SORBS2 Gene

Name	sorbin and SH3 domain containing 2
Description	Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSORBS2 (also known as ArgBP2) is a multifunctional adaptor and RNA‐binding protein whose expression and activity are tightly regulated in a tissue‐ and context‐specific manner. In skeletal muscle, a telomere loop at the 4q35 locus modulates SORBS2 transcription via a cis‐acting mechanism, and its altered expression has been associated with facioscapulohumeral muscular dystrophy. In the heart, SORBS2 is abundantly expressed and localized to intercalated discs where it sustains adhesion and electrical integrity. Its genetic ablation leads to structural and electrical remodeling, recapitulating features of arrhythmogenic cardiomyopathy and congenital heart defects through impaired second heart field development and defective NOTCH/SHH signaling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn various cancers, including cervical, gastric, and bladder carcinomas, SORBS2 acts as a tumor suppressor. Epigenetic repression mechanisms—such as those mediated by HSF1 in cooperation with MORC2 and PRC2—lead to decreased SORBS2 expression, which in turn correlates with enhanced cell migration, proliferation, and anchorage‐independent growth. Mechanistically, SORBS2 exerts part of its antimetastatic function by binding directly to the 3′ untranslated regions of specific tumor‐suppressor mRNAs (e.g. MTUS1 and TFPI) to increase their stability, while its interactions with cytoskeletal proteins (such as α‐actinin, vinculin, and CIP4) underscore its role in organizing actin dynamics and cell adhesion."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional studies indicate that SORBS2 contributes to other essential cellular processes. Its interaction with eEF1A at the plasma membrane suggests involvement in novel signal transduction complexes, while in neuronal tissues, elevated SORBS2 levels have been linked to increased excitatory synaptic transmission and seizure activity—knockdown in the hippocampus reduces AMPA receptor subunit expression and delays the onset of spontaneous recurrent seizures. Furthermore, alternative splicing of the SORBS2 gene yields isoforms with distinct subcellular localizations (including in osteosarcoma cells), emphasizing the protein’s versatile modulatory roles in diverse cellular contexts."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jérôme D Robin, Andrew T Ludlow, Kimberly Batten, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SORBS2 transcription is activated by telomere position effect-over long distance upon telomere shortening in muscle cells from patients with facioscapulohumeral dystrophy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genome Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gr.190660.115"}], "href": "https://doi.org/10.1101/gr.190660.115"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26359233"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26359233"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yonghe Ding, Jingchun Yang, Peng Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockout of SORBS2 Protein Disrupts the Structural Integrity of Intercalated Disc and Manifests Features of Arrhythmogenic Cardiomyopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Heart Assoc (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/JAHA.119.017055"}], "href": "https://doi.org/10.1161/JAHA.119.017055"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32808564"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32808564"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Fei Liang, Bo Wang, Juan Geng, et al. "}, {"type": "b", "children": [{"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "SORBS2"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " is a genetic factor contributing to cardiac malformation of 4q deletion syndrome patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.67481"}], "href": "https://doi.org/10.7554/eLife.67481"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34099102"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34099102"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yuxin Tong, Yan Li, Hui Gu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HSF1, in association with MORC2, downregulates ArgBP2 via the PRC2 family in gastric cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Mol Basis Dis (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbadis.2018.01.011"}], "href": "https://doi.org/10.1016/j.bbadis.2018.01.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29339121"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29339121"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yuxin Tong, Yan Li, Hui Gu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Microchidia protein 2, MORC2, downregulates the cytoskeleton adapter protein, ArgBP2, via histone methylation in gastric cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2015.10.059"}], "href": "https://doi.org/10.1016/j.bbrc.2015.10.059"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26476214"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26476214"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Qi Lv, Fan Dong, Yong Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNA-binding protein SORBS2 suppresses clear cell renal cell carcinoma metastasis by enhancing MTUS1 mRNA stability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-020-03268-1"}], "href": "https://doi.org/10.1038/s41419-020-03268-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33311452"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33311452"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Melanie Liesenfeld, Sandy Mosig, Harald Funke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SORBS2 and TLR3 induce premature senescence in primary human fibroblasts and keratinocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-13-507"}], "href": "https://doi.org/10.1186/1471-2407-13-507"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24165198"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24165198"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Julie Roignot, Thomas Bonacci, Eric Ghigo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oligomerization and phosphorylation dependent regulation of ArgBP2 adaptive capabilities and associated functions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0087130"}], "href": "https://doi.org/10.1371/journal.pone.0087130"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24475245"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24475245"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Beibei Wang, Xin Fan, Lingang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The RNA-binding protein sorbin and SH3 domain-containing 2 are transcriptionally regulated by specificity protein 1 and function as tumor suppressors in bladder cancer by stabilizing tissue factor pathway inhibitor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Carcinog (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mc.23717"}], "href": "https://doi.org/10.1002/mc.23717"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38501385"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38501385"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Annalisa Lamberti, Carmen Sanges, Angela Chambery, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochimie (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biochi.2011.06.006"}], "href": "https://doi.org/10.1016/j.biochi.2011.06.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21689717"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21689717"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Karin Fredriksson-Lidman, Christina M Van Itallie, Amber J Tietgens, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sorbin and SH3 domain-containing protein 2 (SORBS2) is a component of the acto-myosin ring at the apical junctional complex in epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0185448"}], "href": "https://doi.org/10.1371/journal.pone.0185448"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28961272"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28961272"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Damon Hand, Lee E Eiden "}, {"type": "b", "children": [{"type": "t", "text": "Human sorbin is generated via splicing of an alternative transcript from the ArgBP2 gene locus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Peptides (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.peptides.2005.01.016"}], "href": "https://doi.org/10.1016/j.peptides.2005.01.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15949647"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15949647"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Tao Shen, Yan Li, Li-qing Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Expression and localization of ArgBP2 in osteosarcoma MG-63 cells]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi (2012)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22394629"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22394629"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Yuenan Ban, Xiaolan Yang, Dandan Tan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sorbs2 regulates seizure activity by influencing AMPAR-mediated excitatory synaptic transmission in temporal lobe epilepsy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurochem Int (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuint.2024.105727"}], "href": "https://doi.org/10.1016/j.neuint.2024.105727"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38555055"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38555055"}]}]}]}
Synonyms	ARGBP2, PRO0618
Proteins	SRBS2_HUMAN
NCBI Gene ID	8470
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SORBS2 has 8,247 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 127 datasets.

Click the + buttons to view associations for SORBS2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SORBS2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SORBS2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SORBS2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SORBS2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SORBS2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SORBS2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SORBS2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SORBS2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SORBS2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SORBS2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SORBS2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SORBS2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with SORBS2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SORBS2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SORBS2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SORBS2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SORBS2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of SORBS2 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SORBS2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SORBS2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SORBS2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing SORBS2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing SORBS2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SORBS2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SORBS2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing SORBS2 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SORBS2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SORBS2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with SORBS2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with SORBS2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with SORBS2 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SORBS2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with SORBS2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with SORBS2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SORBS2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SORBS2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SORBS2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SORBS2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SORBS2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SORBS2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SORBS2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.