{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSLAMF7, also known as CS1 or CRACC, is a cell surface glycoprotein highly expressed on multiple myeloma cells where it contributes to malignant plasma cell adhesion, survival, and clonogenic growth. Its abundant and tumor‐restricted expression has been exploited therapeutically—for example, with humanized antibodies that block myeloma cell binding to bone marrow stroma and induce potent antibody‐dependent cellular cytotoxicity, ultimately promoting tumor regression. Moreover, transcriptional regulators such as Blimp‐1/PRDM1 influence SLAMF7 expression, further underscoring its role in sustaining the malignant phenotype."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn innate immunity, SLAMF7 exerts critical roles by modulating the effector functions of natural killer cells, monocytes, and macrophages. Engagement of SLAMF7 on NK cells promotes degranulation and cytolytic activity against MHC class I–deficient target cells—a process tightly regulated by its immunoreceptor tyrosine‐based switch motifs and associated adaptor proteins. In monocytes and macrophages, SLAMF7 not only fine‐tunes proinflammatory cytokine production in response to Toll‐like receptor stimulation and differentiation signals but also cooperates with integrin complexes to enhance the phagocytosis of hematopoietic tumor cells."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in malignancy and innate immunity, SLAMF7 is also implicated in the regulation of adaptive immune responses in various autoimmune and inflammatory diseases. Altered expression and alternative splicing of SLAMF7 on B cells, T cells, and natural killer cells have been associated with conditions such as systemic lupus erythematosus, rheumatoid arthritis, IgG4‐related disease, periodontitis, HIV infection, and multiple sclerosis. 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