{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSLCO1B1 encodes the hepatic uptake transporter OATP1B1, which is exclusively expressed on the sinusoidal (basolateral) membrane of hepatocytes and mediates the influx of diverse endogenous compounds (e.g., bilirubin and bile salts) as well as numerous xenobiotics including many clinically important drugs. Genetic variations in SLCO1B1, such as single‐nucleotide polymorphisms and haplotypes, have been shown to alter transporter expression and/or function, thereby influencing both normal bile acid and bilirubin handling and the disposition of substrate drugs."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nA number of investigations have demonstrated that common polymorphisms—most notably the c.521T>C (rs4149056) variant—and associated haplotypes reduce OATP1B1 transport activity. This diminished function leads to increased plasma concentrations of various substrate drugs (such as simvastatin, atorvastatin, pravastatin, pitavastatin, rosuvastatin, methotrexate, and repaglinide), thereby enhancing both therapeutic effects and adverse reactions (e.g., statin-induced myopathy). Furthermore, these genetic differences contribute to interindividual and interethnic variability in drug pharmacokinetics and pharmacodynamics, as reduced transporter efficiency can elevate systemic drug exposure and modify drug–drug interaction profiles."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its direct impact on drug pharmacokinetics, altered SLCO1B1 function plays a critical role in clinical conditions and drug–drug interactions. For instance, concomitant deficiencies in OATP1B1 and its closely related isoform OATP1B3 underlie Rotor syndrome, characterized by impaired hepatic reuptake of conjugated bilirubin. Moreover, inhibition or genetic variation of SLCO1B1 modulates the hepatic uptake of agents such as bosentan and rifampin, influencing their intracellular concentrations and potentially affecting both efficacy and toxicity. Collectively, this body of evidence underscores the importance of SLCO1B1 in determining liver drug uptake and highlights its value as a pharmacogenomic marker for tailoring personalized therapies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "21", "end_ref": "29"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "R G Tirona, B F Leake, G Merino, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Evidence for inverse effects of OATP-C (SLC21A6) 5 and 1b haplotypes on pravastatin kinetics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Pharmacol Ther (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.clpt.2003.12.016"}], "href": "https://doi.org/10.1016/j.clpt.2003.12.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15116054"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15116054"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Mikko Niemi, Elke Schaeffeler, Thomas Lang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Polymorphic organic anion transporting polypeptide 1B1 is a major determinant of repaglinide pharmacokinetics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Pharmacol Ther (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.clpt.2005.01.018"}], "href": "https://doi.org/10.1016/j.clpt.2005.01.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15961978"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15961978"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Edmund Lee, Stephen Ryan, Bruce Birmingham, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Effects of organic anion transporting polypeptide 1B1 haplotype on pharmacokinetics of pravastatin, valsartan, and temocapril."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Pharmacol Ther (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.clpt.2006.01.011"}], "href": "https://doi.org/10.1016/j.clpt.2006.01.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16678545"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16678545"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Wei Zhang, Bang-Ning Yu, Yi-Jing He, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "SLCO1B1 polymorphism markedly affects the pharmacokinetics of simvastatin acid."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacogenet Genomics (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/01.fpc.0000230416.82349.90"}], "href": "https://doi.org/10.1097/01.fpc.0000230416.82349.90"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17108811"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17108811"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "M K Pasanen, H Fredrikson, P J Neuvonen, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Pharmacol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejphar.2008.01.042"}], "href": "https://doi.org/10.1016/j.ejphar.2008.01.042"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18321482"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18321482"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "E Link, S Parish, J Armitage, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SLCO1B1 variants and statin-induced myopathy--a genomewide study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "N Engl J Med (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1056/NEJMoa0801936"}], "href": "https://doi.org/10.1056/NEJMoa0801936"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18650507"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18650507"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Federico Innocenti, Deanna L Kroetz, Erin Schuetz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Oncol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1200/JCO.2008.20.6300"}], "href": "https://doi.org/10.1200/JCO.2008.20.6300"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19349540"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19349540"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Andrew D Johnson, Maryam Kavousi, Albert V Smith, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association meta-analysis for total serum bilirubin levels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddp202"}], "href": "https://doi.org/10.1093/hmg/ddp202"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19414484"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19414484"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Ichiro Ieiri, Shun Higuchi, Yuichi Sugiyama "}, {"type": "b", "children": [{"type": "t", "text": "Genetic polymorphisms of uptake (OATP1B1, 1B3) and efflux (MRP2, BCRP) transporters: implications for inter-individual differences in the pharmacokinetics and pharmacodynamics of statins and other clinically relevant drugs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Expert Opin Drug Metab Toxicol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1517/17425250902976854"}], "href": "https://doi.org/10.1517/17425250902976854"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19442037"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19442037"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Deepak Voora, Svati H Shah, Ivan Spasojevic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The SLCO1B1*5 genetic variant is associated with statin-induced side effects."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Coll Cardiol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jacc.2009.04.053"}], "href": "https://doi.org/10.1016/j.jacc.2009.04.053"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19833260"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19833260"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Lisa R Treviño, Noriko Shimasaki, Wenjian Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Oncol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1200/JCO.2008.20.4156"}], "href": "https://doi.org/10.1200/JCO.2008.20.4156"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19901119"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19901119"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Ruben C Hartkoorn, Wai San Kwan, Victoria Shallcross, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacogenet Genomics (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/FPC.0b013e328335b02d"}], "href": "https://doi.org/10.1097/FPC.0b013e328335b02d"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20051929"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20051929"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "L R Brunham, P J Lansberg, L Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential effect of the rs4149056 variant in SLCO1B1 on myopathy associated with simvastatin and atorvastatin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacogenomics J (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/tpj.2010.92"}], "href": "https://doi.org/10.1038/tpj.2010.92"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21243006"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21243006"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Mikko Niemi, Marja K Pasanen, Pertti J Neuvonen "}, {"type": "b", "children": [{"type": "t", "text": "Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacol Rev (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/pr.110.002857"}], "href": "https://doi.org/10.1124/pr.110.002857"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21245207"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21245207"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Laura B Ramsey, Gitte H Bruun, Wenjian Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genome Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gr.129668.111"}], "href": "https://doi.org/10.1101/gr.129668.111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22147369"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22147369"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Evita van de Steeg, Viktor Stránecký, Hana Hartmannová, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide study of methotrexate clearance replicates SLCO1B1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2012-08-452839"}], "href": "https://doi.org/10.1182/blood-2012-08-452839"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23233662"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23233662"}]}]}]}