{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSIRT7 is a nucleolar protein that acts as a master regulator of ribosome biogenesis. It binds actively transcribed rRNA genes and interacts directly with RNA polymerase I and associated chromatin‐remodeling complexes to stimulate rDNA transcription, ensuring rapid ribosome production and sustaining cell proliferation. In this context, enhanced SIRT7 expression supports robust nucleolar activity, whereas its depletion leads to diminished ribosomal output, cell cycle arrest, and programmed cell death."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn cancer cells SIRT7 exerts context‐dependent effects on gene expression that contribute to tumor maintenance and progression. By selectively deacetylating lysine 18 on histone H3, SIRT7 represses the transcription of specific tumor suppressor genes and modulates oncogenic transcriptional programs. Aberrant SIRT7 expression has been documented in a variety of malignancies—including hepatocellular, breast, colorectal, thyroid, and non‐small cell lung cancers—where it promotes proliferative capacity, anchorage‐independent growth, and metastatic behavior. In addition, SIRT7 expression is regulated by and in turn modulates regulatory noncoding RNAs and factors involved in the hypoxic response, further influencing tumor aggressiveness."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "28"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSIRT7 also plays a critical role in maintaining genome stability through its participation in the DNA damage response. It catalyzes histone desuccinylation—most notably at H3K122—thereby promoting chromatin condensation that facilitates repair of DNA double‐strand breaks. Moreover, SIRT7 contributes to the timely deactivation of ATM signaling following repair and works in concert with RNA helicases to resolve aberrant R loops that could otherwise impede transcriptional elongation and compromise genome integrity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "29", "end_ref": "34"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its nuclear functions, SIRT7 is pivotal for metabolic homeostasis and the regulation of stem cell aging. It modulates the mitochondrial unfolded protein response and is essential for maintaining the quiescence and regenerative capacity of hematopoietic and other somatic stem cells. In addition, SIRT7 helps suppress endoplasmic reticulum stress and may prevent the development of fatty liver disease, while its proper activity is crucial for preserving tissue integrity under chronic stress conditions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "35", "end_ref": "39"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThe enzymatic activity and cellular localization of SIRT7 are finely regulated by post‐translational modifications. 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