SLC22A7 Gene

HGNC Family	Solute carriers (SLC)
Name	solute carrier family 22 (organic anion transporter), member 7
Description	The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSLC22A7, commonly known as organic anion transporter 2 (OAT2), is a bidirectional, facilitative transporter with broad substrate specificity that plays a pivotal role in renal drug and metabolite handling. In the kidney, OAT2 mediates the uptake of various organic anions—including tetracycline and creatinine—to facilitate active tubular secretion and possibly reabsorption. Functional studies in proximal tubular cells have demonstrated that OAT2 not only transports these substrates with high intrinsic clearance compared with other transporters but also contributes to the clinical alterations in serum creatinine observed with certain xenobiotics."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn hepatic tissues and circulating cells such as erythrocytes, OAT2 is equally influential in modulating a diverse set of substrates. It has been shown to transport cyclic guanosine monophosphate (cGMP) with high facilitative activity and to mediate the uptake of orotic acid, nicotinic acid, and glutamate—compounds that affect metabolic regulation and drug disposition. Moreover, detailed kinetic analyses reveal that OAT2 operates via transport mechanisms that do not rely on conventional ion exchange, which may underlie its role in the hepatic clearance of several clinically important high‐permeability drugs."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "11"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditionally, the function and expression of SLC22A7 are subject to complex regulatory mechanisms. Genetic polymorphisms and transcriptional modulation by nuclear receptors—such as LRH-1—and regulatory microRNAs have been shown to influence hepatic OAT2 levels, thereby affecting the pharmacokinetics of its substrates. Considerable interindividual variability in OAT2 expression further underscores its potential impact on both endogenous metabolism and xenobiotic clearance, positioning OAT2 as a potential therapeutic target to modulate drug efficacy and toxicity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "15"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ellappan Babu, Michio Takeda, Shinichi Narikawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human organic anion transporters mediate the transport of tetracycline."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Jpn J Pharmacol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1254/jjp.88.69"}], "href": "https://doi.org/10.1254/jjp.88.69"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11855680"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11855680"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yaofeng Cheng, Arpine Vapurcuyan, Mohammad Shahidullah, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of organic anion transporter 2 in the human kidney and its potential role in the tubular secretion of guanine-containing antiviral drugs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Drug Metab Dispos (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/dmd.111.042036"}], "href": "https://doi.org/10.1124/dmd.111.042036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22190696"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22190696"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Eve-Irene Lepist, Xuexiang Zhang, Jia Hao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Kidney Int (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ki.2014.66"}], "href": "https://doi.org/10.1038/ki.2014.66"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24646860"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24646860"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hong Shen, Tongtong Liu, Bridget L Morse, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of Organic Anion Transporter 2 (SLC22A7): A Highly Efficient Transporter for Creatinine and Species-Dependent Renal Tubular Expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Drug Metab Dispos (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/dmd.114.062364"}], "href": "https://doi.org/10.1124/dmd.114.062364"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25904762"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25904762"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Cheryl D Cropp, Takafumi Komori, James E Shima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Pharmacol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/mol.107.043117"}], "href": "https://doi.org/10.1124/mol.107.043117"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18216183"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18216183"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Christian Fork, Tim Bauer, Stefan Golz, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Human organic anion transporter 2 is distinct from organic anion transporters 1 and 3 with respect to transport function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Renal Physiol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajprenal.00140.2015"}], "href": "https://doi.org/10.1152/ajprenal.00140.2015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26377792"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26377792"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Sumathy Mathialagan, Chester Costales, Laurie Tylaska, et al. "}, {"type": "b", "children": [{"type": "t", "text": "In vitro studies with two human organic anion transporters: OAT2 and OAT7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Xenobiotica (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/00498254.2017.1384595"}], "href": "https://doi.org/10.1080/00498254.2017.1384595"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28945155"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28945155"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Georg Sager, Natalia Smaglyukova, Ole-Martin Fuskevaag "}, {"type": "b", "children": [{"type": "t", "text": "The role of OAT2 (SLC22A7) in the cyclic nucleotide biokinetics of human erythrocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.26409"}], "href": "https://doi.org/10.1002/jcp.26409"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29244191"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29244191"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Emi Kimoto, Sumathy Mathialagan, Laurie Tylaska, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Quantification of Hepatic Organic Anion Transport Proteins OAT2 and OAT7 in Human Liver Tissue and Primary Hepatocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Pharm (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acs.molpharmaceut.8b00320"}], "href": "https://doi.org/10.1021/acs.molpharmaceut.8b00320"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29906129"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29906129"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Keiji Nishibeppu, Shuhei Komatsu, Taisuke Imamura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Plasma microRNA profiles: identification of miR-1229-3p as a novel chemoresistant and prognostic biomarker in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-020-59939-8"}], "href": "https://doi.org/10.1038/s41598-020-59939-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32081926"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32081926"}]}]}]}
Synonyms	hOAT11, OAT2, NLT
Proteins	S22A7_HUMAN
NCBI Gene ID	10864
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SLC22A7 has 4,473 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 112 datasets.

Click the + buttons to view associations for SLC22A7 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SLC22A7 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by SLC22A7 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SLC22A7 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SLC22A7 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SLC22A7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SLC22A7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SLC22A7 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SLC22A7 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SLC22A7 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SLC22A7 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of SLC22A7 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SLC22A7 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SLC22A7 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SLC22A7 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SLC22A7 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SLC22A7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SLC22A7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of SLC22A7 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SLC22A7 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SLC22A7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SLC22A7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SLC22A7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SLC22A7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SLC22A7 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SLC22A7 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with SLC22A7 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with SLC22A7 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SLC22A7 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for SLC22A7 protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with SLC22A7 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with SLC22A7 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SLC22A7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SLC22A7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SLC22A7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SLC22A7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for SLC22A7 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SLC22A7 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SLC22A7 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SLC22A7 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SLC22A7 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with SLC22A7 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.