SLCO3A1 Gene

HGNC Family	Solute carriers (SLC)
Name	solute carrier organic anion transporter family, member 3A1
Description	Enables organic anion transmembrane transporter activity and prostaglandin transmembrane transporter activity. Involved in positive regulation of NF-kappaB transcription factor activity; positive regulation of protein phosphorylation; and prostaglandin transport. Located in basal plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSLCO3A1, also known as OATP3A1, functions as an organic anion transporter with broad substrate specificity. In human brain and testicular tissues, two splice variants have been identified that differ in their C‐terminal sequences and cellular distribution. Both variants mediate the uptake of diverse substrates including prostaglandin E₁/E₂, thyroxine, and various cyclic oligopeptides, suggesting a role in modulating neuropeptide levels (for example, extracellular vasopressin) and potentially influencing neuromodulatory signaling. Comparable variants have been observed in fetal cerebral cortex, where differential expression relative to adult brain hints at developmental regulation of thyroid hormone and other key substrates."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond the central nervous system, genetic studies have implicated SLCO3A1 in cardiovascular pharmacogenomics and neuropsychiatric conditions. Polymorphisms in SLCO3A1 are associated with altered drug‐induced QT interval prolongation, likely due to its role in translocating prostaglandins with cardioprotective properties. Additionally, genome‐wide association meta-analyses have identified SNPs within SLCO3A1 that correlate with vulnerability to nicotine dependence, emphasizing the transporter's broader relevance in drug response and systemic hormonal regulation. Structural analyses of related organic anion transporter subtypes further support SLCO3A1’s specificity for prostaglandin substrates."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSLCO3A1 expression is also modulated under pathological conditions. In cholestasis, hepatic SLCO3A1 is upregulated, with inflammatory mediators such as TNFα triggering its expression through NF-κB and ERK-SP1 signaling pathways, suggesting a compensatory mechanism to maintain bile acid and prostaglandin homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Conversely, in colorectal cancer, epigenetic alterations such as promoter hypermethylation result in significant downregulation of SLCO3A1, potentially impacting the intratissue conversion of estrogen sulfate to biologically active estradiol and thereby influencing tumor biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Moreover, expression studies in both normal and malignant breast tissue reveal that SLCO3A1 localizes to epithelial plasma membranes, implying a role in the uptake of hormones and chemotherapeutic agents, while additional genome-wide linkage and candidate gene analyses in other conditions further underline the systemic significance of SLCO3A1."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Robert D Huber, Bo Gao, Marguerite-Anne Sidler Pfändler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Cell Physiol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpcell.00597.2005"}], "href": "https://doi.org/10.1152/ajpcell.00597.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16971491"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16971491"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "S-Y Chan, A Martín-Santos, L S Loubière, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The expression of thyroid hormone transporters in the human fetal cerebral cortex during early development and in N-Tera-2 neurodifferentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Physiol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1113/jphysiol.2011.207290"}], "href": "https://doi.org/10.1113/jphysiol.2011.207290"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21486766"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21486766"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "S Volpi, C Heaton, K Mack, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Whole genome association study identifies polymorphisms associated with QT prolongation during iloperidone treatment of schizophrenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Psychiatry (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/mp.2008.52"}], "href": "https://doi.org/10.1038/mp.2008.52"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18521091"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18521091"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ke-Sheng Wang, Xuefeng Liu, Qunyuan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ANAPC1 and SLCO3A1 are associated with nicotine dependence: meta-analysis of genome-wide association studies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Drug Alcohol Depend (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.drugalcdep.2012.02.003"}], "href": "https://doi.org/10.1016/j.drugalcdep.2012.02.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22377092"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22377092"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hisanobu Adachi, Takehiro Suzuki, Michiaki Abe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular characterization of human and rat organic anion transporter OATP-D."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Renal Physiol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajprenal.00402.2002"}], "href": "https://doi.org/10.1152/ajprenal.00402.2002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14631946"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14631946"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Qiong Pan, Xiaoxun Zhang, Liangjun Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Solute Carrier Organic Anion Transporter Family Member 3A1 Is a Bile Acid Efflux Transporter in Cholestasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.gastro.2018.07.031"}], "href": "https://doi.org/10.1053/j.gastro.2018.07.031"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30063921"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30063921"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Mingqiao Li, Weihua Wang, Ying Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor necrosis factor α upregulates the bile acid efflux transporter OATP3A1 via multiple signaling pathways in cholestasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jbc.2021.101543"}], "href": "https://doi.org/10.1016/j.jbc.2021.101543"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34971708"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34971708"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Agnieszka Anna Rawłuszko-Wieczorek, Nikodem Horst, Karolina Horbacka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effect of DNA methylation profile on OATP3A1 and OATP4A1 transcript levels in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2015.08.026"}], "href": "https://doi.org/10.1016/j.biopha.2015.08.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26349991"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26349991"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Juergen Kindla, Tilman T Rau, Rudolf Jung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression and localization of the uptake transporters OATP2B1, OATP3A1 and OATP5A1 in non-malignant and malignant breast tissue."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biol Ther (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cbt.11.6.14533"}], "href": "https://doi.org/10.4161/cbt.11.6.14533"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21278488"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21278488"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "May E Montasser, Lawrence C Shimmin, Craig L Hanis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gene by smoking interaction in hypertension: identification of a major quantitative trait locus on chromosome 15q for systolic blood pressure in Mexican-Americans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hypertens (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/hjh.0b013e32831ef54f"}], "href": "https://doi.org/10.1097/hjh.0b013e32831ef54f"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19330903"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19330903"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Shu-Chen Wei, Yan-Yin Tan, Meng-Tzu Weng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SLCO3A1, A novel crohn's disease-associated gene, regulates nf-κB activity and associates with intestinal perforation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0100515"}], "href": "https://doi.org/10.1371/journal.pone.0100515"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24945726"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24945726"}]}]}]}
Synonyms	OATP-D, OATP3A1, OATP-RP3, SLC21A11, OATPRP3, OATPD
Proteins	SO3A1_HUMAN
NCBI Gene ID	28232
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SLCO3A1 has 7,655 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 120 datasets.

Click the + buttons to view associations for SLCO3A1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SLCO3A1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SLCO3A1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SLCO3A1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SLCO3A1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SLCO3A1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SLCO3A1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SLCO3A1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SLCO3A1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SLCO3A1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SLCO3A1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of SLCO3A1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SLCO3A1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SLCO3A1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with SLCO3A1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SLCO3A1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SLCO3A1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SLCO3A1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SLCO3A1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SLCO3A1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SLCO3A1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SLCO3A1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SLCO3A1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SLCO3A1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SLCO3A1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SLCO3A1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with SLCO3A1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with SLCO3A1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with SLCO3A1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SLCO3A1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with SLCO3A1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with SLCO3A1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SLCO3A1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SLCO3A1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SLCO3A1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SLCO3A1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for SLCO3A1 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SLCO3A1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SLCO3A1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SLCO3A1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SLCO3A1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with SLCO3A1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.