{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough the provided abstracts were requested in connection with SLC35G3, none of them describe this solute carrier protein. Instead, they characterize chromatin‐associated factors—namely Friend of PRMT1 (FOP) and CHTOP—that serve as key modulators of gene expression in distinct biological contexts. In one study, FOP is shown to be a critical regulator of γ‑globin expression; its knockdown in adult erythroid progenitors induces fetal hemoglobin (HbF), suggesting that targeting FOP might ameliorate β‑hemoglobinopathies such as β‑thalassemia and sickle cell disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAnother investigation reveals that FOP—encoded by the previously uncharacterized gene C1orf77—is tightly associated with chromatin and subject to arginine methylation, which in turn is essential for the ligand-dependent activation of estrogen receptor target genes. Depletion of FOP almost completely abrogates estradiol-induced promoter occupancy by the estrogen receptor, highlighting its pivotal early role during transcriptional activation in estrogen-responsive pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nA third study describes CHTOP, another chromatin target of protein arginine methyltransferase 1 (PRMT1), which becomes upregulated in microglia following LPS stimulation. CHTOP binds directly to regulatory elements of genes involved in both inflammation and cellular metabolism. Its knockdown not only reduces proinflammatory cytokine expression but also alters metabolic pathways, thereby mitigating microglia-mediated neuroinflammation. This work underscores a coordinated transcriptional regulation of inflammatory and metabolic responses in innate immune cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Thamar Bryn van Dijk, Nynke Gillemans, Farzin Pourfarzad, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fetal globin expression is regulated by Friend of Prmt1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2010-03-274399"}], "href": "https://doi.org/10.1182/blood-2010-03-274399"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20688955"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20688955"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Thamar Bryn van Dijk, Nynke Gillemans, Claudia Stein, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00645-09"}], "href": "https://doi.org/10.1128/MCB.00645-09"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19858291"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19858291"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xin Zhou, Mengfei Lv, Zhongying Duan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CHTOP Promotes Microglia-Mediated Inflammation by Regulating Cell Metabolism and Inflammatory Gene Expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.2300572"}], "href": "https://doi.org/10.4049/jimmunol.2300572"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38117276"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38117276"}]}]}]}