SETD6 Gene

Name	SET domain containing 6
Description	This gene encodes a methyltransferase that adds a methyl group to the histone H2AZ, which is involved in nuclear receptor-dependent transcription. The protein also interacts with several endogenous proteins which are involved in nuclear hormone receptor signaling. A related pseudogene is located on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe protein lysine methyltransferase SETD6 is emerging as a key regulator of inflammatory signaling through its site‐specific methylation of NF‑κB subunits. For example, SETD6 monomethylates the transcription factor RelA (p65) at lysine 310 to render it functionally inert and temper proinflammatory transcription in immune cells. Similar modifications have been observed in transformed urothelial cells, where elevated SETD6 expression promotes cell survival via canonical NF‑κB signaling. In addition, a truncating mutation in SETD6 that impairs its catalytic function has been implicated in familial colorectal cancer type X through a deregulation of both NF‑κB and Wnt pathways."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its impact on signaling pathways, SETD6 directs chromatin regulation by monomethylating histone proteins. It catalyzes the monomethylation of the histone variant H2AZ at lysine 7—a modification that is tightly linked to the control of differentiation marker genes and the maintenance of embryonic stem cell self‐renewal. Moreover, recent proteomic surveys have expanded its repertoire to include modification of canonical histones, further underlining its role in chromatin signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSETD6 also modulates multiple intracellular signaling cascades beyond inflammation. It associates with the estrogen receptor α and partners such as HDAC1 and MTA2—functioning in a context‐dependent manner as both a transcriptional repressor and coactivator of estrogen‐responsive genes in breast carcinoma cells. In parallel, SETD6 methylates non‐histone substrates such as PAK4 to potentiate the Wnt/β‑catenin pathway via enhanced interaction with β‑catenin. Its ability to methylate PLK1 further implicates SETD6 in fine‐tuning the pace of mitosis and cellular proliferation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the realm of transcriptional regulation and oncogenesis, SETD6 influences the function of several key chromatin regulators. It methylates WDR5, a core component of the MLL/SET1 complex, thereby contributing to downstream histone H3K4 trimethylation and gene activation programs that promote cancer cell proliferation and migration. Concurrently, SETD6 methylates BRD4 at lysine 99 to control the expression of genes involved in mRNA translation by directing the recruitment of specific transcription factors. This modification of BRD4 is also critical in the context of viral oncogenesis, as methylated BRD4 better engages with the human papillomavirus E2 protein, thus facilitating viral transcription. Furthermore, methylation of the transcription factor TWIST1 by SETD6 has been shown to repress long noncoding RNA LINC-PINT, thereby promoting epithelial-to-mesenchymal transition in glioma."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAutoregulatory mechanisms and emerging roles in cancer further highlight the multifaceted functions of SETD6. The enzyme undergoes self‐methylation—a modification that facilitates its oligomerization and enhances its overall catalytic activity—thereby fine-tuning its substrate methylation efficiency. In addition, studies suggest a functional interplay between SETD6 and SETD3 in the regulation of apoptotic pathways. Although its role in certain cancers such as oral squamous cell carcinoma remains to be fully elucidated, aberrant SETD6 expression and function have also been linked to lung adenocarcinoma, underlining its potential significance across a spectrum of malignancies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Dan Levy, Alex J Kuo, Yanqi Chang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ni.1968"}], "href": "https://doi.org/10.1038/ni.1968"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21131967"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21131967"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Neelam Mukherjee, Eduardo Cardenas, Roble Bedolla, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SETD6 regulates NF-κB signaling in urothelial cell survival: Implications for bladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.14750"}], "href": "https://doi.org/10.18632/oncotarget.14750"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28122346"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28122346"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Lorena Martín-Morales, Michal Feldman, Zlata Vershinin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SETD6 dominant negative mutation in familial colorectal cancer type X."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddx336"}], "href": "https://doi.org/10.1093/hmg/ddx336"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28973356"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28973356"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Olivier Binda, Ana Sevilla, Gary LeRoy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewal."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Epigenetics (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/epi.23416"}], "href": "https://doi.org/10.4161/epi.23416"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23324626"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23324626"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Olivier Binda "}, {"type": "b", "children": [{"type": "t", "text": "Lysine methyltransferase SETD6 modifies histones on a glycine-lysine motif."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Epigenetics (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15592294.2019.1649529"}], "href": "https://doi.org/10.1080/15592294.2019.1649529"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31370726"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31370726"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Daniel J O'Neill, Stuart Charles Williamson, Dhuha Alkharaif, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SETD6 controls the expression of estrogen-responsive genes and proliferation of breast carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Epigenetics (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/epi.28864"}], "href": "https://doi.org/10.4161/epi.28864"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24751716"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24751716"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Zlata Vershinin, Michal Feldman, Ayelet Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PAK4 Methylation by SETD6 Promotes the Activation of the Wnt/β-Catenin Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M115.697292"}], "href": "https://doi.org/10.1074/jbc.M115.697292"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26841865"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26841865"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Michal Feldman, Zlata Vershinin, Inna Goliand, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The methyltransferase SETD6 regulates Mitotic progression through PLK1 methylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1804407116"}], "href": "https://doi.org/10.1073/pnas.1804407116"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30622182"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30622182"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Ruosi Yao, Yingli Wang, Danyang Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lysines 207 and 325 methylation of WDR5 catalyzed by SETD6 promotes breast cancer cell proliferation and migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2018.6669"}], "href": "https://doi.org/10.3892/or.2018.6669"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30226578"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30226578"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Zlata Vershinin, Michal Feldman, Thilo Werner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BRD4 methylation by the methyltransferase SETD6 regulates selective transcription to control mRNA translation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Adv (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/sciadv.abf5374"}], "href": "https://doi.org/10.1126/sciadv.abf5374"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34039605"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34039605"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Lee Admoni-Elisha, Tzofit Elbaz, Anand Chopra, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TWIST1 methylation by SETD6 selectively antagonizes LINC-PINT expression in glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkac485"}], "href": "https://doi.org/10.1093/nar/gkac485"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35694846"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35694846"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Leny Jose, Elliot J Androphy, Marsha DeSmet "}, {"type": "b", "children": [{"type": "t", "text": "SETD6 Regulates E2-Dependent Human Papillomavirus Transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/jvi.01295-22"}], "href": "https://doi.org/10.1128/jvi.01295-22"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36300937"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36300937"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Lital Estrella Weil, Yulia Shmidov, Margarita Kublanovsky, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oligomerization and Auto-methylation of the Human Lysine Methyltransferase SETD6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2018.08.028"}], "href": "https://doi.org/10.1016/j.jmb.2018.08.028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30189201"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30189201"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Wentao Huang, Hongjing Liu, Tianzhu Lv "}, {"type": "b", "children": [{"type": "t", "text": "Silencing of SETD6 inhibits the tumorigenesis of oral squamous cell carcinoma by inhibiting methylation of PAK4 and RelA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histol Histopathol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14670/HH-18-327"}], "href": "https://doi.org/10.14670/HH-18-327"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33710605"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33710605"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Lee Admoni-Elisha, Elina Abaev-Schneiderman, Ofir Cohn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure-function conservation between the methyltransferases SETD3 and SETD6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochimie (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biochi.2022.05.003"}], "href": "https://doi.org/10.1016/j.biochi.2022.05.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35550916"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35550916"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Jing Xu, Hui Zhou, Ziling Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Investigating the functional role of SETD6 in lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-022-10476-9"}], "href": "https://doi.org/10.1186/s12885-022-10476-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36604642"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36604642"}]}]}]}
Proteins	SETD6_HUMAN
NCBI Gene ID	79918
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SETD6 has 5,036 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 107 datasets.

Click the + buttons to view associations for SETD6 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SETD6 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SETD6 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SETD6 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SETD6 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SETD6 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SETD6 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SETD6 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SETD6 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SETD6 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of SETD6 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SETD6 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SETD6 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SETD6 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SETD6 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SETD6 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing SETD6 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SETD6 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SETD6 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing SETD6 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SETD6 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SETD6 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SETD6 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SETD6 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with SETD6 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with SETD6 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of SETD6 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SETD6 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with SETD6 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SETD6 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SETD6 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SETD6 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SETD6 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SETD6 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SETD6 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SETD6 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SETD6 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of SETD6 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with SETD6 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing SETD6 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of SETD6 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of SETD6 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.