SH3PXD2B Gene

Name	SH3 and PX domains 2B
Description	This gene encodes an adapter protein that is characterized by a PX domain and four Src homology 3 domains. The encoded protein is required for podosome formation and is involved in cell adhesion and migration of numerous cell types. Mutations in this gene are the cause of Frank-ter Haar syndrome (FTHS), and also Borrone Dermato-Cardio-Skeletal (BDCS) syndrome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSH3PXD2B encodes the Tks4 adaptor protein, which is critically involved in the formation of invadopodia and podosomes—specialized actin‐rich membrane structures that enable extracellular matrix degradation and cell invasion. Tks4 functions as a scaffold linking components such as NoxA1 to the Nox1 NADPH oxidase complex, thereby facilitating reactive oxygen species generation that is essential for invadopodia assembly in colon cancer cells. This process is tightly regulated by Src-mediated phosphorylation events, which enable the appropriate binding interactions among Tks4, NoxA1, and other adaptor proteins."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGenetic mutations in SH3PXD2B are the underlying cause of Frank-ter Haar syndrome (FTHS), a disorder characterized by skeletal, cardiovascular, and ocular abnormalities. Loss or reduction of functional Tks4 protein—whether through direct mutations or aberrant regulation—leads not only to impaired formation of actin-based structures but also to developmental defects, including dysregulated osteoblast differentiation and reduced bone homeostasis. Studies in patient-derived cells and knockout mouse models have demonstrated that Tks4 is crucial for normal embryonic development and bone tissue integrity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its roles in developmental processes, Tks4 modulates signaling pathways that regulate cell motility, invasion, and epithelial-to-mesenchymal transition (EMT) in various cancer types, including colon, melanoma, lung, and gastric cancers. Tks4 serves as a scaffold in the epidermal growth factor (EGF) signaling cascade by interacting directly with Src and cortactin, thereby stabilizing active kinase complexes and ensuring proper cytoskeletal reorganization. Its loss or mislocalization leads to aberrant formation of membrane ruffles and lamellipodia, enhanced migratory behavior, and altered expression of EMT markers. The identification of novel interacting partners such as CAPZA1 further underscores the complex role of Tks4 in maintaining cellular architecture and signal transduction during oncogenic progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Davide Gianni, Nicolas Taulet, Céline DerMardirossian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "c-Src-mediated phosphorylation of NoxA1 and Tks4 induces the reactive oxygen species (ROS)-dependent formation of functional invadopodia in human colon cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E10-08-0685"}], "href": "https://doi.org/10.1091/mbc.E10-08-0685"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20943948"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20943948"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Shinji Iizuka, Christopher Abdullah, Matthew D Buschman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role of Tks adaptor proteins in invadopodia formation, growth and metastasis of melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.12954"}], "href": "https://doi.org/10.18632/oncotarget.12954"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27802184"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27802184"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Davide Gianni, Céline DerMardirossian, Gary M Bokoch "}, {"type": "b", "children": [{"type": "t", "text": "Direct interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Cell Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejcb.2010.05.007"}], "href": "https://doi.org/10.1016/j.ejcb.2010.05.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20609497"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20609497"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Zafar Iqbal, Pilar Cejudo-Martin, Arjan de Brouwer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disruption of the podosome adaptor protein TKS4 (SH3PXD2B) causes the skeletal dysplasia, eye, and cardiac abnormalities of Frank-Ter Haar Syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2010.01.009"}], "href": "https://doi.org/10.1016/j.ajhg.2010.01.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20137777"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20137777"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Gábor Bögel, Annamária Gujdár, Miklós Geiszt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Frank-ter Haar syndrome protein Tks4 regulates epidermal growth factor-dependent cell migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.324897"}], "href": "https://doi.org/10.1074/jbc.M111.324897"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22829589"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22829589"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Carla I G Vogel, Brandon Greene, André Scherag, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Non-replication of an association of CTNNBL1 polymorphisms and obesity in a population of Central European ancestry."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Med Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2350-10-14"}], "href": "https://doi.org/10.1186/1471-2350-10-14"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19228371"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19228371"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Ta C Chang, Mislen Bauer, Herminia S Puerta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ophthalmic findings in Frank-ter Haar syndrome: report of a sibling pair."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J AAPOS (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jaapos.2017.07.216"}], "href": "https://doi.org/10.1016/j.jaapos.2017.07.216"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29100834"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29100834"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Virag Vas, Tamás Kovács, Szandra Körmendi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Significance of the Tks4 scaffold protein in bone tissue homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-42250-6"}], "href": "https://doi.org/10.1038/s41598-019-42250-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30962481"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30962481"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Árpád Lányi, Mónika Baráth, Zalán Péterfi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The homolog of the five SH3-domain protein (HOFI/SH3PXD2B) regulates lamellipodia formation and cell spreading."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0023653"}], "href": "https://doi.org/10.1371/journal.pone.0023653"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21886807"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21886807"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Metta Dülk, Bálint Szeder, Gábor Glatz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EGF Regulates the Interaction of Tks4 with Src through Its SH2 and SH3 Domains."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acs.biochem.8b00084"}], "href": "https://doi.org/10.1021/acs.biochem.8b00084"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29928795"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29928795"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Bálint Szeder, Júlia Tárnoki-Zách, Dóra Lakatos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Absence of the Tks4 Scaffold Protein Induces Epithelial-Mesenchymal Transition-Like Changes in Human Colon Cancer Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells8111343"}], "href": "https://doi.org/10.3390/cells8111343"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31671862"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31671862"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Elod Mehes, Monika Barath, Marton Gulyas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enhanced endothelial motility and multicellular sprouting is mediated by the scaffold protein TKS4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-50915-5"}], "href": "https://doi.org/10.1038/s41598-019-50915-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31591456"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31591456"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Anita Kurilla, Loretta László, Tamás Takács, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Studying the Association of TKS4 and CD2AP Scaffold Proteins and Their Implications in the Partial Epithelial-Mesenchymal Transition (EMT) Process."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms242015136"}], "href": "https://doi.org/10.3390/ijms242015136"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37894817"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37894817"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Csaba Ádám, Anna Fekete, Gábor Bőgel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Accumulation of the PX domain mutant Frank-ter Haar syndrome protein Tks4 in aggresomes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Commun Signal (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12964-015-0108-8"}], "href": "https://doi.org/10.1186/s12964-015-0108-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26183326"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26183326"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Mevan Jacksi, Eva Schad, László Buday, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive bioinformatics and experimental analysis of SH3PXD2B reveals its carcinogenic effect in gastric carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Life Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.lfs.2023.121792"}], "href": "https://doi.org/10.1016/j.lfs.2023.121792"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37211344"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37211344"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Mevan Jacksi, Eva Schad, Agnes Tantos "}, {"type": "b", "children": [{"type": "t", "text": "Morphological Changes Induced by TKS4 Deficiency Can Be Reversed by EZH2 Inhibition in Colorectal Carcinoma Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomolecules (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/biom14040445"}], "href": "https://doi.org/10.3390/biom14040445"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38672463"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38672463"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Loretta László, Anita Kurilla, Álmos Tilajka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Unveiling epithelial plasticity regulation in lung cancer: Exploring the cross-talk among Tks4 scaffold protein partners."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E24-03-0103"}], "href": "https://doi.org/10.1091/mbc.E24-03-0103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38985526"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38985526"}]}]}]}
Synonyms	FAD49, TKS4, HOFI, FTHS, KIAA1295
Proteins	SPD2B_HUMAN
NCBI Gene ID	285590
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SH3PXD2B has 5,996 functional associations with biological entities spanning 9 categories (molecular profile, organism, disease, phenotype or trait, functional term, phrase or reference, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 118 datasets.

Click the + buttons to view associations for SH3PXD2B from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SH3PXD2B Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SH3PXD2B gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SH3PXD2B gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SH3PXD2B gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SH3PXD2B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SH3PXD2B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SH3PXD2B gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SH3PXD2B gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SH3PXD2B gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SH3PXD2B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SH3PXD2B gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with SH3PXD2B protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SH3PXD2B gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SH3PXD2B gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SH3PXD2B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SH3PXD2B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with SH3PXD2B gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with SH3PXD2B gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing SH3PXD2B protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SH3PXD2B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SH3PXD2B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing SH3PXD2B protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing SH3PXD2B protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SH3PXD2B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SH3PXD2B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SH3PXD2B gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SH3PXD2B gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with SH3PXD2B gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with SH3PXD2B gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SH3PXD2B gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with SH3PXD2B gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SH3PXD2B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SH3PXD2B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SH3PXD2B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SH3PXD2B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SH3PXD2B gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SH3PXD2B gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SH3PXD2B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SH3PXD2B from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with SH3PXD2B gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with SH3PXD2B gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.