SLC41A1 Gene

HGNC Family	Solute carriers (SLC)
Name	solute carrier family 41 (magnesium transporter), member 1
Description	Enables magnesium:sodium antiporter activity. Involved in cellular response to magnesium ion; intracellular magnesium ion homeostasis; and magnesium ion transmembrane transport. Located in basolateral plasma membrane. Part of protein-containing complex. Implicated in nephronophthisis. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSLC41A1 is a conserved member of the MgtE family of magnesium transporters that was first structurally characterized in humans as a 56‐kDa protein containing 10 putative transmembrane domains, with high homology to bacterial MgtE proteins and broad tissue expression (e.g., heart and testis). Functional studies in heterologous expression systems have revealed that SLC41A1 can mediate saturable Mg²⁺ transport; while in some systems it demonstrates properties of Mg²⁺ uptake (e.g., in Xenopus oocytes), in other contexts—particularly in human embryonic kidney cells—it acts as a Na⁺‐dependent Mg²⁺ efflux carrier (12810078."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRegulation of SLC41A1 is integral to maintaining cellular Mg²⁺ homeostasis. Its activity is modulated by extracellular magnesium levels and by hormonal signals, notably through cAMP‐dependent protein kinase A that affects its transport function and intracellular trafficking. Furthermore, mutations and aberrant splicing events impacting SLC41A1 have been linked to human diseases: a gain‐of‐function mutation leading to enhanced Mg²⁺ efflux has been associated with Parkinson’s disease, while a splice acceptor mutation that disrupts a transmembrane domain is implicated in nephronophthisis‐related ciliopathies (20683486."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGenetic association studies and protein–protein interaction analyses further highlight the clinical and physiological relevance of SLC41A1. Multiple investigations across diverse populations have uncovered variants in SLC41A1 that modify susceptibility to Parkinson’s disease, while studies in renal distal epithelial cells, mesenchymal stromal cells, and placental tissues suggest roles for SLC41A1 in Mg²⁺ homeostasis and osteogenic differentiation. In addition, interactome analyses indicate that SLC41A1 forms transient complexes with proteins involved in post‐translational modification, folding, and trafficking, thereby integrating its function into larger cellular regulatory networks. Observations from studies addressing magnesium deficiency in diabetes also point to a broader contribution of this transporter in sustaining systemic magnesium balance (21812739."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Angela Goytain, Gary A Quamme "}, {"type": "b", "children": [{"type": "t", "text": "Functional characterization of human SLC41A1, a Mg2+ transporter with similarity to prokaryotic MgtE Mg2+ transporters."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Physiol Genomics (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/physiolgenomics.00261.2004"}], "href": "https://doi.org/10.1152/physiolgenomics.00261.2004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15713785"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15713785"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Martin Kolisek, Pierre Launay, Andreas Beck, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SLC41A1 is a novel mammalian Mg2+ carrier."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M707276200"}], "href": "https://doi.org/10.1074/jbc.M707276200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18367447"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18367447"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Tyler Mandt, Yumei Song, Andrew M Scharenberg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SLC41A1 Mg(2+) transport is regulated via Mg(2+)-dependent endosomal recycling through its N-terminal cytoplasmic domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20110807"}], "href": "https://doi.org/10.1042/BJ20110807"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21696366"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21696366"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Martin Kolisek, Axel Nestler, Jürgen Vormann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human gene SLC41A1 encodes for the Na+/Mg²+ exchanger."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Cell Physiol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpcell.00289.2011"}], "href": "https://doi.org/10.1152/ajpcell.00289.2011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22031603"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22031603"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Toby W Hurd, Edgar A Otto, Eikan Mishima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutation of the Mg2+ transporter SLC41A1 results in a nephronophthisis-like phenotype."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Soc Nephrol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1681/ASN.2012101034"}], "href": "https://doi.org/10.1681/ASN.2012101034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23661805"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23661805"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Martin Kolisek, Gerhard Sponder, Lucia Mastrototaro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Substitution p.A350V in Na⁺/Mg²⁺ exchanger SLC41A1, potentially associated with Parkinson's disease, is a gain-of-function mutation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0071096"}], "href": "https://doi.org/10.1371/journal.pone.0071096"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23976986"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23976986"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Axel Nestler, Gerhard Sponder, Katrin Rutschmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nature of SLC41A1 complexes: report on the split-ubiquitin yeast two hybrid assay."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Magnes Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1684/mrh.2013.0339"}], "href": "https://doi.org/10.1684/mrh.2013.0339"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23823179"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23823179"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Martin Kolisek, Carlos Galaviz-Hernández, Fernando Vázquez-Alaniz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SLC41A1 is the only magnesium responsive gene significantly overexpressed in placentas of preeclamptic women."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hypertens Pregnancy (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/10641955.2013.810237"}], "href": "https://doi.org/10.3109/10641955.2013.810237"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23844728"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23844728"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Chih-Hsin Lin, Yih-Ru Wu, Wan-Ling Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Variant R244H in Na+/Mg2+ exchanger SLC41A1 in Taiwanese Parkinson's disease is associated with loss of Mg2+ efflux function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Parkinsonism Relat Disord (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.parkreldis.2014.02.027"}], "href": "https://doi.org/10.1016/j.parkreldis.2014.02.027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24661466"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24661466"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Ling Wang, Lan Cheng, Nan-Nan Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic analysis of SLC41A1 in Chinese Parkinson's disease patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet B Neuropsychiatr Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.b.32365"}], "href": "https://doi.org/10.1002/ajmg.b.32365"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26308152"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26308152"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Lucia Mastrototaro, Uwe Tietjen, Gerhard Sponder, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Insulin Modulates the Na+/Mg2+ Exchanger SLC41A1 and Influences Mg2+ Efflux from Intracellular Stores in Transgenic HEK293 Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Nutr (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3945/jn.115.213918"}], "href": "https://doi.org/10.3945/jn.115.213918"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26355001"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26355001"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Faranak Madadi, Mahmoud Shekari Khaniani, Ehsan Esmaili Shandiz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic Analysis of the ZNF512B, SLC41A1, and ALDH2 Polymorphisms in Parkinson's Disease in the Iranian Population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Test Mol Biomarkers (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/gtmb.2016.0133"}], "href": "https://doi.org/10.1089/gtmb.2016.0133"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27612022"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27612022"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yu-Tzu Tsao, Ya-Yi Shih, Yu-An Liu, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Alzheimer's Disease-Associated SNP rs708727 in "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "SLC41A1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " May Increase Risk for Parkinson's Disease: Report from Enlarged Slovak Study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms23031604"}], "href": "https://doi.org/10.3390/ijms23031604"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35163527"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35163527"}]}]}]}
Synonyms	MGTE
Proteins	S41A1_HUMAN
NCBI Gene ID	254428
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SLC41A1 has 4,814 functional associations with biological entities spanning 9 categories (molecular profile, organism, disease, phenotype or trait, functional term, phrase or reference, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 109 datasets.

Click the + buttons to view associations for SLC41A1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SLC41A1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by SLC41A1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SLC41A1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SLC41A1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SLC41A1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SLC41A1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SLC41A1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SLC41A1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SLC41A1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SLC41A1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SLC41A1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SLC41A1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SLC41A1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SLC41A1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SLC41A1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SLC41A1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with SLC41A1 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SLC41A1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SLC41A1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SLC41A1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SLC41A1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SLC41A1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SLC41A1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with SLC41A1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with SLC41A1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of SLC41A1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SLC41A1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving SLC41A1 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with SLC41A1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with SLC41A1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SLC41A1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SLC41A1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SLC41A1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SLC41A1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SLC41A1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SLC41A1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SLC41A1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SLC41A1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with SLC41A1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with SLC41A1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with SLC41A1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.