{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSLC2A8 (also known as GLUT8) is a facilitative sugar transporter whose functions extend well beyond bulk glucose uptake. In hematological and epithelial cancers, for example, SLC2A8 supports cell proliferation and viability through mechanisms that are not solely related to whole‐cell glucose supply. In multiple myeloma, its activity—alongside that of other GLUT family members—is required for proliferation, while in oesophageal adenocarcinoma, its expression is markedly elevated. In the reproductive system, SLC2A8 is specifically expressed in mature spermatozoa, localizing to the acrosomal region where it likely plays a major role in supplying fuel for sperm function. Moreover, studies examining its trafficking have revealed that SLC2A8 cycles between intracellular compartments and the plasma membrane through AP-2–mediated endocytosis, underscoring the dynamic regulation of its cellular distribution."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": ""}, {"type": "p", "children": [{"type": "t", "text": "\nIn metabolic tissues such as the liver, SLC2A8 fulfills dual roles associated with substrate transport and signal transduction. It mediates the carrier‐dependent uptake of trehalose into hepatocytes—a process essential for the induction of autophagy through activation of AMP-activated protein kinase (AMPK) and subsequent mTORC1 suppression. In parallel, SLC2A8 functions as a key transporter for fructose into hepatocytes, a role critical for de novo lipogenesis and the development of fructose-induced non-alcoholic fatty liver disease (NAFLD)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in cancer and liver metabolism, SLC2A8 is implicated in neurological and developmental processes. Its upregulation in blood has been associated with rapid clinical progression in early Alzheimer’s disease, suggesting its potential as a prognostic biomarker. In the brain, SLC2A8 is detected in the epithelial cells of the choroid plexus and ependymal cells as well as in astrocytic and microglial populations, indicating that it may facilitate the transport of fructose (and potentially other hexoses) and contribute to central nervous system energy homeostasis. Finally, altered placental expression of SLC2A8 has been observed in pregnancies complicated by intrauterine growth restriction, pointing to an important role in the regulation of fetal nutrient delivery."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "10"}]}]}]}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Annette Schürmann, Hubertus Axer, Andrea Scheepers, et al. 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