SLIRP Gene

HGNC Family	RNA binding motif containing (RBM)
Name	SRA stem-loop interacting RNA binding protein
Description	Steroid receptor RNA activator (SRA, or SRA1; MIM 603819) is a complex RNA molecule containing multiple stable stem-loop structures that functions in coactivation of nuclear receptors. SLIRP interacts with stem-loop structure-7 of SRA (STR7) and modulates nuclear receptor transactivation (Hatchell et al., 2006 [PubMed 16762838]).[supplied by OMIM, Mar 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSLIRP is a multifunctional RNA‐binding protein that plays a key role in mitochondrial gene expression by forming a stable complex with LRPPRC. In mitochondria, the LRPPRC–SLIRP complex binds cotranscriptionally to mRNA coding sequences and acts as a global RNA chaperone, safeguarding the integrity, stability, and proper folding of mitochondrial transcripts. Through these functions, SLIRP not only prevents 3′ exonucleolytic degradation but also facilitates the polyadenylation and processing events that are essential for efficient translation of mitochondria‐encoded proteins. Moreover, loss or mutation of SLIRP leads to defects in mitochondrial mRNA loading onto ribosomes and disturbances in the assembly of oxidative phosphorylation complexes, resulting in impaired protein synthesis and mitochondrial dysfunction."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOutside of its canonical mitochondrial roles, SLIRP has been implicated in nuclear signaling and DNA regulation. A portion of the endogenous protein localizes to the nucleus, where it interacts with noncoding RNAs such as SRA and modulates the activity of nuclear receptors, including the androgen receptor. In addition, SLIRP has been shown to associate directly with guanine quadruplex (G4) structures in DNA and to interact with anti‐apoptotic factors like bcl‑2, highlighting its involvement in diverse regulatory networks that bridge mitochondrial function with nuclear gene expression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDefects in SLIRP are also linked to pathological conditions. Variants in SLIRP have been demonstrated to cause mitochondrial encephalomyopathy with deficiencies in oxidative phosphorylation, while alterations in its expression may impact processes such as spermatozoon motility and oxidative stress. These findings underscore the clinical significance of SLIRP, reinforcing its central role in maintaining mitochondrial homeostasis and cellular energy metabolism."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Joshua M Baughman, Roland Nilsson, Vishal M Gohil, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A computational screen for regulators of oxidative phosphorylation implicates SLIRP in mitochondrial RNA homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1000590"}], "href": "https://doi.org/10.1371/journal.pgen.1000590"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19680543"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19680543"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Florin Sasarman, Catherine Brunel-Guitton, Hana Antonicka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LRPPRC and SLIRP interact in a ribonucleoprotein complex that regulates posttranscriptional gene expression in mitochondria."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e10-01-0047"}], "href": "https://doi.org/10.1091/mbc.e10-01-0047"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20200222"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20200222"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Takeshi Chujo, Takayuki Ohira, Yuriko Sakaguchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LRPPRC/SLIRP suppresses PNPase-mediated mRNA decay and promotes polyadenylation in human mitochondria."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gks506"}], "href": "https://doi.org/10.1093/nar/gks506"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22661577"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22661577"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Henrik Spåhr, Agata Rozanska, Xinping Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SLIRP stabilizes LRPPRC via an RRM-PPR protein interface."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkw575"}], "href": "https://doi.org/10.1093/nar/gkw575"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27353330"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27353330"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Stefan J Siira, Henrik Spåhr, Anne-Marie J Shearwood, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LRPPRC-mediated folding of the mitochondrial transcriptome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-017-01221-z"}], "href": "https://doi.org/10.1038/s41467-017-01221-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29146908"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29146908"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Francesco Bruni, Yasmin Proctor-Kent, Robert N Lightowlers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Messenger RNA delivery to mitoribosomes - hints from a bacterial toxin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS J (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/febs.15342"}], "href": "https://doi.org/10.1111/febs.15342"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32329962"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32329962"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Mariia V Baleva, Uliana Piunova, Ivan Chicherin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mitochondrial Protein SLIRP Affects Biosynthesis of Cytochrome c Oxidase Subunits in HEK293T Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms25010093"}], "href": "https://doi.org/10.3390/ijms25010093"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38203264"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38203264"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Esme C Hatchell, Shane M Colley, Dianne J Beveridge, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SLIRP, a small SRA binding protein, is a nuclear receptor corepressor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2006.05.024"}], "href": "https://doi.org/10.1016/j.molcel.2006.05.024"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16762838"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16762838"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "D Trisciuoglio, M Desideri, V Farini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Affinity purification-mass spectrometry analysis of bcl-2 interactome identified SLIRP as a novel interacting protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2015.357"}], "href": "https://doi.org/10.1038/cddis.2015.357"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26866271"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26866271"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Preston Williams, Lin Li, Xiaoli Dong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of SLIRP as a G Quadruplex-Binding Protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Chem Soc (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/jacs.7b07563"}], "href": "https://doi.org/10.1021/jacs.7b07563"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28859475"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28859475"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Dinuka De Silva, Zhentao Zhang, Yuanbo Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction between androgen receptor and coregulator SLIRP is regulated by Ack1 tyrosine kinase and androgen."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-55057-2"}], "href": "https://doi.org/10.1038/s41598-019-55057-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31819114"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31819114"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Dan Shan, Samuel Kofi Arhin, Junzhao Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effects of SLIRP on Sperm Motility and Oxidative Stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/9060356"}], "href": "https://doi.org/10.1155/2020/9060356"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33150185"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33150185"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Le Guo, Bob P H Engelen, Irene M G M Hemel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pathogenic SLIRP variants as a novel cause of autosomal recessive mitochondrial encephalomyopathy with complex I and IV deficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41431-021-00947-1"}], "href": "https://doi.org/10.1038/s41431-021-00947-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34426662"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34426662"}]}]}]}
Synonyms	PD04872, C14ORF156, DC50
Proteins	SLIRP_HUMAN
NCBI Gene ID	81892
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SLIRP has 8,080 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 112 datasets.

Click the + buttons to view associations for SLIRP from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SLIRP Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SLIRP gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SLIRP gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SLIRP gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SLIRP gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SLIRP gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SLIRP gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SLIRP gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SLIRP gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SLIRP gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of SLIRP gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SLIRP gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SLIRP gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with SLIRP protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SLIRP gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SLIRP gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SLIRP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SLIRP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing SLIRP protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SLIRP gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SLIRP protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SLIRP protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing SLIRP protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing SLIRP protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SLIRP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SLIRP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SLIRP gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SLIRP gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of SLIRP protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SLIRP gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SLIRP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SLIRP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SLIRP gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SLIRP gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SLIRP gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SLIRP gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SLIRP from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with SLIRP gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing SLIRP from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of SLIRP gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of SLIRP gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.