| HGNC Family | Serpin peptidase inhibitors (SERPIN) |
| Name | serpin peptidase inhibitor, clade B (ovalbumin), member 7 |
| Description | This gene encodes a member of a family of proteins which function as protease inhibitors. Expression of this gene is upregulated in IgA nephropathy and mutations have been found to cause palmoplantar keratoderma, Nagashima type. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSERPINB7 is an intracellular serine protease inhibitor that plays dual roles in maintaining both skin and renal homeostasis. In the epidermis, SERPINB7 is predominantly expressed in the stratum granulosum and corneum, where it normally restrains protease activity to preserve the structural integrity of the skin barrier. Loss‐of‐function mutations—most notably the recurrent c.796C>T nonsense mutation—abolish its protease‐inhibitory function, leading to Nagashima‐type palmoplantar keratosis (NPPK) characterized by diffuse hyperkeratosis, enhanced water permeation, and compromised epidermal stability. Moreover, aberrations in SERPINB7 function have additionally been implicated in peeling skin syndromes and inflammatory conditions such as psoriasis, where altered expression and cellular mis‐localization contribute to impaired keratinocyte differentiation and abnormal intracellular calcium fluxes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the kidney, the SERPINB7 protein—also known as megsin—is highly expressed in glomerular mesangial cells where it regulates extracellular matrix turnover by modulating the activity of proteolytic enzymes including matrix metalloproteinases and plasmin. Upregulation of SERPINB7 and the presence of specific gene variants have been linked to glomerular diseases such as IgA nephropathy and diabetic nephropathy. Family‐based association studies and meta-analyses indicate that these genetic polymorphisms correlate with mesangial expansion, altered matrix degradation, and overall progression of renal dysfunction. These findings are further supported by investigations into traditional medical correlations that suggest a broader impact of SERPINB7 variation on mesangial cell proliferation, matrix metabolism, and inflammatory responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "23"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its established roles in skin and renal physiology, recent studies have explored therapeutic strategies aimed at restoring SERPINB7 function. For example, topical gentamicin has been used to induce stop-codon readthrough to rescue full-length protein synthesis in NPPK, while research into the molecular mechanisms underlying protease-antiprotease balance continues to inform potential interventions for the treatment of inflammatory skin diseases. In parallel, a broader spectrum of investigations—including serum proteomic analyses in early preterm birth and genome-wide studies in atopic dermatitis—have underscored the need to further elucidate the multifaceted roles of SERPINB7 in diverse clinical settings."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "24"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Akiharu Kubo, Aiko Shiohama, Takashi Sasaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in SERPINB7, encoding a member of the serine protease inhibitor superfamily, cause Nagashima-type palmoplantar keratosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2013.09.015"}], "href": "https://doi.org/10.1016/j.ajhg.2013.09.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24207119"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24207119"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "O Mizuno, T Nomura, S Suzuki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Highly prevalent SERPINB7 founder mutation causes pseudodominant inheritance pattern in Nagashima-type palmoplantar keratosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Dermatol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/bjd.13076"}], "href": "https://doi.org/10.1111/bjd.13076"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24773080"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24773080"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yuka Ohguchi, Toshifumi Nomura, Shotaro Suzuki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gentamicin-Induced Readthrough and Nonsense-Mediated mRNA Decay of SERPINB7 Nonsense Mutant Transcripts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jid.2017.10.014"}], "href": "https://doi.org/10.1016/j.jid.2017.10.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29106929"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29106929"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Zhen Wang, Huaping Zheng, Hong Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Systematic screening and identification of novel psoriasis‑specific genes from the transcriptome of psoriasis‑like keratinocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2018.9782"}], "href": "https://doi.org/10.3892/mmr.2018.9782"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30592269"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30592269"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Eran Cohen-Barak, Wassim Azzam, Jennifer L Koetsier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Acral peeling in Nagashima type palmo-plantar keratosis patients reveals the role of serine protease inhibitor B 7 in keratinocyte adhesion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Dermatol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/exd.14444"}], "href": "https://doi.org/10.1111/exd.14444"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34379845"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34379845"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Tong Xiao, Yan Liu, Tian Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Two novel mutations of SERPINB7 in eight cases of Nagashima-type palmoplantar keratosis in the Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Dermatol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/1346-8138.16310"}], "href": "https://doi.org/10.1111/1346-8138.16310"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35178744"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35178744"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Huaping Zheng, Linna Gu, Fulei Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SerpinB7 deficiency contributes to development of psoriasis via calcium-mediated keratinocyte differentiation dysfunction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-022-05045-8"}], "href": "https://doi.org/10.1038/s41419-022-05045-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35864103"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35864103"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Chen Lyu, Fan Zhang, Tingting Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SERPINB7 mutation causes Nagashima-type palmoplantar keratosis and its spatiotemporal expression in zebrafish."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Dermatol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/exd.14762"}], "href": "https://doi.org/10.1111/exd.14762"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36772997"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36772997"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Reiko Inagi, Toshio Miyata, Toshiyuki Imasawa, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Family-based association study showing that immunoglobulin A nephropathy is associated with the polymorphisms 2093C and 2180T in the 3' untranslated region of the Megsin gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Soc Nephrol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/01.asn.0000130858.00688.46"}], "href": "https://doi.org/10.1097/01.asn.0000130858.00688.46"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15213261"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15213261"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Reiko Inagi, Masaomi Nangaku, Nobuteru Usuda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel serpinopathy in rat kidney and pancreas induced by overexpression of megsin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Soc Nephrol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1681/ASN.2004070600"}], "href": "https://doi.org/10.1681/ASN.2004070600"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15788472"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15788472"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yunfeng Xia, Youji Li, Yong Du, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of MEGSIN 2093C-2180T haplotype at the 3' untranslated region with disease severity and progression of IgA nephropathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nephrol Dial Transplant (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/ndt/gfk096"}], "href": "https://doi.org/10.1093/ndt/gfk096"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16431886"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16431886"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Y F Xia, S Huang, X Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A family-based association study of megsin A23167G polymorphism with susceptibility and progression of IgA nephropathy in a Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Nephrol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.5414/cnp65153"}], "href": "https://doi.org/10.5414/cnp65153"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16550745"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16550745"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Zhao-hui Wang, Nan Chen, Xiao-xia Pan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Association of single nucleotide polymorphism of megsin gene with IgA nephropathy]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Yi Xue Za Zhi (2006)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16796905"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16796905"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Yi-Fei Zhong, Yi-Ping Chen, Yue-Yi Deng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Correlation between traditional Chinese medicine syndromes in primary immunoglobulin A nephropathy and A267G in 5'-untranslated region within exonal of megsin gene]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhong Xi Yi Jie He Xue Bao (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3736/jcim20080506"}], "href": "https://doi.org/10.3736/jcim20080506"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18471408"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18471408"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "D Maixnerová, M Merta, J Reiterová, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The influence of two megsin polymorphisms on the progression of IgA nephropathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Folia Biol (Praha) (2008)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18498720"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18498720"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Shuichi Ohtomo, Masaomi Nangaku, Yuko Izuhara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role of megsin, a serine protease inhibitor, in diabetic mesangial matrix accumulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Kidney Int (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ki.2008.302"}], "href": "https://doi.org/10.1038/ki.2008.302"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18580857"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18580857"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "C S Lim, S M Kim, Y K Oh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Megsin 2093T-2180C haplotype at the 3' untranslated region is associated with poor renal survival in Korean IgA nephropathy patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Nephrol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.5414/cnp70101"}], "href": "https://doi.org/10.5414/cnp70101"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18793525"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18793525"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Song Mao, Xianguo Ren, Songming Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of megsin 2093C/T, 2180C/T and C25663G gene polymorphism with the risk of IgA nephropathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ren Fail (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/0886022X.2014.890058"}], "href": "https://doi.org/10.3109/0886022X.2014.890058"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24575807"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24575807"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Tian-Biao Zhou, Xiao-Neng Mo, Qiu-Ye Kou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of Megsin gene polymorphism with IgA nephropathy risk."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Recept Signal Transduct Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/10799893.2014.936461"}], "href": "https://doi.org/10.3109/10799893.2014.936461"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25007157"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25007157"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Lin-Ting Wei, Rong-Guo Fu, Jie Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of Megsin Gene Variants With IgA Nephropathy in Northwest Chinese Population: A STROBE-Compliant Observational Study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Medicine (Baltimore) (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MD.0000000000002694"}], "href": "https://doi.org/10.1097/MD.0000000000002694"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26871801"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26871801"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Jia Zhang, Guolong Zhang, Cheng Ni, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nagashima-type palmoplantar keratosis in a Chinese Han population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2016.5757"}], "href": "https://doi.org/10.3892/mmr.2016.5757"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27666198"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27666198"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Samuel Parry, Heping Zhang, Joseph Biggio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Maternal serum serpin B7 is associated with early spontaneous preterm birth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Obstet Gynecol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajog.2014.06.035"}], "href": "https://doi.org/10.1016/j.ajog.2014.06.035"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24954659"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24954659"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Eeva Sliz, Laura Huilaja, Anu Pasanen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Uniting biobank resources reveals novel genetic pathways modulating susceptibility for atopic dermatitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Allergy Clin Immunol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jaci.2021.07.043"}], "href": "https://doi.org/10.1016/j.jaci.2021.07.043"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34454985"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34454985"}]}]}]}
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| Synonyms | MEGSIN, PPKN |
| Proteins | SPB7_HUMAN |
| NCBI Gene ID | 8710 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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SERPINB7 has 3,224 functional associations with biological entities spanning 9 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 91 datasets.
Click the + buttons to view associations for SERPINB7 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of SERPINB7 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of SERPINB7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of SERPINB7 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of SERPINB7 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of SERPINB7 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of SERPINB7 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of SERPINB7 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of SERPINB7 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with SERPINB7 gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of SERPINB7 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of SERPINB7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of SERPINB7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| ClinVar Gene-Phenotype Associations | phenotypes associated with SERPINB7 gene from the curated ClinVar Gene-Phenotype Associations dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of SERPINB7 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing SERPINB7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with SERPINB7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with SERPINB7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of SERPINB7 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with SERPINB7 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| dbGAP Gene-Trait Associations | traits associated with SERPINB7 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by SERPINB7 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Curated Gene-Disease Association Evidence Scores | diseases involving SERPINB7 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Curated Gene-Disease Association Evidence Scores 2025 | diseases involving SERPINB7 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with SERPINB7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with SERPINB7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with SERPINB7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with SERPINB7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at SERPINB7 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of SERPINB7 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of SERPINB7 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing SERPINB7 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GAD Gene-Disease Associations | diseases associated with SERPINB7 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GAD High Level Gene-Disease Associations | diseases associated with SERPINB7 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of SERPINB7 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with SERPINB7 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing SERPINB7 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of SERPINB7 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of SERPINB7 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of SERPINB7 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of SERPINB7 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of SERPINB7 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of SERPINB7 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving SERPINB7 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving SERPINB7 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing SERPINB7 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by SERPINB7 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by SERPINB7 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by SERPINB7 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx eQTL 2025 | SNPs regulating expression of SERPINB7 gene from the GTEx eQTL 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of SERPINB7 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of SERPINB7 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of SERPINB7 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with SERPINB7 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of SERPINB7 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of SERPINB7 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of SERPINB7 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of SERPINB7 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of SERPINB7 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| HPO Gene-Disease Associations | phenotypes associated with SERPINB7 gene by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset. | |
| HuBMAP Azimuth Cell Type Annotations | cell types associated with SERPINB7 gene from the HuBMAP Azimuth Cell Type Annotations dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with SERPINB7 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for SERPINB7 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of SERPINB7 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of SERPINB7 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with SERPINB7 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of SERPINB7 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of SERPINB7 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of SERPINB7 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
| LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of SERPINB7 gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| LOCATE Curated Protein Localization Annotations | cellular components containing SERPINB7 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain SERPINB7 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of SERPINB7 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of SERPINB7 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of SERPINB7 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| OMIM Gene-Disease Associations | phenotypes associated with SERPINB7 gene from the curated OMIM Gene-Disease Associations dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of SERPINB7 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of SERPINB7 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving SERPINB7 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving SERPINB7 protein from the Wikipathways PFOCR 2024 dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at SERPINB7 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of SERPINB7 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of SERPINB7 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of SERPINB7 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of SERPINB7 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of SERPINB7 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of SERPINB7 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of SERPINB7 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of SERPINB7 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of SERPINB7 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with SERPINB7 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with SERPINB7 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
