SGMS2 Gene

Name	sphingomyelin synthase 2
Description	Sphingomyelin, a major component of cell and Golgi membranes, is made by the transfer of phosphocholine from phosphatidylcholine onto ceramide, with diacylglycerol as a side product. The protein encoded by this gene is an enzyme that catalyzes this reaction primarily at the cell membrane. The synthesis is reversible, and this enzyme can catalyze the reaction in either direction. The encoded protein is required for cell growth. Three transcript variants encoding the same protein have been found for this gene. There is evidence for more variants, but the full-length nature of their transcripts has not been determined.[provided by RefSeq, Oct 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSGMS2, a plasma membrane‐resident sphingomyelin synthase, catalyzes the conversion of ceramide and phosphatidylcholine into sphingomyelin and diacylglycerol, thereby establishing a critical balance between pro‐survival and pro‐apoptotic lipid messengers. In diverse cell types, its enzymatic activity contributes not only to maintaining sphingomyelin homeostasis in lipid rafts and the plasma membrane but also to regulating downstream signaling events – including those that affect cell growth, apoptosis, and membrane trafficking. Furthermore, studies have shown that proper subcellular localization and posttranslational modifications, as well as homodimer formation, are necessary for SGMS2 to exert its function in orchestrating the generation and compartmentalization of bioactive lipids, which in turn influence key protein–protein interactions and membrane dynamics."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFunctionally, aberrant SGMS2 expression has been linked to a variety of pathological conditions. Enhanced SGMS2 levels have been associated with cancer progression – for example, elevated expression in breast and esophageal carcinomas correlates with suppressed ceramide‐mediated apoptosis, promotion of epithelial–mesenchymal transition via TGF‑β/Smad signaling, and increased invasiveness. In addition, SGMS2 has been implicated in modulating inflammatory pathways such as NFκB activation, in regulating the expression and function of key drug transporters, and in influencing lipid-mediated signaling cascades that underlie metabolic disturbances observed in atherosclerosis and chronic obstructive pulmonary disease. These multifaceted roles underscore its importance as a potential therapeutic target in oncology, inflammation, and metabolic disorders."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGenetic studies have further underscored the pivotal role of SGMS2 in skeletal homeostasis. Pathogenic variants in SGMS2 are causative of a spectrum of bone disorders – ranging from childhood‐onset osteoporosis with calvarial “doughnut” lesions to severe spondylometaphyseal dysplasia – by disrupting normal sphingomyelin metabolism and thereby impairing bone mineralization. In addition, genome‐wide association studies have identified SGMS2 as a determinant affecting serum markers and bone density, reinforcing its central role in maintaining skeletal integrity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "18", "end_ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Fikadu Geta Tafesse, Klazien Huitema, Martin Hermansson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Both sphingomyelin synthases SMS1 and SMS2 are required for sphingomyelin homeostasis and growth in human HeLa cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M702423200"}], "href": "https://doi.org/10.1074/jbc.M702423200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17449912"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17449912"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhiqiang Li, Tiruneh K Hailemariam, Hongwen Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of sphingomyelin synthase (SMS) affects intracellular sphingomyelin accumulation and plasma membrane lipid organization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbalip.2007.05.007"}], "href": "https://doi.org/10.1016/j.bbalip.2007.05.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17616479"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17616479"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Maristella Villani, Marimuthu Subathra, Yeong-Bin Im, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sphingomyelin synthases regulate production of diacylglycerol at the Golgi."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20071240"}], "href": "https://doi.org/10.1042/BJ20071240"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18370930"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18370930"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Tinbo Ding, Zhiqiang Li, Tiruneh Hailemariam, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SMS overexpression and knockdown: impact on cellular sphingomyelin and diacylglycerol metabolism, and cell apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Lipid Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1194/jlr.M700401-JLR200"}], "href": "https://doi.org/10.1194/jlr.M700401-JLR200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17982138"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17982138"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Calvin Yeang, Shweta Varshney, Renxiao Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The domain responsible for sphingomyelin synthase (SMS) activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbalip.2008.07.002"}], "href": "https://doi.org/10.1016/j.bbalip.2008.07.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18694848"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18694848"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jing Liu, Hongqi Zhang, Zhiqiang Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sphingomyelin synthase 2 is one of the determinants for plasma and liver sphingomyelin levels in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/ATVBAHA.109.185223"}], "href": "https://doi.org/10.1161/ATVBAHA.109.185223"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19286635"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19286635"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Philipp Ternes, Jos F H M Brouwers, Joep van den Dikkenberg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sphingomyelin synthase SMS2 displays dual activity as ceramide phosphoethanolamine synthase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Lipid Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1194/jlr.M900230-JLR200"}], "href": "https://doi.org/10.1194/jlr.M900230-JLR200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19454763"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19454763"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Marimuthu Subathra, Asfia Qureshi, Chiara Luberto "}, {"type": "b", "children": [{"type": "t", "text": "Sphingomyelin synthases regulate protein trafficking and secretion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0023644"}], "href": "https://doi.org/10.1371/journal.pone.0023644"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21980337"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21980337"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yasuhiro Hayashi, Yoko Nemoto-Sasaki, Naoki Matsumoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Carboxyl-terminal Tail-mediated Homodimerizations of Sphingomyelin Synthases Are Responsible for Efficient Export from the Endoplasmic Reticulum."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M116.746602"}], "href": "https://doi.org/10.1074/jbc.M116.746602"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27927984"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27927984"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Tiruneh K Hailemariam, Chongmin Huan, Jing Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sphingomyelin synthase 2 deficiency attenuates NFkappaB activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/ATVBAHA.108.168682"}], "href": "https://doi.org/10.1161/ATVBAHA.108.168682"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18566297"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18566297"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Gwendolyn Barceló-Coblijn, Maria Laura Martin, Rodrigo F M de Almeida, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sphingomyelin and sphingomyelin synthase (SMS) in the malignant transformation of glioma cells and in 2-hydroxyoleic acid therapy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1115484108"}], "href": "https://doi.org/10.1073/pnas.1115484108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22106271"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22106271"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Kehong Zheng, Zetao Chen, Haizhan Feng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sphingomyelin synthase 2 promotes an aggressive breast cancer phenotype by disrupting the homoeostasis of ceramide and sphingomyelin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-019-1303-0"}], "href": "https://doi.org/10.1038/s41419-019-1303-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30770781"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30770781"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Dongsheng Mou, Hua Yang, Changhua Qu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pharmacological Activation of Peroxisome Proliferator-Activated Receptor {Delta} Increases Sphingomyelin Synthase Activity in THP-1 Macrophage-Derived Foam Cell."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Inflammation (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10753-016-0389-0"}], "href": "https://doi.org/10.1007/s10753-016-0389-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27278004"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27278004"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Yan Deng, Jia-Chun Hu, Shu-Hua He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sphingomyelin synthase 2 facilitates M2-like macrophage polarization and tumor progression in a mouse model of triple-negative breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Pharmacol Sin (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41401-020-0419-1"}], "href": "https://doi.org/10.1038/s41401-020-0419-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32451413"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32451413"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Qingchun Pan, Bei Li, Jin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA THAP9-AS1 accelerates cell growth of esophageal squamous cell carcinoma through sponging miR-335-5p to regulate SGMS2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2021.153526"}], "href": "https://doi.org/10.1016/j.prp.2021.153526"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34273804"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34273804"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Guiying Jin, Yang Li, Yuwen Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SMS regulates the expression and function of P-gp and MRP2 in Caco-2 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biol Toxicol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10565-016-9348-7"}], "href": "https://doi.org/10.1007/s10565-016-9348-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27394416"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27394416"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Haizhan Feng, Yahui Dong, Kunling Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sphingomyelin synthase 2 promotes the stemness of breast cancer cells via modulating NF-κB signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer Res Clin Oncol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00432-023-05589-y"}], "href": "https://doi.org/10.1007/s00432-023-05589-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38285090"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38285090"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Minna Pekkinen, Paulien A Terhal, Lorenzo D Botto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Osteoporosis and skeletal dysplasia caused by pathogenic variants in SGMS2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "JCI Insight (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/jci.insight.126180"}], "href": "https://doi.org/10.1172/jci.insight.126180"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30779713"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30779713"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Elena Merkuryeva, Tatiana Markova, Anton Tyurin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical and Genetic Characteristics of Calvarial Doughnut Lesions with Bone Fragility in Three Families with a Reccurent "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "SGMS2"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Gene Variant."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms24098021"}], "href": "https://doi.org/10.3390/ijms24098021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37175737"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37175737"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Sandra Pihlström, Sampo Richardt, Kirsi Määttä, et al. "}, {"type": "b", "children": [{"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "SGMS2"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " in primary osteoporosis with facial nerve palsy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Endocrinol (Lausanne) (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fendo.2023.1224318"}], "href": "https://doi.org/10.3389/fendo.2023.1224318"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37886644"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37886644"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Asahi Hishida, Masahiro Nakatochi, Takashi Tamura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study of serum prostate-specific antigen levels based on 1000 Genomes imputed data in Japanese: the Japan Multi-Institutional Collaborative Cohort Study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nagoya J Med Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18999/nagjms.83.1.183"}], "href": "https://doi.org/10.18999/nagjms.83.1.183"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33727749"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33727749"}]}]}]}
Synonyms	SMS2
Proteins	SMS2_HUMAN
NCBI Gene ID	166929
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SGMS2 has 8,514 functional associations with biological entities spanning 9 categories (molecular profile, organism, disease, phenotype or trait, functional term, phrase or reference, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 113 datasets.

Click the + buttons to view associations for SGMS2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SGMS2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SGMS2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SGMS2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SGMS2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SGMS2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SGMS2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SGMS2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SGMS2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SGMS2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SGMS2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SGMS2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SGMS2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SGMS2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SGMS2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with SGMS2 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing SGMS2 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SGMS2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SGMS2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SGMS2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SGMS2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SGMS2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SGMS2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with SGMS2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with SGMS2 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of SGMS2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SGMS2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SGMS2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SGMS2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SGMS2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SGMS2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SGMS2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SGMS2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SGMS2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SGMS2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with SGMS2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with SGMS2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing SGMS2 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of SGMS2 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of SGMS2 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of SGMS2 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SGMS2 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.