{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA thorough review of the provided abstracts reveals that none contain direct information on SLC44A4. Instead, the studies focus on the roles of phosphoinositide 3‐kinase (PI3K) isoforms and their downstream effectors in diverse biological processes such as insulin signaling, cardiac hypertrophy, tumorigenesis, metabolism, and inflammation. These investigations detail how specific PI3K catalytic subunits—especially p110α—mediate receptor tyrosine kinase signaling, growth factor responses, metabolic control, and cell survival through pathways that often converge on Akt, mTOR, and other key effectors."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional studies in the collection further delineate how PI3K-driven signaling regulates vascular development, oncogene-induced reprogramming, and neuronal and bone cell survival. They also illustrate that pharmacological inhibition or genetic modulation of PI3K subunits dramatically impacts diverse physiological and pathological outcomes, ranging from improved insulin sensitivity and cardioprotective effects to diminished tumor growth and metastasis. Importantly, while these findings enhance our understanding of PI3K signaling networks within various tissues, they do not address or offer insights into the function of SLC44A4."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurther contributions in these abstracts examine how PI3K signaling intersects with pathways controlling cell polarity, metabolism, and inflammatory responses, as well as its roles in mediating chemotaxis, autophagy, and stem cell properties in various model systems. Collectively, while these studies underscore the broad significance of PI3K (and its regulatory subunits) in numerous cellular functions and diseases, they do not provide any data regarding the role or function of SLC44A4. Therefore, based solely on the provided abstracts, the biological function of SLC44A4 remains unaddressed."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "19", "end_ref": "39"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Michael S Perkinton, James K Ip, Gemma L Wood, et al. 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