SLC7A7 Gene

HGNC Family Solute carriers (SLC)
Name solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
Description The protein encoded by this gene is the light subunit of a cationic amino acid transporter. This sodium-independent transporter is formed when the light subunit encoded by this gene dimerizes with the heavy subunit transporter protein SLC3A2. This transporter is found in epithelial cell membranes where it transfers cationic and large neutral amino acids from the cell to the extracellular space. Defects in this gene are a cause of lysinuric protein intolerance (LPI). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSLC7A7 encodes the y⁺LAT1 protein, the catalytic light chain of the heterodimeric amino acid transporter complex known as system y⁺L. This transporter is predominantly expressed at the basolateral membrane of epithelial cells in the kidney and intestine, where it facilitates the bidirectional exchange of cationic amino acids—such as arginine, lysine, and ornithine—with neutral amino acids. Defective function of y⁺LAT1 due to a broad spectrum of SLC7A7 mutations is the molecular basis of lysinuric protein intolerance (LPI), a recessively inherited disorder characterized by aminoaciduria, protein intolerance, and multisystem involvement. In addition, studies have demonstrated that mutant forms of y⁺LAT1 may exhibit abnormal subcellular trafficking and impaired heterodimerization with the 4F2hc partner, while transcriptional regulatory mechanisms (including alternative promoter usage) underlie tissue‐specific expression patterns critical for maintaining physiological amino acid homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its well‐established role in epithelial transport, SLC7A7 function is critical in immune regulation. During the differentiation of monocytes into macrophages, there is a marked induction of SLC7A7 expression and an increase in the activity of system y⁺L, which appears to be instrumental in modulating arginine flux. This regulation not only impacts intracellular arginine and lysine levels but also influences macrophage activation and inflammatory responses. Experimental silencing of SLC7A7 in macrophagic and airway epithelial cells leads to an aberrant increase in pro‐inflammatory mediators via NFκB activation, suggesting that under physiological conditions, y⁺LAT1 activity acts as a braking mechanism to restrain inflammation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its classic involvement in LPI and immune cell function, altered SLC7A7 expression is emerging as a factor in other pathological contexts. Overexpression of SLC7A7 has been observed in glioblastoma, where it correlates with increased tumor proliferation and portends a poor prognosis. Moreover, common polymorphisms in SLC7A7 have been linked to an elevated risk of glioma, further highlighting the significance of its regulated amino acid transport in cellular metabolic networks. There is even evidence suggesting that disturbances in this transporter’s activity may contribute to impaired transplacental nutrient exchange in gestational disorders, underscoring the broader physiological importance of SLC7A7."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Maria Pia Sperandeo, Generoso Andria, Gianfranco Sebastio "}, {"type": "b", "children": [{"type": "t", "text": "Lysinuric protein intolerance: update and extended mutation analysis of the SLC7A7 gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.20589"}], "href": "https://doi.org/10.1002/humu.20589"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17764084"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17764084"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Maria P Sperandeo, Simona Paladino, Luigi Maiuri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A y(+)LAT-1 mutant protein interferes with y(+)LAT-2 activity: implications for the molecular pathogenesis of lysinuric protein intolerance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.ejhg.5201376"}], "href": "https://doi.org/10.1038/sj.ejhg.5201376"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15756301"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15756301"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Maria Pia Sperandeo, Patrizia Annunziata, Virginia Ammendola, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lysinuric protein intolerance: identification and functional analysis of mutations of the SLC7A7 gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.9323"}], "href": "https://doi.org/10.1002/humu.9323"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15776427"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15776427"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Mariona Font-Llitjós, Benjamín Rodríguez-Santiago, Meritxell Espino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel SLC7A7 large rearrangements in lysinuric protein intolerance patients involving the same AluY repeat."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ejhg.2008.145"}], "href": "https://doi.org/10.1038/ejhg.2008.145"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18716612"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18716612"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Guoqing Zhang, Ling Cao "}, {"type": "b", "children": [{"type": "t", "text": "New mutations in the SLC7A7 gene of two chinese sisters with lysinuric protein intolerance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pediatr Pulmonol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ppul.23760"}], "href": "https://doi.org/10.1002/ppul.23760"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29058386"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29058386"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Nadia Esseghir, Chiraz Souissi Bouchlaka, Sondess Hadj Fredj, et al. "}, {"type": "b", "children": [{"type": "t", "text": "1471 delTTCT a Common Mutation of Tunisian Patients with Lysinuric Protein Intolerance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Lab (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7754/clin.lab.2015.150519"}], "href": "https://doi.org/10.7754/clin.lab.2015.150519"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26882824"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26882824"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Dong Cui, Yu-Hui Hu, Gen Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Clinical features of children with lysinuric protein intolerance and SLC7A7 gene mutation: an analysis of 3 cases]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhongguo Dang Dai Er Ke Za Zhi (2019)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31014432"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31014432"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Minna Toivonen, Maaria Tringham, Johanna Kurko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interactions of y+LAT1 and 4F2hc in the y+l amino acid transporter complex: consequences of lysinuric protein intolerance-causing mutations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gen Physiol Biophys (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4149/gpb_2013050"}], "href": "https://doi.org/10.4149/gpb_2013050"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23940088"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23940088"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Juha Mykkänen, Minna Toivonen, Maaria Kleemola, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Promoter analysis of the human SLC7A7 gene encoding y+L amino acid transporter-1 (y+LAT-1)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0006-291x(03)00054-8"}], "href": "https://doi.org/10.1016/s0006-291x(03"}, {"type": "t", "text": "00054-8) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12589791"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12589791"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Kirsi Puomila, Olli Simell, Kirsi Huoponen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Two alternative promoters regulate the expression of lysinuric protein intolerance gene SLC7A7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Genet Metab (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ymgme.2006.11.007"}], "href": "https://doi.org/10.1016/j.ymgme.2006.11.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17196863"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17196863"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Amelia Barilli, Bianca Maria Rotoli, Rossana Visigalli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Arginine transport in human monocytic leukemia THP-1 cells during macrophage differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Leukoc Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1189/jlb.0910510"}], "href": "https://doi.org/10.1189/jlb.0910510"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21586674"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21586674"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Amelia Barilli, Bianca Maria Rotoli, Rossana Visigalli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Impaired phagocytosis in macrophages from patients affected by lysinuric protein intolerance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Genet Metab (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ymgme.2012.01.008"}], "href": "https://doi.org/10.1016/j.ymgme.2012.01.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22325938"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22325938"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Bianca Maria Rotoli, Amelia Barilli, Rossana Visigalli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of SLC7A7 Triggers an Inflammatory Phenotype in Human Macrophages and Airway Epithelial Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2018.00508"}], "href": "https://doi.org/10.3389/fimmu.2018.00508"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29616026"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29616026"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Bianca Maria Rotoli, Amelia Barilli, Rossana Visigalli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "y+LAT1 and y+LAT2 contribution to arginine uptake in different human cell models: Implications in the pathophysiology of Lysinuric Protein Intolerance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.14801"}], "href": "https://doi.org/10.1111/jcmm.14801"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31705628"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31705628"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Xiaohui Ji, Xiaoyun Yang, Nan Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Function of SLC7A7 in T-Cell Acute Lymphoblastic Leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000491899"}], "href": "https://doi.org/10.1159/000491899"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30025393"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30025393"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Guilherme M Xavier, Leonidas Panousopoulos, Martyn T Cobourne "}, {"type": "b", "children": [{"type": "t", "text": "Scube3 is expressed in multiple tissues during development but is dispensable for embryonic survival in the mouse."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0055274"}], "href": "https://doi.org/10.1371/journal.pone.0055274"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23383134"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23383134"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Songhua Fan, Yingjie Zhao, Xiaoying Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variants in SLC7A7 are associated with risk of glioma in a Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Biol Med (Maywood) (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1535370213498977"}], "href": "https://doi.org/10.1177/1535370213498977"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23975734"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23975734"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "H Zhang, W J Shi "}, {"type": "b", "children": [{"type": "t", "text": "Association of three common single nucleotide polymorphisms of SLC7A7 with the development of glioma in a Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Mol Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4238/gmr16029026"}], "href": "https://doi.org/10.4238/gmr16029026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28510245"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28510245"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Xiao Huang, Pascale Anderle, Lu Hostettler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of placental nutrient transporters associated with intrauterine growth restriction and pre-eclampsia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Genomics (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12864-018-4518-z"}], "href": "https://doi.org/10.1186/s12864-018-4518-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29499643"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29499643"}]}]}]}
Synonyms MOP-2, LPI, Y+LAT-1, Y+LAT1
Proteins YLAT1_HUMAN
NCBI Gene ID 9056
API
Download Associations
Predicted Functions View SLC7A7's ARCHS4 Predicted Functions.
Co-expressed Genes View SLC7A7's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View SLC7A7's ARCHS4 Predicted Functions.

Functional Associations

SLC7A7 has 7,284 functional associations with biological entities spanning 9 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 114 datasets.

Click the + buttons to view associations for SLC7A7 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles tissues with high or low expression of SLC7A7 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles tissues with high or low expression of SLC7A7 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray tissue samples with high or low expression of SLC7A7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq tissue samples with high or low expression of SLC7A7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles tissues with high or low expression of SLC7A7 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
BioGPS Cell Line Gene Expression Profiles cell lines with high or low expression of SLC7A7 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
BioGPS Human Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of SLC7A7 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of SLC7A7 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of SLC7A7 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CCLE Cell Line Gene Expression Profiles cell lines with high or low expression of SLC7A7 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
CellMarker Gene-Cell Type Associations cell types associated with SLC7A7 gene from the CellMarker Gene-Cell Type Associations dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of SLC7A7 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of SLC7A7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ChEA Transcription Factor Targets 2022 transcription factors binding the promoter of SLC7A7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
ClinVar Gene-Phenotype Associations phenotypes associated with SLC7A7 gene from the curated ClinVar Gene-Phenotype Associations dataset.
CMAP Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of SLC7A7 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores cellular components containing SLC7A7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 cellular components containing SLC7A7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores cellular components co-occuring with SLC7A7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with SLC7A7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of SLC7A7 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene Mutation Profiles cell lines with SLC7A7 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
CTD Gene-Chemical Interactions chemicals interacting with SLC7A7 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
CTD Gene-Disease Associations diseases associated with SLC7A7 gene/protein from the curated CTD Gene-Disease Associations dataset.
DepMap CRISPR Gene Dependency cell lines with fitness changed by SLC7A7 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
DISEASES Curated Gene-Disease Association Evidence Scores 2025 diseases involving SLC7A7 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 diseases associated with SLC7A7 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores diseases co-occuring with SLC7A7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with SLC7A7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
DisGeNET Gene-Disease Associations diseases associated with SLC7A7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
DisGeNET Gene-Phenotype Associations phenotypes associated with SLC7A7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
DrugBank Drug Targets interacting drugs for SLC7A7 protein from the curated DrugBank Drug Targets dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at SLC7A7 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of SLC7A7 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of SLC7A7 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells PubMedIDs of publications reporting gene signatures containing SLC7A7 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
GAD Gene-Disease Associations diseases associated with SLC7A7 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
GAD High Level Gene-Disease Associations diseases associated with SLC7A7 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
GDSC Cell Line Gene Expression Profiles cell lines with high or low expression of SLC7A7 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with SLC7A7 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing SLC7A7 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of SLC7A7 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of SLC7A7 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations kinase perturbations changing expression of SLC7A7 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of SLC7A7 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of SLC7A7 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of SLC7A7 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
GO Biological Process Annotations 2015 biological processes involving SLC7A7 gene from the curated GO Biological Process Annotations 2015 dataset.
GO Biological Process Annotations 2023 biological processes involving SLC7A7 gene from the curated GO Biological Process Annotations 2023 dataset.
GO Biological Process Annotations 2025 biological processes involving SLC7A7 gene from the curated GO Biological Process Annotations2025 dataset.
GO Cellular Component Annotations 2015 cellular components containing SLC7A7 protein from the curated GO Cellular Component Annotations 2015 dataset.
GO Cellular Component Annotations 2023 cellular components containing SLC7A7 protein from the curated GO Cellular Component Annotations 2023 dataset.
GO Cellular Component Annotations 2025 cellular components containing SLC7A7 protein from the curated GO Cellular Component Annotations 2025 dataset.
GO Molecular Function Annotations 2015 molecular functions performed by SLC7A7 gene from the curated GO Molecular Function Annotations 2015 dataset.
GO Molecular Function Annotations 2023 molecular functions performed by SLC7A7 gene from the curated GO Molecular Function Annotations 2023 dataset.
GO Molecular Function Annotations 2025 molecular functions performed by SLC7A7 gene from the curated GO Molecular Function Annotations 2025 dataset.
GTEx eQTL 2025 SNPs regulating expression of SLC7A7 gene from the GTEx eQTL 2025 dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of SLC7A7 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of SLC7A7 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of SLC7A7 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
GWASdb SNP-Disease Associations diseases associated with SLC7A7 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.
GWASdb SNP-Phenotype Associations phenotypes associated with SLC7A7 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles cell lines with high or low expression of SLC7A7 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset.
HMDB Metabolites of Enzymes interacting metabolites for SLC7A7 protein from the curated HMDB Metabolites of Enzymes dataset.
HPA Cell Line Gene Expression Profiles cell lines with high or low expression of SLC7A7 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset.
HPA Tissue Gene Expression Profiles tissues with high or low expression of SLC7A7 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset.
HPA Tissue Protein Expression Profiles tissues with high or low expression of SLC7A7 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset.
HPA Tissue Sample Gene Expression Profiles tissue samples with high or low expression of SLC7A7 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset.
HPO Gene-Disease Associations phenotypes associated with SLC7A7 gene by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with SLC7A7 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
IMPC Knockout Mouse Phenotypes phenotypes of mice caused by SLC7A7 gene knockout from the IMPC Knockout Mouse Phenotypes dataset.
InterPro Predicted Protein Domain Annotations protein domains predicted for SLC7A7 protein from the InterPro Predicted Protein Domain Annotations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of SLC7A7 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of SLC7A7 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of SLC7A7 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles cell lines with SLC7A7 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of SLC7A7 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures small molecule perturbations changing expression of SLC7A7 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset.
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures gene perturbations changing expression of SLC7A7 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of SLC7A7 gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
LOCATE Curated Protein Localization Annotations cellular components containing SLC7A7 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset.
LOCATE Predicted Protein Localization Annotations cellular components predicted to contain SLC7A7 protein from the LOCATE Predicted Protein Localization Annotations dataset.
MGI Mouse Phenotype Associations 2023 phenotypes of transgenic mice caused by SLC7A7 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of SLC7A7 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
MoTrPAC Rat Endurance Exercise Training tissue samples with high or low expression of SLC7A7 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset.
MPO Gene-Phenotype Associations phenotypes of transgenic mice caused by SLC7A7 gene mutations from the MPO Gene-Phenotype Associations dataset.
MSigDB Cancer Gene Co-expression Modules co-expressed genes for SLC7A7 from the MSigDB Cancer Gene Co-expression Modules dataset.
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations gene perturbations changing expression of SLC7A7 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles drug perturbations changing expression of SLC7A7 gene from the NIBR DRUG-seq U2OS MoA Box dataset.
OMIM Gene-Disease Associations phenotypes associated with SLC7A7 gene from the curated OMIM Gene-Disease Associations dataset.
Pathway Commons Protein-Protein Interactions interacting proteins for SLC7A7 from the Pathway Commons Protein-Protein Interactions dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of SLC7A7 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations gene perturbations changing expression of SLC7A7 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PFOCR Pathway Figure Associations 2023 pathways involving SLC7A7 protein from the PFOCR Pathway Figure Associations 2023 dataset.
PFOCR Pathway Figure Associations 2024 pathways involving SLC7A7 protein from the Wikipathways PFOCR 2024 dataset.
Reactome Pathways 2014 pathways involving SLC7A7 protein from the Reactome Pathways dataset.
Reactome Pathways 2024 pathways involving SLC7A7 protein from the Reactome Pathways 2024 dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of SLC7A7 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
Roadmap Epigenomics Cell and Tissue Gene Expression Profiles cell types and tissues with high or low expression of SLC7A7 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at SLC7A7 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of SLC7A7 gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of SLC7A7 gene from the RummaGEO Gene Perturbation Signatures dataset.
SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs drug perturbations changing phosphorylation of SLC7A7 protein from the SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs dataset.
Tabula Sapiens Gene-Cell Associations cell types with high or low expression of SLC7A7 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset.
TargetScan Predicted Conserved microRNA Targets microRNAs regulating expression of SLC7A7 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset.
TargetScan Predicted Nonconserved microRNA Targets microRNAs regulating expression of SLC7A7 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of SLC7A7 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores tissues with high expression of SLC7A7 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 tissues with high expression of SLC7A7 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores tissues with high expression of SLC7A7 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 tissues with high expression of SLC7A7 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores tissues co-occuring with SLC7A7 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with SLC7A7 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.
WikiPathways Pathways 2024 pathways involving SLC7A7 protein from the WikiPathways Pathways 2024 dataset.