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Moreover, LAT1 enables brain drug delivery and facilitates the uptake of PET tracers for glioma imaging, while it also participates in the transport of selective signaling molecules such as S‐nitrosocysteine."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn numerous human cancers—including those of the breast, lung, prostate, gastrointestinal tract, ovary, kidney, and hematopoietic system—as well as in aggressive gliomas, LAT1 is frequently upregulated. Its overexpression, often in partnership with the heavy chain CD98 (encoded by SLC3A2), enhances the uptake of essential amino acids that fuel anabolic processes and activate mTORC1 signaling, thereby promoting cell proliferation, survival, and metastatic progression. Inhibition of LAT1 via small molecule blockers or gene silencing markedly reduces amino acid influx, impairs mTORC1 activity, and sensitizes tumor cells to other treatments, with high LAT1 expression correlating robustly with poor clinical prognosis and aggressive pathological features."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "35"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its prominent role in nutrient uptake and tumor metabolism, LAT1 expression is tightly regulated by a spectrum of intracellular and extracellular cues. Oncogenic transcription factors such as c‐Myc, hypoxia‐inducible factors, and noncoding RNAs (including specific microRNAs and long noncoding RNAs) modulate SLC7A5 expression, thereby integrating metabolic demand with cell‐cycle progression and survival. Structural insights from cryo–electron microscopy studies of the LAT1–CD98 heterodimer have elucidated substrate recognition and transport mechanisms, fueling the development of selective inhibitors. 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