SEMA3E Gene

HGNC Family	Semaphorins (SEMA), Immunoglobulin superfamily domain containing
Name	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
Description	Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. This gene encodes a class 4 semaphorin. This gene encodes a class 3 semaphorin. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSemaphorin 3E (SEMA3E) functions as a versatile guidance cue that orchestrates vascular patterning and angiogenesis. In developmental and ischemic retinopathies, SEMA3E binding to the Plexin‑D1 receptor triggers intracellular cascades—including Rho‐ and Arf6‐dependent pathways—that promote cytoskeletal retraction and normalize endothelial filopodia formation (["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "], ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "]). In human endothelial cells, SEMA3E inhibits migration, tube formation, and sprouting as demonstrated in models of infantile hemangioma (["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "], ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "]). An RNAi screen further revealed that SEMA3E signals via downstream effectors such as SH3BP1 to modulate Rac1 activity and cell collapse (["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "]), while altered levels of SEMA3E in the aqueous humor have been implicated in the vascular dysregulation associated with diabetic retinopathy (["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "]). Moreover, SEMA3E contributes to vascular tone control under pathological conditions such as systemic sclerosis (["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "]).\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of cancer, SEMA3E exhibits complex, context‐dependent functions. On one hand, studies have classified certain class‑3 semaphorins—including SEMA3E—as anti‑tumorigenic agents (["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "]). Conversely, other investigations show that SEMA3E promotes malignant progression. For instance, in metastatic carcinoma cells SEMA3E enhances invasiveness and epithelial‑to‑mesenchymal transition (EMT) via Plexin‑D1–mediated transactivation of oncogenic kinases such as ErbB2 and activation of PI3K/Akt pathways (["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "], ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "], ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "]). In addition, SEMA3E can promote tumor cell survival by suppressing apoptosis triggered by the dependence receptor function of Plexin‑D1 (["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "]). Its expression pattern is further linked to diverse tumor behaviors—being inversely correlated with progression in melanoma (["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "]) while correlating with lymph node metastasis in squamous cell carcinoma of the tongue (["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "]). In colorectal and gastric cancers, a proteolytic fragment of SEMA3E (p61‑SEMA3E) has been implicated in driving EMT and metastasis (["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "], ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "]), whereas altered expression levels have been associated with the prognosis of prostate cancer (["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": "]).\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSEMA3E is also critical for neuronal development. In studies of inherited gonadotropin‐releasing hormone (GnRH) deficiency, a point mutation in SEMA3E was found to impair its neurotrophic function. Normally, wild‑type SEMA3E promotes PI3K‑mediated survival signaling in maturing GnRH neurons, protecting them from apoptosis—a function whose loss contributes to the pathogenesis of Kallmann syndrome (["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": "]).\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond vascular and oncologic roles, SEMA3E modulates immune responses and inflammatory processes. It acts as a potent chemorepellent for neutrophils by inhibiting CXCL8/IL‑8–induced migration and actin polymerization (["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": "]), and its pro‑inflammatory actions have been linked to insulin resistance and carotid atherosclerosis in metabolic syndrome (["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": "]). In the airways, SEMA3E has been shown to modulate both immune and structural cell functions—suggesting its potential as a therapeutic target in allergic asthma (["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": "]).\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yoko Fukushima, Mitsuhiro Okada, Hiroshi Kataoka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in ischemic retinopathy in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI44900"}], "href": "https://doi.org/10.1172/JCI44900"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21505259"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21505259"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Atsuko Sakurai, Xiaoying Jian, Charity J Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphatidylinositol-4-phosphate 5-kinase and GEP100/Brag2 protein mediate antiangiogenic signaling by semaphorin 3E-plexin-D1 through Arf6 protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.259499"}], "href": "https://doi.org/10.1074/jbc.M111.259499"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21795701"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21795701"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Haig Aghajanian, Connie Choi, Vivienne C Ho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Semaphorin 3d and semaphorin 3e direct endothelial motility through distinct molecular signaling pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.544833"}], "href": "https://doi.org/10.1074/jbc.M113.544833"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24825896"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24825896"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hironao Nakayama, Lan Huang, Ryan P Kelly, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Infantile hemangioma-derived stem cells and endothelial cells are inhibited by class 3 semaphorins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2015.06.087"}], "href": "https://doi.org/10.1016/j.bbrc.2015.06.087"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26086095"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26086095"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Aleksandra Tata, David C Stoppel, Shangyu Hong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An image-based RNAi screen identifies SH3BP1 as a key effector of Semaphorin 3E-PlexinD1 signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201309004"}], "href": "https://doi.org/10.1083/jcb.201309004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24841563"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24841563"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Soo Hyun Kwon, Jae Pil Shin, In Taek Kim, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Plexin-D1/Semaphorin 3E pathway may contribute to dysregulation of vascular tone control and defective angiogenesis in systemic sclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Res Ther (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13075-015-0749-4"}], "href": "https://doi.org/10.1186/s13075-015-0749-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26292963"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26292963"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Boaz Kigel, Asya Varshavsky, Ofra Kessler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Successful inhibition of tumor development by specific class-3 semaphorins is associated with expression of appropriate semaphorin receptors by tumor cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0003287"}], "href": "https://doi.org/10.1371/journal.pone.0003287"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18818766"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18818766"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Andrea Casazza, Veronica Finisguerra, Lorena Capparuccia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sema3E-Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI42118"}], "href": "https://doi.org/10.1172/JCI42118"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20664171"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20664171"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Chun-Hsien Tseng, Karl D Murray, Mu-Fan Jou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sema3E/plexin-D1 mediated epithelial-to-mesenchymal transition in ovarian endometrioid cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0019396"}], "href": "https://doi.org/10.1371/journal.pone.0019396"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21559368"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21559368"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Andrea Casazza, Boaz Kigel, Federica Maione, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumour growth inhibition and anti-metastatic activity of a mutated furin-resistant Semaphorin 3E isoform."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Mol Med (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/emmm.201100205"}], "href": "https://doi.org/10.1002/emmm.201100205"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22247010"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22247010"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Jonathan Luchino, Mélanie Hocine, Marie-Claude Amoureux, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Semaphorin 3E expression correlates inversely with Plexin D1 during tumor progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2353/ajpath.2008.080136"}], "href": "https://doi.org/10.2353/ajpath.2008.080136"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18974298"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18974298"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Hani Al-Shareef, Shin-Ichiro Hiraoka, Noriaki Tanaka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Use of NRP1, a novel biomarker, along with VEGF-C, VEGFR-3, CCR7 and SEMA3E, to predict lymph node metastasis in squamous cell carcinoma of the tongue."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2016.5116"}], "href": "https://doi.org/10.3892/or.2016.5116"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27666723"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27666723"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Kiyotaka Hagihara, Naotsugu Haraguchi, Junichi Nishimura, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "The predictive value of semaphorins 3 expression in biopsies for biochemical recurrence of patients with low- and intermediate-risk prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasma (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4149/neo_2013_087"}], "href": "https://doi.org/10.4149/neo_2013_087"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23906303"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23906303"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Anna Cariboni, Valentina André, Sophie Chauvet, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Chemorepellent Semaphorin 3E Negatively Regulates Neutrophil Migration In Vitro and In Vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1601093"}], "href": "https://doi.org/10.4049/jimmunol.1601093"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27913633"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27913633"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Ran-Ran Qin, Ming Song, Yi-Hui Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of Increased Serum Sema3E with TRIB3 Q84R Polymorphism and Carotid Atherosclerosis in Metabolic Syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Clin Lab Sci (2017)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28249916"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28249916"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Hesam Movassagh, Latifa Koussih, Lianyu Shan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The regulatory role of semaphorin 3E in allergic asthma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biochem Cell Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biocel.2018.11.006"}], "href": "https://doi.org/10.1016/j.biocel.2018.11.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30447428"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30447428"}]}]}]}
Synonyms	M-SEMAK, M-SEMAH, COLL-5, SEMAH
Proteins	SEM3E_HUMAN
NCBI Gene ID	9723
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SEMA3E has 6,735 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 122 datasets.

Click the + buttons to view associations for SEMA3E from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SEMA3E Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SEMA3E gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SEMA3E gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SEMA3E gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SEMA3E gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SEMA3E gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SEMA3E gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SEMA3E gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SEMA3E gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SEMA3E gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of SEMA3E gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SEMA3E gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SEMA3E gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SEMA3E gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SEMA3E gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SEMA3E gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SEMA3E gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with SEMA3E gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with SEMA3E gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of SEMA3E gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SEMA3E gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SEMA3E protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SEMA3E protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SEMA3E protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SEMA3E gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SEMA3E gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with SEMA3E gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with SEMA3E gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SEMA3E gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving SEMA3E gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with SEMA3E gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SEMA3E gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SEMA3E gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SEMA3E gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SEMA3E gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SEMA3E gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SEMA3E gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SEMA3E gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SEMA3E from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with SEMA3E gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with SEMA3E gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.