SNX5 Gene

HGNC Family	Sorting nexins (SNX)
Name	sorting nexin 5
Description	This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein functions in endosomal sorting, the phosphoinositide-signaling pathway, and macropinocytosis. This gene may play a role in the tumorigenesis of papillary thyroid carcinoma. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSNX5 is a multifunctional sorting nexin that plays pivotal roles in endosomal trafficking and retromer-mediated transport. In mammalian cells, SNX5—often acting in concert with SNX6 and SNX1—facilitates the retrograde retrieval of the cation-independent mannose-6-phosphate receptor from endosomes to the trans-Golgi network, a function proposed to mirror that of the yeast Vps17p ([."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Structural analyses have further revealed how the BAR and phox homology domains of SNX5 recognize a β‐hairpin sorting motif present in a wide spectrum of cargo proteins, thereby coupling membrane tubulation with cargo enrichment. Moreover, its lipid‐binding properties allow SNX5 to localize to PtdIns3P‐rich endosomes as well as transiently to the plasma membrane in response to growth factor stimulation, and interactions with factors including DOCK180 underscore its broader role in retrograde trafficking ([."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSNX5 is also a key interface in host–pathogen interactions and antiviral defenses. Several pathogens usurp the SNX5 pathway—Chlamydia Inc proteins, for instance, target the unique binding site on the SNX5 phox homology domain—to disrupt normal cellular trafficking ([."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " During viral infections, SNX5 is indispensable for virus‑induced autophagy by stimulating the lipid kinase activity of the class III phosphatidylinositol-3-kinase complex and promoting phosphatidylinositol‑3‑phosphate formation on endosomes; it is further exploited by viruses such as human cytomegalovirus and alphaviruses to modulate glycoprotein trafficking and support replication, while also serving as a negative regulator of RIG-I-mediated antiviral signaling via modulation of receptor ubiquitination and disruption of signalosome assembly ([."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its roles in membrane trafficking and pathogen responses, SNX5 is critical for regulating receptor recycling and signal transduction in various cell types. In renal epithelial cells, SNX5 interacts dynamically with the dopamine D1 receptor, ensuring its proper internalization and recycling—a process essential for modulating blood pressure. Similarly, SNX5 supports insulin receptor expression and signaling in proximal tubule cells, while its aberrant expression in hepatocellular carcinoma has been linked to the inhibition of EGFR internalization, thereby hyperactivating the ERK1/2 pathway and driving tumor proliferation and metastasis. Elevated SNX5 levels are also emerging as potential diagnostic markers in papillary thyroid carcinoma ([."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond these functions, SNX5 contributes to the regulation of organellar contact sites and immune cell dynamics. It directs the association of VPS13A with specific endosomal subdomains, thereby influencing lipid transport at membrane contact sites. In B lymphocytes, SNX5-rich plasma membrane protrusions are essential for actin-dependent cell spreading, immune synapse formation, and the efficient extraction and presentation of antigens ([."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Thomas Wassmer, Naomi Attar, Miriam V Bujny, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.03302"}], "href": "https://doi.org/10.1242/jcs.03302"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17148574"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17148574"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Boris Simonetti, Blessy Paul, Karina Chaudhari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular identification of a BAR domain-containing coat complex for endosomal recycling of transmembrane proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41556-019-0393-3"}], "href": "https://doi.org/10.1038/s41556-019-0393-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31576058"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31576058"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ana Merino-Trigo, Markus C Kerr, Fiona Houghton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sorting nexin 5 is localized to a subdomain of the early endosomes and is recruited to the plasma membrane following EGF stimulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.01561"}], "href": "https://doi.org/10.1242/jcs.01561"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15561769"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15561769"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Shigeo Hara, Etsuko Kiyokawa, Shun-ichiro Iemura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The DHR1 domain of DOCK180 binds to SNX5 and regulates cation-independent mannose 6-phosphate receptor transport."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e08-03-0314"}], "href": "https://doi.org/10.1091/mbc.e08-03-0314"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18596235"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18596235"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Nao Itai, Tsukasa Shimazu, Takayuki Kimura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The phosphorylation of sorting nexin 5 at serine 226 regulates retrograde transport and macropinocytosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0207205"}], "href": "https://doi.org/10.1371/journal.pone.0207205"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30419003"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30419003"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Blessy Paul, Hyun Sung Kim, Markus C Kerr, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural basis for the hijacking of endosomal sorting nexin proteins by "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Chlamydia trachomatis"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.22311"}], "href": "https://doi.org/10.7554/eLife.22311"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28226239"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28226239"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Xiaonan Dong, Yuting Yang, Zhongju Zou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sorting nexin 5 mediates virus-induced autophagy and immunity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41586-020-03056-z"}], "href": "https://doi.org/10.1038/s41586-020-03056-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33328639"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33328639"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Gregor Maschkowitz, Sabine Gärtner, Heike Hofmann-Winkler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction of Human Cytomegalovirus Tegument Proteins ppUL35 and ppUL35A with Sorting Nexin 5 Regulates Glycoprotein B (gpUL55) Localization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.00013-18"}], "href": "https://doi.org/10.1128/JVI.00013-18"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29444945"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29444945"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Ryan Schuchman, Andy Kilianski, Amanda Piper, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comparative Characterization of the Sindbis Virus Proteome from Mammalian and Invertebrate Hosts Identifies nsP2 as a Component of the Virion and Sorting Nexin 5 as a Significant Host Factor for Alphavirus Replication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.00694-18"}], "href": "https://doi.org/10.1128/JVI.00694-18"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29743363"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29743363"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jing Li, Tian Chen, Tao Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SNX5 inhibits RLR-mediated antiviral signaling by targeting RIG-I-VISA signalosome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.11.121"}], "href": "https://doi.org/10.1016/j.bbrc.2019.11.121"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31806368"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31806368"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Qingqing Zhou, Tingting Huang, Zhiyuan Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of SNX5 predicts poor prognosis and promotes hepatocellular carcinoma progression by modulating the EGFR-ERK1/2 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-019-1131-9"}], "href": "https://doi.org/10.1038/s41388-019-1131-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31819169"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31819169"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Van Anthony M Villar, Ines Armando, Hironobu Sanada, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "SNX5 promotes antigen presentation in B cells by dual regulation of actin and lysosomal dynamics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Life Sci Alliance (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26508/lsa.202402917"}], "href": "https://doi.org/10.26508/lsa.202402917"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39448266"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39448266"}]}]}]}
Proteins	SNX5_HUMAN
NCBI Gene ID	27131
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SNX5 has 7,896 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 114 datasets.

Click the + buttons to view associations for SNX5 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SNX5 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SNX5 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SNX5 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SNX5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SNX5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SNX5 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SNX5 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SNX5 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SNX5 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SNX5 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SNX5 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with SNX5 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SNX5 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SNX5 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SNX5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SNX5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SNX5 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SNX5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SNX5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing SNX5 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing SNX5 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SNX5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SNX5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SNX5 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SNX5 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with SNX5 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with SNX5 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of SNX5 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SNX5 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with SNX5 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SNX5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SNX5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SNX5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SNX5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SNX5 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SNX5 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SNX5 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SNX5 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with SNX5 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with SNX5 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of SNX5 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.