{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSLAMF1 (CD150) functions as a pivotal receptor for measles virus and analogous morbilliviruses by mediating viral attachment, entry, and subsequent infection of immune cells. Work in human polarized epithelial and transgenic mouse models has demonstrated that wild‐type measles virus exploits discrete receptor‐binding sites on its attachment protein to engage SLAMF1, thereby dictating tissue tropism and influencing early infection events in lymphoid and airway compartments. Moreover, structural and mutational analyses have revealed that even minimal alterations in the viral haemagglutinin protein can modulate SLAMF1 binding and trigger membrane fusion—processes that are critical for virus entry even under conditions where canonical receptor expression is absent or weak."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "9"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in mediating viral entry, SLAMF1 serves as an important costimulatory and signaling receptor on a variety of immune cells including mature T lymphocytes, dendritic cells, and natural killer cells. Engagement of SLAMF1 triggers signaling cascades—often via its association with adaptor proteins such as SAP—that influence CD28‐independent T cell proliferation, cytokine (notably IFN‑γ) production, and the maturation status of antigen‐presenting cells. SLAMF1 also regulates key intracellular pathways such as MAPK and Akt and modulates responses downstream of Toll‑like receptor 4, thereby enhancing antimicrobial responses (for example, facilitating autophagy in macrophages and neutrophils) and shaping Th1 cytokine patterns in infections like tuberculosis and leprosy. Furthermore, its involvement in viral vector entry into quiescent lymphocytes via a macropinocytosis‐like mechanism underscores the broader immunoregulatory influence of SLAMF1."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "25"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSLAMF1 expression and function extend to the regulation of immune homeostasis and oncogenesis. In malignancies such as chronic lymphocytic leukemia and Hodgkin lymphoma, altered levels of SLAMF1 correlate with disease aggressiveness, altered cytokine profiles, and deregulated pro‑survival signaling (via pathways such as Akt and MAPK), thereby influencing cell migration, autophagic flux, and therapeutic responses. In parallel, genetic polymorphisms and even translational regulatory elements within the SLAMF1 mRNA contribute to its differential expression in autoimmune conditions—including systemic lupus erythematosus and rheumatoid arthritis—and B cell malignancies. Together, these data underscore the multifaceted role of SLAMF1 as not only a viral receptor and costimulatory molecule but also as a central modulator of immune regulation with profound implications for infectious diseases, autoimmunity, and cancer biology."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "26", "end_ref": "34"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Maino Tahara, Makoto Takeda, Yuta Shirogane, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Measles virus infects both polarized epithelial and immune cells by using distinctive receptor-binding sites on its hemagglutinin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.02691-07"}], "href": "https://doi.org/10.1128/JVI.02691-07"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18287234"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18287234"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Claudia S Antunes Ferreira, Marie Frenzke, Vincent H J Leonard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Measles virus infection of alveolar macrophages and dendritic cells precedes spread to lymphatic organs in transgenic mice expressing human signaling lymphocytic activation molecule (SLAM, CD150)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.01559-09"}], "href": "https://doi.org/10.1128/JVI.01559-09"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20042501"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20042501"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Nicolas Massé, Michelle Ainouze, Benjamin Néel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Measles virus (MV) hemagglutinin: evidence that attachment sites for MV receptors SLAM and CD46 overlap on the globular head."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.78.17.9051-9063.2004"}], "href": "https://doi.org/10.1128/JVI.78.17.9051-9063.2004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15308701"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15308701"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Makoto Takeda, Maino Tahara, Takao Hashiguchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A human lung carcinoma cell line supports efficient measles virus growth and syncytium formation via a SLAM- and CD46-independent mechanism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.01264-07"}], "href": "https://doi.org/10.1128/JVI.01264-07"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17715217"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17715217"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Maria Bieringer, Jung Woo Han, Sabine Kendl, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Experimental adaptation of wild-type canine distemper virus (CDV) to the human entry receptor CD150."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0057488"}], "href": "https://doi.org/10.1371/journal.pone.0057488"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23554862"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23554862"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Bumsuk Hahm, Nathalie Arbour, Denise Naniche, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Measles virus infects and suppresses proliferation of T lymphocytes from transgenic mice bearing human signaling lymphocytic activation molecule."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/jvi.77.6.3505-3515.2003"}], "href": "https://doi.org/10.1128/jvi.77.6.3505-3515.2003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12610126"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12610126"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Qin Xu, Peng Zhang, Chunling Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of amino acid residues involved in the interaction between measles virus Haemagglutin (MVH) and its human cell receptor (signaling lymphocyte activation molecule, SLAM)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biochem Mol Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.5483/bmbrep.2006.39.4.406"}], "href": "https://doi.org/10.5483/bmbrep.2006.39.4.406"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16889684"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16889684"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yuta Shirogane, Takao Hashiguchi, Yusuke Yanagi "}, {"type": "b", "children": [{"type": "t", "text": "Weak "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "cis"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " and "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "trans"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Interactions of the Hemagglutinin with Receptors Trigger Fusion Proteins of Neuropathogenic Measles Virus Isolates."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.01727-19"}], "href": "https://doi.org/10.1128/JVI.01727-19"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31619560"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31619560"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Daniel Gonçalves-Carneiro, Jane A McKeating, Dalan Bailey "}, {"type": "b", "children": [{"type": "t", "text": "The Measles Virus Receptor SLAMF1 Can Mediate Particle Endocytosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.02255-16"}], "href": "https://doi.org/10.1128/JVI.02255-16"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28100610"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28100610"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "M Kruse, E Meinl, G Henning, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Signaling lymphocytic activation molecule is expressed on mature CD83+ dendritic cells and is up-regulated by IL-1 beta."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.167.4.1989"}], "href": "https://doi.org/10.4049/jimmunol.167.4.1989"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11489980"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11489980"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Chengjun Li, Cristiana Iosef, Christina Y H Jia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dual functional roles for the X-linked lymphoproliferative syndrome gene product SAP/SH2D1A in signaling through the signaling lymphocyte activation molecule (SLAM) family of immune receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M206649200"}], "href": "https://doi.org/10.1074/jbc.M206649200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12458214"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12458214"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Bumsuk Hahm, Nathalie Arbour, Michael B A Oldstone "}, {"type": "b", "children": [{"type": "t", "text": "Measles virus interacts with human SLAM receptor on dendritic cells to cause immunosuppression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Virology (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.virol.2004.03.011"}], "href": "https://doi.org/10.1016/j.virol.2004.03.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15193925"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15193925"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Cecilia Frecha, Camille Lévy, Caroline Costa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Measles virus glycoprotein-pseudotyped lentiviral vector-mediated gene transfer into quiescent lymphocytes requires binding to both SLAM and CD46 entry receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.00324-11"}], "href": "https://doi.org/10.1128/JVI.00324-11"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21450813"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21450813"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Inna G Ovsyannikova, Iana H Haralambieva, Robert A Vierkant, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The association of CD46, SLAM and CD209 cellular receptor gene SNPs with variations in measles vaccine-induced immune responses: a replication study and examination of novel polymorphisms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Hered (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000331585"}], "href": "https://doi.org/10.1159/000331585"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22086389"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22086389"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Neelam Dhiman, Gregory A Poland, Julie M Cunningham, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Variations in measles vaccine-specific humoral immunity by polymorphisms in SLAM and CD46 measles virus receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Allergy Clin Immunol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jaci.2007.04.036"}], "href": "https://doi.org/10.1016/j.jaci.2007.04.036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17560639"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17560639"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Svitlana V Mikhalap, Larysa M Shlapatska, Olga V Yurchenko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The adaptor protein SH2D1A regulates signaling through CD150 (SLAM) in B cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2004-04-1273"}], "href": "https://doi.org/10.1182/blood-2004-04-1273"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15315965"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15315965"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Virginia Pasquinelli, María F Quiroga, Gustavo J Martínez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of signaling lymphocytic activation molecule-associated protein interrupts IFN-gamma production in human tuberculosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.172.2.1177"}], "href": "https://doi.org/10.4049/jimmunol.172.2.1177"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14707094"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14707094"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "María F Quiroga, Gustavo J Martínez, Virginia Pasquinelli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of signaling lymphocytic activation molecule triggers a signaling cascade that enhances Th1 responses in human intracellular infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.173.6.4120"}], "href": "https://doi.org/10.4049/jimmunol.173.6.4120"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15356162"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15356162"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Margaret A Jordan, Julie M Fletcher, Roby Jose, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of SLAM in NKT cell development revealed by transgenic complementation in NOD mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1003305"}], "href": "https://doi.org/10.4049/jimmunol.1003305"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21357537"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21357537"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Mariya Y Yurchenko, Larysa M Kovalevska, Larysa M Shlapatska, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CD150 regulates JNK1/2 activation in normal and Hodgkin's lymphoma B cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunol Cell Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/icb.2010.14"}], "href": "https://doi.org/10.1038/icb.2010.14"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20231852"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20231852"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Stefan Mehrle, Susanne Frank, Jan Schmidt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SAP and SLAM expression in anti-CD3 activated lymphocytes correlates with cytotoxic activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunol Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1440-1711.2004.01302.x"}], "href": "https://doi.org/10.1111/j.1440-1711.2004.01302.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15661039"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15661039"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Joaquín Miguel Pellegrini, Florencia Sabbione, María Paula Morelli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neutrophil autophagy during human active tuberculosis is modulated by SLAMF1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15548627.2020.1825273"}], "href": "https://doi.org/10.1080/15548627.2020.1825273"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32954947"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32954947"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Chunyan Ma, Ninghai Wang, Cynthia Detre, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Receptor signaling lymphocyte-activation molecule family 1 (Slamf1) regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by recruiting a Beclin-1/Vps34/ultraviolet radiation resistance-associated gene (UVRAG) complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.367060"}], "href": "https://doi.org/10.1074/jbc.M112.367060"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22493499"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22493499"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Laurence Menard, Tineke Cantaert, Nicolas Chamberlain, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Signaling lymphocytic activation molecule (SLAM)/SLAM-associated protein pathway regulates human B-cell tolerance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Allergy Clin Immunol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jaci.2013.10.051"}], "href": "https://doi.org/10.1016/j.jaci.2013.10.051"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24373350"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24373350"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Maria P Karampetsou, Denis Comte, Abel Suárez-Fueyo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Signaling Lymphocytic Activation Molecule Family Member 1 Engagement Inhibits T Cell-B Cell Interaction and Diminishes Interleukin-6 Production and Plasmablast Differentiation in Systemic Lupus Erythematosus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Rheumatol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/art.40682"}], "href": "https://doi.org/10.1002/art.40682"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30058241"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30058241"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Cinzia Bologna, Roberta Buonincontri, Sara Serra, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SLAMF1 regulation of chemotaxis and autophagy determines CLL patient response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI83013"}], "href": "https://doi.org/10.1172/JCI83013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26619119"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26619119"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Gian Matteo Rigolin, Elena Saccenti, Aurora Melandri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "In chronic lymphocytic leukaemia, SLAMF1 deregulation is associated with genomic complexity and independently predicts a worse outcome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Haematol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/bjh.16865"}], "href": "https://doi.org/10.1111/bjh.16865"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32578873"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32578873"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Valeriia Shcherbina, Inna Gordiienko, Larysa Shlapatska, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CD150 and CD180 are negative regulators of IL-10 expression and secretion in chronic lymphocytic leukemia B cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasma (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4149/neo_2021_210104N8"}], "href": "https://doi.org/10.4149/neo_2021_210104N8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33904315"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33904315"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "L V Putlyaeva, A M Schwartz, K V Korneev, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upstream open reading frames regulate translation of the long isoform of SLAMF1 mRNA that encodes costimulatory receptor CD150."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (Mosc) (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1134/S0006297914120165"}], "href": "https://doi.org/10.1134/S0006297914120165"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25716736"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25716736"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "M Yurchenko, L M Shlapatska, O L Romanets, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CD150-mediated Akt signalling pathway in normal and malignant B cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Oncol (2011)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21423089"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21423089"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Shi-Dong Chen, Hong-Qi Li, Xue-Ning Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-Wide Association Study Identifies SLAMF1 Affecting the Rate of Memory Decline."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Alzheimers Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/JAD-191214"}], "href": "https://doi.org/10.3233/JAD-191214"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31985465"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31985465"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Anqi Li, Zhanfeng Zhang, Xiaochen Ru, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of SLAMF1 as an immune-related key gene associated with rheumatoid arthritis and verified in mice collagen-induced arthritis model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2022.961129"}], "href": "https://doi.org/10.3389/fimmu.2022.961129"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36110846"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36110846"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Inna Gordiienko, Larysa Shlapatska, Valeriia Kholodniuk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The interplay of CD150 and CD180 receptor pathways contribute to the pathobiology of chronic lymphocytic leukemia B cells by selective inhibition of Akt and MAPK signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0185940"}], "href": "https://doi.org/10.1371/journal.pone.0185940"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28982149"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28982149"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Yi You, Zhe Wang, Guo-Hong Deng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Detection and functional evaluation of -262A/T and -188A/G polymorphisms of SLAM gene in patients with systemic lupus erythematosus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Rheumatol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3899/jrheum.091390"}], "href": "https://doi.org/10.3899/jrheum.091390"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20810499"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20810499"}]}]}]}