HGNC Family | Structural maintenance of chromosomes proteins (SMC) |
Name | structural maintenance of chromosomes 6 |
Description | Enables DNA secondary structure binding activity and ubiquitin protein ligase binding activity. Involved in several processes, including cellular senescence; negative regulation by host of viral genome replication; and telomere maintenance via recombination. Located in chromosome and nuclear body. Part of Smc5-Smc6 complex. Is active in nucleus. [provided by Alliance of Genome Resources, Mar 2025] |
Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe Smc5/6 complex, with SMC6 as a core subunit, plays a central role in antiviral defense by restricting gene expression from extrachromosomal viral DNA. For instance, in hepatitis B virus (HBV)–infected cells the complex binds to the viral covalently closed circular DNA and represses its transcription until the virus hijacks the host’s ubiquitin ligase machinery to target Smc5/6 for degradation, thereby relieving the block on viral gene expression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " Similar antiviral roles are observed with other viruses: the papillomavirus E2 protein interacts with the Smc5/6 complex to support viral genome maintenance"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", while in HIV-1–like lentiviruses and unintegrated HIV-1, recruitment of Smc5/6 (directly or via accessory factors like SLF2) promotes chromatin compaction and epigenetic silencing of the viral genome."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Moreover, selective binding to circular DNA and recognition of transcription‐induced positive supercoils further highlight its role in impeding viral transcription."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its antiviral functions, SMC6 is integral to maintaining genome integrity through its involvement in DNA repair and replication. Studies have shown that depletion of the Smc5/6 complex decreases sister chromatid homologous recombination, compromises the mitotic assembly of replicated chromosomes, and disrupts the proper resolution of topological stress during replication."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "11"}]}, {"type": "t", "text": " The SUMO ligase activity provided by the hMMS21 subunit modifies SMC6 and other DNA repair proteins, facilitating homologous recombination and proper repair of double-strand breaks."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " Broader analyses and reviews further underscore the complex’s role in replication fork maintenance, coordination with topoisomerase IIα to resolve replication intermediates, participation in alternative telomere lengthening, and its essential requirement for cell viability by preventing spontaneous DNA damage."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond DNA repair, the architectural features of the Smc5/6 complex are critical for higher‐order chromosome organization. Detailed structural studies reveal that SMC6, as part of a dynamic complex, contributes to the formation of toroidal, rod–like configurations with specialized “latch” and “hub” domains that are essential for linking DNA segments and promoting micro‐compaction. These structural insights, complemented by integrative reviews of interphase chromatin folding, underscore how the complex’s architecture enables it to manage DNA topology during transcription and facilitate proper chromosome segregation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "21", "end_ref": "24"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Adrien Decorsière, Henrik Mueller, Pieter C van Breugel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature17170"}], "href": "https://doi.org/10.1038/nature17170"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26983541"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26983541"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Christopher M Murphy, Yanping Xu, Feng Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hepatitis B Virus X Protein Promotes Degradation of SMC5/6 to Enhance HBV Replication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2016.08.026"}], "href": "https://doi.org/10.1016/j.celrep.2016.08.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27626656"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27626656"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Congrong Niu, Christine M Livingston, Li Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Smc5/6 Complex Restricts HBV when Localized to ND10 without Inducing an Innate Immune Response and Is Counteracted by the HBV X Protein Shortly after Infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0169648"}], "href": "https://doi.org/10.1371/journal.pone.0169648"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28095508"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28095508"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Peris Bentley, Min Jie Alvin Tan, Alison A McBride, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The SMC5/6 Complex Interacts with the Papillomavirus E2 Protein and Influences Maintenance of Viral Episomal DNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.00356-18"}], "href": "https://doi.org/10.1128/JVI.00356-18"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29848583"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29848583"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Liane Dupont, Stuart Bloor, James C Williamson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Host Microbe (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.chom.2021.03.001"}], "href": "https://doi.org/10.1016/j.chom.2021.03.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33811831"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33811831"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Ishak D Irwan, Hal P Bogerd, Bryan R Cullen "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic silencing by the SMC5/6 complex mediates HIV-1 latency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Microbiol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41564-022-01264-z"}], "href": "https://doi.org/10.1038/s41564-022-01264-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36376394"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36376394"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Aurélie Diman, Gaël Panis, Cédric Castrogiovanni, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human Smc5/6 recognises transcription-generated positive DNA supercoils."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-024-50646-w"}], "href": "https://doi.org/10.1038/s41467-024-50646-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39242537"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39242537"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Patrick Ryan Potts, Hongtao Yu "}, {"type": "b", "children": [{"type": "t", "text": "Human MMS21/NSE2 is a SUMO ligase required for DNA repair."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.25.16.7021-7032.2005"}], "href": "https://doi.org/10.1128/MCB.25.16.7021-7032.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16055714"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16055714"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Patrick Ryan Potts, Matthew H Porteus, Hongtao Yu "}, {"type": "b", "children": [{"type": "t", "text": "Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.emboj.7601218"}], "href": "https://doi.org/10.1038/sj.emboj.7601218"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16810316"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16810316"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Patrick Ryan Potts, Hongtao Yu "}, {"type": "b", "children": [{"type": "t", "text": "The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb1259"}], "href": "https://doi.org/10.1038/nsmb1259"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17589526"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17589526"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Elaine M Taylor, Alice C Copsey, Jessica J R Hudson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00767-07"}], "href": "https://doi.org/10.1128/MCB.00767-07"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18086888"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18086888"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Stephanie Pebernard, J Jefferson P Perry, John A Tainer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nse1 RING-like domain supports functions of the Smc5-Smc6 holocomplex in genome stability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e08-02-0226"}], "href": "https://doi.org/10.1091/mbc.e08-02-0226"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18667531"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18667531"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Anna K Stephan, Maciej Kliszczak, Ciaran G Morrison "}, {"type": "b", "children": [{"type": "t", "text": "The Nse2/Mms21 SUMO ligase of the Smc5/6 complex in the maintenance of genome stability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2011.04.067"}], "href": "https://doi.org/10.1016/j.febslet.2011.04.067"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21550342"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21550342"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Lina Marcela Gallego-Paez, Hiroshi Tanaka, Masashige Bando, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Smc5/6-mediated regulation of replication progression contributes to chromosome assembly during mitosis in human cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E13-01-0020"}], "href": "https://doi.org/10.1091/mbc.E13-01-0020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24258023"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24258023"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Kristian Jeppsson, Takaharu Kanno, Katsuhiko Shirahige, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The maintenance of chromosome structure: positioning and functioning of SMC complexes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Rev Mol Cell Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nrm3857"}], "href": "https://doi.org/10.1038/nrm3857"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25145851"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25145851"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Dideke E Verver, Yi Zheng, Dave Speijer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Non-SMC Element 2 (NSMCE2) of the SMC5/6 Complex Helps to Resolve Topological Stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms17111782"}], "href": "https://doi.org/10.3390/ijms17111782"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27792189"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27792189"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Josyf C Mychaleckyj, Alexandre Havt, Uma Nayak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-Wide Analysis in Brazilians Reveals Highly Differentiated Native American Genome Regions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Evol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/molbev/msw249"}], "href": "https://doi.org/10.1093/molbev/msw249"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28100790"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28100790"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Francesco Rossi, Anne Helbling-Leclerc, Ryotaro Kawasumi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SMC5/6 acts jointly with Fanconi anemia factors to support DNA repair and genome stability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embr.201948222"}], "href": "https://doi.org/10.15252/embr.201948222"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31867888"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31867888"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Andrés Bueno Venegas, Toyoaki Natsume, Masato Kanemaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inducible Degradation of the Human SMC5/6 Complex Reveals an Essential Role Only during Interphase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2020.107533"}], "href": "https://doi.org/10.1016/j.celrep.2020.107533"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32320646"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32320646"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Dylan F Fingerman, David R O'Leary, Ava R Hansen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The SMC5/6 complex prevents genotoxicity upon APOBEC3A-mediated replication stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s44318-024-00137-x"}], "href": "https://doi.org/10.1038/s44318-024-00137-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38886582"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38886582"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Aaron Alt, Hung Q Dang, Owen S Wells, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Specialized interfaces of Smc5/6 control hinge stability and DNA association."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms14011"}], "href": "https://doi.org/10.1038/ncomms14011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28134253"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28134253"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "M Adamus, E Lelkes, D Potesil, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular Insights into the Architecture of the Human SMC5/6 Complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2020.04.024"}], "href": "https://doi.org/10.1016/j.jmb.2020.04.024"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32389690"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32389690"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Diego Serrano, Gustavo Cordero, Ryo Kawamura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Smc5/6 Core Complex Is a Structure-Specific DNA Binding and Compacting Machine."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2020.11.011"}], "href": "https://doi.org/10.1016/j.molcel.2020.11.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33301731"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33301731"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Shamayita Roy, Hemanta Adhikary, Damien D'Amours "}, {"type": "b", "children": [{"type": "t", "text": "The SMC5/6 complex: folding chromosomes back into shape when genomes take a break."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkae103"}], "href": "https://doi.org/10.1093/nar/gkae103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38375830"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38375830"}]}]}]}
|
Synonyms | SMC6L1, HSMC6, SMC-6 |
Proteins | SMC6_HUMAN |
NCBI Gene ID | 79677 |
API | |
Download Associations | |
Predicted Functions |
![]() |
Co-expressed Genes |
![]() |
Expression in Tissues and Cell Lines |
![]() |
SMC6 has 5,794 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 104 datasets.
Click the + buttons to view associations for SMC6 from the datasets below.
If available, associations are ranked by standardized value
Dataset | Summary | |
---|---|---|
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of SMC6 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of SMC6 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of SMC6 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of SMC6 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of SMC6 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of SMC6 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of SMC6 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of SMC6 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of SMC6 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of SMC6 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
CCLE Cell Line Proteomics | Cell lines associated with SMC6 protein from the CCLE Cell Line Proteomics dataset. | |
CellMarker Gene-Cell Type Associations | cell types associated with SMC6 gene from the CellMarker Gene-Cell Type Associations dataset. | |
ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of SMC6 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
ChEA Transcription Factor Targets | transcription factors binding the promoter of SMC6 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of SMC6 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of SMC6 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing SMC6 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing SMC6 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
COMPARTMENTS Experimental Protein Localization Evidence Scores | cellular components containing SMC6 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 | cellular components containing SMC6 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with SMC6 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with SMC6 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of SMC6 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
COSMIC Cell Line Gene Mutation Profiles | cell lines with SMC6 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
CTD Gene-Disease Associations | diseases associated with SMC6 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with SMC6 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with SMC6 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DisGeNET Gene-Disease Associations | diseases associated with SMC6 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
DisGeNET Gene-Phenotype Associations | phenotypes associated with SMC6 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at SMC6 gene from the ENCODE Histone Modification Site Profiles dataset. | |
ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of SMC6 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
ENCODE Transcription Factor Targets | transcription factors binding the promoter of SMC6 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing SMC6 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of SMC6 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
GeneRIF Biological Term Annotations | biological terms co-occuring with SMC6 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing SMC6 from the GeneSigDB Published Gene Signatures dataset. | |
GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of SMC6 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of SMC6 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of SMC6 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of SMC6 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of SMC6 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of SMC6 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
GO Biological Process Annotations 2015 | biological processes involving SMC6 gene from the curated GO Biological Process Annotations 2015 dataset. | |
GO Biological Process Annotations 2023 | biological processes involving SMC6 gene from the curated GO Biological Process Annotations 2023 dataset. | |
GO Biological Process Annotations 2025 | biological processes involving SMC6 gene from the curated GO Biological Process Annotations2025 dataset. | |
GO Cellular Component Annotations 2015 | cellular components containing SMC6 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
GO Cellular Component Annotations 2023 | cellular components containing SMC6 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
GO Cellular Component Annotations 2025 | cellular components containing SMC6 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
GO Molecular Function Annotations 2015 | molecular functions performed by SMC6 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
GO Molecular Function Annotations 2023 | molecular functions performed by SMC6 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
GO Molecular Function Annotations 2025 | molecular functions performed by SMC6 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
GTEx eQTL 2025 | SNPs regulating expression of SMC6 gene from the GTEx eQTL 2025 dataset. | |
GTEx Tissue Gene Expression Profiles | tissues with high or low expression of SMC6 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of SMC6 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of SMC6 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
GWASdb SNP-Disease Associations | diseases associated with SMC6 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
GWASdb SNP-Phenotype Associations | phenotypes associated with SMC6 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of SMC6 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of SMC6 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
HPA Tissue Gene Expression Profiles | tissues with high or low expression of SMC6 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
HPA Tissue Protein Expression Profiles | tissues with high or low expression of SMC6 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of SMC6 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
Hub Proteins Protein-Protein Interactions | interacting hub proteins for SMC6 from the curated Hub Proteins Protein-Protein Interactions dataset. | |
HuGE Navigator Gene-Phenotype Associations | phenotypes associated with SMC6 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
IMPC Knockout Mouse Phenotypes | phenotypes of mice caused by SMC6 gene knockout from the IMPC Knockout Mouse Phenotypes dataset. | |
InterPro Predicted Protein Domain Annotations | protein domains predicted for SMC6 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of SMC6 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of SMC6 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of SMC6 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with SMC6 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of SMC6 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of SMC6 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of SMC6 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of SMC6 gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
LOCATE Curated Protein Localization Annotations | cellular components containing SMC6 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain SMC6 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by SMC6 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
MiRTarBase microRNA Targets | microRNAs targeting SMC6 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of SMC6 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of SMC6 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
NURSA Protein Complexes | protein complexs containing SMC6 protein recovered by IP-MS from the NURSA Protein Complexes dataset. | |
Pathway Commons Protein-Protein Interactions | interacting proteins for SMC6 from the Pathway Commons Protein-Protein Interactions dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of SMC6 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of SMC6 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PFOCR Pathway Figure Associations 2023 | pathways involving SMC6 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
PFOCR Pathway Figure Associations 2024 | pathways involving SMC6 protein from the Wikipathways PFOCR 2024 dataset. | |
Reactome Pathways 2024 | pathways involving SMC6 protein from the Reactome Pathways 2024 dataset. | |
Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of SMC6 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of SMC6 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset. | |
Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of SMC6 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at SMC6 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of SMC6 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of SMC6 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
Sanger Dependency Map Cancer Cell Line Proteomics | cell lines associated with SMC6 protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset. | |
TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of SMC6 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of SMC6 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of SMC6 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of SMC6 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of SMC6 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of SMC6 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of SMC6 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with SMC6 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with SMC6 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
WikiPathways Pathways 2024 | pathways involving SMC6 protein from the WikiPathways Pathways 2024 dataset. | |