/s00439-021-02289-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34076780"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34076780"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jeffery G Herman, Gary G Meadows "}, {"type": "b", "children": [{"type": "t", "text": "Increased class 3 semaphorin expression modulates the invasive and adhesive properties of prostate cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2007)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17390026"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17390026"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Lijuan Yin, Jingjing Li, Jing Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MAOA promotes prostate cancer cell perineural invasion through SEMA3C/PlexinA2/NRP1-cMET signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-020-01615-2"}], "href": "https://doi.org/10.1038/s41388-020-01615-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33420365"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33420365"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Kevin J Tam, Daniel H F Hui, Wilson W Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Semaphorin 3 C drives epithelial-to-mesenchymal transition, invasiveness, and stem-like characteristics in prostate cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-017-11914-6"}], "href": "https://doi.org/10.1038/s41598-017-11914-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28904399"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28904399"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Kevin J Tam, Liangliang Liu, Michael Hsing, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinically-observed FOXA1 mutations upregulate SEMA3C through transcriptional derepression in prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-024-57854-w"}], "href": "https://doi.org/10.1038/s41598-024-57854-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38528115"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38528115"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jianghong Man, Jocelyn Shoemake, Wenchao Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sema3C promotes the survival and tumorigenicity of glioma stem cells through Rac1 activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2014.10.055"}], "href": "https://doi.org/10.1016/j.celrep.2014.10.055"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25464848"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25464848"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Haidong Zhang, Hui Ma, Wenling Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased Expression of Sema3C Indicates a Poor Prognosis and Is Regulated by miR-142-5p in Glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Pharm Bull (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1248/bpb.b19-00818"}], "href": "https://doi.org/10.1248/bpb.b19-00818"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32238705"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32238705"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Cary Esselens, Jordi Malapeira, Núria Colomé, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The cleavage of semaphorin 3C induced by ADAMTS1 promotes cell migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.055129"}], "href": "https://doi.org/10.1074/jbc.M109.055129"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19915008"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19915008"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Hideyo Miyato, Nelson Hirokazu Tsuno, Joji Kitayama "}, {"type": "b", "children": [{"type": "t", "text": "Semaphorin 3C is involved in the progression of gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.12003"}], "href": "https://doi.org/10.1111/cas.12003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22924992"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22924992"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Xuejun Xu, Zhiping Zhao, Shixiang Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased semaphorin 3c expression promotes tumor growth and metastasis in pancreatic ductal adenocarcinoma by activating the ERK1/2 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2017.03.014"}], "href": "https://doi.org/10.1016/j.canlet.2017.03.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28315433"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28315433"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Muhammad Faraz Arshad Malik, Lucy K Satherley, Eleri L Davies, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of Semaphorin 3C in Breast Cancer and its Impact on Adhesion and Invasion of Breast Cancer Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anticancer Res (2016)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26977026"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26977026"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Zachary Cole-Healy, Patricia Vergani, Keith Hunter, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The relationship between semaphorin 3C and microvessel density in the progression of breast and oral neoplasia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Mol Pathol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexmp.2015.03.041"}], "href": "https://doi.org/10.1016/j.yexmp.2015.03.041"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25910410"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25910410"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Yelena Mumblat, Ofra Kessler, Neta Ilan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Full-Length Semaphorin-3C Is an Inhibitor of Tumor Lymphangiogenesis and Metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-14-2464"}], "href": "https://doi.org/10.1158/0008-5472.CAN-14-2464"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25808871"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25808871"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Shira Toledano, Huayi Lu, Agustina Palacio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Sema3C Mutant Resistant to Cleavage by Furin (FR-Sema3C) Inhibits Choroidal Neovascularization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0168122"}], "href": "https://doi.org/10.1371/journal.pone.0168122"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28036336"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28036336"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "N Mejhert, F Wilfling, D Esteve, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Semaphorin 3C is a novel adipokine linked to extracellular matrix composition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetologia (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00125-013-2931-z"}], "href": "https://doi.org/10.1007/s00125-013-2931-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23666167"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23666167"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Ji Sun Nam, Chul Woo Ahn, Hye Jun Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Semaphorin 3 C is a Novel Adipokine Representing Exercise-Induced Improvements of Metabolism in Metabolically Healthy Obese Young Males."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-020-67004-7"}], "href": "https://doi.org/10.1038/s41598-020-67004-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32561824"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32561824"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Luca Ducoli, Saumya Agrawal, Eliane Sibler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LETR1 is a lymphatic endothelial-specific lncRNA governing cell proliferation and migration through KLF4 and SEMA3C."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-021-21217-0"}], "href": "https://doi.org/10.1038/s41467-021-21217-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33568674"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33568674"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Parvin Yenki, Hans H Adomat, Christopher J Ong "}, {"type": "b", "children": [{"type": "t", "text": "SEMA3C induces androgen synthesis in prostatic stromal cells through paracrine signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Prostate (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pros.24107"}], "href": "https://doi.org/10.1002/pros.24107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33503318"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33503318"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Parvin Yenki, Satyam Bhasin, Liang Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Semaphorin 3C promotes de novo steroidogenesis in prostate cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocr Relat Cancer (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1530/ERC-23-0010"}], "href": "https://doi.org/10.1530/ERC-23-0010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37800655"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37800655"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Bo Hye Kim, Do Yeon Kim, Yejin Ahn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Semaphorin-3C Is Upregulated in Polycystic Kidney Epithelial Cells and Inhibits Angiogenesis of Glomerular Endothelial Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Nephrol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000508263"}], "href": "https://doi.org/10.1159/000508263"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32610315"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32610315"}]}]}]}
Synonyms	SEME, SEMAE
Proteins	SEM3C_HUMAN
NCBI Gene ID	10512
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SEMA3C has 14,495 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 128 datasets.

Click the + buttons to view associations for SEMA3C from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SEMA3C Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SEMA3C gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SEMA3C gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SEMA3C gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SEMA3C gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SEMA3C gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SEMA3C gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SEMA3C gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SEMA3C gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SEMA3C gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of SEMA3C gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SEMA3C gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SEMA3C gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with SEMA3C protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SEMA3C gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SEMA3C gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SEMA3C gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SEMA3C gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of SEMA3C gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing SEMA3C protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SEMA3C gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SEMA3C protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SEMA3C protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing SEMA3C protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing SEMA3C protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SEMA3C protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SEMA3C protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SEMA3C gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SEMA3C gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with SEMA3C gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with SEMA3C gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with SEMA3C gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of SEMA3C protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SEMA3C gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for SEMA3C protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving SEMA3C gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with SEMA3C gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SEMA3C gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SEMA3C gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SEMA3C gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SEMA3C gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.