{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSMARCA5 (also known as SNF2H) is a critical ATP‐dependent chromatin remodeling enzyme that drives nucleosome sliding and spacing, thereby regulating chromatin accessibility for essential DNA‐dependent processes. It functions as the catalytic engine in several multi‐subunit complexes (ACF, CHRAC, RSF, B–WICH) that interpret nucleosomal cues—including flanking DNA length, nucleosome acidic patches, and dynamic conformational changes achieved via dimerization and rapid “continuous‐sampling” of chromatin substrates—to coordinate transcription, replication, and repair. These general mechanistic features have been underscored by studies employing biochemical, live‐cell imaging, and structural approaches."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSMARCA5 is rapidly deployed to sites of DNA damage—such as double‐strand breaks induced by ionizing radiation and UV‐lesions during transcriptional stalling—where it promotes the spreading of ubiquitin modifications and the recruitment of key repair factors (e.g. BRCA1, KU proteins, XRCC1) to damaged chromatin. In addition, SMARCA5 is loaded onto DNA replication origins through interaction with factors like Cdt1, thereby facilitating the proper re‐establishment of nucleosome organization during S phase. Its participation in coordinating efficient repair is further highlighted by studies demonstrating that antagonistic remodeling activities (for example between CHD3.1 and ACF1–SMARCA5) ensure the precise modulation of heterochromatin structure in response to damage."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}, {"type": "fg_fs", "start_ref": "13", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its classic chromatin‐remodeling role, emerging evidence indicates that SMARCA5 is subject to regulation by noncoding RNAs. In several malignancies—including glioblastoma, colorectal, cervical, and multiple myeloma—circular RNA SMARCA5 (circSMARCA5) has been shown to act as a tumor suppressor by “sponging” oncogenic microRNAs (such as miR‐151‐5p, miR‐100, miR‐552, or miR‐181b‐5p) and consequently modulating downstream effectors (for example, splicing factors, TIMP3, and signaling intermediates in the Wnt or YAP1 pathways). In some cases, oncogenic fusions such as EWSR1–SMARCA5 further reveal the dualistic nature of SMARCA5 deregulation in cancer."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "19", "end_ref": "29"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAberrant SMARCA5 expression has been documented in multiple tumor types. Overexpression in breast, gastric, ovarian, and glioma tissues is associated with enhanced proliferative, invasive, and chemoresistant phenotypes—activities mediated, in part, by altered cell cycle regulators (such as cyclins, p21) and survival pathways (for example, NF‐κB signaling). In addition, interactions with transcription factors like C/EBPβ and CTCF, as well as participation in viral processes (e.g. facilitating HSV‐1 replication), further delineate its diverse cellular roles. Moreover, cooperative partnerships with noncatalytic subunits and accessory proteins (including Rsf‑1, WSTF, and nuclear myosin 1) as well as associations with components of the Cohesin complex underscore SMARCA5’s multifaceted contributions to oncogenesis and normal developmental processes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "30", "end_ref": "41"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nHigh‐resolution mechanistic investigations have elucidated key features of SMARCA5 function. Structural studies reveal that its ATPase domain undergoes nucleotide‐dependent conformational changes—often triggered by interactions with the nucleosome’s acidic patch—that are critical for coupling ATP hydrolysis to unidirectional DNA translocation. In parallel, analyses of reconstituted remodeling complexes, supported by chromatin proteomic surveys and studies on muscle regeneration, underscore how accessory factors (such as ACF1, WSTF, and even lncRNAs like lncMREF) and reader modules collaboratively fine‐tune SMARCA5’s remodeling output to maintain genomic stability and proper gene expression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "42", "end_ref": "46"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jian Yu, Qing-Guo Xu, Zhen-Guang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hepatol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jhep.2018.01.012"}], "href": "https://doi.org/10.1016/j.jhep.2018.01.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29378234"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29378234"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Li Lan, Ayako Ui, Satoshi Nakajima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The ACF1 complex is required for DNA double-strand break repair in human cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2010.12.003"}], "href": "https://doi.org/10.1016/j.molcel.2010.12.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21172662"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21172662"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Raymond A Poot, Ludmila Bozhenok, Debbie L C van den Berg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Williams syndrome transcription factor interacts with PCNA to target chromatin remodelling by ISWI to replication foci."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1196"}], "href": "https://doi.org/10.1038/ncb1196"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15543136"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15543136"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Piergiorgio Percipalle, Nathalie Fomproix, Erica Cavellán, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The chromatin remodelling complex WSTF-SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.embor.7400657"}], "href": "https://doi.org/10.1038/sj.embor.7400657"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16514417"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16514417"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Erica Cavellán, Patrik Asp, Piergiorgio Percipalle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M600233200"}], "href": "https://doi.org/10.1074/jbc.M600233200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16603771"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16603771"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Alejandra Loyola, Jing-Yi Huang, Gary LeRoy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional analysis of the subunits of the chromatin assembly factor RSF."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.23.19.6759-6768.2003"}], "href": "https://doi.org/10.1128/MCB.23.19.6759-6768.2003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12972596"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12972596"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Fabian Erdel, Thomas Schubert, Caroline Marth, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human ISWI chromatin-remodeling complexes sample nucleosomes via transient binding reactions and become immobilized at active sites."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1003438107"}], "href": "https://doi.org/10.1073/pnas.1003438107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20974961"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20974961"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Nicola Wiechens, Vijender Singh, Triantaffyllos Gkikopoulos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Chromatin Remodelling Enzymes SNF2H and SNF2L Position Nucleosomes adjacent to CTCF and Other Transcription Factors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1005940"}], "href": "https://doi.org/10.1371/journal.pgen.1005940"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27019336"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27019336"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jean Paul Armache, Nathan Gamarra, Stephanie L Johnson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cryo-EM structures of remodeler-nucleosome intermediates suggest allosteric control through the nucleosome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.46057"}], "href": "https://doi.org/10.7554/eLife.46057"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31210637"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31210637"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "John D Leonard, Geeta J Narlikar "}, {"type": "b", "children": [{"type": "t", "text": "A nucleotide-driven switch regulates flanking DNA length sensing by a dimeric chromatin remodeler."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2015.01.008"}], "href": "https://doi.org/10.1016/j.molcel.2015.01.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25684208"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25684208"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Nathan Gamarra, Stephanie L Johnson, Michael J Trnka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The nucleosomal acidic patch relieves auto-inhibition by the ISWI remodeler SNF2h."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.35322"}], "href": "https://doi.org/10.7554/eLife.35322"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29664398"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29664398"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Hai T Dao, Barbara E Dul, Geoffrey P Dann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A basic motif anchoring ISWI to nucleosome acidic patch regulates nucleosome spacing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Chem Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41589-019-0413-4"}], "href": "https://doi.org/10.1038/s41589-019-0413-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31819269"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31819269"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Godelieve Smeenk, Wouter W Wiegant, Jurgen A Marteijn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Poly(ADP-ribosyl)ation links the chromatin remodeler SMARCA5/SNF2H to RNF168-dependent DNA damage signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.109413"}], "href": "https://doi.org/10.1242/jcs.109413"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23264744"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23264744"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "A C Mueller, D Sun, A Dutta "}, {"type": "b", "children": [{"type": "t", "text": "The miR-99 family regulates the DNA damage response through its target SNF2H."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2012.131"}], "href": "https://doi.org/10.1038/onc.2012.131"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22525276"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22525276"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Karolin Klement, Martijn S Luijsterburg, Jordan B Pinder, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Opposing ISWI- and CHD-class chromatin remodeling activities orchestrate heterochromatic DNA repair."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201405077"}], "href": "https://doi.org/10.1083/jcb.201405077"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25533843"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25533843"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Özge Z Aydin, Jurgen A Marteijn, Cristina Ribeiro-Silva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human ISWI complexes are targeted by SMARCA5 ATPase and SLIDE domains to help resolve lesion-stalled transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gku565"}], "href": "https://doi.org/10.1093/nar/gku565"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24990377"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24990377"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Kevin F Bryant, Robert C Colgrove, David M Knipe "}, {"type": "b", "children": [{"type": "t", "text": "Cellular SNF2H chromatin-remodeling factor promotes herpes simplex virus 1 immediate-early gene expression and replication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "mBio (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/mBio.00330-10"}], "href": "https://doi.org/10.1128/mBio.00330-10"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21249171"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21249171"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Yoshiko Kubota, Shinji Shimizu, Shinji Yasuhira, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SNF2H interacts with XRCC1 and is involved in repair of H2O2-induced DNA damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "DNA Repair (Amst) (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.dnarep.2016.03.010"}], "href": "https://doi.org/10.1016/j.dnarep.2016.03.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27268481"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27268481"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Davide Barbagallo, Angela Caponnetto, Matilde Cirnigliaro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircSMARCA5 Inhibits Migration of Glioblastoma Multiforme Cells by Regulating a Molecular Axis Involving Splicing Factors SRSF1/SRSF3/PTB."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms19020480"}], "href": "https://doi.org/10.3390/ijms19020480"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29415469"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29415469"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Zuhua Li, Ye Zhou, Guohua Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Using circular RNA SMARCA5 as a potential novel biomarker for hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Chim Acta (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cca.2019.02.001"}], "href": "https://doi.org/10.1016/j.cca.2019.02.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30716279"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30716279"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "J-J Dai C Tian, L Liang "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of circular RNA SMARCA5/microRNA-620 axis in the regulation of cervical cancer cell proliferation, invasion and migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201812_16622"}], "href": "https://doi.org/10.26355/eurrev_201812_16622"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30575898"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30575898"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Haiyan Liu, Yan Wu, Shunye Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circ-SMARCA5 suppresses progression of multiple myeloma by targeting miR-767-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-019-6088-0"}], "href": "https://doi.org/10.1186/s12885-019-6088-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31601173"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31601173"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Xiaofei Miao, Zhong Xi, Ye Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circ-SMARCA5 suppresses colorectal cancer progression via downregulating miR-39-3p and upregulating ARID4B."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dig Liver Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.dld.2020.07.019"}], "href": "https://doi.org/10.1016/j.dld.2020.07.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32807692"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32807692"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Stefania Tommasi, Rosamaria Pinto, Katia Danza, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-151-5p, targeting chromatin remodeler SMARCA5, as a marker for the BRCAness phenotype."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.10345"}], "href": "https://doi.org/10.18632/oncotarget.10345"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27385001"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27385001"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Shiwei Yang, Shanyu Gao, Tongming Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA SMARCA5 functions as an anti-tumor candidate in colon cancer by sponging microRNA-552."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2021.1899519"}], "href": "https://doi.org/10.1080/15384101.2021.1899519"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33749508"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33749508"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Xin Xie, Fu-Kang Sun, Xin Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A circular RNA, circSMARCA5, inhibits prostate cancer proliferative, migrative, and invasive capabilities via the miR-181b-5p/miR-17-3p-TIMP3 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.203408"}], "href": "https://doi.org/10.18632/aging.203408"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34390329"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34390329"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Janos Sumegi, Jun Nishio, Marilu Nelson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel t(4;22)(q31;q12) produces an EWSR1-SMARCA5 fusion in extraskeletal Ewing sarcoma/primitive neuroectodermal tumor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mod Pathol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/modpathol.2010.201"}], "href": "https://doi.org/10.1038/modpathol.2010.201"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21113140"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21113140"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Haiyang Wang, Liping Tan, Xuchen Dong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-146b-5p suppresses the malignancy of GSC/MSC fusion cells by targeting SMARCA5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.103489"}], "href": "https://doi.org/10.18632/aging.103489"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32632040"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32632040"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Bahauddeen M Alrfaei, Paul Clark, Raghu Vemuganti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA miR-100 Decreases Glioblastoma Growth by Targeting SMARCA5 and ErbB3 in Tumor-Initiating Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Technol Cancer Res Treat (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1533033820960748"}], "href": "https://doi.org/10.1177/1533033820960748"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32945237"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32945237"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Nozomi Sugimoto, Takashi Yugawa, Masayoshi Iizuka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chromatin remodeler sucrose nonfermenting 2 homolog (SNF2H) is recruited onto DNA replication origins through interaction with Cdc10 protein-dependent transcript 1 (Cdt1) and promotes pre-replication complex formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.256123"}], "href": "https://doi.org/10.1074/jbc.M111.256123"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21937426"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21937426"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Quanxiu Jin, Xiaoyun Mao, Bo Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of SMARCA5 correlates with cell proliferation and migration in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-014-2791-2"}], "href": "https://doi.org/10.1007/s13277-014-2791-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25377162"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25377162"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Carolina Oliveira Gigek, Luara Carolina Frias Lisboa, Mariana Ferreira Leal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SMARCA5 methylation and expression in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Invest (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/07357907.2010.543365"}], "href": "https://doi.org/10.3109/07357907.2010.543365"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21261476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21261476"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Xi He, Hua-Ying Fan, Joseph D Garlick, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Diverse regulation of SNF2h chromatin remodeling by noncatalytic subunits."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi702304p"}], "href": "https://doi.org/10.1021/bi702304p"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18553938"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18553938"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Fabian Erdel, Karsten Rippe "}, {"type": "b", "children": [{"type": "t", "text": "Binding kinetics of human ISWI chromatin-remodelers to DNA repair sites elucidate their target location mechanism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleus (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/nucl.2.2.15209"}], "href": "https://doi.org/10.4161/nucl.2.2.15209"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21738833"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21738833"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Andrew Melvin, Sharon Mudie, Sonia Rocha "}, {"type": "b", "children": [{"type": "t", "text": "The chromatin remodeler ISWI regulates the cellular response to hypoxia: role of FIH."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E11-02-0163"}], "href": "https://doi.org/10.1091/mbc.E11-02-0163"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21900490"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21900490"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Ximena P Steinberg, Matias I Hepp, Yaiza Fernández García, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human CCAAT/enhancer-binding protein β interacts with chromatin remodeling complexes of the imitation switch subfamily."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi201593q"}], "href": "https://doi.org/10.1021/bi201593q"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22242598"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22242598"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Mariano Oppikofer, Meredith Sagolla, Benjamin Haley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Non-canonical reader modules of BAZ1A promote recovery from DNA damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-017-00866-0"}], "href": "https://doi.org/10.1038/s41467-017-00866-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29021563"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29021563"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Tomas Zikmund, Helena Paszekova, Juraj Kokavec, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of ISWI ATPase SMARCA5 (SNF2H) in Acute Myeloid Leukemia Cells Inhibits Proliferation and Chromatid Cohesion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms21062073"}], "href": "https://doi.org/10.3390/ijms21062073"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32197313"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32197313"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Monica L Bomber, Jing Wang, Qi Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human SMARCA5 is continuously required to maintain nucleosome spacing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2022.12.018"}], "href": "https://doi.org/10.1016/j.molcel.2022.12.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36630954"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36630954"}]}, {"type": "r", "ref": 40, "children": [{"type": "t", "text": "Zhijia Zhang, Yanxia Sang, Zhengan Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Negative Correlation Between Circular RNA SMARC5 and MicroRNA 432, and Their Clinical Implications in Bladder Cancer Patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Technol Cancer Res Treat (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/15330338211039110"}], "href": "https://doi.org/10.1177/15330338211039110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34482767"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34482767"}]}, {"type": "r", "ref": 41, "children": [{"type": "t", "text": "Xiao-Chun Zhao, Ping An, Xiu-Ying Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of hSNF2H in glioma promotes cell proliferation, invasion, and chemoresistance through its interaction with Rsf-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-015-4579-4"}], "href": "https://doi.org/10.1007/s13277-015-4579-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26666816"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26666816"}]}, {"type": "r", "ref": 42, "children": [{"type": "t", "text": "Xi He, Hua-Ying Fan, Geeta J Narlikar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human ACF1 alters the remodeling strategy of SNF2h."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M603008200"}], "href": "https://doi.org/10.1074/jbc.M603008200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16877760"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16877760"}]}, {"type": "r", "ref": 43, "children": [{"type": "t", "text": "Joseph A Goldman, Joseph D Garlick, Robert E Kingston "}, {"type": "b", "children": [{"type": "t", "text": "Chromatin remodeling by imitation switch (ISWI) class ATP-dependent remodelers is stimulated by histone variant H2A.Z."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.072348"}], "href": "https://doi.org/10.1074/jbc.M109.072348"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19940112"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19940112"}]}, {"type": "r", "ref": 44, "children": [{"type": "t", "text": "Robert F Levendosky, Gregory D Bowman "}, {"type": "b", "children": [{"type": "t", "text": "Asymmetry between the two acidic patches dictates the direction of nucleosome sliding by the ISWI chromatin remodeler."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.45472"}], "href": "https://doi.org/10.7554/eLife.45472"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31094676"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31094676"}]}, {"type": "r", "ref": 45, "children": [{"type": "t", "text": "Monica Soldi, Tiziana Bonaldi "}, {"type": "b", "children": [{"type": "t", "text": "The proteomic investigation of chromatin functional domains reveals novel synergisms among distinct heterochromatin components."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Proteomics (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/mcp.M112.024307"}], "href": "https://doi.org/10.1074/mcp.M112.024307"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23319141"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23319141"}]}, {"type": "r", "ref": 46, "children": [{"type": "t", "text": "Wei Lv, Wei Jiang, Hongmei Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA lncMREF promotes myogenic differentiation and muscle regeneration by interacting with the Smarca5/p300 complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkac854"}], "href": "https://doi.org/10.1093/nar/gkac854"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36200826"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36200826"}]}]}]}