{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSLIT3 plays a pivotal role in embryonic development by promoting vascular growth and orchestrating tissue remodeling. It is secreted by vascular cells to stimulate angiogenesis through enhancing endothelial proliferation, motility, and network formation—processes essential for proper organogenesis. Moreover, genetic studies have linked altered SLIT3 function with developmental defects such as impaired diaphragm formation and decreased bone mineral density, highlighting its importance in morphogenesis and tissue maintenance."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the nervous system, SLIT3 functions as a guidance cue that regulates axonal pathfinding. It exerts repulsive effects on developing neurons—including dopaminergic axons—thereby influencing neural circuit formation and connectivity. Alterations in SLIT3 levels and genetic copy number variations have been associated with neuropsychiatric conditions, suggesting that its modulatory role in neurite outgrowth contributes to behavioral phenotypes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSLIT3 also exhibits potent tumor‐suppressive properties across several cancers. Reduced expression or silencing of SLIT3 is linked to enhanced tumor cell proliferation, migration, and invasion—often through deregulation of pathways such as CXCR4 signaling, matrix metalloproteinase activity, and epithelial–mesenchymal transition. Restoring SLIT3 function in models of lung, colon, and bladder carcinomas, among others, suppresses malignant behavior, underscoring its potential as a therapeutic target in oncology."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in development and tumor suppression, SLIT3 modulates cell migration in various contexts. It influences the motility of non‐neuronal cells alike—enhancing chemotactic responses in monocytes and regulating the migratory dynamics of hematopoietic progenitors via modulation of the actin cytoskeleton. Such activity is mediated, at least in part, through RhoA signaling, thereby contributing to efficient cell homing and inflammatory regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGenetic and epigenetic studies further reveal the multifaceted regulation of SLIT3. Detailed mapping of its genomic architecture has uncovered extensive alternative splicing, while intronic regions of SLIT3 give rise to microRNAs (such as miR‐218) that may interplay with its own signaling. Variants and methylation changes in the SLIT3 locus have been associated with metabolic alterations—including insulin resistance and obesity—as well as with inflammatory conditions like aberrant labor mediator expression, periodontal disease, and even anomalies in tissue such as ectopic pregnancies and impaired corneal healing. 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"}, {"type": "b", "children": [{"type": "t", "text": "Isolated congenital diaphragm hernia associated with homozygous SLIT3 gene variant in dizygous twins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Med Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejmg.2021.104215"}], "href": "https://doi.org/10.1016/j.ejmg.2021.104215"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33933663"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33933663"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Rachel Hammond, Valerie Vivancos, Arifa Naeem, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Identification of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "slit3"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " as a locus affecting nicotine preference in zebrafish and human smoking behaviour."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.51295"}], "href": "https://doi.org/10.7554/eLife.51295"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32209227"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32209227"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Rebecca Marlow, Phyllis Strickland, Ji Shin Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SLITs suppress tumor growth in vivo by silencing Sdf1/Cxcr4 within breast epithelium."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-08-1357"}], "href": "https://doi.org/10.1158/0008-5472.CAN-08-1357"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18829537"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18829537"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Alexandra E Denk, Simone Kaufmann, Klaus Stark, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Slit3 inhibits Robo3-induced invasion of synovial fibroblasts in rheumatoid arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Res Ther (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/ar2955"}], "href": "https://doi.org/10.1186/ar2955"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20298552"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20298552"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Cai Feng Dai, Yi Zhou Jiang, Yan Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression and roles of Slit/Robo in human ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histochem Cell Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00418-011-0806-2"}], "href": "https://doi.org/10.1007/s00418-011-0806-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21465248"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21465248"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Chao Zhang, Hui Guo, Bin Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effects of Slit3 silencing on the invasive ability of lung carcinoma A549 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2015.4031"}], "href": "https://doi.org/10.3892/or.2015.4031"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26045181"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26045181"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Feng Gu, Yongjie Ma, Jiao Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Function of Slit/Robo signaling in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Med (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11684-015-0416-9"}], "href": "https://doi.org/10.1007/s11684-015-0416-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26542734"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26542734"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Lui Ng, Ariel K M Chow, Johnny H W Man, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Suppression of Slit3 induces tumor proliferation and chemoresistance in hepatocellular carcinoma through activation of GSK3β/β-catenin pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-018-4326-5"}], "href": "https://doi.org/10.1186/s12885-018-4326-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29859044"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29859044"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "J Wang, X F Yu, N Ouyang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Expression and prognosis effect of methylation-regulated SLIT3 and SPARCL1 genes in smoking-related lung adenocarcinoma]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Yi Xue Za Zhi (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3760/cma.j.issn.0376-2491.2019.20.007"}], "href": "https://doi.org/10.3760/cma.j.issn.0376-2491.2019.20.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31154721"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31154721"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Yu Tang, Jingxuan Cai, Bo Lv "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA ubiquitin-binding protein domain protein 10 antisense RNA 1 inhibits colon adenocarcinoma progression via the miR-515-5p/slit guidance ligand 3 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.2024396"}], "href": "https://doi.org/10.1080/21655979.2021.2024396"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35034539"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35034539"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Xiaoyu Duan, Lingdian Wang, Zhifeng Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA PGM5-AS1 Inhibits the Progression of Bladder Cancer by Regulating miR-587/SLIT3 Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Crit Rev Eukaryot Gene Expr (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1615/CritRevEukaryotGeneExpr.2022042376"}], "href": "https://doi.org/10.1615/CritRevEukaryotGeneExpr.2022042376"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36017912"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36017912"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Sacha B Geutskens, Peter L Hordijk, Paula B van Hennik "}, {"type": "b", "children": [{"type": "t", "text": "The chemorepellent Slit3 promotes monocyte migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.0903898"}], "href": "https://doi.org/10.4049/jimmunol.0903898"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21078908"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21078908"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Sacha B Geutskens, William D Andrews, Anne-Marieke D van Stalborch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Control of human hematopoietic stem/progenitor cell migration by the extracellular matrix protein Slit3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lab Invest (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/labinvest.2012.81"}], "href": "https://doi.org/10.1038/labinvest.2012.81"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22614124"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22614124"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Melissa Little, Bree Rumballe, Kylie Georgas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Conserved modularity and potential for alternate splicing in mouse and human Slit genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Dev Biol (2002)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12141424"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12141424"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "YongYong Shi, XinZhi Zhao, Lan Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic structure adds power to detect schizophrenia susceptibility at SLIT3 in the Chinese Han population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genome Res (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gr.1758204"}], "href": "https://doi.org/10.1101/gr.1758204"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15231749"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15231749"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Carla I G Vogel, Brandon Greene, André Scherag, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Non-replication of an association of CTNNBL1 polymorphisms and obesity in a population of Central European ancestry."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Med Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2350-10-14"}], "href": "https://doi.org/10.1186/1471-2350-10-14"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19228371"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19228371"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Xiaoyi Zhou, Xiaojun Chen, Lingmin Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polymorphisms involved in the miR-218-LAMB3 pathway and susceptibility of cervical cancer, a case-control study in Chinese women."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gynecol Oncol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ygyno.2010.01.020"}], "href": "https://doi.org/10.1016/j.ygyno.2010.01.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20163849"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20163849"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Hongyu Guan, Gouhong Wei, Jueheng Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Down-regulation of miR-218-2 and its host gene SLIT3 cooperate to promote invasion and progression of thyroid cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2013-1053"}], "href": "https://doi.org/10.1210/jc.2013-1053"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23720784"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23720784"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Rheal A Towner, Randy L Jensen, Brian Vaillant, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Experimental validation of 5 in-silico predicted glioma biomarkers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuro Oncol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/neuonc/not124"}], "href": "https://doi.org/10.1093/neuonc/not124"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24158112"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24158112"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Ratana Lim, Gillian Barker, Martha Lappas "}, {"type": "b", "children": [{"type": "t", "text": "SLIT3 is increased in supracervical human foetal membranes and in labouring myometrium and regulates pro-inflammatory mediators."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Reprod Immunol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/aji.12181"}], "href": "https://doi.org/10.1111/aji.12181"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24286238"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24286238"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "J W Daily, M Liu, S Park "}, {"type": "b", "children": [{"type": "t", "text": "High genetic risk scores of SLIT3, PLEKHA5 and PPP2R2C variants increased insulin resistance and interacted with coffee and caffeine consumption in middle-aged adults."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nutr Metab Cardiovasc Dis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.numecd.2018.09.009"}], "href": "https://doi.org/10.1016/j.numecd.2018.09.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30454882"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30454882"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Wei Zhong, Youmei Peng, Erli Yue, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Abnormal expression of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "SLIT3"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " induces intravillous vascularization dysplasia in ectopic pregnancy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PeerJ (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7717/peerj.14850"}], "href": "https://doi.org/10.7717/peerj.14850"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36793891"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36793891"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Xiaoxiao Liu, Baolei Li, Shuyun Wang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "The Role of SLIT3-ROBO4 Signaling in Endoplasmic Reticulum Stress-Induced Delayed Corneal Epithelial and Nerve Regeneration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Invest Ophthalmol Vis Sci (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1167/iovs.65.5.8"}], "href": "https://doi.org/10.1167/iovs.65.5.8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38700874"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38700874"}]}]}]}