SEMA5A Gene

HGNC Family	Semaphorins (SEMA)
Name	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
Description	This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development. This gene has been implicated as an autism susceptibility gene.[provided by RefSeq, Jan 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSEMA5A is a multifunctional protein that plays a pivotal role in neural development. Early studies established that SEMA5A functions as a transmembrane guidance cue involved in axon directionality, synapse formation, and neuronal survival through its high‐affinity interaction with plexin‐B3."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Follow‐up genome‐wide and expression analyses implicated SEMA5A dysregulation in neurodevelopmental disorders such as autism spectrum disorder (ASD) and intellectual disability, with decreased expression observed in autistic brains"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In addition, independent studies identified significant genetic associations and rare de novo deletions affecting SEMA5A in patients with ASD and Parkinson’s disease (PD), suggesting that aberrant SEMA5A expression and/or mutation contribute to altered neurogenesis, neuronal apoptosis, and synaptic connectivity"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Moreover, investigations into neuropsychiatric conditions such as obsessive–compulsive disorder have further underscored a role for SEMA5A in regulating excitatory synapse formation and behavior."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the oncologic arena, SEMA5A exhibits context‐dependent functions that both promote and suppress tumor progression. In several studies on pancreatic cancer, SEMA5A expression (or secretion) has been linked to enhanced tumorigenesis, invasion, and metastasis, with evidence showing that its ectopic expression accelerates tumor growth in vivo"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " In gliomas, stimulation of the SEMA5A receptor plexin‐B3 triggers intracellular signaling that reduces Rac1 activation, leading to inhibited cell motility and promoting astrocytic differentiation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Similar regulatory themes are observed in gastric cancer, where SEMA5A upregulates MMP9 via MEK/ERK pathway activation to facilitate invasion"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ", and in colorectal and bladder cancers, where circular RNAs derived from SEMA5A modulate oncogenic pathways by sponging microRNAs and enhancing cell cycle regulators"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " In contrast, in lung adenocarcinoma and in certain melanoma subtypes, reduced or altered SEMA5A levels have been associated with suppression of proliferation and migratory behaviors, underscoring its dualistic nature in tumorigenesis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": " A broad review also summarizes that SEMA5A participates in cancer transformation beyond the nervous system"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": ", and additional work indicates that in the tumor microenvironment of pancreatic ductal adenocarcinoma, macrophage‐derived SEMA5A can promote the Warburg effect and metastatic outgrowth via its receptor PLXNB3."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in neural development and cancer, SEMA5A is increasingly recognized as an important immunomodulator in inflammatory and autoimmune disorders. In chronic spontaneous urticaria, elevated SEMA5A levels in the skin are linked to increased IL‑17A expression in both T cells and mast cells, suggesting that SEMA5A may drive local inflammatory cascades."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": " Similarly, in rheumatoid arthritis, SEMA5A derived from the synovial microenvironment engages its receptors on fibroblasts, activating the PI3K/AKT/mTOR pathway and leading to enhanced cytokine secretion, cellular proliferation, migration, and reduced ferroptosis, thereby contributing to synovial hyperplasia and joint damage"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Stefania Artigiani, Paolo Conrotto, Pietro Fazzari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Plexin-B3 is a functional receptor for semaphorin 5A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.embor.7400189"}], "href": "https://doi.org/10.1038/sj.embor.7400189"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15218527"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15218527"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Demetrius M Maraganore, Mariza de Andrade, Timothy G Lesnick, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High-resolution whole-genome association study of Parkinson disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1086/496902"}], "href": "https://doi.org/10.1086/496902"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16252231"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16252231"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "M Melin, B Carlsson, H Anckarsater, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Constitutional downregulation of SEMA5A expression in autism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuropsychobiology (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000096040"}], "href": "https://doi.org/10.1159/000096040"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17028446"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17028446"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Lauren A Weiss, Dan E Arking, Mark J Daly, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A genome-wide linkage and association scan reveals novel loci for autism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature08490"}], "href": "https://doi.org/10.1038/nature08490"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19812673"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19812673"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hai-rong Dong, Ye Hua, Xin-sheng Ding "}, {"type": "b", "children": [{"type": "t", "text": "[Correlation study of semaphorin 5a with risk of Parkinson's disease in a Chinese Han population]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Yi Xue Za Zhi (2009)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19957501"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19957501"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Anne-Laure Mosca-Boidron, Lucie Gueneau, Guillaume Huguet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A de novo microdeletion of SEMA5A in a boy with autism spectrum disorder and intellectual disability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ejhg.2015.211"}], "href": "https://doi.org/10.1038/ejhg.2015.211"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26395558"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26395558"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Kader Semra Karatas, Ilkay Bahceci, Tahsin Gokhan Telatar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Relationship between disease and disease severity and semaphorin 5A and hemogram level in obsessive-compulsive disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nord J Psychiatry (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/08039488.2021.1896779"}], "href": "https://doi.org/10.1080/08039488.2021.1896779"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33771090"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33771090"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Anguraj Sadanandam, Michelle L Varney, Seema Singh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High gene expression of semaphorin 5A in pancreatic cancer is associated with tumor growth, invasion and metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.25166"}], "href": "https://doi.org/10.1002/ijc.25166"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20073063"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20073063"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Sugandha Saxena, Abhilasha Purohit, Michelle L Varney, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Semaphorin-5A maintains epithelial phenotype of malignant pancreatic cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-018-5204-x"}], "href": "https://doi.org/10.1186/s12885-018-5204-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30577767"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30577767"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "X Li, J W S Law, A Y W Lee "}, {"type": "b", "children": [{"type": "t", "text": "Semaphorin 5A and plexin-B3 regulate human glioma cell motility and morphology through Rac1 and the actin cytoskeleton."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2011.256"}], "href": "https://doi.org/10.1038/onc.2011.256"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21706053"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21706053"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Guoqing Pan, Xiangling Zhang, Junyu Ren, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Semaphorin 5A, an axon guidance molecule, enhances the invasion and metastasis of human gastric cancer through activation of MMP9."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Oncol Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12253-012-9550-8"}], "href": "https://doi.org/10.1007/s12253-012-9550-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22821546"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22821546"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Qianli Ye, Shixing Liu, Shiqiang Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA circSEMA5A facilitates colorectal cancer development by regulating microRNA-195-5p to target CCNE1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2023.110649"}], "href": "https://doi.org/10.1016/j.cellsig.2023.110649"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37164546"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37164546"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Lei Wang, Haoran Li, Qingdong Qiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA circSEMA5A promotes bladder cancer progression by upregulating ENO1 and SEMA5A expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.103971"}], "href": "https://doi.org/10.18632/aging.103971"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33176280"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33176280"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Simona D'Aguanno, Elisabetta Valentini, Maria Grazia Tupone, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Semaphorin 5A drives melanoma progression: role of Bcl-2, miR-204 and c-Myb."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-018-0933-x"}], "href": "https://doi.org/10.1186/s13046-018-0933-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30454024"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30454024"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Anna V Komina, Nadezhda V Palkina, Mariya B Aksenenko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Semaphorin-5A downregulation is associated with enhanced migration and invasion of BRAF-positive melanoma cells under vemurafenib treatment in melanomas with heterogeneous BRAF status."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Melanoma Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/CMR.0000000000000621"}], "href": "https://doi.org/10.1097/CMR.0000000000000621"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31116162"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31116162"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Konrad Dziobek, Marcin Opławski, Beniamin O Grabarek, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Assessment of the Usefulness of the SEMA5A Concentration Profile Changes as a Molecular Marker in Endometrial Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Pharm Biotechnol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2174/1389201020666190911113611"}], "href": "https://doi.org/10.2174/1389201020666190911113611"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31544715"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31544715"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Kun Wang, Min He, Xin Fan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SEMA5A-PLXNB3 Axis Promotes PDAC Liver Metastasis Outgrowth through Enhancing the Warburg Effect."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol Res (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2023/3274467"}], "href": "https://doi.org/10.1155/2023/3274467"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36741230"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36741230"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Matanis Lobna, Eiza Nasren, Sabag Adi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Expression of IL-17, in Chronic Spontaneous Urticaria Is Linked to Semaphorin5A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomolecules (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/biom11030373"}], "href": "https://doi.org/10.3390/biom11030373"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33801296"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33801296"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Qi Cheng, Mo Chen, Mengdan Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Semaphorin 5A suppresses ferroptosis through activation of PI3K-AKT-mTOR signaling in rheumatoid arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-022-05065-4"}], "href": "https://doi.org/10.1038/s41419-022-05065-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35835748"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35835748"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Chipeng Xiao, Chen Lv, Siyuan Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TSP1 is the essential domain of SEMA5A involved in pannus formation in rheumatoid arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Rheumatology (Oxford) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/rheumatology/keab133"}], "href": "https://doi.org/10.1093/rheumatology/keab133"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33616619"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33616619"}]}]}]}
Synonyms	SEMAF, SEMF
Proteins	SEM5A_HUMAN
NCBI Gene ID	9037
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SEMA5A has 9,613 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 122 datasets.

Click the + buttons to view associations for SEMA5A from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SEMA5A Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by SEMA5A gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SEMA5A gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SEMA5A gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SEMA5A gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SEMA5A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SEMA5A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SEMA5A gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SEMA5A gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SEMA5A gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SEMA5A gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of SEMA5A gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SEMA5A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SEMA5A gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SEMA5A gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SEMA5A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SEMA5A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SEMA5A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of SEMA5A gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SEMA5A gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SEMA5A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SEMA5A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SEMA5A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SEMA5A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SEMA5A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SEMA5A gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with SEMA5A gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with SEMA5A gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with SEMA5A gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SEMA5A gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for SEMA5A protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with SEMA5A gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with SEMA5A gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SEMA5A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SEMA5A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SEMA5A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SEMA5A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SEMA5A gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SEMA5A gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SEMA5A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SEMA5A from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.