{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe collection of abstracts provided overwhelmingly centers on the role of the astrocytic water channel aquaporin‐4 (AQP4) in central nervous system physiology and pathology. Many studies demonstrate that AQP4, which is highly localized to astrocytic end‐feet at key brain barriers, facilitates rapid transcellular water movement that is critical for the clearance of brain edema, the maintenance of water–ion homeostasis, and the dynamic regulation of the glymphatic pathway. Furthermore, AQP4‐dependent water flux contributes to astrocyte migration and influences neuronal excitability, seizure propagation, and even synaptic plasticity in various models of brain injury and disease."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistic investigations across these studies have revealed that the polarized expression of AQP4—often established by interactions with adapter proteins such as α‐syntrophin—is essential for mediating bidirectional water exchange across the blood–brain and cerebrospinal fluid interfaces. This polarized localization underpins various processes, including efficient clearance of extracellular potassium following neuronal activity, regulation of cellular volume (e.g., via interactions with TRPV4 and SUR1‐TRPM4 complexes), and modulation of astrocyte reactivity in conditions such as ischemia, trauma, and neuroinflammation. Additionally, several reports address its influence on tissue diffusion properties, glymphatic transport of solutes, and even aspects of synaptic plasticity and cognitive function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "28"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nImportantly, despite the original query requesting a summary of SLC27A4 function, none of the provided abstracts address SLC27A4. SLC27A4 encodes fatty acid transport protein 4 (FATP4), which is implicated in fatty acid uptake and lipid metabolism (and, when mutated, in conditions such as ichthyosis prematurity syndrome). In contrast, the literature here is solely dedicated to elucidating AQP4‐mediated water transport and its downstream effects on brain homeostasis, edema formation/resolution, and astrocyte physiology. Thus, while these studies provide a comprehensive overview of AQP4 function in the central nervous system"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "29", "end_ref": "36"}]}, {"type": "t", "text": ", no insights regarding SLC27A4 are offered.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zsolt Vajda, Michael Pedersen, Ernst-Martin Füchtbauer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Delayed onset of brain edema and mislocalization of aquaporin-4 in dystrophin-null transgenic mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.192457099"}], "href": "https://doi.org/10.1073/pnas.192457099"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12232046"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12232046"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mahmood Amiry-Moghaddam, Takashi Otsuka, Patricia D Hurn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An alpha-syntrophin-dependent pool of AQP4 in astroglial end-feet confers bidirectional water flow between blood and brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0437946100"}], "href": "https://doi.org/10.1073/pnas.0437946100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12578959"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12578959"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Eugen Solenov, Hiroyuki Watanabe, Geoffrey T Manley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sevenfold-reduced osmotic water permeability in primary astrocyte cultures from AQP-4-deficient mice, measured by a fluorescence quenching method."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Cell Physiol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpcell.00298.2003"}], "href": "https://doi.org/10.1152/ajpcell.00298.2003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14576087"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14576087"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Mahmood Amiry-Moghaddam, Anne Williamson, Maria Palomba, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Delayed K+ clearance associated with aquaporin-4 mislocalization: phenotypic defects in brains of alpha-syntrophin-null mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.2336064100"}], "href": "https://doi.org/10.1073/pnas.2336064100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14597704"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14597704"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Mahmood Amiry-Moghaddam, Rong Xue, Finn-Mogens Haug, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alpha-syntrophin deletion removes the perivascular but not endothelial pool of aquaporin-4 at the blood-brain barrier and delays the development of brain edema in an experimental model of acute hyponatremia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.03-0869fje"}], "href": "https://doi.org/10.1096/fj.03-0869fje"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14734638"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14734638"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Marios C Papadopoulos, Geoffrey T Manley, Sanjeev Krishna, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.04-1723fje"}], "href": "https://doi.org/10.1096/fj.04-1723fje"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15208268"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15208268"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Samira Saadoun, Marios C Papadopoulos, Hiroyuki Watanabe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of aquaporin-4 in astroglial cell migration and glial scar formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.02680"}], "href": "https://doi.org/10.1242/jcs.02680"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16303850"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16303850"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Devin K Binder, Xiaoming Yao, Zsolt Zador, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Glia (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/glia.20318"}], "href": "https://doi.org/10.1002/glia.20318"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16470808"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16470808"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Marlise de Castro Ribeiro, Lorenz Hirt, Julien Bogousslavsky, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Time course of aquaporin expression after transient focal cerebral ischemia in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci Res (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jnr.20819"}], "href": "https://doi.org/10.1002/jnr.20819"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16511868"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16511868"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "A S Verkman, Devin K Binder, Orin Bloch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Three distinct roles of aquaporin-4 in brain function revealed by knockout mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamem.2006.02.018"}], "href": "https://doi.org/10.1016/j.bbamem.2006.02.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16564496"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16564496"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Xiao-Ning Zeng, Xiu-Lan Sun, Lin Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aquaporin-4 deficiency down-regulates glutamate uptake and GLT-1 expression in astrocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Neurosci (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mcn.2006.09.008"}], "href": "https://doi.org/10.1016/j.mcn.2006.09.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17074507"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17074507"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Javier Ruiz-Ederra, Hua Zhang, A S Verkman "}, {"type": "b", "children": [{"type": "t", "text": "Evidence against functional interaction between aquaporin-4 water channels and Kir4.1 potassium channels in retinal Müller cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M703236200"}], "href": "https://doi.org/10.1074/jbc.M703236200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17525153"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17525153"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Hua Zhang, A S Verkman "}, {"type": "b", "children": [{"type": "t", "text": "Aquaporin-4 independent Kir4.1 K+ channel function in brain glial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Neurosci (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mcn.2007.08.007"}], "href": "https://doi.org/10.1016/j.mcn.2007.08.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17869537"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17869537"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Jianping Zhou, Hui Kong, Xiangdong Hua, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Altered blood-brain barrier integrity in adult aquaporin-4 knockout mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuroreport (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/WNR.0b013e3282f2b4eb"}], "href": "https://doi.org/10.1097/WNR.0b013e3282f2b4eb"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18281883"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18281883"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Hui Kong, Yi Fan, Juan Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AQP4 knockout impairs proliferation, migration and neuronal differentiation of adult neural stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.035758"}], "href": "https://doi.org/10.1242/jcs.035758"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19033383"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19033383"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Natalia Guillén, María A Navarro, Carmen Arnal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Microarray analysis of hepatic gene expression identifies new genes involved in steatotic liver."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Physiol Genomics (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/physiolgenomics.90339.2008"}], "href": "https://doi.org/10.1152/physiolgenomics.90339.2008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19258494"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19258494"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Joakim Klar, Martina Schweiger, Robert Zimmerman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in the fatty acid transport protein 4 gene cause the ichthyosis prematurity syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2009.06.021"}], "href": "https://doi.org/10.1016/j.ajhg.2009.06.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19631310"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19631310"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Jérôme Badaut, Stephen Ashwal, Arash Adami, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Brain water mobility decreases after astrocytic aquaporin-4 inhibition using RNA interference."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cereb Blood Flow Metab (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/jcbfm.2010.163"}], "href": "https://doi.org/10.1038/jcbfm.2010.163"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20877385"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20877385"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Alexander S Thrane, Phillip M Rappold, Takumi Fujita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1015217108"}], "href": "https://doi.org/10.1073/pnas.1015217108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21187412"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21187412"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Lihua Li, Hua Zhang, Michel Varrin-Doyer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Proinflammatory role of aquaporin-4 in autoimmune neuroinflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.10-177279"}], "href": "https://doi.org/10.1096/fj.10-177279"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21257712"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21257712"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Valentina Benfenati, Marco Caprini, Melania Dovizio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An aquaporin-4/transient receptor potential vanilloid 4 (AQP4/TRPV4) complex is essential for cell-volume control in astrocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1012867108"}], "href": "https://doi.org/10.1073/pnas.1012867108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21262839"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21262839"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Nadia Nabil Haj-Yasein, Gry Fluge Vindedal, Martine Eilert-Olsen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1110655108"}], "href": "https://doi.org/10.1073/pnas.1110655108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21990350"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21990350"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Shannon R Hinson, Michael F Romero, Bogdan F Gh Popescu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular outcomes of neuromyelitis optica (NMO)-IgG binding to aquaporin-4 in astrocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1109980108"}], "href": "https://doi.org/10.1073/pnas.1109980108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22128336"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22128336"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Nadia Nabil Haj-Yasein, Vidar Jensen, Ivar Østby, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aquaporin-4 regulates extracellular space volume dynamics during high-frequency synaptic stimulation: a gene deletion study in mouse hippocampus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Glia (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/glia.22319"}], "href": "https://doi.org/10.1002/glia.22319"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22419561"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22419561"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Zeguang Ren, Jeffrey J Iliff, Lijun Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "'Hit & Run' model of closed-skull traumatic brain injury (TBI) reveals complex patterns of post-traumatic AQP4 dysregulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cereb Blood Flow Metab (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/jcbfm.2013.30"}], "href": "https://doi.org/10.1038/jcbfm.2013.30"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23443171"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23443171"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Yang Wang, Jun Huang, Yuanyuan Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-29b is a therapeutic target in cerebral ischemia associated with aquaporin 4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cereb Blood Flow Metab (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/jcbfm.2015.156"}], "href": "https://doi.org/10.1038/jcbfm.2015.156"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26126866"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26126866"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Andrew O Jo, Daniel A Ryskamp, Tam T T Phuong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRPV4 and AQP4 Channels Synergistically Regulate Cell Volume and Calcium Homeostasis in Retinal Müller Glia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.1987-15.2015"}], "href": "https://doi.org/10.1523/JNEUROSCI.1987-15.2015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26424896"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26424896"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Jacqueline A Hubbard, Mike S Hsu, Marcus M Seldin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of the Astrocyte Water Channel Aquaporin-4 in the Mouse Brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "ASN Neuro (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1759091415605486"}], "href": "https://doi.org/10.1177/1759091415605486"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26489685"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26489685"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Zhiqiang Xu, Na Xiao, Yali Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Neurodegener (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13024-015-0056-1"}], "href": "https://doi.org/10.1186/s13024-015-0056-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26526066"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26526066"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Jacqueline A Hubbard, Jenny I Szu, Jennifer M Yonan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of astrocyte glutamate transporter-1 (GLT1) and aquaporin-4 (AQP4) expression in a model of epilepsy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Neurol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.expneurol.2016.05.003"}], "href": "https://doi.org/10.1016/j.expneurol.2016.05.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27155358"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27155358"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Maosheng Xia, Li Yang, Guangfeng Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mechanism of depression as a risk factor in the development of Alzheimer's disease: the function of AQP4 and the glymphatic system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Psychopharmacology (Berl) (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00213-016-4473-9"}], "href": "https://doi.org/10.1007/s00213-016-4473-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27837334"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27837334"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Alex J Smith, Xiaoming Yao, James A Dix, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.27679"}], "href": "https://doi.org/10.7554/eLife.27679"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28826498"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28826498"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Jesse A Stokum, Min S Kwon, Seung K Woo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SUR1-TRPM4 and AQP4 form a heteromultimeric complex that amplifies ion/water osmotic coupling and drives astrocyte swelling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Glia (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/glia.23231"}], "href": "https://doi.org/10.1002/glia.23231"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28906027"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28906027"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Yolanda Ohene, Ian F Harrison, Payam Nahavandi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Non-invasive MRI of brain clearance pathways using multiple echo time arterial spin labelling: an aquaporin-4 study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuroimage (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuroimage.2018.12.026"}], "href": "https://doi.org/10.1016/j.neuroimage.2018.12.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30557661"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30557661"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Humberto Mestre, Lauren M Hablitz, Anna Lr Xavier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aquaporin-4-dependent glymphatic solute transport in the rodent brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.40070"}], "href": "https://doi.org/10.7554/eLife.40070"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30561329"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30561329"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Hongwei Wang, Xiaoxiao Zheng, Jing Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA MALAT1 silencing protects against cerebral ischemia-reperfusion injury through miR-145 to regulate AQP4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biomed Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12929-020-00635-0"}], "href": "https://doi.org/10.1186/s12929-020-00635-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32138732"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32138732"}]}]}]}