SLC27A5 Gene

HGNC Family	Solute carriers (SLC), Acyl-CoA synthetase family (ACS)
Name	solute carrier family 27 (fatty acid transporter), member 5
Description	The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSLC27A5, also known as FATP5, is a liver‐specific enzyme that plays a central role in the uptake and intracellular trafficking of fatty acids as well as in bile acid metabolism. Functioning as a bile acid–CoA ligase, SLC27A5 is essential for the conjugation of primary bile acids with glycine and taurine, a process that facilitates efficient lipid absorption. Furthermore, genetic studies have identified common promoter variants and novel mutations in SLC27A5 that are associated with metabolic dysregulation, including insulin resistance, nonalcoholic fatty liver disease, and even type 2 diabetes, in addition to congenital defects in bile acid conjugation which can lead to fat‐soluble vitamin deficiencies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of hepatocellular carcinoma (HCC), SLC27A5 exhibits tumor‐suppressive properties. Its downregulation—whether by DNA hypermethylation or other mechanisms—results in the loss of its antiproliferative effects and contributes to tumor progression, poor prognosis, and resistance to sorafenib therapy. Mechanistically, SLC27A5 deficiency triggers alterations in lipid profiles that lead to oxidative stress through increased lipid peroxidation and the accumulation of toxic by‐products such as 4-hydroxy-2-nonenal. These modifications activate the KEAP1/NRF2 axis and upregulate downstream targets (for example, TXNRD1 and GSR) that impair ferroptosis. In addition to its canonical metabolic roles, SLC27A5 has been shown to regulate alternative splicing of key mRNAs via interaction with IGF2BP3; this non-canonical function influences the expression of splice variants (notably of PIP4K2A) that modulate PI3K signaling and metastatic potential."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in metabolism and cancer, SLC27A5 is implicated in liver fibrosis and cholestatic liver disease. Its deficiency or mutation can lead to an accumulation of unconjugated bile acids—particularly cholic acid—which in turn activates hepatic stellate cells via increased expression of early growth response protein 3 (EGR3). This biochemical disturbance predisposes the liver to fibrotic remodeling. Indeed, reports of missense mutations in SLC27A5 in patients exhibiting cholestatic features highlight the enzyme’s importance in maintaining bile acid homeostasis and preventing liver injury under stress conditions such as prematurity or parenteral nutrition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Eva Fisher, Inke Nitz, Inka Lindner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Candidate gene association study of type 2 diabetes in a nested case-control study of the EPIC-Potsdam cohort - role of fat assimilation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Nutr Food Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mnfr.200600162"}], "href": "https://doi.org/10.1002/mnfr.200600162"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17266179"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17266179"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "A Auinger, L Valenti, M Pfeuffer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A promoter polymorphism in the liver-specific fatty acid transport protein 5 is associated with features of the metabolic syndrome and steatosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Horm Metab Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1055/s-0030-1267186"}], "href": "https://doi.org/10.1055/s-0030-1267186"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20945272"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20945272"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Kenneth D R Setchell, James E Heubi, Sohela Shah, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic defects in bile acid conjugation cause fat-soluble vitamin deficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.gastro.2013.02.004"}], "href": "https://doi.org/10.1053/j.gastro.2013.02.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23415802"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23415802"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Qingzhu Gao, Guiji Zhang, Yaqiu Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SLC27A5 deficiency activates NRF2/TXNRD1 pathway by increased lipid peroxidation in HCC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41418-019-0399-1"}], "href": "https://doi.org/10.1038/s41418-019-0399-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31367013"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31367013"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Feng-Li Xu, Xiao-Hong Wu, Chang Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SLC27A5 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by downregulating glutathione reductase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-023-05558-w"}], "href": "https://doi.org/10.1038/s41419-023-05558-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36635256"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36635256"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Dan Nie, Xin Tang, Haijun Deng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Metabolic Enzyme SLC27A5 Regulates PIP4K2A pre-mRNA Splicing as a Noncanonical Mechanism to Suppress Hepatocellular Carcinoma Metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Adv Sci (Weinh) (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/advs.202305374"}], "href": "https://doi.org/10.1002/advs.202305374"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38059827"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38059827"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Catherine P K Chong, Philippa B Mills, Patricia McClean, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bile acid-CoA ligase deficiency--a new inborn error of bile acid metabolism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Inherit Metab Dis (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10545-011-9416-3"}], "href": "https://doi.org/10.1007/s10545-011-9416-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22089923"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22089923"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Kang Wu, Yi Liu, Jie Xia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of SLC27A5 Activates Hepatic Stellate Cells and Promotes Liver Fibrosis via Unconjugated Cholic Acid."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Adv Sci (Weinh) (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/advs.202304408"}], "href": "https://doi.org/10.1002/advs.202304408"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37957540"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37957540"}]}]}]}
Synonyms	VLCSH2, VLCS-H2, VLACSR, FATP-5, ACSVL6, ACSB, BACS, FACVL3, FATP5
Proteins	S27A5_HUMAN
NCBI Gene ID	10998
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SLC27A5 has 4,915 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 111 datasets.

Click the + buttons to view associations for SLC27A5 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SLC27A5 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by SLC27A5 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SLC27A5 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SLC27A5 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SLC27A5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SLC27A5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SLC27A5 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SLC27A5 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SLC27A5 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SLC27A5 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SLC27A5 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SLC27A5 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SLC27A5 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SLC27A5 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SLC27A5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SLC27A5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SLC27A5 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SLC27A5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SLC27A5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SLC27A5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SLC27A5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SLC27A5 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SLC27A5 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with SLC27A5 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with SLC27A5 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SLC27A5 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with SLC27A5 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SLC27A5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SLC27A5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SLC27A5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SLC27A5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SLC27A5 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SLC27A5 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SLC27A5 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SLC27A5 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with SLC27A5 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with SLC27A5 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of SLC27A5 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with SLC27A5 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing SLC27A5 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of SLC27A5 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.