{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSLC2A2 encodes the facilitative glucose transporter GLUT2, a low‐affinity, high‐capacity protein that plays a pivotal role in mediating bidirectional fluxes of glucose (and related sugars) across the plasma membranes of key metabolic tissues such as liver, kidney, and intestine. GLUT2 not only serves as the primary conduit for glucose reabsorption in the kidney and clearance in the liver but also functions as a glucose sensor—its cellular location and expression being tightly regulated by nutrient availability and transcription factors (for example, HNF‐1α) that coordinate its expression. In addition, studies have demonstrated that GLUT2 contributes to the transport of non‐glucose substrates such as glycerophosphoinositols and even dehydroascorbic acid, thereby influencing vitamin C bioavailability. Furthermore, its regulated translocation to specific membrane domains (for instance, the apical membrane in enterocytes under high‐glucose conditions) underlines the dynamic control of tissue‐specific glucose uptake. These observations underscore the importance of transcriptional control, post‐translational modifications and substrate interactions in determining GLUT2 function across tissues."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGenetic studies have repeatedly implicated SLC2A2 variants in the modulation of glycemic traits and type 2 diabetes risk. Common polymorphisms are associated with modest elevations in fasting plasma glucose and altered rates of progression from impaired glucose tolerance to overt diabetes, while certain rare mutations cause Fanconi–Bickel syndrome—a glycogen storage disorder with variable phenotypic severity. In addition, variant alleles have been linked to differences in dietary sugar preference and even to altered responsiveness to antidiabetic agents such as metformin, suggesting that liver GLUT2 expression (as evidenced by significant cis‐eQTL effects) is critical for drug action. Intriguingly, some associations extend to extra‐metabolic traits, including prostate cancer risk, thus broadening the clinical implications of SLC2A2 variation. Collectively, these genetic findings highlight the multifaceted consequences of altered GLUT2 activity on both metabolic homeostasis and disease susceptibility."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "25"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional functional analyses have further refined our understanding of GLUT2’s structure–function relationships. In vitro studies using engineered mutations and naturally occurring variants have revealed that even subtle alterations in protein structure can modify transport kinetics, influence membrane trafficking and ultimately affect insulin secretion and β‐cell differentiation. Complementary work investigating the SLC2A2 promoter has provided insights into gene‐specific regulation—even though some promoter variants appear not to alter disease risk. Moreover, GLUT2’s substrate specificity extends beyond glucose to include other molecules (such as dehydroascorbic acid), and investigations into its role in insulin receptor internalization have hinted at broader signaling interactions. Such studies, taken together with observations in cancer models (where altered GLUT2 expression may serve as a diagnostic or prognostic marker), underscore the clinical relevance of both its transport and sensor functions. These multifaceted investigations—including those into chromatin regulation and related protein interactions—highlight GLUT2 as a key determinant of cellular and whole‐organism metabolic homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "26", "end_ref": "34"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Nobuhiro Ban, Yuichiro Yamada, Yoshimichi Someya, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Intestinal dehydroascorbic acid (DHA) transport mediated by the facilitative sugar transporters, GLUT2 and GLUT8."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.436790"}], "href": "https://doi.org/10.1074/jbc.M112.436790"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23396969"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23396969"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Chiara Ghezzi, Donald D F Loo, Ernest M Wright "}, {"type": "b", "children": [{"type": "t", "text": "Physiology of renal glucose handling via SGLT1, SGLT2 and GLUT2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetologia (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00125-018-4656-5"}], "href": "https://doi.org/10.1007/s00125-018-4656-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30132032"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30132032"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Laura J McCulloch, Martijn van de Bunt, Matthias Braun, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "The mutation spectrum of the facilitative glucose transporter gene SLC2A2 (GLUT2) in patients with Fanconi-Bickel syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genet (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00439-001-0638-6"}], "href": "https://doi.org/10.1007/s00439-001-0638-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11810292"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11810292"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Inês Barroso, Jian'an Luan, Rita P S Middelberg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pbio.0000020"}], "href": "https://doi.org/10.1371/journal.pbio.0000020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14551916"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14551916"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Cristen J Willer, Lori L Bonnycastle, Karen N Conneely, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Screening of 134 single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes replicates association with 12 SNPs in nine genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/db06-0461"}], "href": "https://doi.org/10.2337/db06-0461"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17192490"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17192490"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Karen M Eny, Thomas M S Wolever, Bénédicte Fontaine-Bisson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variant in the glucose transporter type 2 is associated with higher intakes of sugars in two distinct populations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Physiol Genomics (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/physiolgenomics.00148.2007"}], "href": "https://doi.org/10.1152/physiolgenomics.00148.2007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18349384"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18349384"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Josée Dupuis, Claudia Langenberg, Inga Prokopenko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.520"}], "href": "https://doi.org/10.1038/ng.520"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20081858"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20081858"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Tamra E Meyer, Eric Boerwinkle, Alanna C Morrison, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Diabetes genes and prostate cancer in the Atherosclerosis Risk in Communities study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Epidemiol Biomarkers Prev (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1055-9965.EPI-09-0902"}], "href": "https://doi.org/10.1158/1055-9965.EPI-09-0902"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20142250"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20142250"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "T W Boesgaard, N Grarup, T Jørgensen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetologia (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00125-010-1753-5"}], "href": "https://doi.org/10.1007/s00125-010-1753-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20419449"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20419449"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Sarah Catharina Grünert, Karl Otfried Schwab, Martin Pohl, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fanconi-Bickel syndrome: GLUT2 mutations associated with a mild phenotype."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Genet Metab (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ymgme.2011.11.200"}], "href": "https://doi.org/10.1016/j.ymgme.2011.11.200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22214819"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22214819"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "F H Sansbury, S E Flanagan, J A L Houghton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SLC2A2 mutations can cause neonatal diabetes, suggesting GLUT2 may have a role in human insulin secretion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetologia (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00125-012-2595-0"}], "href": "https://doi.org/10.1007/s00125-012-2595-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22660720"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22660720"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Lydie Izakovicova Holla, Petra Borilova Linhartova, Svetlana Lucanova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GLUT2 and TAS1R2 Polymorphisms and Susceptibility to Dental Caries."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Caries Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000430958"}], "href": "https://doi.org/10.1159/000430958"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26112465"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26112465"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Kaixin Zhou, Sook Wah Yee, Eric L Seiser, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.3632"}], "href": "https://doi.org/10.1038/ng.3632"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27500523"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27500523"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Leszek Szablewski "}, {"type": "b", "children": [{"type": "t", "text": "Glucose Transporters in Brain: In Health and in Alzheimer's Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Alzheimers Dis (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/JAD-160841"}], "href": "https://doi.org/10.3233/JAD-160841"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27858715"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27858715"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Osatohanmwen J Enogieru, Peter M U Ung, Sook Wah Yee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional and structural analysis of rare SLC2A2 variants associated with Fanconi-Bickel syndrome and metabolic traits."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.23758"}], "href": "https://doi.org/10.1002/humu.23758"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30950137"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30950137"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Yu Lei, Qiaoling Hu, Jiang Gu "}, {"type": "b", "children": [{"type": "t", "text": "Expressions of Carbohydrate Response Element Binding Protein and Glucose Transporters in Liver Cancer and Clinical Significance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Oncol Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12253-019-00708-y"}], "href": "https://doi.org/10.1007/s12253-019-00708-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31407220"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31407220"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "A M Møller, N M Jensen, J Pildal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Studies of genetic variability of the glucose transporter 2 promoter in patients with type 2 diabetes mellitus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jcem.86.5.7499"}], "href": "https://doi.org/10.1210/jcem.86.5.7499"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11344224"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11344224"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "G C Banks, L J Deterding, K B Tomer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hormone-mediated dephosphorylation of specific histone H1 isoforms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M104641200"}], "href": "https://doi.org/10.1074/jbc.M104641200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11479299"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11479299"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Hansol Lee, Raymond Habas, Cory Abate-Shen "}, {"type": "b", "children": [{"type": "t", "text": "MSX1 cooperates with histone H1b for inhibition of transcription and myogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1098096"}], "href": "https://doi.org/10.1126/science.1098096"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15192231"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15192231"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Philippe Fonteyne, Veerle Casneuf, Patrick Pauwels, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of hexokinases and glucose transporters in treated and untreated oesophageal adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histol Histopathol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14670/HH-24.971"}], "href": "https://doi.org/10.14670/HH-24.971"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19554504"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19554504"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "G V Kulkarni, T Chng, K M Eny, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of GLUT2 and TAS1R2 genotypes with risk for dental caries."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Caries Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000345652"}], "href": "https://doi.org/10.1159/000345652"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23257979"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23257979"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Aurélien Michau, Ghislaine Guillemain, Alexandra Grosfeld, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in SLC2A2 gene reveal hGLUT2 function in pancreatic β cell development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.469189"}], "href": "https://doi.org/10.1074/jbc.M113.469189"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23986439"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23986439"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Martial Boutchueng-Djidjou, Gabriel Collard-Simard, Suzanne Fortier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Proteomics (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/mcp.M114.047159"}], "href": "https://doi.org/10.1074/mcp.M114.047159"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25687571"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25687571"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Emi Ono, Hiroyuki Murota, Yuki Mori, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sweat glucose and GLUT2 expression in atopic dermatitis: Implication for clinical manifestation and treatment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0195960"}], "href": "https://doi.org/10.1371/journal.pone.0195960"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29677207"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29677207"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Wolfgang Rathmann, Klaus Strassburger, Brenda Bongaerts, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A variant of the glucose transporter gene SLC2A2 modifies the glycaemic response to metformin therapy in recently diagnosed type 2 diabetes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetologia (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00125-018-4759-z"}], "href": "https://doi.org/10.1007/s00125-018-4759-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30413829"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30413829"}]}]}]}