SNX10 Gene

HGNC Family	Sorting nexins (SNX)
Name	sorting nexin 10
Description	This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene may play a role in regulating endosome homeostasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSNX10 plays a central role in bone homeostasis by regulating osteoclast differentiation and function. Studies have shown that SNX10 is robustly up‐regulated during RANKL‐induced osteoclast formation and is necessary for proper vesicular trafficking and ruffled border formation, which is essential for acidification and bone resorption. Mutations in SNX10 lead to defects in osteoclast activity that underlie human osteopetrosis, as demonstrated by genetic findings in diverse patient populations and in mouse models. Structural investigations of SNX10 have further revealed that disease‐associated mutations destabilize its extended phox homology domain, impairing its ability to induce vacuolation and compromising osteoclast function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in bone remodeling, SNX10 is a key regulator of intracellular membrane trafficking. Ectopic expression of SNX10 has been observed to induce the formation of giant vacuoles, a process that depends on its phosphoinositide 3‐phosphate binding via the conserved PX domain and requires sequences in the C-terminal region. This vacuolating function reflects a broader contribution of SNX10 to endosome homeostasis. Moreover, SNX10 is essential for ciliogenesis, where it interacts with the V-ATPase complex at centrosomes and facilitates ciliary membrane extension through regulation of vesicular trafficking."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSNX10 has also emerged as an important tumor suppressor in several epithelial cancers. In colorectal cancer, down-regulation of SNX10 is associated with aberrant activation of oncogenic pathways such as SRC-STAT3 and mTOR-CTNNB1, largely due to its role in mediating autophagic degradation processes. By controlling chaperone-mediated autophagy, SNX10 influences the stability of key regulatory proteins—including p21—which in turn affects cell proliferation and survival. Furthermore, in the gastrointestinal tract, SNX10 contributes to the maintenance of the intestinal barrier and stem cell function, with its deficiency promoting inflammatory responses and impairing mucosal healing."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional studies indicate that SNX10 influences broader aspects of cellular and tissue physiology. It participates in the regulation of macrophage function and has been implicated in the pathogenesis of liver ischemia-reperfusion injury by modulating inflammatory responses. Altered SNX10 expression levels have also been associated with cardiac conditions such as atrial fibrillation, pointing to a wider relevance in maintaining cellular homeostasis across different organ systems."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "19", "end_ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Memet Aker, Alex Rouvinski, Saar Hashavia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An SNX10 mutation causes malignant osteopetrosis of infancy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Genet (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jmedgenet-2011-100520"}], "href": "https://doi.org/10.1136/jmedgenet-2011-100520"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22499339"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22499339"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Alessandra Pangrazio, Anders Fasth, Andrea Sbardellati, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SNX10 mutations define a subgroup of human autosomal recessive osteopetrosis with variable clinical severity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Bone Miner Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jbmr.1849"}], "href": "https://doi.org/10.1002/jbmr.1849"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23280965"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23280965"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "C H Zhu, L R Morse, R A Battaglino "}, {"type": "b", "children": [{"type": "t", "text": "SNX10 is required for osteoclast formation and resorption activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.24029"}], "href": "https://doi.org/10.1002/jcb.24029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22174188"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22174188"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Eva-Lena Stattin, Petra Henning, Joakim Klar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SNX10 gene mutation leading to osteopetrosis with dysfunctional osteoclasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-017-02533-2"}], "href": "https://doi.org/10.1038/s41598-017-02533-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28592808"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28592808"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Liang Ye, Leslie R Morse, Li Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Osteopetrorickets due to Snx10 deficiency in mice results from both failed osteoclast activity and loss of gastric acid-dependent calcium absorption."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1005057"}], "href": "https://doi.org/10.1371/journal.pgen.1005057"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25811986"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25811986"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yentl Huybrechts, Wim Van Hul "}, {"type": "b", "children": [{"type": "t", "text": "Osteopetrosis associated with PLEKHM1 and SNX10 genes, both involved in osteoclast vesicular trafficking."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bone (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bone.2022.116520"}], "href": "https://doi.org/10.1016/j.bone.2022.116520"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35981699"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35981699"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Ting Zhou, Caixia Zeng, Qiong Xi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SNX10 gene mutation in infantile malignant osteopetrosis: A case report and literature review."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhong Nan Da Xue Xue Bao Yi Xue Ban (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.11817/j.issn.1672-7347.2021.190322"}], "href": "https://doi.org/10.11817/j.issn.1672-7347.2021.190322"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33678645"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33678645"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Tingting Xu, Jinxin Xu, Yinghua Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure of human SNX10 reveals insights into its role in human autosomal recessive osteopetrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proteins (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/prot.24689"}], "href": "https://doi.org/10.1002/prot.24689"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25212774"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25212774"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Bo Xiao, Nana Liu, Lixia Hou, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Sorting nexin 10 induces giant vacuoles in mammalian cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M608884200"}], "href": "https://doi.org/10.1074/jbc.M608884200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17012226"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17012226"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yanqun Chen, Bin Wu, Liangliang Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cr.2011.134"}], "href": "https://doi.org/10.1038/cr.2011.134"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21844891"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21844891"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Jinxin Xu, Tingting Xu, Bin Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure of sorting nexin 11 (SNX11) reveals a novel extended phox homology (PX) domain critical for inhibition of SNX10-induced vacuolation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.449306"}], "href": "https://doi.org/10.1074/jbc.M112.449306"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23615901"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23615901"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Sulin Zhang, Zhiwen Yang, Weilian Bao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SNX10 (sorting nexin 10) inhibits colorectal cancer initiation and progression by controlling autophagic degradation of SRC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15548627.2019.1632122"}], "href": "https://doi.org/10.1080/15548627.2019.1632122"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31208298"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31208298"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Sulin Zhang, Bin Hu, Yan You, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sorting nexin 10 acts as a tumor suppressor in tumorigenesis and progression of colorectal cancer through regulating chaperone mediated autophagy degradation of p21"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "Cip1/WAF1"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": "."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2018.01.045"}], "href": "https://doi.org/10.1016/j.canlet.2018.01.045"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29355659"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29355659"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Yunchen Le, Sulin Zhang, Jiahui Ni, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sorting nexin 10 controls mTOR activation through regulating amino-acid metabolism in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-018-0719-2"}], "href": "https://doi.org/10.1038/s41419-018-0719-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29867114"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29867114"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Xu Wang, Jiahui Ni, Yan You, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SNX10-mediated LPS sensing causes intestinal barrier dysfunction via a caspase-5-dependent signaling cascade."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embj.2021108080"}], "href": "https://doi.org/10.15252/embj.2021108080"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34747049"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34747049"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Weilian Bao, Yan You, Jiahui Ni, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibiting sorting nexin 10 promotes mucosal healing through SREBP2-mediated stemness restoration of intestinal stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Adv (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/sciadv.adh5016"}], "href": "https://doi.org/10.1126/sciadv.adh5016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37647408"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37647408"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Yaozong Wang, Naikun Sun, Zheyi Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression Pattern of miR-301b in Osteosarcoma and Its Relevance with Osteosarcoma Cellular Behaviors via Modulating SNX10."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Genet (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10528-022-10241-4"}], "href": "https://doi.org/10.1007/s10528-022-10241-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35732962"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35732962"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Yan You, Wei-Lian Bao, Su-Lin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sorting Nexin 10 Mediates Metabolic Reprogramming of Macrophages in Atherosclerosis Through the Lyn-Dependent TFEB Signaling Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.119.315516"}], "href": "https://doi.org/10.1161/CIRCRESAHA.119.315516"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32316875"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32316875"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Dongming Wu, Yong Wang, Jian Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SNX10 promoted liver IR injury by facilitating macrophage M1 polarization via NLRP3 inflammasome activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Immunol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molimm.2024.01.009"}], "href": "https://doi.org/10.1016/j.molimm.2024.01.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38271879"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38271879"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Jianping Yao, Jian Hou, Linhua Lv, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Does Decreased SNX10 Serve as a Novel Risk Factor in Atrial Fibrillation of the Valvular Heart Disease? - A Case-Control Study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Braz J Cardiovasc Surg (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.21470/1678-9741-2019-0413"}], "href": "https://doi.org/10.21470/1678-9741-2019-0413"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33594863"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33594863"}]}]}]}
Synonyms	OPTB8
Proteins	SNX10_HUMAN
NCBI Gene ID	29887
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SNX10 has 7,552 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 122 datasets.

Click the + buttons to view associations for SNX10 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SNX10 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SNX10 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SNX10 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SNX10 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SNX10 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SNX10 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SNX10 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SNX10 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SNX10 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SNX10 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of SNX10 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SNX10 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SNX10 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SNX10 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SNX10 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SNX10 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SNX10 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with SNX10 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with SNX10 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SNX10 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SNX10 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SNX10 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SNX10 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SNX10 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SNX10 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SNX10 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with SNX10 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with SNX10 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with SNX10 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of SNX10 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SNX10 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving SNX10 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving SNX10 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with SNX10 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with SNX10 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SNX10 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SNX10 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SNX10 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SNX10 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SNX10 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SNX10 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.