SESN1 Gene

Name	sestrin 1
Description	This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe sestrin family, originally identified through disruption of the PA26 gene (PMID:"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", comprises highly conserved stress‐inducible proteins that include SESN1. SESN1 is induced by p53 and a variety of cellular stresses, and it functions as a cysteine sulfinyl reductase that regenerates overoxidized peroxiredoxins to reestablish antioxidant defense (PMID:."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, in conditions such as low shear stress encountered with rapamycin‐eluting stents, SESN1 is implicated in redox regulation (PMID:"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", while sestrins collectively also coordinate MAPK activation in immune cells, thereby modulating T‑cell responses (PMID:."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of cancer, SESN1 acts as a tumor suppressor by modulating mTORC1 signaling and cellular stress responses. In follicular lymphoma, loss of SESTRIN1 disrupts p53‐mediated mTORC1 control and facilitates oncogenic mRNA translation under genotoxic stress (PMID:."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Similarly, in head and neck squamous cell carcinoma, reduced SESN1 expression—often linked to elevated miR‑377‑3p levels—is associated with enhanced proliferation, migration, and invasion (PMID:"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "and PMID:."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Biochemical studies have established efficient recombinant production of sestrins to further elucidate these tumor‐suppressive mechanisms (PMID:"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ", and preliminary evidence suggests that metformin can modulate SESN1 function to enhance radiosensitivity in breast cancer cells (PMID:."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSESN1 is also a critical regulator in metabolic and cardiovascular contexts. Genome‐wide analyses have pinpointed SESN1 as a causal gene influencing plasma cholesterol levels by modulating cholesterol biosynthesis (PMID:."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " In endothelial cells, overexpression of SESN1 mitigates oxidized low‑density lipoprotein–induced inflammation, apoptosis, and endothelial–mesenchymal transition by stimulating AMPK–SIRT1 and Nrf2 signaling pathways (PMID:."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " The messenger RNA stability of SESN1, enhanced by binding of IGF2BP3, further underlines its protective role against atherosclerosis (PMID:."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " In addition, circulating SESN1 has been investigated as a potential biomarker in hypertension (PMID:"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "and frailty—with the unexpected observation that higher serum levels may associate with reduced physical function in older individuals (PMID:."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nWithin skeletal muscle and other non‐cancerous tissues, SESN1 functions as a safeguard against tissue degeneration. In skeletal muscle, downregulation of SESN1 with inactivity and aging contributes to atrophy, while its activation—acting downstream of longevity factors such as FOXO3—ameliorates senescence and promotes regeneration (PMID:"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "and PMID:."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": " Furthermore, in polycystic ovary syndrome models, reduced SESN1 expression in granulosa-like cells leads to impaired autophagy, increased reactive oxygen species generation, and diminished cell proliferation, suggesting that SESN1 modulation may offer a novel therapeutic strategy (PMID:."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "H Peeters, P Debeer, A Bairoch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genet (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00439-003-0917-5"}], "href": "https://doi.org/10.1007/s00439-003-0917-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12607115"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12607115"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Andrei V Budanov, Anna A Sablina, Elena Feinstein, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1095569"}], "href": "https://doi.org/10.1126/science.1095569"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15105503"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15105503"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Junxia Zhang, Zhimei Wang, Junjie Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rapamycin attenuates endothelial apoptosis induced by low shear stress via mTOR and sestrin1 related redox regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mediators Inflamm (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2014/769608"}], "href": "https://doi.org/10.1155/2014/769608"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24587596"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24587596"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Alessio Lanna, Daniel C O Gomes, Bojana Muller-Durovic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A sestrin-dependent Erk-Jnk-p38 MAPK activation complex inhibits immunity during aging."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ni.3665"}], "href": "https://doi.org/10.1038/ni.3665"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28114291"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28114291"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Elisa Oricchio, Natalya Katanayeva, Maria Christine Donaldson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic and epigenetic inactivation of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "SESTRIN1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " controls mTORC1 and response to EZH2 inhibition in follicular lymphoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Transl Med (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scitranslmed.aak9969"}], "href": "https://doi.org/10.1126/scitranslmed.aak9969"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28659443"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28659443"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Mariama El Baroudi, Jean-Pascal Machiels, Sandra Schmitz "}, {"type": "b", "children": [{"type": "t", "text": "Expression of SESN1, UHRF1BP1, and miR-377-3p as prognostic markers in mutated TP53 squamous cell carcinoma of the head and neck."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biol Ther (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384047.2017.1373212"}], "href": "https://doi.org/10.1080/15384047.2017.1373212"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28886272"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28886272"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Chi Zhang, Lin Ren, Hongjian Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SESN1, negatively regulated by miR-377-3p, suppresses invasive growth of head and neck squamous cell carcinoma by interaction with SMAD3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Cell (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13577-022-00719-z"}], "href": "https://doi.org/10.1007/s13577-022-00719-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35622213"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35622213"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "N Rai, R Kumar, Md A Haque, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[A study of recombinant human sestrin 1 and sestrin 2 proteins produced in a prokaryotic system]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol (Mosk) (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7868/S0026898417020173"}], "href": "https://doi.org/10.7868/S0026898417020173"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28707664"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28707664"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Fatemeh Saffari, Abdoalmabood Momeni, Mehrzad Ramezani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Metformin Caused Radiosensitivity of Breast Cancer Cells through the Expression Modulation of miR-21-5p/SESN1axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asian Pac J Cancer Prev (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.31557/APJCP.2023.24.11.3715"}], "href": "https://doi.org/10.31557/APJCP.2023.24.11.3715"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38019229"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38019229"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Zhonggang Li, James A Votava, Gregory J M Zajac, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrating Mouse and Human Genetic Data to Move beyond GWAS and Identify Causal Genes in Cholesterol Metabolism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Metab (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cmet.2020.02.015"}], "href": "https://doi.org/10.1016/j.cmet.2020.02.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32197071"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32197071"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Feng Gao, Yongcheng Zhao, Bin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SESN1 attenuates the Ox‑LDL‑induced inflammation, apoptosis and endothelial‑mesenchymal transition of human umbilical vein endothelial cells by regulating AMPK/SIRT1/LOX1 signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2022.12678"}], "href": "https://doi.org/10.3892/mmr.2022.12678"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35293601"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35293601"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Feng Gao, Bin Zhang, Chunwei Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IGF2BP3 stabilizes SESN1 mRNA to mitigate oxidized low-density lipoprotein-induced oxidative stress and endothelial dysfunction in human umbilical vein endothelial cells by activating Nrf2 signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Prostaglandins Other Lipid Mediat (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prostaglandins.2024.106832"}], "href": "https://doi.org/10.1016/j.prostaglandins.2024.106832"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38460759"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38460759"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Cao Fang, Zicong Yang, Lei Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating Sestrin Levels Are Increased in Hypertension Patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dis Markers (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/3787295"}], "href": "https://doi.org/10.1155/2020/3787295"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32626541"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32626541"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Begoña Sanz, Chloe Rezola-Pardo, Haritz Arrieta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serum Sestrin-1 Concentration Is Higher in Frail than Non-Frail Older People Living in Nursing Homes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Environ Res Public Health (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijerph19031079"}], "href": "https://doi.org/10.3390/ijerph19031079"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35162104"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35162104"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Nina Zeng, Randall F D'Souza, Cameron J Mitchell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sestrins are differentially expressed with age in the skeletal muscle of men: A cross-sectional analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Gerontol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.exger.2018.05.006"}], "href": "https://doi.org/10.1016/j.exger.2018.05.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29751091"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29751091"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Ying Jing, Yuesheng Zuo, Liang Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SESN1 is a FOXO3 effector that counteracts human skeletal muscle ageing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Prolif (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cpr.13455"}], "href": "https://doi.org/10.1111/cpr.13455"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37199024"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37199024"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Xiaoyuan Xu, Xinli Song, Xiaohua Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of sestrin 1 alleviates polycystic ovary syndrome by decreasing autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.202872"}], "href": "https://doi.org/10.18632/aging.202872"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33883304"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33883304"}]}]}]}
Synonyms	SEST1, PA26
Proteins	SESN1_HUMAN
NCBI Gene ID	27244
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SESN1 has 9,270 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 117 datasets.

Click the + buttons to view associations for SESN1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SESN1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SESN1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SESN1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SESN1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SESN1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SESN1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SESN1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SESN1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SESN1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of SESN1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SESN1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SESN1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SESN1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SESN1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SESN1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SESN1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SESN1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SESN1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SESN1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SESN1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SESN1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SESN1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SESN1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with SESN1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with SESN1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with SESN1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of SESN1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SESN1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving SESN1 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with SESN1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SESN1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SESN1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SESN1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SESN1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SESN1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SESN1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SESN1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SESN1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with SESN1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of SESN1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with SESN1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.