SHC3 Gene

HGNC Family	SH2 domain containing
Name	SHC (Src homology 2 domain containing) transforming protein 3
Description	Enables phosphotyrosine residue binding activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within glutamatergic synaptic transmission and learning or memory. Predicted to be located in cytosol. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSHC3, also known as ShcC or Rai, is a neural adaptor protein that modulates receptor‐mediated signaling events essential for neuronal differentiation and survival. It interacts with the cytoplasmic tail of amyloid precursor protein (APP) in a tyrosine phosphorylation–dependent manner, thereby influencing downstream gene expression and apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, SHC3 engages with activated receptor tyrosine kinases—including those linked to ALK‐dependent signaling—to promote differentiation and survival in neural cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Notably, genetic variants in SHC3 have also been associated with nicotine dependence, supporting a role for this adaptor protein in modulating behavioral and neuropsychiatric functions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAberrant expression and activation of SHC3 contribute to tumorigenesis and cancer progression in diverse malignancies. In hepatocellular carcinoma, elevated SHC3 levels promote epithelial–mesenchymal transition and metastasis via interactions that trigger MEK/ERK signaling cascades."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In glioblastoma, increased SHC3 phosphorylation is linked to a more migratory, invasive stem/progenitor cell phenotype"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", and in thyroid carcinomas, SHC3 associates with oncogenic RET oncoproteins to enhance PI3K/Akt survival signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " A developmental switch from Shc1 to SHC3 accompanies neuronal maturation; when dysregulated—as observed in neuroblastoma—this switch correlates with decreased differentiation, sustained ERK/Akt activation, and aggressive tumor behavior."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "10"}]}, {"type": "t", "text": " Furthermore, amplification of SHC3 in ependymomas"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "and its association with clinical outcomes in multiple myeloma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "underscore its oncogenic potential. SHC3 levels are further modulated in glioma cells in a cell density–dependent manner through focal adhesion kinase (Fak) activation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": ", and its expression is also detected in enteric glial cells, suggesting broader pathological involvement."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond developmental and oncogenic contexts, SHC3 facilitates cellular adaptation to stress. In hypoxic neuroblastoma cells, SHC3 sustains HIF‑1α expression and promotes anti-apoptotic signaling that enhances cell survival under low oxygen tensions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": " Moreover, overexpression of SHC3 in drug‐resistant breast cancer cells drives chemoresistance by mediating ErbB2 nuclear translocation and subsequent COX2 upregulation, which in turn increases P‑glycoprotein activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": " In hypoxic T lymphocytes, SHC3 further contributes to survival by augmenting Akt and NF‑κB pathway activation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Philip E Tarr, Roberta Roncarati, Giuliana Pelicci, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110286200"}], "href": "https://doi.org/10.1074/jbc.M110286200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11877420"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11877420"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Izumi Miyake, Yuko Hakomori, Azusa Shinohara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of anaplastic lymphoma kinase is responsible for hyperphosphorylation of ShcC in neuroblastoma cell lines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1205735"}], "href": "https://doi.org/10.1038/sj.onc.1205735"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12185581"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12185581"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Giuliana Pelicci, Flavia Troglio, Alessandra Bodini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.22.20.7351-7363.2002"}], "href": "https://doi.org/10.1128/MCB.22.20.7351-7363.2002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12242309"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12242309"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "M D Li, D Sun, X-Y Lou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Linkage and association studies in African- and Caucasian-American populations demonstrate that SHC3 is a novel susceptibility locus for nicotine dependence."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Psychiatry (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.mp.4001933"}], "href": "https://doi.org/10.1038/sj.mp.4001933"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17179996"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17179996"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yun Liu, Xinran Zhang, Baicai Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Demethylation-Induced Overexpression of Shc3 Drives c-Raf-Independent Activation of MEK/ERK in HCC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-17-2432"}], "href": "https://doi.org/10.1158/0008-5472.CAN-17-2432"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29330146"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29330146"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Barbara Ortensi, Daniela Osti, Serena Pellegatta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rai is a new regulator of neural progenitor migration and glioblastoma invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/stem.1056"}], "href": "https://doi.org/10.1002/stem.1056"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22311806"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22311806"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Valentina De Falco, Valentina Guarino, Luca Malorni, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RAI(ShcC/N-Shc)-dependent recruitment of GAB 1 to RET oncoproteins potentiates PI 3-K signalling in thyroid tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1208776"}], "href": "https://doi.org/10.1038/sj.onc.1208776"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15940252"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15940252"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Lorenzo Magrassi, Luciano Conti, Andrea Lanterna, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Shc3 affects human high-grade astrocytomas survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1208708"}], "href": "https://doi.org/10.1038/sj.onc.1208708"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15870690"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15870690"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Izumi Miyake, Yuko Hakomori, Yoko Misu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Domain-specific function of ShcC docking protein in neuroblastoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1208523"}], "href": "https://doi.org/10.1038/sj.onc.1208523"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15735675"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15735675"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "I Miyake, M Ohira, A Nakagawara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinct role of ShcC docking protein in the differentiation of neuroblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2008.413"}], "href": "https://doi.org/10.1038/onc.2008.413"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18997821"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18997821"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Lorenzo Magrassi, Nicola Marziliano, Frediano Inzani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EDG3 and SHC3 on chromosome 9q22 are co-amplified in human ependymomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2009.08.023"}], "href": "https://doi.org/10.1016/j.canlet.2009.08.023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19748727"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19748727"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Annette J Vangsted, Tobias Wirenfeldt Klausen, Peter Gimsing, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The importance of a sub-region on chromosome 19q13.3 for prognosis of multiple myeloma patients after high-dose treatment and stem cell support: a linkage disequilibrium mapping in RAI and CD3EAP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Hematol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00277-010-1105-z"}], "href": "https://doi.org/10.1007/s00277-010-1105-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21046104"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21046104"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Alberto Azzalin, Elena Moretti, Eloisa Arbustini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cell density modulates SHC3 expression and survival of human glioblastoma cells through Fak activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurooncol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11060-014-1551-x"}], "href": "https://doi.org/10.1007/s11060-014-1551-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25062668"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25062668"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "V Villanacci, G Bassotti, B Ortensi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of the Rai (Shc C) adaptor protein in the human enteric nervous system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurogastroenterol Motil (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-2982.2007.01017.x"}], "href": "https://doi.org/10.1111/j.1365-2982.2007.01017.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17919311"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17919311"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Mattia Criscuoli, Irene Filippi, Daniela Osti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Shc protein RAI promotes an adaptive cell survival program in hypoxic neuroblastoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.26247"}], "href": "https://doi.org/10.1002/jcp.26247"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29057481"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29057481"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Yun Liu, Fang Cao, Fantong Xia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Shc3 facilitates breast cancer drug resistance by interacting with ErbB2 to initiate ErbB2/COX2/MDR1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.5768"}], "href": "https://doi.org/10.1002/cam4.5768"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36880347"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36880347"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Mattia Criscuoli, Cristina Ulivieri, Irene Filippi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Shc protein Rai enhances T-cell survival under hypoxia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.29461"}], "href": "https://doi.org/10.1002/jcp.29461"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31944299"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31944299"}]}]}]}
Synonyms	NSHC, SHCC, N-SHC
Proteins	SHC3_HUMAN
NCBI Gene ID	53358
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SHC3 has 5,155 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 115 datasets.

Click the + buttons to view associations for SHC3 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SHC3 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SHC3 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SHC3 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SHC3 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SHC3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SHC3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SHC3 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SHC3 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SHC3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SHC3 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of SHC3 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SHC3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SHC3 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SHC3 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SHC3 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SHC3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SHC3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SHC3 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SHC3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SHC3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SHC3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing SHC3 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SHC3 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with SHC3 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with SHC3 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SHC3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with SHC3 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SHC3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SHC3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SHC3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SHC3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SHC3 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SHC3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SHC3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SHC3 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with SHC3 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with SHC3 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of SHC3 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with SHC3 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing SHC3 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of SHC3 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.