{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSialic acid‐binding immunoglobulin‐type lectins represent an important family of receptors expressed primarily on immune cells, where they mediate both inhibitory and activating signals to fine‐tune immune responses. In particular, SIGLECL1 has been identified as a member of this family whose expression is significantly upregulated in patient cohorts with early-onset dementia that display features overlapping Alzheimer disease and frontotemporal dementia. This elevated expression suggests that SIGLECL1 may be involved in modulating neuroimmune interactions and, by extension, influence neuroinflammatory processes that contribute to the progression of neurodegenerative disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAlthough the precise mechanistic role of SIGLECL1 in dementia pathobiology remains to be fully elucidated, its association with increased expression in affected individuals underscores its potential as a key immunomodulatory factor. This finding aligns with the broader understanding of sialic acid‐binding immunoglobulin‐type lectins as regulators capable of shifting the balance between protective and deleterious inflammatory responses under pathological conditions, thereby offering novel insights into possible therapeutic targets for neurodegenerative diseases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Antonella Rendina, Denise Drongitis, Aldo Donizetti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CD33 and SIGLECL1 Immunoglobulin Superfamily Involved in Dementia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neuropathol Exp Neurol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jnen/nlaa055"}], "href": "https://doi.org/10.1093/jnen/nlaa055"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32647856"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32647856"}]}]}]}