| HGNC Family | Semaphorins (SEMA), Immunoglobulin superfamily domain containing |
| Name | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F |
| Description | This gene encodes a member of the semaphorin III family of secreted signaling proteins that are involved in axon guidance during neuronal development. The encoded protein contains an N-terminal Sema domain, an immunoglobulin loop and a C-terminal basic domain. This gene is expressed by the endothelial cells where it was found to act in an autocrine fashion to induce apoptosis, inhibit cell proliferation and survival, and function as an anti-tumorigenic agent. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSEMA3F is a secreted class‐3 semaphorin originally characterized as an axon guidance molecule, but it has emerged as a potent tumor suppressor and anti‐angiogenic factor in diverse solid tumors. In several studies, reduced SEMA3F levels in highly metastatic melanoma, lung, breast, ovarian, colorectal, head and neck, liver, and prostate cancers correlated with increased tumor cell adhesion, invasion, and abnormal neovascularization – findings that support its role as a metastasis inhibitor. Moreover, SEMA3F expression is frequently lost or epigenetically silenced (via promoter hypermethylation or transcriptional repression by oncoproteins such as Id2 and ZEB1) in advanced cancers, and its restoration leads to increased apoptosis, normalization of tumor borders, reduced VEGF-dependent activation of endothelial cells, and suppression of cancer cell stemness. Collectively, these studies underscore the importance of SEMA3F in maintaining a suppressive tumor microenvironment and indicate that its loss contributes to tumor progression and metastasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "27"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistically, SEMA3F exerts its multifaceted inhibitory effects by binding primarily to neuropilin‐2 (and in some contexts neuropilin‐1) and forming complexes with plexin receptors, which together trigger downstream signaling cascades. These cascades lead to rapid cytoskeletal collapse via inactivation of small GTPases (such as RhoA) and disruption of actin dynamics, as well as inhibition of PI3K/Akt/mTOR and MAPK pathways that are critical for cell migration, focal adhesion, and survival. In addition to its role in tumor biology, SEMA3F has been implicated in modulating immune cell migration and retention—affecting neutrophil dynamics and therapeutic responsiveness in lymphomas—thereby broadening its clinical relevance to inflammatory and other pathological conditions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "28", "end_ref": "30"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Patrick Nasarre, Bruno Constantin, Lydie Rouhaud, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Semaphorin SEMA3F and VEGF have opposing effects on cell attachment and spreading."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasia (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1476-5586(03)80020-9"}], "href": "https://doi.org/10.1016/s1476-5586(03"}, {"type": "t", "text": "80020-9) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12659673"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12659673"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Diane R Bielenberg, Yasuhiro Hida, Akio Shimizu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Semaphorin 3F, a chemorepulsant for endothelial cells, induces a poorly vascularized, encapsulated, nonmetastatic tumor phenotype."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI21378"}], "href": "https://doi.org/10.1172/JCI21378"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15520858"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15520858"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Sophie Kusy, Patrick Nasarre, Daniel Chan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Selective suppression of in vivo tumorigenicity by semaphorin SEMA3F in lung cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasia (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1593/neo.04721"}], "href": "https://doi.org/10.1593/neo.04721"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15967098"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15967098"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Manabu Futamura, Hiroki Kamino, Yuji Miyamoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Possible role of semaphorin 3F, a candidate tumor suppressor gene at 3p21.3, in p53-regulated tumor angiogenesis suppression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-06-2485"}], "href": "https://doi.org/10.1158/0008-5472.CAN-06-2485"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17308083"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17308083"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Noga Guttmann-Raviv, Niva Shraga-Heled, Asya Varshavsky, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Semaphorin-3A and semaphorin-3F work together to repel endothelial cells and to inhibit their survival by induction of apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M609711200"}], "href": "https://doi.org/10.1074/jbc.M609711200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17569671"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17569671"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jia-jia Zhang, Yu-nong Wu, Jin-hai Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Effect of human semaphorin-3F gene transient transfection on the proliferation of tongue carcinoma cells]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Kou Qiang Yi Xue Za Zhi (2007)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18476556"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18476556"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Akio Shimizu, Akiko Mammoto, Joseph E Italiano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ABL2/ARG tyrosine kinase mediates SEMA3F-induced RhoA inactivation and cytoskeleton collapse in human glioma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M804520200"}], "href": "https://doi.org/10.1074/jbc.M804520200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18660502"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18660502"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Boaz Kigel, Asya Varshavsky, Ofra Kessler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Successful inhibition of tumor development by specific class-3 semaphorins is associated with expression of appropriate semaphorin receptors by tumor cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0003287"}], "href": "https://doi.org/10.1371/journal.pone.0003287"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18818766"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18818766"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jonathan Clarhaut, Robert M Gemmill, Vincent A Potiron, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ZEB-1, a repressor of the semaphorin 3F tumor suppressor gene in lung cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasia (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1593/neo.81074"}], "href": "https://doi.org/10.1593/neo.81074"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19177200"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19177200"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Joke Beuten, Dawn Garcia, Timothy C Brand, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Semaphorin 3B and 3F single nucleotide polymorphisms are associated with prostate cancer risk and poor prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Urol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.juro.2009.06.016"}], "href": "https://doi.org/10.1016/j.juro.2009.06.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19683737"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19683737"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Alexander Fassold, Werner Falk, Sven Anders, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Soluble neuropilin-2, a nerve repellent receptor, is increased in rheumatoid arthritis synovium and aggravates sympathetic fiber repulsion and arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Rheum (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/art.24860"}], "href": "https://doi.org/10.1002/art.24860"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19790074"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19790074"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Tetsuo Fujimaki, Kimihiko Kato, Kiyoshi Yokoi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of genetic variants in SEMA3F, CLEC16A, LAMA3, and PCSK2 with myocardial infarction in Japanese individuals."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Atherosclerosis (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.atherosclerosis.2009.11.050"}], "href": "https://doi.org/10.1016/j.atherosclerosis.2009.11.050"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20036365"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20036365"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Doina Joseph, Shuk-Mei Ho, Viqar Syed "}, {"type": "b", "children": [{"type": "t", "text": "Hormonal regulation and distinct functions of semaphorin-3B and semaphorin-3F in ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Ther (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1535-7163.MCT-09-0664"}], "href": "https://doi.org/10.1158/1535-7163.MCT-09-0664"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20124444"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20124444"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Feng Wu, Qi Zhou, Jing Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endogenous axon guiding chemorepulsant semaphorin-3F inhibits the growth and metastasis of colorectal carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-10-0839"}], "href": "https://doi.org/10.1158/1078-0432.CCR-10-0839"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21349996"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21349996"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Silvia Coma, Akio Shimizu, Michael Klagsbrun "}, {"type": "b", "children": [{"type": "t", "text": "Hypoxia induces tumor and endothelial cell migration in a semaphorin 3F- and VEGF-dependent manner via transcriptional repression of their common receptor neuropilin 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Adh Migr (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cam.5.3.16294"}], "href": "https://doi.org/10.4161/cam.5.3.16294"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21610314"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21610314"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Gaofeng Xiong, Chi Wang, B Mark Evers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RORα suppresses breast tumor invasion by inducing SEMA3F expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-11-2762"}], "href": "https://doi.org/10.1158/0008-5472.CAN-11-2762"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22350413"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22350413"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Hon-Kit Wong, Akio Shimizu, Nathaniel D Kirkpatrick, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Merlin/NF2 regulates angiogenesis in schwannomas through a Rac1/semaphorin 3F-dependent mechanism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasia (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1593/neo.111600"}], "href": "https://doi.org/10.1593/neo.111600"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22431917"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22431917"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Anima Buehler, Nicholas Sitaras, Sandra Favret, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Semaphorin 3F forms an anti-angiogenic barrier in outer retina."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2013.04.008"}], "href": "https://doi.org/10.1016/j.febslet.2013.04.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23603393"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23603393"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Daniella Arêas Mendes-da-Cruz, Anne Colette Brignier, Vahid Asnafi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Semaphorin 3F and neuropilin-2 control the migration of human T-cell precursors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0103405"}], "href": "https://doi.org/10.1371/journal.pone.0103405"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25068647"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25068647"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Jun Rao, Zhi-Hang Zhou, Jing Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Semaphorin-3F suppresses the stemness of colorectal cancer cells by inactivating Rac1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2014.12.040"}], "href": "https://doi.org/10.1016/j.canlet.2014.12.040"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25529012"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25529012"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Zhi-hang Zhou, Jun Rao, Jing Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SEMA3F prevents metastasis of colorectal cancer by PI3K-AKT-dependent down-regulation of the ASCL2-CXCR4 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pathol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/path.4541"}], "href": "https://doi.org/10.1002/path.4541"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25866254"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25866254"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Colleen L Doçi, Constantinos M Mikelis, Michail S Lionakis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic Identification of SEMA3F as an Antilymphangiogenic Metastasis Suppressor Gene in Head and Neck Squamous Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-14-3121"}], "href": "https://doi.org/10.1158/0008-5472.CAN-14-3121"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25952650"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25952650"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Hironao Nakayama, Sarah Bruneau, Nora Kochupurakkal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of mTOR Signaling by Semaphorin 3F-Neuropilin 2 Interactions In Vitro and In Vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep11789"}], "href": "https://doi.org/10.1038/srep11789"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26156437"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26156437"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Julien Bollard, Patrick Massoma, Cécile Vercherat, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The axon guidance molecule semaphorin 3F is a negative regulator of tumor progression and proliferation in ileal neuroendocrine tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.5481"}], "href": "https://doi.org/10.18632/oncotarget.5481"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26447612"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26447612"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Guanlin Wu "}, {"type": "b", "children": [{"type": "t", "text": "Clinical relevance of semaphorin-3F in patients with prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Invest Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.25011/cim.v42i3.33094"}], "href": "https://doi.org/10.25011/cim.v42i3.33094"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31563162"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31563162"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Ke Ye, Xiwu Ouyang, Zhiming Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SEMA3F Promotes Liver Hepatocellular Carcinoma Metastasis by Activating Focal Adhesion Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "DNA Cell Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/dna.2019.4904"}], "href": "https://doi.org/10.1089/dna.2019.4904"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31968181"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31968181"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Núria Moragas, Patricia Fernandez-Nogueira, Leire Recalde-Percaz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The SEMA3F-NRP1/NRP2 axis is a key factor in the acquisition of invasive traits in in situ breast ductal carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer Res (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13058-024-01871-0"}], "href": "https://doi.org/10.1186/s13058-024-01871-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39138514"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39138514"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Wen Xie, Wei Su, Lijuan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SSeCKS/AKAP12 induces repulsion between human prostate cancer and microvessel endothelial cells through the activation of Semaphorin 3F."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2017.07.043"}], "href": "https://doi.org/10.1016/j.bbrc.2017.07.043"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28698137"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28698137"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Bryce W Duncan, Vishwa Mohan, Sarah D Wade, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Semaphorin3F Drives Dendritic Spine Pruning Through Rho-GTPase Signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Neurobiol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12035-021-02373-2"}], "href": "https://doi.org/10.1007/s12035-021-02373-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33856648"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33856648"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Qiong Li, Naya Ma, Xinlei Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reverse effect of Semaphorin-3F on rituximab resistance in diffuse large B-cell lymphoma via the Hippo pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Chin Med J (Engl) (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/CM9.0000000000002686"}], "href": "https://doi.org/10.1097/CM9.0000000000002686"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37114652"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37114652"}]}]}]}
|
| Synonyms | SEMA-IV, SEMA4, SEMAK |
| Proteins | SEM3F_HUMAN |
| NCBI Gene ID | 6405 |
| API | |
| Download Associations | |
| Predicted Functions |
 |
| Co-expressed Genes |
|
| Expression in Tissues and Cell Lines |
|
SEMA3F has 6,335 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 105 datasets.
Click the + buttons to view associations for SEMA3F from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of SEMA3F gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of SEMA3F gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of SEMA3F gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of SEMA3F gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of SEMA3F gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of SEMA3F gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of SEMA3F gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of SEMA3F gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of SEMA3F gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with SEMA3F gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of SEMA3F gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of SEMA3F gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of SEMA3F gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of SEMA3F gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing SEMA3F protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with SEMA3F protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with SEMA3F protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of SEMA3F gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with SEMA3F gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| CTD Gene-Chemical Interactions | chemicals interacting with SEMA3F gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
| CTD Gene-Disease Associations | diseases associated with SEMA3F gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| DeepCoverMOA Drug Mechanisms of Action | small molecule perturbations with high or low expression of SEMA3F protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by SEMA3F gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with SEMA3F gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with SEMA3F gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with SEMA3F gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with SEMA3F gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with SEMA3F gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at SEMA3F gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of SEMA3F gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of SEMA3F gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing SEMA3F from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GAD Gene-Disease Associations | diseases associated with SEMA3F gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GAD High Level Gene-Disease Associations | diseases associated with SEMA3F gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of SEMA3F gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with SEMA3F gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing SEMA3F from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of SEMA3F gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of SEMA3F gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of SEMA3F gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of SEMA3F gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of SEMA3F gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of SEMA3F gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GlyGen Glycosylated Proteins | ligands (chemical) binding SEMA3F protein from the GlyGen Glycosylated Proteins dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving SEMA3F gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving SEMA3F gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving SEMA3F gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing SEMA3F protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by SEMA3F gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by SEMA3F gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by SEMA3F gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of SEMA3F gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of SEMA3F gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of SEMA3F gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of SEMA3F gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with SEMA3F gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with SEMA3F gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of SEMA3F gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of SEMA3F gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of SEMA3F gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of SEMA3F protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of SEMA3F gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| Hub Proteins Protein-Protein Interactions | interacting hub proteins for SEMA3F from the curated Hub Proteins Protein-Protein Interactions dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with SEMA3F gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| IMPC Knockout Mouse Phenotypes | phenotypes of mice caused by SEMA3F gene knockout from the IMPC Knockout Mouse Phenotypes dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for SEMA3F protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of SEMA3F gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEGG Pathways | pathways involving SEMA3F protein from the KEGG Pathways dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of SEMA3F gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of SEMA3F gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with SEMA3F gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of SEMA3F gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of SEMA3F gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of SEMA3F gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
| LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of SEMA3F gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain SEMA3F protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by SEMA3F gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of SEMA3F gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of SEMA3F gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
| MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by SEMA3F gene mutations from the MPO Gene-Phenotype Associations dataset. | |
| MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of SEMA3F gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of SEMA3F gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| NURSA Protein Complexes | protein complexs containing SEMA3F protein recovered by IP-MS from the NURSA Protein Complexes dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for SEMA3F from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of SEMA3F gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of SEMA3F gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving SEMA3F protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving SEMA3F protein from the Wikipathways PFOCR 2024 dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of SEMA3F gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of SEMA3F gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at SEMA3F gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of SEMA3F gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of SEMA3F gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| SynGO Synaptic Gene Annotations | synaptic terms associated with SEMA3F gene from the SynGO Synaptic Gene Annotations dataset. | |
| Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of SEMA3F gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of SEMA3F gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of SEMA3F gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of SEMA3F gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of SEMA3F protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of SEMA3F protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of SEMA3F protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of SEMA3F protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with SEMA3F protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with SEMA3F protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
| WikiPathways Pathways 2014 | pathways involving SEMA3F protein from the Wikipathways Pathways 2014 dataset. | |
