HGNC Family | Solute carriers (SLC) |
Name | solute carrier family 2 (facilitated glucose transporter), member 4 |
Description | This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). [provided by RefSeq, Jul 2008] |
Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSLC2A4, which encodes the GLUT4 protein, is the primary insulin‐responsive glucose transporter that governs the uptake of glucose into muscle and adipose cells. In the basal state, GLUT4 is sequestered in intracellular vesicles, but upon insulin stimulation it is rapidly mobilized and translocated to the plasma membrane, thereby facilitating efficient glucose disposal and maintaining systemic glucose homeostasis. Moreover, increased expression of GLUT4—as seen with strength training and exercise—enhances insulin sensitivity and can ameliorate insulin‐resistant states, while its overexpression in skeletal muscle has been shown to improve metabolic profiles. This central role of GLUT4 in insulin‐mediated glucose uptake has been demonstrated in studies ranging from muscle and adipose cell models to in vivo physiological investigations."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nA complex network of signaling cascades and regulatory kinases tightly controls the intracellular trafficking, expression, and activity of GLUT4. Insulin activates the PI3K–Akt pathway along with downstream effectors (such as AS160 and TUG) to regulate both the exocytosis and retention of GLUT4‐containing vesicles. Various modulators, including MAP kinases, oxidative stress (as induced by overnutrition) and hormonal signals like leptin and estrogen, further tune GLUT4’s functional delivery at the cell surface. Importantly, perturbations in these pathways are linked not only to insulin resistance in conditions such as type 2 diabetes, gestational diabetes and polycystic ovary syndrome but also to aberrant GLUT4 localization in malignancies and other metabolic disorders, emphasizing its broad physiological and pathophysiological importance."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to dynamic trafficking, GLUT4’s proper function depends on a cohort of auxiliary molecules that ensure its correct intracellular sorting, posttranslational modification, and transcriptional regulation. Proteins such as EHD1, Dennd4C, and Daxx have been implicated in the formation, perinuclear retention, and insulin‐stimulated recycling of GLUT4 vesicles, while structural modifications (for example, N‐glycosylation) are critical for its stability and accurate targeting. Transcription factors including MEF2, along with regulators like PGC-1 and LPIN1, modulate GLUT4 gene expression in response to metabolic and environmental cues. These multifaceted regulatory mechanisms are further influenced by pharmacological agents (metformin, phytochemicals), physiological stress, and even viral infections that switch glucose transporter profiles to meet altered cellular energy demands. Together, these findings underscore that modulation of GLUT4 trafficking and expression is central to metabolic adaptation and represents a promising target for therapeutic intervention in insulin resistance, diabetes, obesity, certain cancers, and other metabolic disorders."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "21", "end_ref": "47"}, {"type": "fg_f", "ref": "43"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Nia J Bryant, Roland Govers, David E James "}, {"type": "b", "children": [{"type": "t", "text": "Regulated transport of the glucose transporter GLUT4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Rev Mol Cell Biol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nrm782"}], "href": "https://doi.org/10.1038/nrm782"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11994746"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11994746"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mads K Holten, Morten Zacho, Michael Gaster, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Strength training increases insulin-mediated glucose uptake, GLUT4 content, and insulin signaling in skeletal muscle in patients with type 2 diabetes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/diabetes.53.2.294"}], "href": "https://doi.org/10.2337/diabetes.53.2.294"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14747278"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14747278"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Sean L McGee, Bryce J W van Denderen, Kirsten F Howlett, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/db07-0843"}], "href": "https://doi.org/10.2337/db07-0843"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18184930"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18184930"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Lorena Eguez, Adrian Lee, Jose A Chavez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Full intracellular retention of GLUT4 requires AS160 Rab GTPase activating protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Metab (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cmet.2005.09.005"}], "href": "https://doi.org/10.1016/j.cmet.2005.09.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16213228"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16213228"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Birgit Gustafson, Shahram Hedjazifar, Silvia Gogg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Insulin resistance and impaired adipogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Trends Endocrinol Metab (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.tem.2015.01.006"}], "href": "https://doi.org/10.1016/j.tem.2015.01.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25703677"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25703677"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Heikki A Koistinen, Dana Galuska, Alexander V Chibalin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/diabetes.52.5.1066"}], "href": "https://doi.org/10.2337/diabetes.52.5.1066"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12716734"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12716734"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Christian J Carlson, Sandra Koterski, Richard J Sciotti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enhanced basal activation of mitogen-activated protein kinases in adipocytes from type 2 diabetes: potential role of p38 in the downregulation of GLUT4 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/diabetes.52.3.634"}], "href": "https://doi.org/10.2337/diabetes.52.3.634"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12606502"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12606502"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Annette M Shewan, Ellen M van Dam, Sally Martin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GLUT4 recycles via a trans-Golgi network (TGN) subdomain enriched in Syntaxins 6 and 16 but not TGN38: involvement of an acidic targeting motif."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e02-06-0315"}], "href": "https://doi.org/10.1091/mbc.e02-06-0315"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12631717"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12631717"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Marc U Baumann, Sylvie Deborde, Nicholas P Illsley "}, {"type": "b", "children": [{"type": "t", "text": "Placental glucose transfer and fetal growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrine (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1385/ENDO:19:1:13"}], "href": "https://doi.org/10.1385/ENDO:19:1:13"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12583599"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12583599"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jonathan S Bogan, Natalie Hendon, Adrienne E McKee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional cloning of TUG as a regulator of GLUT4 glucose transporter trafficking."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature01989"}], "href": "https://doi.org/10.1038/nature01989"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14562105"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14562105"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Samuel K McBrayer, Javelin C Cheng, Seema Singhal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multiple myeloma exhibits novel dependence on GLUT4, GLUT8, and GLUT11: implications for glucose transporter-directed therapy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2011-09-377846"}], "href": "https://doi.org/10.1182/blood-2011-09-377846"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22452979"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22452979"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Christine Y Christ-Roberts, Thongchai Pratipanawatr, Wilailak Pratipanawatr, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exercise training increases glycogen synthase activity and GLUT4 expression but not insulin signaling in overweight nondiabetic and type 2 diabetic subjects."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Metabolism (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.metabol.2004.03.022"}], "href": "https://doi.org/10.1016/j.metabol.2004.03.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15334390"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15334390"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Guenther Boden, Carol Homko, Carlos A Barrero, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Excessive caloric intake acutely causes oxidative stress, GLUT4 carbonylation, and insulin resistance in healthy men."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Transl Med (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scitranslmed.aac4765"}], "href": "https://doi.org/10.1126/scitranslmed.aac4765"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26355033"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26355033"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "A Hammarstedt, P-A Jansson, C Wesslau, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reduced expression of PGC-1 and insulin-signaling molecules in adipose tissue is associated with insulin resistance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0006-291x(03)00014-7"}], "href": "https://doi.org/10.1016/s0006-291x(03"}, {"type": "t", "text": "00014-7) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12565902"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12565902"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Yongjun Yu, Tobi G Maguire, James C Alwine "}, {"type": "b", "children": [{"type": "t", "text": "Human cytomegalovirus activates glucose transporter 4 expression to increase glucose uptake during infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.01967-10"}], "href": "https://doi.org/10.1128/JVI.01967-10"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21147915"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21147915"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Muheeb Beg, Nazish Abdullah, Fathima Shazna Thowfeik, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinct Akt phosphorylation states are required for insulin regulated Glut4 and Glut1-mediated glucose uptake."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.26896"}], "href": "https://doi.org/10.7554/eLife.26896"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28589878"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28589878"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Sophie E Leney, Jeremy M Tavaré "}, {"type": "b", "children": [{"type": "t", "text": "The molecular basis of insulin-stimulated glucose uptake: signalling, trafficking and potential drug targets."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Endocrinol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1677/JOE-09-0037"}], "href": "https://doi.org/10.1677/JOE-09-0037"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19389739"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19389739"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Yacir Benomar, Nadia Naour, Alain Aubourg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Insulin and leptin induce Glut4 plasma membrane translocation and glucose uptake in a human neuronal cell line by a phosphatidylinositol 3-kinase- dependent mechanism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2005-1464"}], "href": "https://doi.org/10.1210/en.2005-1464"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16497805"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16497805"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "A Ericsson, B Hamark, T L Powell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glucose transporter isoform 4 is expressed in the syncytiotrophoblast of first trimester human placenta."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Reprod (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/humrep/deh596"}], "href": "https://doi.org/10.1093/humrep/deh596"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15528266"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15528266"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Jonathan S Bogan, Konstantin V Kandror "}, {"type": "b", "children": [{"type": "t", "text": "Biogenesis and regulation of insulin-responsive vesicles containing GLUT4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Opin Cell Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ceb.2010.03.012"}], "href": "https://doi.org/10.1016/j.ceb.2010.03.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20417083"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20417083"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Adilson Guilherme, Neil A Soriano, Paul S Furcinitti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M401918200"}], "href": "https://doi.org/10.1074/jbc.M401918200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15247266"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15247266"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Peter Razeghi, Martin E Young, Jun Ying, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of metabolic gene expression in failing human heart before and after mechanical unloading."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cardiology (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000063122"}], "href": "https://doi.org/10.1159/000063122"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12145475"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12145475"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Rasmus S Biensø, Stine Ringholm, Kristian Kiilerich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GLUT4 and glycogen synthase are key players in bed rest-induced insulin resistance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/db11-0884"}], "href": "https://doi.org/10.2337/db11-0884"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22403297"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22403297"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Rok Herman, Nika Aleksandra Kravos, Mojca Jensterle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Metformin and Insulin Resistance: A Review of the Underlying Mechanisms behind Changes in GLUT4-Mediated Glucose Transport."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms23031264"}], "href": "https://doi.org/10.3390/ijms23031264"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35163187"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35163187"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "John B Knight, Craig A Eyster, Beth A Griesel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of the human GLUT4 gene promoter: interaction between a transcriptional activator and myocyte enhancer factor 2A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.2432756100"}], "href": "https://doi.org/10.1073/pnas.2432756100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14630949"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14630949"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Michelle Colomiere, Michael Permezel, Martha Lappas "}, {"type": "b", "children": [{"type": "t", "text": "Diabetes and obesity during pregnancy alter insulin signalling and glucose transporter expression in maternal skeletal muscle and subcutaneous adipose tissue."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Endocrinol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1677/JME-09-0091"}], "href": "https://doi.org/10.1677/JME-09-0091"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19955252"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19955252"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Giorgos N Kraniou, David Cameron-Smith, Mark Hargreaves "}, {"type": "b", "children": [{"type": "t", "text": "Acute exercise and GLUT4 expression in human skeletal muscle: influence of exercise intensity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Appl Physiol (1985) (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/japplphysiol.01489.2005"}], "href": "https://doi.org/10.1152/japplphysiol.01489.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16763099"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16763099"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "R Govers "}, {"type": "b", "children": [{"type": "t", "text": "Molecular mechanisms of GLUT4 regulation in adipocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes Metab (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.diabet.2014.01.005"}], "href": "https://doi.org/10.1016/j.diabet.2014.01.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24656589"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24656589"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Charles A Stuart, Mary E A Howell, Yi Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Insulin-stimulated translocation of glucose transporter (GLUT) 12 parallels that of GLUT4 in normal muscle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2009-0162"}], "href": "https://doi.org/10.1210/jc.2009-0162"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19549745"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19549745"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Steffen Weber-Carstens, Joanna Schneider, Tobias Wollersheim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Critical illness myopathy and GLUT4: significance of insulin and muscle contraction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Respir Crit Care Med (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1164/rccm.201209-1649OC"}], "href": "https://doi.org/10.1164/rccm.201209-1649OC"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23239154"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23239154"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Pablo Garrido, Javier Morán, Ana Alonso, et al. "}, {"type": "b", "children": [{"type": "t", "text": "17β-estradiol activates glucose uptake via GLUT4 translocation and PI3K/Akt signaling pathway in MCF-7 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2012-1558"}], "href": "https://doi.org/10.1210/en.2012-1558"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23546602"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23546602"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Mark Larance, Georg Ramm, David E James "}, {"type": "b", "children": [{"type": "t", "text": "The GLUT4 code."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2007-0282"}], "href": "https://doi.org/10.1210/me.2007-0282"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17717074"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17717074"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Vanessa van Harmelen, Mikael Rydén, Eva Sjölin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A role of lipin in human obesity and insulin resistance: relation to adipocyte glucose transport and GLUT4 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Lipid Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1194/jlr.M600272-JLR200"}], "href": "https://doi.org/10.1194/jlr.M600272-JLR200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17035674"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17035674"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Pablo Garrido, Fernando G Osorio, Javier Morán, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of GLUT4 induces metabolic reprogramming and impairs viability of breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.24698"}], "href": "https://doi.org/10.1002/jcp.24698"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24931902"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24931902"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Ulla Kampmann, Britt Christensen, Thomas Svava Nielsen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GLUT4 and UBC9 protein expression is reduced in muscle from type 2 diabetic patients with severe insulin resistance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0027854"}], "href": "https://doi.org/10.1371/journal.pone.0027854"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22114711"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22114711"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Michal Armoni, Chava Harel, Fabiana Bar-Yoseph, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Free fatty acids repress the GLUT4 gene expression in cardiac muscle via novel response elements."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M502740200"}], "href": "https://doi.org/10.1074/jbc.M502740200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16096283"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16096283"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "L Al-Khalili, M Forsgren, K Kannisto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enhanced insulin-stimulated glycogen synthesis in response to insulin, metformin or rosiglitazone is associated with increased mRNA expression of GLUT4 and peroxisomal proliferator activator receptor gamma co-activator 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetologia (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00125-005-1741-3"}], "href": "https://doi.org/10.1007/s00125-005-1741-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15864539"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15864539"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Vassiliki S Lalioti, Silvia Vergarajauregui, Diego Pulido, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The insulin-sensitive glucose transporter, GLUT4, interacts physically with Daxx. Two proteins with capacity to bind Ubc9 and conjugated to SUMO1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110294200"}], "href": "https://doi.org/10.1074/jbc.M110294200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11842083"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11842083"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Yoshimi Haga, Kumiko Ishii, Tadashi Suzuki "}, {"type": "b", "children": [{"type": "t", "text": "N-glycosylation is critical for the stability and intracellular trafficking of glucose transporter GLUT4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.253955"}], "href": "https://doi.org/10.1074/jbc.M111.253955"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21757715"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21757715"}]}, {"type": "r", "ref": 40, "children": [{"type": "t", "text": "Edward O Ojuka, Veeraj Goyaram, James A H Smith "}, {"type": "b", "children": [{"type": "t", "text": "The role of CaMKII in regulating GLUT4 expression in skeletal muscle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Endocrinol Metab (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpendo.00091.2012"}], "href": "https://doi.org/10.1152/ajpendo.00091.2012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22496345"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22496345"}]}, {"type": "r", "ref": 41, "children": [{"type": "t", "text": "Hiroyuki Sano, Grantley R Peck, Arminja N Kettenbach, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.C111.228908"}], "href": "https://doi.org/10.1074/jbc.C111.228908"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21454697"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21454697"}]}, {"type": "r", "ref": 42, "children": [{"type": "t", "text": "Roberto Mioni, Silvia Chiarelli, Nadia Xamin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evidence for the presence of glucose transporter 4 in the endometrium and its regulation in polycystic ovary syndrome patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2003-032028"}], "href": "https://doi.org/10.1210/jc.2003-032028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15292352"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15292352"}]}, {"type": "r", "ref": 43, "children": [{"type": "t", "text": "M H Reichkendler, P Auerbach, M Rosenkilde, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exercise training favors increased insulin-stimulated glucose uptake in skeletal muscle in contrast to adipose tissue: a randomized study using FDG PET imaging."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Endocrinol Metab (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpendo.00128.2013"}], "href": "https://doi.org/10.1152/ajpendo.00128.2013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23800880"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23800880"}]}, {"type": "r", "ref": 44, "children": [{"type": "t", "text": "Paweł Jan Stanirowski, Dariusz Szukiewicz, Michał Pyzlak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Impact of pre-gestational and gestational diabetes mellitus on the expression of glucose transporters GLUT-1, GLUT-4 and GLUT-9 in human term placenta."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrine (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12020-016-1202-4"}], "href": "https://doi.org/10.1007/s12020-016-1202-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27981520"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27981520"}]}, {"type": "r", "ref": 45, "children": [{"type": "t", "text": "Abu Sadat Md Sayem, Aditya Arya, Hamed Karimian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Action of Phytochemicals on Insulin Signaling Pathways Accelerating Glucose Transporter (GLUT4) Protein Translocation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Molecules (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/molecules23020258"}], "href": "https://doi.org/10.3390/molecules23020258"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29382104"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29382104"}]}, {"type": "r", "ref": 46, "children": [{"type": "t", "text": "Wei Liao, M T Audrey Nguyen, Takeshi Imamura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lentiviral short hairpin ribonucleic acid-mediated knockdown of GLUT4 in 3T3-L1 adipocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2005-1638"}], "href": "https://doi.org/10.1210/en.2005-1638"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16497797"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16497797"}]}, {"type": "r", "ref": 47, "children": [{"type": "t", "text": "Giorgos N Kraniou, David Cameron-Smith, Mark Hargreaves "}, {"type": "b", "children": [{"type": "t", "text": "Effect of short-term training on GLUT-4 mRNA and protein expression in human skeletal muscle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Physiol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1113/expphysiol.2004.027409"}], "href": "https://doi.org/10.1113/expphysiol.2004.027409"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15184360"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15184360"}]}]}]}
|
Synonyms | GLUT4 |
Proteins | GTR4_HUMAN |
NCBI Gene ID | 6517 |
API | |
Download Associations | |
Predicted Functions |
![]() |
Co-expressed Genes |
![]() |
Expression in Tissues and Cell Lines |
![]() |
SLC2A4 has 8,486 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 118 datasets.
Click the + buttons to view associations for SLC2A4 from the datasets below.
If available, associations are ranked by standardized value
Dataset | Summary | |
---|---|---|
Achilles Cell Line Gene Essentiality Profiles | cell lines with fitness changed by SLC2A4 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset. | |
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of SLC2A4 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of SLC2A4 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of SLC2A4 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of SLC2A4 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of SLC2A4 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of SLC2A4 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of SLC2A4 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of SLC2A4 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of SLC2A4 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
CellMarker Gene-Cell Type Associations | cell types associated with SLC2A4 gene from the CellMarker Gene-Cell Type Associations dataset. | |
ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of SLC2A4 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
ChEA Transcription Factor Targets | transcription factors binding the promoter of SLC2A4 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of SLC2A4 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of SLC2A4 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing SLC2A4 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing SLC2A4 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with SLC2A4 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with SLC2A4 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of SLC2A4 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
COSMIC Cell Line Gene Mutation Profiles | cell lines with SLC2A4 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
CTD Gene-Chemical Interactions | chemicals interacting with SLC2A4 gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
CTD Gene-Disease Associations | diseases associated with SLC2A4 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
DepMap CRISPR Gene Dependency | cell lines with fitness changed by SLC2A4 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
DISEASES Curated Gene-Disease Association Evidence Scores | diseases involving SLC2A4 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset. | |
DISEASES Curated Gene-Disease Association Evidence Scores 2025 | diseases involving SLC2A4 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset. | |
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with SLC2A4 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with SLC2A4 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with SLC2A4 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DisGeNET Gene-Disease Associations | diseases associated with SLC2A4 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
DisGeNET Gene-Phenotype Associations | phenotypes associated with SLC2A4 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at SLC2A4 gene from the ENCODE Histone Modification Site Profiles dataset. | |
ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of SLC2A4 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
ENCODE Transcription Factor Targets | transcription factors binding the promoter of SLC2A4 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing SLC2A4 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
GAD Gene-Disease Associations | diseases associated with SLC2A4 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
GAD High Level Gene-Disease Associations | diseases associated with SLC2A4 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of SLC2A4 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
GeneRIF Biological Term Annotations | biological terms co-occuring with SLC2A4 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing SLC2A4 from the GeneSigDB Published Gene Signatures dataset. | |
GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of SLC2A4 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of SLC2A4 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of SLC2A4 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of SLC2A4 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of SLC2A4 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of SLC2A4 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
GO Biological Process Annotations 2015 | biological processes involving SLC2A4 gene from the curated GO Biological Process Annotations 2015 dataset. | |
GO Biological Process Annotations 2023 | biological processes involving SLC2A4 gene from the curated GO Biological Process Annotations 2023 dataset. | |
GO Biological Process Annotations 2025 | biological processes involving SLC2A4 gene from the curated GO Biological Process Annotations2025 dataset. | |
GO Cellular Component Annotations 2015 | cellular components containing SLC2A4 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
GO Cellular Component Annotations 2023 | cellular components containing SLC2A4 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
GO Cellular Component Annotations 2025 | cellular components containing SLC2A4 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
GO Molecular Function Annotations 2015 | molecular functions performed by SLC2A4 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
GO Molecular Function Annotations 2023 | molecular functions performed by SLC2A4 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
GO Molecular Function Annotations 2025 | molecular functions performed by SLC2A4 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
GTEx eQTL 2025 | SNPs regulating expression of SLC2A4 gene from the GTEx eQTL 2025 dataset. | |
GTEx Tissue Gene Expression Profiles | tissues with high or low expression of SLC2A4 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of SLC2A4 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of SLC2A4 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of SLC2A4 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
Guide to Pharmacology Chemical Ligands of Receptors | ligands (chemical) binding SLC2A4 receptor from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset. | |
GWAS Catalog SNP-Phenotype Associations | phenotypes associated with SLC2A4 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset. | |
GWASdb SNP-Disease Associations | diseases associated with SLC2A4 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
GWASdb SNP-Phenotype Associations | phenotypes associated with SLC2A4 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of SLC2A4 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of SLC2A4 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
HPA Tissue Gene Expression Profiles | tissues with high or low expression of SLC2A4 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
HPA Tissue Protein Expression Profiles | tissues with high or low expression of SLC2A4 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of SLC2A4 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
Hub Proteins Protein-Protein Interactions | interacting hub proteins for SLC2A4 from the curated Hub Proteins Protein-Protein Interactions dataset. | |
HuGE Navigator Gene-Phenotype Associations | phenotypes associated with SLC2A4 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
InterPro Predicted Protein Domain Annotations | protein domains predicted for SLC2A4 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of SLC2A4 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
KEA Substrates of Kinases | kinases that phosphorylate SLC2A4 protein from the curated KEA Substrates of Kinases dataset. | |
KEGG Pathways | pathways involving SLC2A4 protein from the KEGG Pathways dataset. | |
Kinase Library Serine Threonine Kinome Atlas | kinases that phosphorylate SLC2A4 protein from the Kinase Library Serine Threonine Atlas dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of SLC2A4 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of SLC2A4 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of SLC2A4 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of SLC2A4 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
LOCATE Curated Protein Localization Annotations | cellular components containing SLC2A4 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain SLC2A4 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by SLC2A4 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
MiRTarBase microRNA Targets | microRNAs targeting SLC2A4 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of SLC2A4 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of SLC2A4 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by SLC2A4 gene mutations from the MPO Gene-Phenotype Associations dataset. | |
MSigDB Cancer Gene Co-expression Modules | co-expressed genes for SLC2A4 from the MSigDB Cancer Gene Co-expression Modules dataset. | |
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of SLC2A4 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of SLC2A4 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
Pathway Commons Protein-Protein Interactions | interacting proteins for SLC2A4 from the Pathway Commons Protein-Protein Interactions dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of SLC2A4 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of SLC2A4 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PFOCR Pathway Figure Associations 2023 | pathways involving SLC2A4 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
PFOCR Pathway Figure Associations 2024 | pathways involving SLC2A4 protein from the Wikipathways PFOCR 2024 dataset. | |
Phosphosite Textmining Biological Term Annotations | biological terms co-occuring with SLC2A4 protein in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset. | |
PhosphoSitePlus Substrates of Kinases | kinases that phosphorylate SLC2A4 protein from the curated PhosphoSitePlus Substrates of Kinases dataset. | |
PID Pathways | pathways involving SLC2A4 protein from the PID Pathways dataset. | |
Reactome Pathways 2014 | pathways involving SLC2A4 protein from the Reactome Pathways dataset. | |
Reactome Pathways 2024 | pathways involving SLC2A4 protein from the Reactome Pathways 2024 dataset. | |
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of SLC2A4 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of SLC2A4 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at SLC2A4 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of SLC2A4 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of SLC2A4 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
SynGO Synaptic Gene Annotations | synaptic terms associated with SLC2A4 gene from the SynGO Synaptic Gene Annotations dataset. | |
Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of SLC2A4 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of SLC2A4 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of SLC2A4 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of SLC2A4 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of SLC2A4 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of SLC2A4 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of SLC2A4 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of SLC2A4 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with SLC2A4 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with SLC2A4 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
WikiPathways Pathways 2014 | pathways involving SLC2A4 protein from the Wikipathways Pathways 2014 dataset. | |
WikiPathways Pathways 2024 | pathways involving SLC2A4 protein from the WikiPathways Pathways 2024 dataset. | |